SK16372002A3 - Zolpidem hemitartrát - Google Patents

Zolpidem hemitartrát Download PDF

Info

Publication number: SK16372002A3
Authority: SK; Slovakia
Prior art keywords: zolpidem hemitartrate; zolpidem; hemitartrate; preparing; microns
Prior art date: 2000-04-24

Application number

SK1637-2002A

Other languages

English (en)

Slovak (sk)

Inventor

Judith Aronhime

Ben-Zion Dolitzky

Marco Kordova

David Leonov

Erzebet Meszaros-Sos

Szaboles Salyi

Anchel Schwartz

Csaba Szabo

Shlomo Zavurov

Original Assignee

Teva Pharmaceutical Industries Ltd.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-04-24

Filing date

2001-04-24

Publication date

2003-04-01

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27394001&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SK16372002(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2001-04-24 Application filed by Teva Pharmaceutical Industries Ltd. filed Critical Teva Pharmaceutical Industries Ltd.

2003-04-01 Publication of SK16372002A3 publication Critical patent/SK16372002A3/sk

Links

VXRDAMSNTXUHFX-CEAXSRTFSA-N zolpidem tartrate Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O.N1=C2C=CC(C)=CN2C(CC(=O)N(C)C)=C1C1=CC=C(C)C=C1.N1=C2C=CC(C)=CN2C(CC(=O)N(C)C)=C1C1=CC=C(C)C=C1 VXRDAMSNTXUHFX-CEAXSRTFSA-N 0.000 title claims abstract description 437
238000002360 preparation method Methods 0.000 claims abstract description 41
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 143
238000000034 method Methods 0.000 claims description 66
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 61
ZAFYATHCZYHLPB-UHFFFAOYSA-N zolpidem Chemical compound N1=C2C=CC(C)=CN2C(CC(=O)N(C)C)=C1C1=CC=C(C)C=C1 ZAFYATHCZYHLPB-UHFFFAOYSA-N 0.000 claims description 59
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 56
YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims description 54
238000004519 manufacturing process Methods 0.000 claims description 46
229960001475 zolpidem Drugs 0.000 claims description 46
239000002245 particle Substances 0.000 claims description 43
239000007787 solid Substances 0.000 claims description 42
KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 38
XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 34
239000002002 slurry Substances 0.000 claims description 30
239000000843 powder Substances 0.000 claims description 29
JHGHLTNIQXXXNV-UHFFFAOYSA-N 2-[6-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridin-3-yl]acetic acid Chemical compound C1=CC(C)=CC=C1C1=C(CC(O)=O)N2C=C(C)C=CC2=N1 JHGHLTNIQXXXNV-UHFFFAOYSA-N 0.000 claims description 24
ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims description 24
239000002904 solvent Substances 0.000 claims description 23
ROSDSFDQCJNGOL-UHFFFAOYSA-N Dimethylamine Chemical compound CNC ROSDSFDQCJNGOL-UHFFFAOYSA-N 0.000 claims description 20
239000008194 pharmaceutical composition Substances 0.000 claims description 20
LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims description 17
208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 claims description 16
206010022437 insomnia Diseases 0.000 claims description 16
FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 claims description 16
230000008569 process Effects 0.000 claims description 15
238000000634 powder X-ray diffraction Methods 0.000 claims description 12
239000012453 solvate Substances 0.000 claims description 12
239000003937 drug carrier Substances 0.000 claims description 11
-1 zolpidic acid halide Chemical class 0.000 claims description 11
238000006243 chemical reaction Methods 0.000 claims description 9
238000002425 crystallisation Methods 0.000 claims description 9
230000008025 crystallization Effects 0.000 claims description 9
238000010438 heat treatment Methods 0.000 claims description 9
NGNBDVOYPDDBFK-UHFFFAOYSA-N 2-[2,4-di(pentan-2-yl)phenoxy]acetyl chloride Chemical compound CCCC(C)C1=CC=C(OCC(Cl)=O)C(C(C)CCC)=C1 NGNBDVOYPDDBFK-UHFFFAOYSA-N 0.000 claims description 8
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 8
238000005660 chlorination reaction Methods 0.000 claims description 6
150000004683 dihydrates Chemical class 0.000 claims description 6
230000000694 effects Effects 0.000 claims description 5
150000004685 tetrahydrates Chemical class 0.000 claims description 5
NBTOZLQBSIZIKS-UHFFFAOYSA-N methoxide Chemical compound [O-]C NBTOZLQBSIZIKS-UHFFFAOYSA-N 0.000 claims description 4
230000007704 transition Effects 0.000 claims description 3
238000004140 cleaning Methods 0.000 claims description 2
239000011877 solvent mixture Substances 0.000 claims description 2
239000012429 reaction media Substances 0.000 claims 3
239000006184 cosolvent Substances 0.000 claims 2
239000012046 mixed solvent Substances 0.000 claims 2
DYKCZVHJLMDZEP-UHFFFAOYSA-N 2,3-dihydroxybutanedioic acid tetrahydrate Chemical compound O.O.O.O.OC(=O)C(O)C(O)C(O)=O DYKCZVHJLMDZEP-UHFFFAOYSA-N 0.000 claims 1
JRHCWUHRAPRBOO-UHFFFAOYSA-N 2,3-dihydroxybutanedioic acid;propan-2-one Chemical compound CC(C)=O.CC(C)=O.OC(=O)C(O)C(O)C(O)=O JRHCWUHRAPRBOO-UHFFFAOYSA-N 0.000 claims 1
VISZEEGRTIEHAO-UHFFFAOYSA-N C(C)(=O)OCC.C(C(O)C(O)C(=O)O)(=O)O.C(C)OC(C)=O Chemical compound C(C)(=O)OCC.C(C(O)C(O)C(=O)O)(=O)O.C(C)OC(C)=O VISZEEGRTIEHAO-UHFFFAOYSA-N 0.000 claims 1
QQPOCXHZISEODZ-UHFFFAOYSA-N C(C)(C)O.C(C(O)C(O)C(=O)O)(=O)O.C(C)(C)O Chemical compound C(C)(C)O.C(C(O)C(O)C(=O)O)(=O)O.C(C)(C)O QQPOCXHZISEODZ-UHFFFAOYSA-N 0.000 claims 1
VDGOTZAKEQIVOP-UHFFFAOYSA-N C(CCC)O.C(C(O)C(O)C(=O)O)(=O)O.C(CCC)O Chemical compound C(CCC)O.C(C(O)C(O)C(=O)O)(=O)O.C(CCC)O VDGOTZAKEQIVOP-UHFFFAOYSA-N 0.000 claims 1
150000001805 chlorine compounds Chemical group 0.000 claims 1
150000004820 halides Chemical class 0.000 claims 1
239000006163 transport media Substances 0.000 claims 1
238000002411 thermogravimetry Methods 0.000 description 25
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238000002844 melting Methods 0.000 description 7
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238000000113 differential scanning calorimetry Methods 0.000 description 6
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238000002441 X-ray diffraction Methods 0.000 description 5
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238000003795 desorption Methods 0.000 description 5
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108010010803 Gelatin Proteins 0.000 description 4
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239000003085 diluting agent Substances 0.000 description 4
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235000019322 gelatine Nutrition 0.000 description 4
235000011852 gelatine desserts Nutrition 0.000 description 4
239000000463 material Substances 0.000 description 4
150000004682 monohydrates Chemical class 0.000 description 4
150000003839 salts Chemical class 0.000 description 4
238000003786 synthesis reaction Methods 0.000 description 4
150000004684 trihydrates Chemical class 0.000 description 4
VXRDAMSNTXUHFX-UHFFFAOYSA-N 2,3-dihydroxybutanedioic acid;n,n-dimethyl-2-[6-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridin-3-yl]acetamide Chemical compound OC(=O)C(O)C(O)C(O)=O.N1=C2C=CC(C)=CN2C(CC(=O)N(C)C)=C1C1=CC=C(C)C=C1.N1=C2C=CC(C)=CN2C(CC(=O)N(C)C)=C1C1=CC=C(C)C=C1 VXRDAMSNTXUHFX-UHFFFAOYSA-N 0.000 description 3
229920002472 Starch Polymers 0.000 description 3
239000002253 acid Substances 0.000 description 3
229940094070 ambien Drugs 0.000 description 3
239000002775 capsule Substances 0.000 description 3
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238000001704 evaporation Methods 0.000 description 3
239000007789 gas Substances 0.000 description 3
210000001035 gastrointestinal tract Anatomy 0.000 description 3
238000004128 high performance liquid chromatography Methods 0.000 description 3
229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 3
HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Substances [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 3
238000002156 mixing Methods 0.000 description 3
VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 3
239000012071 phase Substances 0.000 description 3
239000008107 starch Substances 0.000 description 3
229940032147 starch Drugs 0.000 description 3
235000019698 starch Nutrition 0.000 description 3
FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 2
239000001358 L(+)-tartaric acid Substances 0.000 description 2
235000011002 L(+)-tartaric acid Nutrition 0.000 description 2
FEWJPZIEWOKRBE-LWMBPPNESA-N L-(+)-Tartaric acid Natural products OC(=O)[C@@H](O)[C@H](O)C(O)=O FEWJPZIEWOKRBE-LWMBPPNESA-N 0.000 description 2
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
229920000168 Microcrystalline cellulose Polymers 0.000 description 2
FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 2
GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 2
230000009471 action Effects 0.000 description 2
150000001338 aliphatic hydrocarbons Chemical class 0.000 description 2
238000004458 analytical method Methods 0.000 description 2
239000007864 aqueous solution Substances 0.000 description 2
150000004945 aromatic hydrocarbons Chemical class 0.000 description 2
238000002144 chemical decomposition reaction Methods 0.000 description 2
239000007810 chemical reaction solvent Substances 0.000 description 2
239000011248 coating agent Substances 0.000 description 2
238000000576 coating method Methods 0.000 description 2
239000012043 crude product Substances 0.000 description 2
238000004807 desolvation Methods 0.000 description 2
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150000004677 hydrates Chemical class 0.000 description 2
239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 2
235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 2
UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 2
239000012535 impurity Substances 0.000 description 2
239000008101 lactose Substances 0.000 description 2
235000019359 magnesium stearate Nutrition 0.000 description 2
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125000000896 monocarboxylic acid group Chemical group 0.000 description 2
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SCVFZCLFOSHCOH-UHFFFAOYSA-M potassium acetate Chemical compound [K+].CC([O-])=O SCVFZCLFOSHCOH-UHFFFAOYSA-M 0.000 description 2
BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 2
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ONDPHDOFVYQSGI-UHFFFAOYSA-N zinc nitrate Chemical compound [Zn+2].[O-][N+]([O-])=O.[O-][N+]([O-])=O ONDPHDOFVYQSGI-UHFFFAOYSA-N 0.000 description 2
ONBWNNUYXGJKKD-UHFFFAOYSA-N 1,4-bis(2-ethylhexoxy)-1,4-dioxobutane-2-sulfonic acid;sodium Chemical compound [Na].CCCCC(CC)COC(=O)CC(S(O)(=O)=O)C(=O)OCC(CC)CCCC ONBWNNUYXGJKKD-UHFFFAOYSA-N 0.000 description 1
IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
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GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 1
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NDLPOXTZKUMGOV-UHFFFAOYSA-N oxo(oxoferriooxy)iron hydrate Chemical compound O.O=[Fe]O[Fe]=O NDLPOXTZKUMGOV-UHFFFAOYSA-N 0.000 description 1
239000001814 pectin Substances 0.000 description 1
235000010987 pectin Nutrition 0.000 description 1
229920001277 pectin Polymers 0.000 description 1
239000000825 pharmaceutical preparation Substances 0.000 description 1
230000000144 pharmacologic effect Effects 0.000 description 1
239000003444 phase transfer catalyst Substances 0.000 description 1
RLOWWWKZYUNIDI-UHFFFAOYSA-N phosphinic chloride Chemical compound ClP=O RLOWWWKZYUNIDI-UHFFFAOYSA-N 0.000 description 1
239000006187 pill Substances 0.000 description 1
239000004014 plasticizer Substances 0.000 description 1
229920000058 polyacrylate Polymers 0.000 description 1
229920001223 polyethylene glycol Polymers 0.000 description 1
239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 1
235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
229940068968 polysorbate 80 Drugs 0.000 description 1
229920000053 polysorbate 80 Polymers 0.000 description 1
235000013809 polyvinylpolypyrrolidone Nutrition 0.000 description 1
229920000523 polyvinylpolypyrrolidone Polymers 0.000 description 1
235000011056 potassium acetate Nutrition 0.000 description 1
OTYBMLCTZGSZBG-UHFFFAOYSA-L potassium sulfate Chemical compound [K+].[K+].[O-]S([O-])(=O)=O OTYBMLCTZGSZBG-UHFFFAOYSA-L 0.000 description 1
229910052939 potassium sulfate Inorganic materials 0.000 description 1
235000011151 potassium sulphates Nutrition 0.000 description 1
229920003124 powdered cellulose Polymers 0.000 description 1
235000019814 powdered cellulose Nutrition 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
238000004445 quantitative analysis Methods 0.000 description 1
239000011347 resin Substances 0.000 description 1
229920005989 resin Polymers 0.000 description 1
238000012552 review Methods 0.000 description 1
235000010413 sodium alginate Nutrition 0.000 description 1
239000000661 sodium alginate Substances 0.000 description 1
229940005550 sodium alginate Drugs 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
229940045902 sodium stearyl fumarate Drugs 0.000 description 1
239000007790 solid phase Substances 0.000 description 1
238000007614 solvation Methods 0.000 description 1
239000000600 sorbitol Substances 0.000 description 1
238000004611 spectroscopical analysis Methods 0.000 description 1
238000003756 stirring Methods 0.000 description 1
238000000859 sublimation Methods 0.000 description 1
230000008022 sublimation Effects 0.000 description 1
150000008163 sugars Chemical class 0.000 description 1
239000003765 sweetening agent Substances 0.000 description 1
230000002194 synthesizing effect Effects 0.000 description 1
239000007916 tablet composition Substances 0.000 description 1
238000012360 testing method Methods 0.000 description 1
238000001757 thermogravimetry curve Methods 0.000 description 1
239000004408 titanium dioxide Substances 0.000 description 1
125000003944 tolyl group Chemical group 0.000 description 1
238000000844 transformation Methods 0.000 description 1
238000007039 two-step reaction Methods 0.000 description 1
238000005292 vacuum distillation Methods 0.000 description 1
229920002554 vinyl polymer Polymers 0.000 description 1
239000001993 wax Substances 0.000 description 1
238000005550 wet granulation Methods 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Epidemiology (AREA)
Anesthesiology (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Other Liquid Machine Or Engine Such As Wave Power Use (AREA)
Suspension Of Electric Lines Or Cables (AREA)
Amplifiers (AREA)
Supply Devices, Intensifiers, Converters, And Telemotors (AREA)

SK1637-2002A 2000-04-24 2001-04-24 Zolpidem hemitartrát SK16372002A3 (sk)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US19929800P	2000-04-24	2000-04-24
US20602500P	2000-05-22	2000-05-22
US22536400P	2000-08-14	2000-08-14
PCT/US2001/013175 WO2001080857A1 (en)	2000-04-24	2001-04-24	Zolpidem hemitartrate

Publications (1)

Publication Number	Publication Date
SK16372002A3 true SK16372002A3 (sk)	2003-04-01

Family

ID=27394001

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK1637-2002A SK16372002A3 (sk)	2000-04-24	2001-04-24	Zolpidem hemitartrát

Country Status (21)

Country	Link
US (8)	US20020077332A1 (sh)
EP (1)	EP1292304B1 (sh)
JP (3)	JP2003531173A (sh)
KR (1)	KR20030069796A (sh)
AT (4)	ATE335481T1 (sh)
AU (2)	AU5721301A (sh)
CA (1)	CA2406982A1 (sh)
CZ (1)	CZ20023775A3 (sh)
DE (7)	DE04010435T1 (sh)
DK (1)	DK1292304T3 (sh)
ES (4)	ES2239558T3 (sh)
HR (1)	HRP20020909A2 (sh)
HU (1)	HUP0300701A2 (sh)
IL (1)	IL152411A0 (sh)
NZ (1)	NZ522015A (sh)
PL (1)	PL358548A1 (sh)
PT (3)	PT1541146E (sh)
SE (1)	SE5292304T3 (sh)
SK (1)	SK16372002A3 (sh)
WO (1)	WO2001080857A1 (sh)
YU (1)	YU79402A (sh)

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US6869970B2 (en)	2002-02-04	2005-03-22	Novartis Ag	Crystalline salt forms of valsartan
JP2006516139A (ja)	2002-12-18	2006-06-22	マリンクロッド・インコーポレイテッド	ヘテロアリールアセトアミド化合物の合成
WO2004087703A1 (en) *	2003-03-12	2004-10-14	Sun Pharmaceutical Industries Limited	Process for the preparation of n,n,6-trimethyl-2-(4-methylphenyl)-imidazo[1,2-a]pyridine-3-acetamide
EP1660496A1 (en) *	2003-07-31	2006-05-31	Ranbaxy Laboratories Limited	Process for the synthesis of zolpidem
JP5179757B2 (ja) *	2004-02-17	2013-04-10	トランセプトファーマシューティカルズ，インコーポレイティド	口腔粘膜を介して催眠剤をデリバリーするための組成物及びその使用方法
WO2006008636A2 (en) *	2004-07-16	2006-01-26	Ranbaxy Laboratories Limited	Processes for the preparation of zolpidem and its hemitartrate
US20070225322A1 (en) *	2005-05-25	2007-09-27	Transoral Pharmaceuticals, Inc.	Compositions and methods for treating middle-of-the night insomnia
US20070287740A1 (en) *	2005-05-25	2007-12-13	Transcept Pharmaceuticals, Inc.	Compositions and methods of treating middle-of-the night insomnia
EP1883408A4 (en) *	2005-05-25	2009-11-11	Transcept Pharmaceuticals Inc	SOLID COMPOSITIONS AND METHODS FOR TREATMENT OF INSOMNIA IN THE NIGHT
AU2006283703A1 (en) *	2005-08-19	2007-03-01	Aventis Pharmaceuticals Inc.	Combination of a hypnotic agent and substituted bis aryl and heteroaryl compound and therapeutic application thereof
CA2617975A1 (en) *	2005-08-19	2007-03-01	Aventis Pharmaceuticals Inc.	Combination of a hypnotic agent and r(+)-alpha-(2,3-dimethoxy-phenyl)-1-[2-(4-fluorophenl)ethyl]-4-piperidinemethanol and therapeutic application thereof
EP1948655A1 (en) *	2005-10-03	2008-07-30	Mallinckrodt, Inc.	Process for preparing zolpidem hemitartrate and tartrate polymorphs
EP1948134A2 (en) *	2005-10-17	2008-07-30	Mallinckrodt, Inc.	Polymorph transformation of zolpidem in tablet matrix
US20070098788A1 (en) *	2005-10-28	2007-05-03	Gore Subhash P	Non-benzodiazepine hypnotic compositions
EA016264B1 (ru)	2006-03-31	2012-03-30	Янссен Фармацевтика Н.В.	Бензоимидазол-2-илпиримидины и пиразины в качестве модуляторов рецептора гистамина н
US20080132535A1 (en) *	2006-11-30	2008-06-05	Transcept Pharmaceuticals, Inc.	Stabilized Zolpidem Pharmaceutical Compositions
US20080145425A1 (en) *	2006-12-15	2008-06-19	Pliva Research & Development Limited	Pharmaceutical composition of zolpidem
US9371311B2 (en)	2008-06-30	2016-06-21	Janssen Pharmaceutica Nv	Benzoimidazol-2-yl pyrimidine derivatives
EP2303869A2 (en) *	2008-06-30	2011-04-06	Janssen Pharmaceutica, N.V.	Process for the preparation of benzoimidazol-2-yl pyrimidine derivatives
UA113491C2 (xx)	2009-11-27	2017-02-10		Аморфна та кристалічна форма гемітартрату genz 112638 як інгібітор глюкозилкерамідсинтази
WO2011115069A1 (ja) *	2010-03-19	2011-09-22	第一三共株式会社	結晶の網羅的探索
PL2964229T3 (pl) *	2013-03-06	2020-05-18	Janssen Pharmaceutica Nv	Benzoimidazol-2-ilo pirymidynowe modulatory receptora histaminowego H<sub>4</sub>

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FR2606410B1 (fr) *	1986-11-07	1989-02-24	Synthelabo	Imidazopyridines, leur preparation et leur application en therapeutique
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2001
- 2001-04-24 AT AT04010435T patent/ATE335481T1/de not_active IP Right Cessation
- 2001-04-24 JP JP2001577956A patent/JP2003531173A/ja not_active Withdrawn
- 2001-04-24 PL PL01358548A patent/PL358548A1/xx not_active Application Discontinuation
- 2001-04-24 DE DE04010435T patent/DE04010435T1/de active Pending
- 2001-04-24 DE DE20122435U patent/DE20122435U1/de not_active Expired - Lifetime
- 2001-04-24 AT AT05001922T patent/ATE348613T1/de not_active IP Right Cessation
- 2001-04-24 ES ES04010651T patent/ES2239558T3/es not_active Expired - Lifetime
- 2001-04-24 CA CA002406982A patent/CA2406982A1/en not_active Abandoned
- 2001-04-24 SE SE01930705T patent/SE5292304T3/xx unknown
- 2001-04-24 PT PT05001922T patent/PT1541146E/pt unknown
- 2001-04-24 YU YU79402A patent/YU79402A/sh unknown
- 2001-04-24 HU HU0300701A patent/HUP0300701A2/hu unknown
- 2001-04-24 DE DE60125429T patent/DE60125429T2/de not_active Expired - Fee Related
- 2001-04-24 ES ES04010435T patent/ES2238941T3/es not_active Expired - Lifetime
- 2001-04-24 DE DE04010651T patent/DE04010651T1/de active Pending
- 2001-04-24 CZ CZ20023775A patent/CZ20023775A3/cs unknown
- 2001-04-24 US US09/841,025 patent/US20020077332A1/en not_active Abandoned
- 2001-04-24 ES ES01930705T patent/ES2248321T3/es not_active Expired - Lifetime
- 2001-04-24 AT AT01930705T patent/ATE308324T1/de not_active IP Right Cessation
- 2001-04-24 PT PT04010435T patent/PT1473036E/pt unknown
- 2001-04-24 SK SK1637-2002A patent/SK16372002A3/sk not_active Application Discontinuation
- 2001-04-24 DE DE60114617T patent/DE60114617T2/de not_active Expired - Fee Related
- 2001-04-24 DK DK01930705T patent/DK1292304T3/da active
- 2001-04-24 AT AT04010651T patent/ATE338550T1/de not_active IP Right Cessation
- 2001-04-24 AU AU5721301A patent/AU5721301A/xx active Pending
- 2001-04-24 AU AU2001257213A patent/AU2001257213B2/en not_active Ceased
- 2001-04-24 WO PCT/US2001/013175 patent/WO2001080857A1/en active IP Right Grant
- 2001-04-24 ES ES05001922T patent/ES2277301T3/es not_active Expired - Lifetime
- 2001-04-24 IL IL15241101A patent/IL152411A0/xx unknown
- 2001-04-24 KR KR1020027014220A patent/KR20030069796A/ko not_active Application Discontinuation
- 2001-04-24 NZ NZ522015A patent/NZ522015A/en unknown
- 2001-04-24 PT PT04010651T patent/PT1475093E/pt unknown
- 2001-04-24 EP EP01930705A patent/EP1292304B1/en not_active Revoked
- 2001-04-24 DE DE60122944T patent/DE60122944T2/de not_active Expired - Fee Related
- 2001-04-24 DE DE60122216T patent/DE60122216T2/de not_active Expired - Fee Related
2002
- 2002-11-15 HR HR20020909A patent/HRP20020909A2/hr not_active Application Discontinuation
2004
- 2004-05-24 US US10/853,338 patent/US20040220212A1/en not_active Abandoned
- 2004-05-24 US US10/853,033 patent/US20040220211A1/en not_active Abandoned
- 2004-05-24 US US10/853,345 patent/US20040220213A1/en not_active Abandoned
- 2004-05-24 US US10/853,031 patent/US20040220210A1/en not_active Abandoned
- 2004-05-24 US US10/852,912 patent/US20040214858A1/en not_active Abandoned
- 2004-05-24 US US10/853,640 patent/US20040214859A1/en not_active Abandoned
2006
- 2006-02-09 JP JP2006033099A patent/JP2006137778A/ja active Pending
- 2006-06-27 JP JP2006177160A patent/JP2006249105A/ja active Pending
- 2006-10-25 US US11/588,122 patent/US20070037843A1/en not_active Abandoned

Also Published As

Publication number	Publication date
US20040220211A1 (en)	2004-11-04
DE60122944D1 (de)	2006-10-19
DE60122944T2 (de)	2007-04-12
EP1292304A1 (en)	2003-03-19
DE60122216T2 (de)	2007-08-30
US20070037843A1 (en)	2007-02-15
IL152411A0 (en)	2003-05-29
US20040214858A1 (en)	2004-10-28
PL358548A1 (en)	2004-08-09
DE60125429D1 (de)	2007-02-01
EP1292304A4 (en)	2003-07-23
KR20030069796A (ko)	2003-08-27
ES2277301T3 (es)	2007-07-01
HRP20020909A2 (en)	2004-08-31
DE20122435U1 (de)	2005-10-06
AU5721301A (en)	2001-11-07
YU79402A (sh)	2006-03-03
DE04010435T1 (de)	2005-09-01
CA2406982A1 (en)	2001-11-01
PT1475093E (pt)	2006-11-30
US20040220210A1 (en)	2004-11-04
ES2238941T3 (es)	2007-04-01
HUP0300701A2 (hu)	2003-07-28
DE60125429T2 (de)	2007-09-27
PT1541146E (pt)	2007-01-31
NZ522015A (en)	2004-08-27
ES2238941T1 (es)	2005-09-16
PT1473036E (pt)	2006-10-31
US20040220213A1 (en)	2004-11-04
EP1292304B1 (en)	2005-11-02
WO2001080857A1 (en)	2001-11-01
US20020077332A1 (en)	2002-06-20
US20040214859A1 (en)	2004-10-28
JP2006249105A (ja)	2006-09-21
SE5292304T3 (sh)	2005-11-02
ATE338550T1 (de)	2006-09-15
DE60122216D1 (de)	2006-09-21
DK1292304T3 (da)	2005-12-19
US20040220212A1 (en)	2004-11-04
DE04010651T1 (de)	2005-09-01
DE60114617T2 (de)	2006-07-27
ATE335481T1 (de)	2006-09-15
WO2001080857A9 (en)	2002-06-27
ATE308324T1 (de)	2005-11-15
DE60114617D1 (de)	2005-12-08
JP2006137778A (ja)	2006-06-01
ATE348613T1 (de)	2007-01-15
ES2248321T3 (es)	2006-03-16
AU2001257213B2 (en)	2005-09-29
JP2003531173A (ja)	2003-10-21
CZ20023775A3 (cs)	2003-10-15
ES2239558T1 (es)	2005-10-01
ES2239558T3 (es)	2007-04-01

Legal Events

Date	Code	Title	Description
2010-04-07	FC9A	Refused patent application

Publication	Publication Date	Title
US20070037843A1 (en)	2007-02-15	Zolpidem hemitartrate
AU2001257213A1 (en)	2002-01-24	Zolpidem hemitartrate
TWI826446B (zh)	2023-12-21	Tlr7/tlr8抑制劑之晶型
JP2018123154A (ja)	2018-08-09	イバブラジン塩酸塩の形態ｉｖ
JPH09221479A (ja)	1997-08-26	アミノベンゼンスルホン酸誘導体一水和物及びその製造方法
EP1473036B1 (en)	2006-08-09	Zolpidem hemitartrate solvate
ZA200208454B (en)	2003-10-20	Zolpidem hemitartrate.
RU2792005C2 (ru)	2023-03-15	Кристаллические формы ингибитора tlr7/tlr8
EP1674468A1 (en)	2006-06-28	Polymorphs of clopidogrel hydrobromide
WO2022224269A1 (en)	2022-10-27	Co-crystals, salts and solid forms of niraparib
US7977330B2 (en)	2011-07-12	Salts and crystal modifications thereof