FI115908B - Uusi, hyvin selektiivinen menetelmä enantiomeeripuhtaiden fenyylillä substituoitujen 1,4-dihydropyridiini-3,5-dikarboksyylihappojohdannaisten valmistamiseksi - Google Patents

Uusi, hyvin selektiivinen menetelmä enantiomeeripuhtaiden fenyylillä substituoitujen 1,4-dihydropyridiini-3,5-dikarboksyylihappojohdannaisten valmistamiseksi Download PDF

Info

Publication number
FI115908B
FI115908B FI955825A FI955825A FI115908B FI 115908 B FI115908 B FI 115908B FI 955825 A FI955825 A FI 955825A FI 955825 A FI955825 A FI 955825A FI 115908 B FI115908 B FI 115908B
Authority
FI
Finland
Prior art keywords
general formula
enantiomerically pure
carbon atoms
formula
phenyl
Prior art date
Application number
FI955825A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI955825A (fi
FI955825A0 (fi
Inventor
Bodo Junge
Peter Fey
Rudolf Schohe-Loop
Joachim Mittendorf
Heinrich Meier
Johannes Kaulen
Laak Kai Van
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of FI955825A0 publication Critical patent/FI955825A0/fi
Publication of FI955825A publication Critical patent/FI955825A/fi
Application granted granted Critical
Publication of FI115908B publication Critical patent/FI115908B/fi

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36Oxygen or sulfur atoms
    • C07D207/402,5-Pyrrolidine-diones
    • C07D207/4162,5-Pyrrolidine-diones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D249/00Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/081,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
FI955825A 1994-12-05 1995-12-04 Uusi, hyvin selektiivinen menetelmä enantiomeeripuhtaiden fenyylillä substituoitujen 1,4-dihydropyridiini-3,5-dikarboksyylihappojohdannaisten valmistamiseksi FI115908B (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4443168A DE4443168A1 (de) 1994-12-05 1994-12-05 Neues hochselektives Verfahren zur Herstellung von enantiomerenreinen phenylsubstituierten 1,4-Dihydropyridin-3,5-dicarbonsäurederivaten
DE4443168 1994-12-05

Publications (3)

Publication Number Publication Date
FI955825A0 FI955825A0 (fi) 1995-12-04
FI955825A FI955825A (fi) 1996-06-06
FI115908B true FI115908B (fi) 2005-08-15

Family

ID=6534908

Family Applications (1)

Application Number Title Priority Date Filing Date
FI955825A FI115908B (fi) 1994-12-05 1995-12-04 Uusi, hyvin selektiivinen menetelmä enantiomeeripuhtaiden fenyylillä substituoitujen 1,4-dihydropyridiini-3,5-dikarboksyylihappojohdannaisten valmistamiseksi

Country Status (27)

Country Link
US (4) US5700948A (pl)
EP (2) EP0716081B1 (pl)
JP (1) JP3891500B2 (pl)
KR (1) KR100396011B1 (pl)
CN (5) CN1079793C (pl)
AT (1) ATE322482T1 (pl)
AU (1) AU702274B2 (pl)
CA (1) CA2164276C (pl)
CZ (1) CZ296438B6 (pl)
DE (2) DE4443168A1 (pl)
DK (1) DK0716081T3 (pl)
ES (1) ES2262138T3 (pl)
FI (1) FI115908B (pl)
HU (1) HU214683B (pl)
IL (1) IL116225A (pl)
MX (1) MX9504954A (pl)
MY (1) MY112938A (pl)
NO (1) NO312832B1 (pl)
NZ (1) NZ280578A (pl)
PL (1) PL183604B1 (pl)
PT (1) PT716081E (pl)
RU (1) RU2155752C2 (pl)
SG (1) SG73352A1 (pl)
SI (1) SI0716081T1 (pl)
SK (1) SK282428B6 (pl)
TW (1) TW310324B (pl)
ZA (1) ZA9510263B (pl)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102533154B1 (ko) 2022-09-22 2023-05-17 임태형 안전계단 난간대

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3932646A (en) * 1971-04-10 1976-01-13 Farbenfabriken Bayer Ag Pharmaceutical compositions containing unsymmetrical esters of 1,4-dihydropyridine 3,5-dicarboxylate
JPS6058239B2 (ja) * 1978-07-20 1985-12-19 山之内製薬株式会社 新規セフアロスポリン誘導体
DE2911029C2 (de) * 1979-03-21 1985-03-14 Kombi-Lift Montage- Und Handelsgesellschaft Mbh, 5650 Solingen Vorrichtung zum Haltern der Führungsrollen für die Lastseile eines Fassadenseilaufzuges in einem oben am Gebäude fest angeordneten Gehäuse
GR850872B (pl) * 1984-04-16 1985-11-25 Yamanouchi Pharma Co Ltd
US4539302A (en) * 1984-04-30 1985-09-03 E. I. Du Pont De Nemours And Company Recovery of zerovalent nickel complexes
DE3423105A1 (de) * 1984-06-22 1986-01-02 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung optisch aktiver 1,4-dihydropyridine

Also Published As

Publication number Publication date
SG73352A1 (en) 2000-06-20
PT716081E (pt) 2006-08-31
PL311539A1 (en) 1996-06-10
US5910593A (en) 1999-06-08
JP3891500B2 (ja) 2007-03-14
EP1443043A2 (de) 2004-08-04
HU9503438D0 (en) 1996-01-29
HUT74292A (en) 1996-11-28
MY112938A (en) 2001-10-31
DE4443168A1 (de) 1996-06-13
NZ280578A (en) 1996-10-28
CN1216054C (zh) 2005-08-24
HU214683B (hu) 1998-04-28
AU702274B2 (en) 1999-02-18
CZ296438B6 (cs) 2006-03-15
US5700948A (en) 1997-12-23
DK0716081T3 (da) 2006-08-07
CA2164276A1 (en) 1996-06-06
CN1269358A (zh) 2000-10-11
NO954885D0 (no) 1995-12-01
NO312832B1 (no) 2002-07-08
IL116225A0 (en) 1996-03-31
CA2164276C (en) 2007-04-10
ATE322482T1 (de) 2006-04-15
NO954885L (no) 1996-06-06
ES2262138T3 (es) 2006-11-16
CN1269362A (zh) 2000-10-11
SK282428B6 (sk) 2002-01-07
RU2155752C2 (ru) 2000-09-10
EP1443043A3 (de) 2005-02-02
SK152695A3 (en) 1996-06-05
KR100396011B1 (ko) 2003-11-10
USRE36607E (en) 2000-03-07
CN1269357A (zh) 2000-10-11
KR960022463A (ko) 1996-07-18
CN1079793C (zh) 2002-02-27
CN1094926C (zh) 2002-11-27
PL183604B1 (pl) 2002-06-28
US5849924A (en) 1998-12-15
EP0716081A1 (de) 1996-06-12
ZA9510263B (en) 1996-06-12
CN1131664A (zh) 1996-09-25
FI955825A (fi) 1996-06-06
TW310324B (pl) 1997-07-11
JPH08225529A (ja) 1996-09-03
CZ320595A3 (en) 1996-06-12
AU3915095A (en) 1996-06-13
FI955825A0 (fi) 1995-12-04
CN1269359A (zh) 2000-10-11
MX9504954A (es) 1997-01-31
CN1105102C (zh) 2003-04-09
IL116225A (en) 2000-06-29
DE59511043D1 (de) 2006-05-18
EP0716081B1 (de) 2006-04-05
SI0716081T1 (sl) 2006-06-30
CN1094486C (zh) 2002-11-20

Similar Documents

Publication Publication Date Title
EP1125924B1 (en) Intermediate for the synthesis of amlodipine, preparation process and corresponding utilization
EP1831166B1 (en) Optical resolution method of amlodipine
RU2287527C2 (ru) Соединения, используемые при получении производных камптотецина
FI115908B (fi) Uusi, hyvin selektiivinen menetelmä enantiomeeripuhtaiden fenyylillä substituoitujen 1,4-dihydropyridiini-3,5-dikarboksyylihappojohdannaisten valmistamiseksi
JP5017101B2 (ja) 不斉四置換炭素原子含有化合物の製法
FI83641B (fi) Foerfarande foer framstaellning av 2(n-bensyl-n-metylamino)-etylmetyl-2,6-dimetyl-4-(m-nitrofenyl) -1,4-dihydropyridin-3,5-dikarboxylat och dess hydrokloridsalt.
US20080009617A1 (en) 3-(4-piperidinyl)-2,3,4,5-tetrahydro-1,3-benzodiazepin-2(1h)-on
CA2536608C (en) New highly selective process for the preparation of enantiomerically pure phenyl-substituted 1,4-dihydropyridine-3,5-dicarboxylic acid derivatives
JP3241741B2 (ja) 「3−(7−アミジノ−2−ナフチル)−2−フェニルプロピオン酸誘導体の製造方法」
FI94242B (fi) Menetelmä heterosyklisten johdannaisten valmistamiseksi
KR100354806B1 (ko) 암로디핀 베실레이트의 신규 중간체 및 그의 제조방법
EP0949247B1 (en) Process for the preparation of piperidinylidene derivatives
US6342607B1 (en) 3-phenyl-2, 6-dioxopiperidin-3-yl propionamide derivatives and method for preparing same
JPH072774A (ja) ジヒドロピリジン誘導体、その製造法、該誘導体を含有する医薬組成物および高血圧症の治療薬の製造を目的とする該誘導体の使用方法
JPH07196612A (ja) 1,4−ジヒドロピリジン誘導体及びそれを用いる1,4−ジヒドロピリジンカルボン酸誘導体の製造方法
MXPA01004227A (es) Procedimiento para la preparacion de 4-((2'-5'-diamino-6'-halopirimidin- 4'-il)amino)- ciclopent-2- enilmetanoles
JPH0160466B2 (pl)

Legal Events

Date Code Title Description
FG Patent granted

Ref document number: 115908

Country of ref document: FI

PC Transfer of assignment of patent

Owner name: BAYER SCHERING PHARMA AKTIENGESELLSCHAFT

Free format text: BAYER SCHERING PHARMA AKTIENGESELLSCHAFT

PC Transfer of assignment of patent

Owner name: BAYER SCHERING PHARMA AKTIENGESELLSCHAFT

Free format text: BAYER SCHERING PHARMA AKTIENGESELLSCHAFT

MM Patent lapsed