SK10452003A3 - Príprava kyseliny D-pantoténovej a/alebo jej solí ako prísad do krmív - Google Patents

Príprava kyseliny D-pantoténovej a/alebo jej solí ako prísad do krmív Download PDF

Info

Publication number: SK10452003A3
Authority: SK; Slovakia
Prior art keywords: solution; pantothenic acid; pantothenate; calcium; weight
Prior art date: 2001-02-21

Application number

SK1045-2003A

Other languages

English (en)

Slovak (sk)

Inventor

Kai-Uwe Baldenius

Christine Beck

Andreas Fischer

Hans-Peter Harz

Markus Lohscheidt

Martin Leemann

Original Assignee

Basf Aktiengesellschaft

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-02-21

Filing date

2002-02-20

Publication date

2004-02-03

2002-02-20 Application filed by Basf Aktiengesellschaft filed Critical Basf Aktiengesellschaft

2004-02-03 Publication of SK10452003A3 publication Critical patent/SK10452003A3/sk

Links

GHOKWGTUZJEAQD-UHFFFAOYSA-N pantothenic acid Chemical compound OCC(C)(C)C(O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-UHFFFAOYSA-N 0.000 title claims abstract description 145
150000003839 salts Chemical class 0.000 title claims abstract description 30
238000004519 manufacturing process Methods 0.000 title abstract description 14
241001465754 Metazoa Species 0.000 title abstract description 4
239000000654 additive Substances 0.000 title abstract description 3
230000000996 additive effect Effects 0.000 title abstract 2
GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 claims description 135
238000000855 fermentation Methods 0.000 claims description 81
230000004151 fermentation Effects 0.000 claims description 81
238000000034 method Methods 0.000 claims description 66
UCMIRNVEIXFBKS-UHFFFAOYSA-N beta-alanine Chemical compound NCCC(O)=O UCMIRNVEIXFBKS-UHFFFAOYSA-N 0.000 claims description 65
235000019161 pantothenic acid Nutrition 0.000 claims description 61
239000011713 pantothenic acid Substances 0.000 claims description 61
229940055726 pantothenic acid Drugs 0.000 claims description 53
230000008569 process Effects 0.000 claims description 53
239000012528 membrane Substances 0.000 claims description 40
239000000203 mixture Substances 0.000 claims description 38
229940000635 beta-alanine Drugs 0.000 claims description 27
239000002253 acid Substances 0.000 claims description 24
239000011575 calcium Substances 0.000 claims description 22
150000001768 cations Chemical class 0.000 claims description 21
239000001963 growth medium Substances 0.000 claims description 19
150000002500 ions Chemical class 0.000 claims description 17
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 16
229910052791 calcium Inorganic materials 0.000 claims description 16
FAPWYRCQGJNNSJ-UBKPKTQASA-L calcium D-pantothenic acid Chemical compound [Ca+2].OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O.OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O FAPWYRCQGJNNSJ-UBKPKTQASA-L 0.000 claims description 16
238000002360 preparation method Methods 0.000 claims description 16
238000001035 drying Methods 0.000 claims description 15
ONSCBWDZUUNMMK-UBKPKTQASA-L magnesium;3-[[(2r)-2,4-dihydroxy-3,3-dimethylbutanoyl]amino]propanoate Chemical compound [Mg+2].OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O.OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O ONSCBWDZUUNMMK-UBKPKTQASA-L 0.000 claims description 14
241000193830 Bacillus <bacterium> Species 0.000 claims description 11
239000007900 aqueous suspension Substances 0.000 claims description 11
244000005700 microbiome Species 0.000 claims description 10
FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims description 9
230000015572 biosynthetic process Effects 0.000 claims description 9
229960002079 calcium pantothenate Drugs 0.000 claims description 9
239000011777 magnesium Substances 0.000 claims description 9
229910052749 magnesium Inorganic materials 0.000 claims description 9
VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 8
ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims description 7
AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 claims description 7
239000000920 calcium hydroxide Substances 0.000 claims description 7
229910001861 calcium hydroxide Inorganic materials 0.000 claims description 7
150000001793 charged compounds Chemical class 0.000 claims description 7
230000002074 deregulated effect Effects 0.000 claims description 7
230000005684 electric field Effects 0.000 claims description 7
239000011591 potassium Substances 0.000 claims description 7
GHOKWGTUZJEAQD-SSDOTTSWSA-N 3-[[(2s)-2,4-dihydroxy-3,3-dimethylbutanoyl]amino]propanoic acid Chemical class OCC(C)(C)[C@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-SSDOTTSWSA-N 0.000 claims description 6
KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims description 6
239000003674 animal food additive Substances 0.000 claims description 6
239000006052 feed supplement Substances 0.000 claims description 6
238000009472 formulation Methods 0.000 claims description 6
239000003014 ion exchange membrane Substances 0.000 claims description 6
239000000725 suspension Substances 0.000 claims description 6
QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims description 5
241000894006 Bacteria Species 0.000 claims description 5
AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims description 4
240000004808 Saccharomyces cerevisiae Species 0.000 claims description 4
KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims description 4
229910000019 calcium carbonate Inorganic materials 0.000 claims description 4
229960000310 isoleucine Drugs 0.000 claims description 4
AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims description 4
ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 claims description 4
239000001095 magnesium carbonate Substances 0.000 claims description 4
229910000021 magnesium carbonate Inorganic materials 0.000 claims description 4
VTHJTEIRLNZDEV-UHFFFAOYSA-L magnesium dihydroxide Chemical compound [OH-].[OH-].[Mg+2] VTHJTEIRLNZDEV-UHFFFAOYSA-L 0.000 claims description 4
239000000347 magnesium hydroxide Substances 0.000 claims description 4
229910001862 magnesium hydroxide Inorganic materials 0.000 claims description 4
238000006386 neutralization reaction Methods 0.000 claims description 4
238000012545 processing Methods 0.000 claims description 4
239000004474 valine Substances 0.000 claims description 4
241000233866 Fungi Species 0.000 claims description 3
241001112741 Bacillaceae Species 0.000 claims description 2
241000193744 Bacillus amyloliquefaciens Species 0.000 claims description 2
241000194108 Bacillus licheniformis Species 0.000 claims description 2
BRPQOXSCLDDYGP-UHFFFAOYSA-N calcium oxide Chemical compound [O-2].[Ca+2] BRPQOXSCLDDYGP-UHFFFAOYSA-N 0.000 claims description 2
239000000292 calcium oxide Substances 0.000 claims description 2
ODINCKMPIJJUCX-UHFFFAOYSA-N calcium oxide Inorganic materials [Ca]=O ODINCKMPIJJUCX-UHFFFAOYSA-N 0.000 claims description 2
229910001414 potassium ion Inorganic materials 0.000 claims description 2
229910001415 sodium ion Inorganic materials 0.000 claims description 2
239000000243 solution Substances 0.000 description 115
108090000623 proteins and genes Proteins 0.000 description 34
239000002609 medium Substances 0.000 description 31
235000014469 Bacillus subtilis Nutrition 0.000 description 30
244000063299 Bacillus subtilis Species 0.000 description 26
239000000047 product Substances 0.000 description 24
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 21
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 21
239000008103 glucose Substances 0.000 description 21
238000000909 electrodialysis Methods 0.000 description 19
QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 18
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 18
-1 alkaline earth metal salts Chemical class 0.000 description 15
210000004027 cell Anatomy 0.000 description 15
238000005341 cation exchange Methods 0.000 description 14
239000002585 base Substances 0.000 description 13
229940041514 candida albicans extract Drugs 0.000 description 13
230000000694 effects Effects 0.000 description 13
239000002243 precursor Substances 0.000 description 13
239000012266 salt solution Substances 0.000 description 13
239000011734 sodium Substances 0.000 description 13
239000012138 yeast extract Substances 0.000 description 13
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 12
239000012141 concentrate Substances 0.000 description 12
108090000790 Enzymes Proteins 0.000 description 11
102000004190 Enzymes Human genes 0.000 description 11
PXEDJBXQKAGXNJ-QTNFYWBSSA-L disodium L-glutamate Chemical compound [Na+].[Na+].[O-]C(=O)[C@@H](N)CCC([O-])=O PXEDJBXQKAGXNJ-QTNFYWBSSA-L 0.000 description 11
229940088598 enzyme Drugs 0.000 description 11
235000013923 monosodium glutamate Nutrition 0.000 description 11
229940073490 sodium glutamate Drugs 0.000 description 11
ZLHZLMOSPGACSZ-NSHDSACASA-N (6s)-2-nitro-6-[[4-(trifluoromethoxy)phenyl]methoxy]-6,7-dihydro-5h-imidazo[2,1-b][1,3]oxazine Chemical compound O([C@H]1CN2C=C(N=C2OC1)[N+](=O)[O-])CC1=CC=C(OC(F)(F)F)C=C1 ZLHZLMOSPGACSZ-NSHDSACASA-N 0.000 description 10
NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 10
239000000126 substance Substances 0.000 description 10
KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 9
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 9
QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 9
229910021529 ammonia Inorganic materials 0.000 description 9
229910052799 carbon Inorganic materials 0.000 description 9
230000001965 increasing effect Effects 0.000 description 9
101150076071 panD gene Proteins 0.000 description 9
239000007921 spray Substances 0.000 description 9
101150079396 trpC2 gene Proteins 0.000 description 9
UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 8
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 8
239000001110 calcium chloride Substances 0.000 description 8
229910001628 calcium chloride Inorganic materials 0.000 description 8
235000011148 calcium chloride Nutrition 0.000 description 8
239000012634 fragment Substances 0.000 description 8
239000007789 gas Substances 0.000 description 8
229940014662 pantothenate Drugs 0.000 description 8
238000000926 separation method Methods 0.000 description 8
239000003011 anion exchange membrane Substances 0.000 description 7
150000001450 anions Chemical class 0.000 description 7
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 7
101150051152 coaX gene Proteins 0.000 description 7
239000001301 oxygen Substances 0.000 description 7
229910052760 oxygen Inorganic materials 0.000 description 7
239000013612 plasmid Substances 0.000 description 7
230000001954 sterilising effect Effects 0.000 description 7
238000004659 sterilization and disinfection Methods 0.000 description 7
239000002028 Biomass Substances 0.000 description 6
TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 6
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
230000006696 biosynthetic metabolic pathway Effects 0.000 description 6
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
239000013530 defoamer Substances 0.000 description 6
238000001914 filtration Methods 0.000 description 6
229910052757 nitrogen Inorganic materials 0.000 description 6
101150081585 panB gene Proteins 0.000 description 6
101150028586 panE gene Proteins 0.000 description 6
239000001509 sodium citrate Substances 0.000 description 6
NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 6
238000001694 spray drying Methods 0.000 description 6
VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 5
241000588724 Escherichia coli Species 0.000 description 5
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 5
101100242684 Mesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099) panD1 gene Proteins 0.000 description 5
229910000147 aluminium phosphate Inorganic materials 0.000 description 5
BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 5
229910052921 ammonium sulfate Inorganic materials 0.000 description 5
235000011130 ammonium sulphate Nutrition 0.000 description 5
238000005119 centrifugation Methods 0.000 description 5
101150048956 coaA gene Proteins 0.000 description 5
239000000706 filtrate Substances 0.000 description 5
101150043028 ilvD gene Proteins 0.000 description 5
238000001802 infusion Methods 0.000 description 5
239000003550 marker Substances 0.000 description 5
230000002018 overexpression Effects 0.000 description 5
229910052700 potassium Inorganic materials 0.000 description 5
229910052708 sodium Inorganic materials 0.000 description 5
238000003786 synthesis reaction Methods 0.000 description 5
VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 4
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
235000011114 ammonium hydroxide Nutrition 0.000 description 4
230000008901 benefit Effects 0.000 description 4
239000007795 chemical reaction product Substances 0.000 description 4
101150109763 coaW gene Proteins 0.000 description 4
230000003831 deregulation Effects 0.000 description 4
238000012239 gene modification Methods 0.000 description 4
238000010353 genetic engineering Methods 0.000 description 4
230000005017 genetic modification Effects 0.000 description 4
235000013617 genetically modified food Nutrition 0.000 description 4
238000010438 heat treatment Methods 0.000 description 4
101150105723 ilvD1 gene Proteins 0.000 description 4
239000000463 material Substances 0.000 description 4
BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 4
239000003960 organic solvent Substances 0.000 description 4
239000000843 powder Substances 0.000 description 4
239000007787 solid Substances 0.000 description 4
238000003756 stirring Methods 0.000 description 4
101150061166 tetR gene Proteins 0.000 description 4
QHKABHOOEWYVLI-UHFFFAOYSA-N 3-methyl-2-oxobutanoic acid Chemical compound CC(C)C(=O)C(O)=O QHKABHOOEWYVLI-UHFFFAOYSA-N 0.000 description 3
NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonium chloride Substances [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 3
RGJOEKWQDUBAIZ-IBOSZNHHSA-N CoASH Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCS)O[C@H]1N1C2=NC=NC(N)=C2N=C1 RGJOEKWQDUBAIZ-IBOSZNHHSA-N 0.000 description 3
108020004414 DNA Proteins 0.000 description 3
CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 3
235000014680 Saccharomyces cerevisiae Nutrition 0.000 description 3
150000007513 acids Chemical class 0.000 description 3
238000004458 analytical method Methods 0.000 description 3
125000000129 anionic group Chemical group 0.000 description 3
239000007864 aqueous solution Substances 0.000 description 3
RGJOEKWQDUBAIZ-UHFFFAOYSA-N coenzime A Natural products OC1C(OP(O)(O)=O)C(COP(O)(=O)OP(O)(=O)OCC(C)(C)C(O)C(=O)NCCC(=O)NCCS)OC1N1C2=NC=NC(N)=C2N=C1 RGJOEKWQDUBAIZ-UHFFFAOYSA-N 0.000 description 3
239000005516 coenzyme A Substances 0.000 description 3
229940093530 coenzyme a Drugs 0.000 description 3
230000003247 decreasing effect Effects 0.000 description 3
KDTSHFARGAKYJN-UHFFFAOYSA-N dephosphocoenzyme A Natural products OC1C(O)C(COP(O)(=O)OP(O)(=O)OCC(C)(C)C(O)C(=O)NCCC(=O)NCCS)OC1N1C2=NC=NC(N)=C2N=C1 KDTSHFARGAKYJN-UHFFFAOYSA-N 0.000 description 3
238000005868 electrolysis reaction Methods 0.000 description 3
238000002474 experimental method Methods 0.000 description 3
239000012530 fluid Substances 0.000 description 3
238000005187 foaming Methods 0.000 description 3
230000014509 gene expression Effects 0.000 description 3
235000003869 genetically modified organism Nutrition 0.000 description 3
238000002744 homologous recombination Methods 0.000 description 3
230000006801 homologous recombination Effects 0.000 description 3
238000005342 ion exchange Methods 0.000 description 3
229910001629 magnesium chloride Inorganic materials 0.000 description 3
238000012986 modification Methods 0.000 description 3
230000004048 modification Effects 0.000 description 3
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 3
102000004169 proteins and genes Human genes 0.000 description 3
230000001105 regulatory effect Effects 0.000 description 3
239000004576 sand Substances 0.000 description 3
238000011146 sterile filtration Methods 0.000 description 3
235000000346 sugar Nutrition 0.000 description 3
229960004295 valine Drugs 0.000 description 3
229940088594 vitamin Drugs 0.000 description 3
229930003231 vitamin Natural products 0.000 description 3
235000013343 vitamin Nutrition 0.000 description 3
239000011782 vitamin Substances 0.000 description 3
HNZZAEBYPPNVOF-DHYYHALDSA-N (2s)-2-amino-3-methylbutanoic acid;(2s,3s)-2-amino-3-methylpentanoic acid Chemical compound CC(C)[C@H](N)C(O)=O.CC[C@H](C)[C@H](N)C(O)=O HNZZAEBYPPNVOF-DHYYHALDSA-N 0.000 description 2
SERHXTVXHNVDKA-BYPYZUCNSA-N (R)-pantolactone Chemical compound CC1(C)COC(=O)[C@@H]1O SERHXTVXHNVDKA-BYPYZUCNSA-N 0.000 description 2
OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 2
241000276408 Bacillus subtilis subsp. subtilis str. 168 Species 0.000 description 2
235000010469 Glycine max Nutrition 0.000 description 2
PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 description 2
108091028043 Nucleic acid sequence Proteins 0.000 description 2
229910019142 PO4 Inorganic materials 0.000 description 2
108010009736 Protein Hydrolysates Proteins 0.000 description 2
KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 2
QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 2
239000004098 Tetracycline Substances 0.000 description 2
QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 description 2
XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
239000001166 ammonium sulphate Substances 0.000 description 2
238000000889 atomisation Methods 0.000 description 2
239000000872 buffer Substances 0.000 description 2
239000007853 buffer solution Substances 0.000 description 2
KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 description 2
159000000007 calcium salts Chemical class 0.000 description 2
239000003610 charcoal Substances 0.000 description 2
239000003795 chemical substances by application Substances 0.000 description 2
WIIZWVCIJKGZOK-RKDXNWHRSA-N chloramphenicol Chemical compound ClC(Cl)C(=O)N[C@H](CO)[C@H](O)C1=CC=C([N+]([O-])=O)C=C1 WIIZWVCIJKGZOK-RKDXNWHRSA-N 0.000 description 2
229960005091 chloramphenicol Drugs 0.000 description 2
239000013611 chromosomal DNA Substances 0.000 description 2
238000010367 cloning Methods 0.000 description 2
230000009089 cytolysis Effects 0.000 description 2
230000006378 damage Effects 0.000 description 2
238000010908 decantation Methods 0.000 description 2
238000012217 deletion Methods 0.000 description 2
230000037430 deletion Effects 0.000 description 2
230000029087 digestion Effects 0.000 description 2
239000008394 flocculating agent Substances 0.000 description 2
235000013312 flour Nutrition 0.000 description 2
235000019253 formic acid Nutrition 0.000 description 2
238000005469 granulation Methods 0.000 description 2
230000003179 granulation Effects 0.000 description 2
XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 2
239000002054 inoculum Substances 0.000 description 2
239000007788 liquid Substances 0.000 description 2
159000000003 magnesium salts Chemical class 0.000 description 2
239000012533 medium component Substances 0.000 description 2
230000002503 metabolic effect Effects 0.000 description 2
230000037353 metabolic pathway Effects 0.000 description 2
238000002156 mixing Methods 0.000 description 2
238000002703 mutagenesis Methods 0.000 description 2
231100000350 mutagenesis Toxicity 0.000 description 2
235000021317 phosphate Nutrition 0.000 description 2
229910052698 phosphorus Inorganic materials 0.000 description 2
BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 2
239000003531 protein hydrolysate Substances 0.000 description 2
239000013049 sediment Substances 0.000 description 2
239000011780 sodium chloride Substances 0.000 description 2
239000007858 starting material Substances 0.000 description 2
239000001574 stearyl tartrate Substances 0.000 description 2
229960002180 tetracycline Drugs 0.000 description 2
229930101283 tetracycline Natural products 0.000 description 2
235000019364 tetracycline Nutrition 0.000 description 2
150000003522 tetracyclines Chemical class 0.000 description 2
230000001131 transforming effect Effects 0.000 description 2
230000009261 transgenic effect Effects 0.000 description 2
LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 description 2
239000002351 wastewater Substances 0.000 description 2
OTOIIPJYVQJATP-BYPYZUCNSA-N (R)-pantoic acid Chemical compound OCC(C)(C)[C@@H](O)C(O)=O OTOIIPJYVQJATP-BYPYZUCNSA-N 0.000 description 1
108010070495 2-dehydropantoate 2-reductase Proteins 0.000 description 1
QYNUQALWYRSVHF-ABLWVSNPSA-N 5,10-methylenetetrahydrofolic acid Chemical compound C1N2C=3C(=O)NC(N)=NC=3NCC2CN1C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 QYNUQALWYRSVHF-ABLWVSNPSA-N 0.000 description 1
QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
241000589291 Acinetobacter Species 0.000 description 1
241000004176 Alphacoronavirus Species 0.000 description 1
DHMQDGOQFOQNFH-UHFFFAOYSA-M Aminoacetate Chemical compound NCC([O-])=O DHMQDGOQFOQNFH-UHFFFAOYSA-M 0.000 description 1
108020000948 Antisense Oligonucleotides Proteins 0.000 description 1
241000186063 Arthrobacter Species 0.000 description 1
108010005694 Aspartate 4-decarboxylase Proteins 0.000 description 1
241000193752 Bacillus circulans Species 0.000 description 1
241000193749 Bacillus coagulans Species 0.000 description 1
241000193747 Bacillus firmus Species 0.000 description 1
241000193422 Bacillus lentus Species 0.000 description 1
241000194103 Bacillus pumilus Species 0.000 description 1
108700040634 Bacillus subtilis Vpr Proteins 0.000 description 1
241000193388 Bacillus thuringiensis Species 0.000 description 1
241000219310 Beta vulgaris subsp. vulgaris Species 0.000 description 1
241000149420 Bothrometopus brevis Species 0.000 description 1
241000186146 Brevibacterium Species 0.000 description 1
240000001817 Cereus hexagonus Species 0.000 description 1
241000819038 Chichester Species 0.000 description 1
108091026890 Coding region Proteins 0.000 description 1
229920002261 Corn starch Polymers 0.000 description 1
241000186031 Corynebacteriaceae Species 0.000 description 1
241000186216 Corynebacterium Species 0.000 description 1
241000186226 Corynebacterium glutamicum Species 0.000 description 1
239000001692 EU approved anti-caking agent Substances 0.000 description 1
241000196324 Embryophyta Species 0.000 description 1
241000588722 Escherichia Species 0.000 description 1
101100493587 Escherichia coli (strain K12) avtA gene Proteins 0.000 description 1
BDAGIHXWWSANSR-UHFFFAOYSA-M Formate Chemical compound [O-]C=O BDAGIHXWWSANSR-UHFFFAOYSA-M 0.000 description 1
108700039691 Genetic Promoter Regions Proteins 0.000 description 1
241000193385 Geobacillus stearothermophilus Species 0.000 description 1
244000068988 Glycine max Species 0.000 description 1
101100028493 Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) pan2 gene Proteins 0.000 description 1
239000007836 KH2PO4 Substances 0.000 description 1
241000588748 Klebsiella Species 0.000 description 1
QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 description 1
JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 1
102000016943 Muramidase Human genes 0.000 description 1
108010014251 Muramidase Proteins 0.000 description 1
108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 description 1
229910002651 NO3 Inorganic materials 0.000 description 1
229920000557 Nafion® Polymers 0.000 description 1
NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 1
241001310335 Paenibacillus lentimorbus Species 0.000 description 1
OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 description 1
241000588769 Proteus <enterobacteria> Species 0.000 description 1
241000589516 Pseudomonas Species 0.000 description 1
108010034634 Repressor Proteins Proteins 0.000 description 1
102000009661 Repressor Proteins Human genes 0.000 description 1
241000589180 Rhizobium Species 0.000 description 1
241000235070 Saccharomyces Species 0.000 description 1
240000000111 Saccharum officinarum Species 0.000 description 1
235000007201 Saccharum officinarum Nutrition 0.000 description 1
241000831652 Salinivibrio sharmensis Species 0.000 description 1
241000607142 Salmonella Species 0.000 description 1
PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
229920002472 Starch Polymers 0.000 description 1
101100125907 Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) ilvC1 gene Proteins 0.000 description 1
229930006000 Sucrose Natural products 0.000 description 1
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
235000021536 Sugar beet Nutrition 0.000 description 1
241000193396 Virgibacillus pantothenticus Species 0.000 description 1
101100056949 Wolinella succinogenes (strain ATCC 29543 / DSM 1740 / LMG 7466 / NCTC 11488 / FDC 602W) ansA gene Proteins 0.000 description 1
240000008042 Zea mays Species 0.000 description 1
235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
235000002017 Zea mays subsp mays Nutrition 0.000 description 1
238000004026 adhesive bonding Methods 0.000 description 1
229910052783 alkali metal Inorganic materials 0.000 description 1
150000001340 alkali metals Chemical class 0.000 description 1
229910052784 alkaline earth metal Inorganic materials 0.000 description 1
101150050280 alsD gene Proteins 0.000 description 1
150000001412 amines Chemical class 0.000 description 1
229940024606 amino acid Drugs 0.000 description 1
150000001413 amino acids Chemical class 0.000 description 1
239000000908 ammonium hydroxide Substances 0.000 description 1
150000003863 ammonium salts Chemical class 0.000 description 1
150000001449 anionic compounds Chemical class 0.000 description 1
101150082095 ansB gene Proteins 0.000 description 1
239000000074 antisense oligonucleotide Substances 0.000 description 1
238000012230 antisense oligonucleotides Methods 0.000 description 1
229940009098 aspartate Drugs 0.000 description 1
108010002447 aspartate-alpha-decarboxylase Proteins 0.000 description 1
JPNZKPRONVOMLL-UHFFFAOYSA-N azane;octadecanoic acid Chemical class [NH4+].CCCCCCCCCCCCCCCCCC([O-])=O JPNZKPRONVOMLL-UHFFFAOYSA-N 0.000 description 1
230000001580 bacterial effect Effects 0.000 description 1
238000010923 batch production Methods 0.000 description 1
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
238000010170 biological method Methods 0.000 description 1
238000013452 biotechnological production Methods 0.000 description 1
101150031021 birA gene Proteins 0.000 description 1
230000000903 blocking effect Effects 0.000 description 1
235000020299 breve Nutrition 0.000 description 1
FAPWYRCQGJNNSJ-CTWWJBIBSA-L calcium;3-[[(2s)-2,4-dihydroxy-3,3-dimethylbutanoyl]amino]propanoate Chemical compound [Ca+2].OCC(C)(C)[C@H](O)C(=O)NCCC([O-])=O.OCC(C)(C)[C@H](O)C(=O)NCCC([O-])=O FAPWYRCQGJNNSJ-CTWWJBIBSA-L 0.000 description 1
QRTVQUYKMVAQBJ-UHFFFAOYSA-L calcium;3-aminopropanoate Chemical compound [Ca+2].NCCC([O-])=O.NCCC([O-])=O QRTVQUYKMVAQBJ-UHFFFAOYSA-L 0.000 description 1
239000004202 carbamide Substances 0.000 description 1
210000000170 cell membrane Anatomy 0.000 description 1
230000001413 cellular effect Effects 0.000 description 1
230000002759 chromosomal effect Effects 0.000 description 1
239000013065 commercial product Substances 0.000 description 1
239000000306 component Substances 0.000 description 1
238000010276 construction Methods 0.000 description 1
238000010924 continuous production Methods 0.000 description 1
235000005822 corn Nutrition 0.000 description 1
239000008120 corn starch Substances 0.000 description 1
238000002425 crystallisation Methods 0.000 description 1
230000008025 crystallization Effects 0.000 description 1
230000007812 deficiency Effects 0.000 description 1
238000011161 development Methods 0.000 description 1
230000018109 developmental process Effects 0.000 description 1
238000000502 dialysis Methods 0.000 description 1
235000005911 diet Nutrition 0.000 description 1
230000037213 diet Effects 0.000 description 1
239000006185 dispersion Substances 0.000 description 1
238000010494 dissociation reaction Methods 0.000 description 1
230000005593 dissociations Effects 0.000 description 1
238000009826 distribution Methods 0.000 description 1
238000002036 drum drying Methods 0.000 description 1
SQNZJJAZBFDUTD-UHFFFAOYSA-N durene Chemical compound CC1=CC(C)=C(C)C=C1C SQNZJJAZBFDUTD-UHFFFAOYSA-N 0.000 description 1
239000003792 electrolyte Substances 0.000 description 1
230000008030 elimination Effects 0.000 description 1
238000003379 elimination reaction Methods 0.000 description 1
239000003623 enhancer Substances 0.000 description 1
230000009088 enzymatic function Effects 0.000 description 1
238000001704 evaporation Methods 0.000 description 1
230000008020 evaporation Effects 0.000 description 1
239000011552 falling film Substances 0.000 description 1
239000003925 fat Substances 0.000 description 1
230000009123 feedback regulation Effects 0.000 description 1
239000010419 fine particle Substances 0.000 description 1
238000011010 flushing procedure Methods 0.000 description 1
235000021588 free fatty acids Nutrition 0.000 description 1
108091006104 gene-regulatory proteins Proteins 0.000 description 1
102000034356 gene-regulatory proteins Human genes 0.000 description 1
239000011521 glass Substances 0.000 description 1
BHEPBYXIRTUNPN-UHFFFAOYSA-N hydridophosphorus(.) (triplet) Chemical compound [PH] BHEPBYXIRTUNPN-UHFFFAOYSA-N 0.000 description 1
101150033780 ilvB gene Proteins 0.000 description 1
101150090497 ilvC gene Proteins 0.000 description 1
101150099953 ilvE gene Proteins 0.000 description 1
101150077793 ilvH gene Proteins 0.000 description 1
101150060643 ilvN gene Proteins 0.000 description 1
230000001939 inductive effect Effects 0.000 description 1
238000011081 inoculation Methods 0.000 description 1
150000007529 inorganic bases Chemical class 0.000 description 1
229910052500 inorganic mineral Inorganic materials 0.000 description 1
230000002452 interceptive effect Effects 0.000 description 1
239000003456 ion exchange resin Substances 0.000 description 1
229920003303 ion-exchange polymer Polymers 0.000 description 1
238000002955 isolation Methods 0.000 description 1
229960000274 lysozyme Drugs 0.000 description 1
235000010335 lysozyme Nutrition 0.000 description 1
239000004325 lysozyme Substances 0.000 description 1
230000007246 mechanism Effects 0.000 description 1
238000013508 migration Methods 0.000 description 1
230000005012 migration Effects 0.000 description 1
235000010755 mineral Nutrition 0.000 description 1
239000011707 mineral Substances 0.000 description 1
235000013379 molasses Nutrition 0.000 description 1
229910000402 monopotassium phosphate Inorganic materials 0.000 description 1
235000019796 monopotassium phosphate Nutrition 0.000 description 1
230000035772 mutation Effects 0.000 description 1
230000003472 neutralizing effect Effects 0.000 description 1
229910052759 nickel Inorganic materials 0.000 description 1
229920001542 oligosaccharide Polymers 0.000 description 1
150000002482 oligosaccharides Chemical class 0.000 description 1
150000002891 organic anions Chemical class 0.000 description 1
150000007530 organic bases Chemical class 0.000 description 1
239000002245 particle Substances 0.000 description 1
238000009928 pasteurization Methods 0.000 description 1
239000010452 phosphate Substances 0.000 description 1
239000008363 phosphate buffer Substances 0.000 description 1
150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
239000011574 phosphorus Substances 0.000 description 1
229910052697 platinum Inorganic materials 0.000 description 1
GNSKLFRGEWLPPA-UHFFFAOYSA-M potassium dihydrogen phosphate Chemical compound [K+].OP(O)([O-])=O GNSKLFRGEWLPPA-UHFFFAOYSA-M 0.000 description 1
229910000160 potassium phosphate Inorganic materials 0.000 description 1
235000011009 potassium phosphates Nutrition 0.000 description 1
239000010970 precious metal Substances 0.000 description 1
230000001376 precipitating effect Effects 0.000 description 1
229940002612 prodrug Drugs 0.000 description 1
239000000651 prodrug Substances 0.000 description 1
238000011084 recovery Methods 0.000 description 1
230000008929 regeneration Effects 0.000 description 1
238000011069 regeneration method Methods 0.000 description 1
210000003705 ribosome Anatomy 0.000 description 1
238000012216 screening Methods 0.000 description 1
238000011218 seed culture Methods 0.000 description 1
150000004760 silicates Chemical class 0.000 description 1
229910052938 sodium sulfate Inorganic materials 0.000 description 1
235000011152 sodium sulphate Nutrition 0.000 description 1
239000011343 solid material Substances 0.000 description 1
239000002904 solvent Substances 0.000 description 1
UNFWWIHTNXNPBV-WXKVUWSESA-N spectinomycin Chemical compound O([C@@H]1[C@@H](NC)[C@@H](O)[C@H]([C@@H]([C@H]1O1)O)NC)[C@]2(O)[C@H]1O[C@H](C)CC2=O UNFWWIHTNXNPBV-WXKVUWSESA-N 0.000 description 1
229960000268 spectinomycin Drugs 0.000 description 1
229910001220 stainless steel Inorganic materials 0.000 description 1
239000010935 stainless steel Substances 0.000 description 1
239000008107 starch Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
150000008163 sugars Chemical class 0.000 description 1
239000006228 supernatant Substances 0.000 description 1
208000024891 symptom Diseases 0.000 description 1
239000010409 thin film Substances 0.000 description 1
239000011573 trace mineral Substances 0.000 description 1
235000013619 trace mineral Nutrition 0.000 description 1
238000013518 transcription Methods 0.000 description 1
230000035897 transcription Effects 0.000 description 1
108091006106 transcriptional activators Proteins 0.000 description 1
238000010361 transduction Methods 0.000 description 1
230000026683 transduction Effects 0.000 description 1
238000012546 transfer Methods 0.000 description 1
230000009466 transformation Effects 0.000 description 1
238000013519 translation Methods 0.000 description 1
238000011144 upstream manufacturing Methods 0.000 description 1
150000003722 vitamin derivatives Chemical class 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/10—Animal feeding-stuffs obtained by microbiological or biochemical processes
- A23K10/12—Animal feeding-stuffs obtained by microbiological or biochemical processes by fermentation of natural products, e.g. of vegetable material, animal waste material or biomass
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/174—Vitamins

Landscapes

Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Organic Chemistry (AREA)
Polymers & Plastics (AREA)
Biotechnology (AREA)
Wood Science & Technology (AREA)
Health & Medical Sciences (AREA)
Biochemistry (AREA)
Microbiology (AREA)
Food Science & Technology (AREA)
Animal Husbandry (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Genetics & Genomics (AREA)
General Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Biomedical Technology (AREA)
Sustainable Development (AREA)
Physiology (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Fodder In General (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

SK1045-2003A 2001-02-21 2002-02-20 Príprava kyseliny D-pantoténovej a/alebo jej solí ako prísad do krmív SK10452003A3 (sk)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE10108223A DE10108223A1 (de)	2001-02-21	2001-02-21	Verfahren zur Herstellung von D-Pantothensäure und/oder deren Salze als Zusatz zu Tierfuttermitteln
PCT/EP2002/001766 WO2002066666A2 (de)	2001-02-21	2002-02-20	Verfahren zur herstellung von d-pantothensäure und/oder deren salze als zusatz zu tierfuttermitteln

Publications (1)

Publication Number	Publication Date
SK10452003A3 true SK10452003A3 (sk)	2004-02-03

Family

ID=7674921

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK1045-2003A SK10452003A3 (sk)	2001-02-21	2002-02-20	Príprava kyseliny D-pantoténovej a/alebo jej solí ako prísad do krmív

Country Status (23)

Country	Link
US (1)	US7824891B2 (et)
EP (1)	EP1362118B1 (et)
JP (1)	JP2004531236A (et)
KR (1)	KR20030075204A (et)
CN (1)	CN1294273C (et)
AT (1)	ATE342372T1 (et)
AU (1)	AU2002250978B2 (et)
BR (1)	BR0207474A (et)
CA (1)	CA2438949A1 (et)
CZ (1)	CZ20032223A3 (et)
DE (2)	DE10108223A1 (et)
EE (1)	EE200300406A (et)
ES (1)	ES2274967T3 (et)
HU (1)	HUP0303304A3 (et)
IL (1)	IL157496A0 (et)
IN (1)	IN2003CH01315A (et)
MX (1)	MX240870B (et)
NO (1)	NO20033707L (et)
PL (1)	PL363989A1 (et)
RU (1)	RU2292397C2 (et)
SK (1)	SK10452003A3 (et)
UA (1)	UA77669C2 (et)
WO (1)	WO2002066666A2 (et)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE10108225A1 (de)	2001-02-21	2002-10-10	Basf Ag	Verfahren zur Herstellung von D-Pantothensäure und/oder deren Salze als Zusatz zu Tierfuttermitteln
DE10344200A1 (de) *	2003-09-22	2005-05-04	Basf Ag	Verfahren zur Herstellung eines D-Pantothensäure und/oder deren Salze enthaltendes Tierfuttersupplement
DE202017007249U1 (de) *	2016-03-07	2020-04-23	Glycom A/S	Abtrennung von Oligosacchariden aus der Fermentationsbrühe
WO2019058377A1 (en) *	2017-09-19	2019-03-28	Evogene Ltd.	BACTERIAL GENES AND ISOLATES FOR CONFINING INSECT RESISTANCE
CN111621541A (zh) *	2019-02-27	2020-09-04	上海艾美晶生物科技有限公司	使用电渗析技术拆分光学异构体的方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB562267A (en)	1941-08-08	1944-06-26	Hoffmann La Roche	Process for the manufacture of a crystallised, non-hygroscopic calcium salt of d-pantothenic acid
EP0493060A3 (en) *	1990-12-25	1993-04-14	Takeda Chemical Industries, Ltd.	Production method of d-pantothenic acid and plasmids and microorganisms thereof
JP3710497B2 (ja) *	1992-09-25	2005-10-26	ビーエーエスエフアクチェンゲゼルシャフト	Ｄ−パント酸、ｄ−パントテン酸およびそれらの塩の製造法
PT822989E (pt) *	1995-04-21	2001-07-31	Basf Ag	Processo para a producao de d-pantotenato de calcio
SK284235B6 (en)	1997-10-04	2004-11-03	Forschungszentrum Juelich Gmbh	Method for microbial production of amino acids of the aspartate and/or glutamate family and agents which can be used in the said method
AT407050B (de)	1997-12-29	2000-11-27	Chemie Linz Gmbh	Verfahren zur herstellung von l-asparaginsäure
US6110342A (en) *	1998-07-21	2000-08-29	Archer Daniels Midland Company	Process for production of amino acid hydrochloride and caustic via electrodialysis water splitting
DE19855313A1 (de)	1998-12-01	2000-06-08	Degussa	Verfahren zur fermentativen Herstellung von D-Pantothensäure durch Verstärkung des panD-Gens in Mikroorganismen
DK1050219T3 (da)	1999-05-05	2003-03-17	Degussa	Foderstofadditiver indeholdende D-pantothensyre og/eller salte deraf og fremgangsmåder til fremstilling deraf
AU7708700A (en)	1999-09-21	2001-04-24	Basf Aktiengesellschaft	Methods and microorganisms for production of panto-compounds
US8232081B2 (en) *	1999-09-21	2012-07-31	Basf Se	Methods and microorganisms for production of panto-compounds
FR2799754A1 (fr) *	1999-10-18	2001-04-20	Roquette Freres	Procede de separation et de purification d'acide lactique a partir d'un milieu de fermentation
DE10021515A1 (de) *	2000-05-03	2001-11-08	Degussa	Verfahren zur Herstellung von Erdalkalisalzen der D-Pantothensäure
CA2422817A1 (en)	2000-09-20	2003-03-19	Basf Aktiengesellschaft	Animal feed supplement containing d-pantothenic acid and/or its salts, improved method for the production thereof, and its use
PL373006A1 (en)	2001-01-19	2005-08-08	Basf Aktiengesellschaft	Processes for enhanced production of pantothenate
HU227432B1 (hu)	2001-01-19	2011-06-28	Basf Ag	Mikroorganizmusok és eljárások pantotenát fokozott termelésére

2001
- 2001-02-21 DE DE10108223A patent/DE10108223A1/de not_active Withdrawn
2002
- 2002-02-20 AU AU2002250978A patent/AU2002250978B2/en not_active Ceased
- 2002-02-20 IL IL15749602A patent/IL157496A0/xx unknown
- 2002-02-20 CA CA002438949A patent/CA2438949A1/en not_active Abandoned
- 2002-02-20 EP EP02719874A patent/EP1362118B1/de not_active Expired - Lifetime
- 2002-02-20 HU HU0303304A patent/HUP0303304A3/hu unknown
- 2002-02-20 WO PCT/EP2002/001766 patent/WO2002066666A2/de active IP Right Grant
- 2002-02-20 KR KR20037010981A patent/KR20030075204A/ko not_active Application Discontinuation
- 2002-02-20 US US10/468,610 patent/US7824891B2/en not_active Expired - Fee Related
- 2002-02-20 CN CNB028053303A patent/CN1294273C/zh not_active Expired - Fee Related
- 2002-02-20 SK SK1045-2003A patent/SK10452003A3/sk not_active Application Discontinuation
- 2002-02-20 BR BR0207474-5A patent/BR0207474A/pt not_active IP Right Cessation
- 2002-02-20 ES ES02719874T patent/ES2274967T3/es not_active Expired - Lifetime
- 2002-02-20 UA UA2003098597A patent/UA77669C2/uk unknown
- 2002-02-20 EE EEP200300406A patent/EE200300406A/et unknown
- 2002-02-20 DE DE50208413T patent/DE50208413D1/de not_active Expired - Lifetime
- 2002-02-20 PL PL02363989A patent/PL363989A1/xx not_active Application Discontinuation
- 2002-02-20 RU RU2003128534/13A patent/RU2292397C2/ru not_active IP Right Cessation
- 2002-02-20 CZ CZ20032223A patent/CZ20032223A3/cs unknown
- 2002-02-20 AT AT02719874T patent/ATE342372T1/de not_active IP Right Cessation
- 2002-02-20 JP JP2002566370A patent/JP2004531236A/ja active Pending
- 2002-02-20 MX MXPA03007383 patent/MX240870B/es active IP Right Grant
2003
- 2003-08-20 NO NO20033707A patent/NO20033707L/no not_active Application Discontinuation
- 2003-08-21 IN IN1315CH2003 patent/IN2003CH01315A/xx unknown

Also Published As

Publication number	Publication date
CN1492935A (zh)	2004-04-28
NO20033707D0 (no)	2003-08-20
DE10108223A1 (de)	2002-10-10
JP2004531236A (ja)	2004-10-14
RU2292397C2 (ru)	2007-01-27
CZ20032223A3 (cs)	2003-11-12
CA2438949A1 (en)	2002-08-29
IN2003CH01315A (en)	2005-11-25
MXPA03007383A (es)	2004-03-16
US7824891B2 (en)	2010-11-02
NO20033707L (no)	2003-10-20
ATE342372T1 (de)	2006-11-15
EP1362118A2 (de)	2003-11-19
HUP0303304A2 (hu)	2004-01-28
HUP0303304A3 (en)	2007-09-28
IL157496A0 (en)	2004-03-28
CN1294273C (zh)	2007-01-10
US20040072306A1 (en)	2004-04-15
UA77669C2 (en)	2007-01-15
RU2003128534A (ru)	2005-04-10
DE50208413D1 (de)	2006-11-23
WO2002066666A2 (de)	2002-08-29
EP1362118B1 (de)	2006-10-11
ES2274967T3 (es)	2007-06-01
KR20030075204A (ko)	2003-09-22
BR0207474A (pt)	2004-03-02
MX240870B (es)	2006-10-09
PL363989A1 (en)	2004-11-29
AU2002250978B2 (en)	2007-03-01
WO2002066666A3 (de)	2003-07-17
EE200300406A (et)	2003-12-15

Legal Events

Date	Code	Title	Description
2010-12-07	FC9A	Refused patent application

Publication	Publication Date	Title
US7824891B2 (en)	2010-11-02	Method for producing D-pantothenic acid and/or salts thereof via purification by electrodialysis as an additive for animal feed
KR20030038751A (ko)	2003-05-16	Ｄ-판토텐산 또는 그의 염을 포함하는 동물 사료 보충물,그의 개선된 제조 방법 및 그의 용도
US7781192B2 (en)	2010-08-24	Method for producing D-pantothenic acid and/or a salt thereof via purification by cation exchange as additive for animal food
SK10432003A3 (sk)	2004-02-03	Príprava kyseliny D-pantoténovej a/alebo jej solí ako prísad do krmív
US7727748B2 (en)	2010-06-01	Method for producing D-pantothenic acid and/or salts thereof via purification by anion exchange as an additive for animal feed
JP2004529632A (ja)	2004-09-30	パントテン酸塩の改良された製造方法