SI3438116T1 - Označeni nukleotidi - Google Patents

Označeni nukleotidi

Info

Publication number
SI3438116T1
SI3438116T1 SI200332618T SI200332618T SI3438116T1 SI 3438116 T1 SI3438116 T1 SI 3438116T1 SI 200332618 T SI200332618 T SI 200332618T SI 200332618 T SI200332618 T SI 200332618T SI 3438116 T1 SI3438116 T1 SI 3438116T1
Authority
SI
Slovenia
Prior art keywords
labelled nucleotides
labelled
nucleotides
nucleoside
linker
Prior art date
Application number
SI200332618T
Other languages
English (en)
Inventor
John Milton
Silke Ruediger
Xiaohai Liu
Original Assignee
Illumina Cambridge Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=31946334&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SI3438116(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US10/227,131 external-priority patent/US7057026B2/en
Application filed by Illumina Cambridge Limited filed Critical Illumina Cambridge Limited
Publication of SI3438116T1 publication Critical patent/SI3438116T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
SI200332618T 2002-08-23 2003-08-22 Označeni nukleotidi SI3438116T1 (sl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/227,131 US7057026B2 (en) 2001-12-04 2002-08-23 Labelled nucleotides
EP18195197.1A EP3438116B1 (en) 2002-08-23 2003-08-22 Labelled nucleotides

Publications (1)

Publication Number Publication Date
SI3438116T1 true SI3438116T1 (sl) 2021-07-30

Family

ID=31946334

Family Applications (3)

Application Number Title Priority Date Filing Date
SI200332583T SI3147292T1 (sl) 2002-08-23 2003-08-22 Označeni nukleotidi
SI200332500A SI2119722T1 (sl) 2002-08-23 2003-08-22 Označeni nukleotidi
SI200332618T SI3438116T1 (sl) 2002-08-23 2003-08-22 Označeni nukleotidi

Family Applications Before (2)

Application Number Title Priority Date Filing Date
SI200332583T SI3147292T1 (sl) 2002-08-23 2003-08-22 Označeni nukleotidi
SI200332500A SI2119722T1 (sl) 2002-08-23 2003-08-22 Označeni nukleotidi

Country Status (12)

Country Link
EP (5) EP1560838B1 (sl)
AT (1) ATE431354T1 (sl)
AU (1) AU2003259352A1 (sl)
CY (3) CY1118471T1 (sl)
DE (1) DE60327649D1 (sl)
DK (4) DK3438116T3 (sl)
ES (4) ES2326077T3 (sl)
GB (1) GB2395953A (sl)
HU (2) HUE032483T2 (sl)
PT (3) PT3147292T (sl)
SI (3) SI3147292T1 (sl)
WO (1) WO2004018493A1 (sl)

Families Citing this family (104)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9708358B2 (en) 2000-10-06 2017-07-18 The Trustees Of Columbia University In The City Of New York Massive parallel method for decoding DNA and RNA
WO2002029003A2 (en) 2000-10-06 2002-04-11 The Trustees Of Columbia University In The City Of New York Massive parallel method for decoding dna and rna
GB0129012D0 (en) 2001-12-04 2002-01-23 Solexa Ltd Labelled nucleotides
US11008359B2 (en) 2002-08-23 2021-05-18 Illumina Cambridge Limited Labelled nucleotides
US7414116B2 (en) 2002-08-23 2008-08-19 Illumina Cambridge Limited Labelled nucleotides
EP1560838B1 (en) 2002-08-23 2009-05-13 Illumina Cambridge Limited Labelled nucleotides
EP3795577A1 (en) 2002-08-23 2021-03-24 Illumina Cambridge Limited Modified nucleotides
US8637650B2 (en) 2003-11-05 2014-01-28 Genovoxx Gmbh Macromolecular nucleotide compounds and methods for using the same
WO2005084367A2 (en) 2004-03-03 2005-09-15 The Trustees Of Columbia University In The City Of New York Photocleavable fluorescent nucleotides for dna sequencing on chip constructed by site-specific coupling chemistry
WO2006064199A1 (en) * 2004-12-13 2006-06-22 Solexa Limited Improved method of nucleotide detection
GB0427236D0 (en) * 2004-12-13 2005-01-12 Solexa Ltd Improved method of nucleotide detection
GB0509508D0 (en) * 2005-05-10 2005-06-15 Solexa Ltd Improved polymerases
WO2007002204A2 (en) 2005-06-21 2007-01-04 The Trustees Of Columbia University In The City Of New York Pyrosequencing methods and related compostions
GB0514936D0 (en) 2005-07-20 2005-08-24 Solexa Ltd Preparation of templates for nucleic acid sequencing
GB0517097D0 (en) 2005-08-19 2005-09-28 Solexa Ltd Modified nucleosides and nucleotides and uses thereof
GB2446084B (en) 2005-10-31 2011-03-02 Univ Columbia Synthesis of four color 3-o-allyl modified photocleavable fluorescent nucleotides and related methods
US8796432B2 (en) 2005-10-31 2014-08-05 The Trustees Of Columbia University In The City Of New York Chemically cleavable 3'-o-allyl-DNTP-allyl-fluorophore fluorescent nucleotide analogues and related methods
EP3373174A1 (en) 2006-03-31 2018-09-12 Illumina, Inc. Systems and devices for sequence by synthesis analysis
WO2007114693A2 (en) 2006-04-04 2007-10-11 Keygene N.V. High throughput detection of molecular markers based on aflp and high throughput sequencing
US8178360B2 (en) 2006-05-18 2012-05-15 Illumina Cambridge Limited Dye compounds and the use of their labelled conjugates
US8921073B2 (en) 2006-06-23 2014-12-30 Illumina, Inc. Devices and systems for creation of DNA cluster arrays
EP2038425B1 (en) 2006-07-12 2010-09-15 Keygene N.V. High throughput physical mapping using aflp
WO2008042067A2 (en) 2006-09-28 2008-04-10 Illumina, Inc. Compositions and methods for nucleotide sequencing
US7754429B2 (en) 2006-10-06 2010-07-13 Illumina Cambridge Limited Method for pair-wise sequencing a plurity of target polynucleotides
US8568979B2 (en) 2006-10-10 2013-10-29 Illumina, Inc. Compositions and methods for representational selection of nucleic acids from complex mixtures using hybridization
GB2457402B (en) 2006-12-01 2011-10-19 Univ Columbia Four-color DNA sequencing by synthesis using cleavable fluorescent nucleotide reversible terminators
BRPI0719923B1 (pt) 2006-12-05 2021-08-17 Agilent Technologies Inc Métodos para sequenciamento de um ácido nucléico alvo, para conversão de um componente de ocorrência não natural em uma molécula de ácido nucléico em um componente de ocorrência natural, para terminar uma síntese de ácido nucléico, e para realizar o sequenciamento de sanger ou tipo sanger, e compostos
US11940413B2 (en) 2007-02-05 2024-03-26 IsoPlexis Corporation Methods and devices for sequencing nucleic acids in smaller batches
US11035823B2 (en) 2009-03-17 2021-06-15 Qiagen Sciences, Llc Methods and devices for sequencing nucleic acids in smaller batches
US8481259B2 (en) 2007-02-05 2013-07-09 Intelligent Bio-Systems, Inc. Methods and devices for sequencing nucleic acids in smaller batches
US7678894B2 (en) * 2007-05-18 2010-03-16 Helicos Biosciences Corporation Nucleotide analogs
US9163053B2 (en) 2007-05-18 2015-10-20 Fluidigm Corporation Nucleotide analogs
US9115163B2 (en) 2007-10-19 2015-08-25 The Trustees Of Columbia University In The City Of New York DNA sequence with non-fluorescent nucleotide reversible terminators and cleavable label modified nucleotide terminators
EP4310194A2 (en) * 2007-10-19 2024-01-24 The Trustees of Columbia University in the City of New York Design and synthesis of cleavable fluorescent nucleotides as reversible terminators for dna sequencing by synthesis
US8617811B2 (en) 2008-01-28 2013-12-31 Complete Genomics, Inc. Methods and compositions for efficient base calling in sequencing reactions
DK2268834T3 (en) 2008-03-17 2015-02-02 Stichting Genetwister Ip EXPRESSION-CONNECTED GENDISCOVERY
CN102124018A (zh) 2008-04-29 2011-07-13 生命科技公司 可维持从核苷酸模板酶促合成双链核苷酸的非天然聚合酶底物及其使用的方法
KR101677772B1 (ko) 2008-06-11 2016-11-18 레이저젠, 인코퍼레이티드 뉴클레오타이드 및 뉴클레오사이드 그리고 시퀀싱에서의 이들의 이용 방법
ES2403312T3 (es) 2009-01-13 2013-05-17 Keygene N.V. Nuevas estrategias para la secuenciación del genoma
US9315860B2 (en) 2009-10-26 2016-04-19 Genovoxx Gmbh Conjugates of nucleotides and method for the application thereof
US20120070829A1 (en) 2010-09-10 2012-03-22 Bio-Rad Laboratories, Inc. Size selection of dna for chromatin analysis
CA2825815C (en) 2011-01-31 2017-09-05 Illumina, Inc. Methods for reducing nucleic acid damage
EP2702171A1 (de) 2011-04-27 2014-03-05 Cherkasov, Dmitry Methoden und komponenten zur detektion von nukleinsäureketten
US20150086981A1 (en) 2011-05-04 2015-03-26 Genovoxx Gmbh Nucleoside-triphosphate conjugate and methods for the use thereof
WO2012162429A2 (en) 2011-05-23 2012-11-29 The Trustees Of Columbia University In The City Of New York Dna sequencing by synthesis using raman and infrared spectroscopy detection
WO2013009175A1 (en) 2011-07-08 2013-01-17 Keygene N.V. Sequence based genotyping based on oligonucleotide ligation assays
EP3670523B1 (en) 2011-09-13 2021-08-11 Agilent Technologies, Inc. 3'-oh unblocked, fast photocleavable terminating nucleotides and their use in methods for nucleic acid sequencing
HRP20211523T1 (hr) * 2011-09-23 2021-12-24 Illumina, Inc. Pripravci za sekvenciranje nukleinske kiseline
US8754244B1 (en) 2013-03-08 2014-06-17 Illumina Cambridge Limited Rhodamine compounds and their use as fluorescent labels
AU2013380645B2 (en) 2013-03-08 2018-03-15 Illumina Cambridge Ltd Polymethine compounds and their use as fluorescent labels
CA2902992C (en) 2013-03-08 2020-08-25 Illumina Cambridge Ltd Rhodamine compounds and their use as fluorescent labels
US9873913B2 (en) 2013-03-08 2018-01-23 Roche Molecular Systems, Inc. Mutation testing
US9146248B2 (en) 2013-03-14 2015-09-29 Intelligent Bio-Systems, Inc. Apparatus and methods for purging flow cells in nucleic acid sequencing instruments
US9591268B2 (en) 2013-03-15 2017-03-07 Qiagen Waltham, Inc. Flow cell alignment methods and systems
US10648026B2 (en) 2013-03-15 2020-05-12 The Trustees Of Columbia University In The City Of New York Raman cluster tagged molecules for biological imaging
KR101874680B1 (ko) 2013-03-15 2018-07-04 일루미나 케임브리지 리미티드 변형된 뉴클레오사이드 또는 뉴클레오타이드
WO2015015913A1 (ja) 2013-07-31 2015-02-05 株式会社 日立ハイテクノロジーズ 核酸分析用フローセル、及び核酸分析装置
CN103667469A (zh) * 2013-11-29 2014-03-26 武汉科技大学 一种基于万能碱基的dna测序方法
US10537889B2 (en) 2013-12-31 2020-01-21 Illumina, Inc. Addressable flow cell using patterned electrodes
GB201408077D0 (en) 2014-05-07 2014-06-18 Illumina Cambridge Ltd Polymethine compounds and their use as fluorescent labels
GB201414098D0 (en) 2014-08-08 2014-09-24 Illumina Cambridge Ltd Modified nucleotide linkers
WO2016065248A1 (en) 2014-10-23 2016-04-28 Complete Genomics, Inc. Signal confinement sequencing (scs) and nucleotide analogues for signal confinement sequencing
GB201508858D0 (en) 2015-05-22 2015-07-01 Illumina Cambridge Ltd Polymethine compounds with long stokes shifts and their use as fluorescent labels
GB201516987D0 (en) 2015-09-25 2015-11-11 Illumina Cambridge Ltd Polymethine compounds and their use as fluorescent labels
US10465232B1 (en) 2015-10-08 2019-11-05 Trace Genomics, Inc. Methods for quantifying efficiency of nucleic acid extraction and detection
EP3363898B1 (en) 2015-10-13 2022-11-30 Japan Agency for Marine-Earth Science and Technology Double-stranded rna fragmentation method and use thereof
WO2017185026A1 (en) * 2016-04-22 2017-10-26 Complete Genomics, Inc. Reversibly blocked nucleoside analogues and their use
US10385214B2 (en) 2016-09-30 2019-08-20 Illumina Cambridge Limited Fluorescent dyes and their uses as biomarkers
KR102512190B1 (ko) 2016-12-22 2023-03-21 일루미나 케임브리지 리미티드 쿠마린 화합물 및 형광 표지로서의 이의 용도
GB2567124A (en) 2017-05-08 2019-04-10 Vysoka Akola Chemicko Tech V Praze Imaging agents and methods
US20210164008A1 (en) 2017-05-26 2021-06-03 Nuclera Nucleics Ltd. Use of Terminal Transferase Enzyme in Nucleic Acid Synthesis
WO2019023951A1 (zh) 2017-08-01 2019-02-07 深圳华大智造科技有限公司 核酸测序方法
GB201716931D0 (en) 2017-10-16 2017-11-29 Illumina Cambridge Ltd New fluorescent compounds and their use as biomarkers
US11293061B2 (en) 2018-12-26 2022-04-05 Illumina Cambridge Limited Sequencing methods using nucleotides with 3′ AOM blocking group
CA3103636A1 (en) 2019-03-01 2020-09-10 Illumina Cambridge Limited Tertiary amine substituted coumarin compounds and their uses as fluorescent labels
NL2023327B1 (en) 2019-03-01 2020-09-17 Illumina Inc Multiplexed fluorescent detection of analytes
WO2020178231A1 (en) 2019-03-01 2020-09-10 Illumina, Inc. Multiplexed fluorescent detection of analytes
EP3931263A1 (en) 2019-03-01 2022-01-05 Illumina Cambridge Limited Exocyclic amine substituted coumarin compounds and their uses as fluorescent labels
US11421271B2 (en) 2019-03-28 2022-08-23 Illumina Cambridge Limited Methods and compositions for nucleic acid sequencing using photoswitchable labels
KR20220107231A (ko) 2019-11-27 2022-08-02 일루미나 케임브리지 리미티드 사이클로옥타테트라엔 함유 염료 및 조성물
US11188778B1 (en) 2020-05-05 2021-11-30 Illumina, Inc. Equalization-based image processing and spatial crosstalk attenuator
US11787831B2 (en) 2020-06-22 2023-10-17 Illumina Cambridge Limited Nucleosides and nucleotides with 3′ acetal blocking group
JP2023539411A (ja) 2020-07-28 2023-09-14 イルミナ ケンブリッジ リミテッド 置換クマリン色素及び蛍光標識としての使用
EP4237581A1 (en) 2020-10-30 2023-09-06 Element Biosciences, Inc. Reagents for massively parallel nucleic acid sequencing
US20220195517A1 (en) 2020-12-17 2022-06-23 Illumina Cambridge Limited Long stokes shift chromenoquinoline dyes and uses in sequencing applications
US20220195516A1 (en) 2020-12-17 2022-06-23 Illumina Cambridge Limited Methods, systems and compositions for nucleic acid sequencing
US20220195196A1 (en) 2020-12-17 2022-06-23 Illumina Cambridge Limited Alkylpyridinium coumarin dyes and uses in sequencing applications
US20220195518A1 (en) 2020-12-22 2022-06-23 Illumina Cambridge Limited Methods and compositions for nucleic acid sequencing
CN117295751A (zh) 2021-05-05 2023-12-26 伊鲁米纳剑桥有限公司 含有双硼稠合杂环的荧光染料及其在测序中的用途
KR20240009435A (ko) 2021-05-20 2024-01-22 일루미나, 인코포레이티드 합성에 의한 시퀀싱을 위한 조성물 및 방법
CA3224382A1 (en) 2021-06-29 2023-01-05 Amirali Kia Self-learned base caller, trained using oligo sequences
US11455487B1 (en) 2021-10-26 2022-09-27 Illumina Software, Inc. Intensity extraction and crosstalk attenuation using interpolation and adaptation for base calling
WO2023003757A1 (en) 2021-07-19 2023-01-26 Illumina Software, Inc. Intensity extraction with interpolation and adaptation for base calling
AU2022319125A1 (en) 2021-07-28 2024-01-18 Illumina, Inc. Quality score calibration of basecalling systems
KR20240035413A (ko) 2021-08-03 2024-03-15 일루미나, 인코포레이티드 다중 염기 호출자 모델을 사용한 염기 호출
US20230047225A1 (en) 2021-08-14 2023-02-16 Illumina, Inc. Polymerases, compositions, and methods of use
WO2023186815A1 (en) 2022-03-28 2023-10-05 Illumina Cambridge Limited Labeled avidin and methods for sequencing
US20230313292A1 (en) 2022-03-29 2023-10-05 Illumina Cambridge Limited Chromenoquinoline dyes and uses in sequencing
CA3222797A1 (en) 2022-03-31 2023-10-05 Ramesh NEELAKANDAN Nucleosides and nucleotides with 3' vinyl blocking group
AU2023246851A1 (en) 2022-03-31 2024-01-18 Illumina, Inc. Compositions and methods for improving sequencing signals
US20230383342A1 (en) 2022-05-31 2023-11-30 Illumina Cambridge Limited Compositions and methods for nucleic acid sequencing
US20230416279A1 (en) 2022-06-28 2023-12-28 Illumina Cambridge Limited Fluorescent dyes containing fused tetracyclic bis-boron heterocycle and uses in sequencing
WO2024059852A1 (en) 2022-09-16 2024-03-21 Illumina, Inc. Cluster segmentation and conditional base calling
US20240140939A1 (en) 2022-09-30 2024-05-02 Illumina Cambridge Limited Compositions and methods for reducing photo damage during sequencing

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US227131A (en) 1880-05-04 Heney o
DE3906357A1 (de) 1989-03-01 1990-09-06 Boehringer Mannheim Gmbh Neue acyclische nucleosid-analoga, verfahren zu ihrer herstellung und verwendung dieser verbindungen als antivirale arzneimittel
US5547839A (en) 1989-06-07 1996-08-20 Affymax Technologies N.V. Sequencing of surface immobilized polymers utilizing microflourescence detection
US5302509A (en) 1989-08-14 1994-04-12 Beckman Instruments, Inc. Method for sequencing polynucleotides
EP0450060A1 (en) 1989-10-26 1991-10-09 Sri International Dna sequencing
WO1994024120A1 (en) 1993-04-13 1994-10-27 Naxcor Non-nucleosidic coumarin derivatives as polynucleotide-crosslinking agents
WO1996027025A1 (en) 1995-02-27 1996-09-06 Ely Michael Rabani Device, compounds, algorithms, and methods of molecular characterization and manipulation with molecular parallelism
US6485944B1 (en) 1997-10-10 2002-11-26 President And Fellows Of Harvard College Replica amplification of nucleic acid arrays
WO1999057321A1 (en) 1998-05-01 1999-11-11 Arizona Board Of Regents Method of determining the nucleotide sequence of oligonucleotides and dna molecules
JP2002521064A (ja) 1998-07-30 2002-07-16 ソレックサ リミテッド アレイ生体分子およびシークエンシングにおけるその使用
ATE508200T1 (de) 1999-02-23 2011-05-15 Caliper Life Sciences Inc Sequenzierung durch inkorporation
US7270951B1 (en) 1999-03-10 2007-09-18 Asm Scientific, Inc. Method for direct nucleic acid sequencing
US6309836B1 (en) 1999-10-05 2001-10-30 Marek Kwiatkowski Compounds for protecting hydroxyls and methods for their use
GB0013276D0 (en) 2000-06-01 2000-07-26 Amersham Pharm Biotech Uk Ltd Nucleotide analogues
WO2002029003A2 (en) 2000-10-06 2002-04-11 The Trustees Of Columbia University In The City Of New York Massive parallel method for decoding dna and rna
DE10120797B4 (de) 2001-04-27 2005-12-22 Genovoxx Gmbh Verfahren zur Analyse von Nukleinsäureketten
US6753449B2 (en) 2001-10-09 2004-06-22 Arqule, Inc. Cleavable linker for solid phase synthesis
US7057026B2 (en) 2001-12-04 2006-06-06 Solexa Limited Labelled nucleotides
EP1560838B1 (en) 2002-08-23 2009-05-13 Illumina Cambridge Limited Labelled nucleotides
EP3795577A1 (en) 2002-08-23 2021-03-24 Illumina Cambridge Limited Modified nucleotides
GB0326073D0 (en) 2003-11-07 2003-12-10 Solexa Ltd Improvements in or relating to polynucleotide arrays

Also Published As

Publication number Publication date
EP3438116A1 (en) 2019-02-06
HUE055068T2 (hu) 2021-10-28
ATE431354T1 (de) 2009-05-15
DE60327649D1 (de) 2009-06-25
EP3848380A1 (en) 2021-07-14
ES2326077T3 (es) 2009-09-30
SI3147292T1 (sl) 2019-01-31
EP3147292B1 (en) 2018-09-26
DK1560838T3 (da) 2009-09-07
GB2395953A (en) 2004-06-09
CY1120882T1 (el) 2019-12-11
SI2119722T1 (sl) 2017-03-31
PT3147292T (pt) 2018-11-22
ES2694651T3 (es) 2018-12-26
WO2004018493A1 (en) 2004-03-04
EP2119722B1 (en) 2016-10-26
ES2864086T3 (es) 2021-10-13
EP1560838A1 (en) 2005-08-10
CY1118471T1 (el) 2017-07-12
HUE032483T2 (en) 2017-09-28
EP3438116B1 (en) 2021-02-17
PT2119722T (pt) 2016-12-12
PT3438116T (pt) 2021-03-23
EP3147292A1 (en) 2017-03-29
CY1123971T1 (el) 2022-05-27
DK3438116T3 (da) 2021-03-22
GB0405882D0 (en) 2004-04-21
ES2604951T3 (es) 2017-03-10
AU2003259352A1 (en) 2004-03-11
DK2119722T3 (en) 2016-12-12
EP2119722A1 (en) 2009-11-18
EP1560838B1 (en) 2009-05-13
DK3147292T3 (en) 2018-12-03

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