SI3329909T1 - Fenfluramin za uporabo pri zdravljenju Dravetovega sindroma - Google Patents
Fenfluramin za uporabo pri zdravljenju Dravetovega sindromaInfo
- Publication number
- SI3329909T1 SI3329909T1 SI201431811T SI201431811T SI3329909T1 SI 3329909 T1 SI3329909 T1 SI 3329909T1 SI 201431811 T SI201431811 T SI 201431811T SI 201431811 T SI201431811 T SI 201431811T SI 3329909 T1 SI3329909 T1 SI 3329909T1
- Authority
- SI
- Slovenia
- Prior art keywords
- fenfluramine
- treatment
- dravet syndrome
- dravet
- syndrome
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
- A61K31/36—Compounds containing methylenedioxyphenyl groups, e.g. sesamin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Emergency Medicine (AREA)
- Analytical Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Pathology (AREA)
- General Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13/887,014 US9549909B2 (en) | 2013-05-03 | 2013-05-03 | Method for the treatment of dravet syndrome |
EP18152406.7A EP3329909B1 (en) | 2013-05-03 | 2014-05-01 | Fenfluramine for use in the treatment of dravet syndrome |
Publications (1)
Publication Number | Publication Date |
---|---|
SI3329909T1 true SI3329909T1 (sl) | 2021-08-31 |
Family
ID=50729472
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI201431811T SI3329909T1 (sl) | 2013-05-03 | 2014-05-01 | Fenfluramin za uporabo pri zdravljenju Dravetovega sindroma |
Country Status (17)
Country | Link |
---|---|
US (13) | US9549909B2 (sl) |
EP (2) | EP2991637B1 (sl) |
JP (3) | JP6441313B2 (sl) |
AU (4) | AU2014261329B2 (sl) |
BR (1) | BR112015027282A8 (sl) |
CA (1) | CA2909335C (sl) |
CY (1) | CY1124298T1 (sl) |
DK (2) | DK3329909T3 (sl) |
ES (2) | ES2666657T3 (sl) |
HR (1) | HRP20210819T1 (sl) |
HU (1) | HUE054577T2 (sl) |
LT (1) | LT3329909T (sl) |
NO (1) | NO3092234T3 (sl) |
PL (2) | PL3329909T3 (sl) |
PT (2) | PT3329909T (sl) |
SI (1) | SI3329909T1 (sl) |
WO (1) | WO2014177676A1 (sl) |
Families Citing this family (49)
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GB2514054A (en) | 2011-09-29 | 2014-11-12 | Gw Pharma Ltd | A pharmaceutical composition comprising the phytocannabinoids cannabidivarin (CBDV) and cannabidiol (CBD) |
US9549909B2 (en) | 2013-05-03 | 2017-01-24 | The Katholieke Universiteit Leuven | Method for the treatment of dravet syndrome |
GB2530001B (en) | 2014-06-17 | 2019-01-16 | Gw Pharma Ltd | Use of cannabidiol in the reduction of convulsive seizure frequency in treatment-resistant epilepsy |
KR102245345B1 (ko) * | 2014-09-29 | 2021-04-28 | 조게닉스 인터내셔널 리미티드 | 의약품 배포 제어를 위한 제어 시스템 |
GB2531282A (en) | 2014-10-14 | 2016-04-20 | Gw Pharma Ltd | Use of cannabinoids in the treatment of epilepsy |
GB2531281A (en) | 2014-10-14 | 2016-04-20 | Gw Pharma Ltd | Use of cannabidiol in the treatment of intractable epilepsy |
GB2531278A (en) | 2014-10-14 | 2016-04-20 | Gw Pharma Ltd | Use of cannabidiol in the treatment of intractable epilepsy |
HRP20220822T1 (hr) * | 2015-02-25 | 2022-10-28 | The Regents Of The University Of California | 5ht agonisti za liječenje poremećaja epilepsije |
JP6668045B2 (ja) * | 2015-05-15 | 2020-03-18 | ゾゲニクス インターナショナル リミテッド | ドラベ症候群を処置するための選択的5−ht受容体アゴニストおよびアンタゴニスト |
GB2539472A (en) | 2015-06-17 | 2016-12-21 | Gw Res Ltd | Use of cannabinoids in the treatment of epilepsy |
GB2541191A (en) | 2015-08-10 | 2017-02-15 | Gw Pharma Ltd | Use of cannabinoids in the treatment of epilepsy |
KR102481631B1 (ko) * | 2015-08-24 | 2022-12-27 | 조게닉스 인터내셔널 리미티드 | 펜플루라민을 사용하여 레녹스-가스토 증후군을 치료하는 방법 |
SG11201802870RA (en) | 2015-10-09 | 2018-05-30 | Univ Southampton | Modulation of gene expression and screening for deregulated protein expression |
AU2016370653A1 (en) | 2015-12-14 | 2018-06-21 | Cold Spring Harbor Laboratory | Antisense oligomers for treatment of Autosomal Dominant Mental Retardation-5 and Dravet Syndrome |
KR102688278B1 (ko) | 2015-12-22 | 2024-07-26 | 조게닉스 인터내셔널 리미티드 | 펜플루라민 조성물 및 그 제조 방법 |
US20170174614A1 (en) | 2015-12-22 | 2017-06-22 | Zogenix International Limited | Metabolism resistant fenfluramine analogs and methods of using the same |
GB2548873B (en) | 2016-03-31 | 2020-12-02 | Gw Res Ltd | Use of Cannabidiol in the Treatment of SturgeWeber Syndrome |
GB2551987A (en) | 2016-07-01 | 2018-01-10 | Gw Res Ltd | Oral cannabinoid formulations |
GB2551986A (en) | 2016-07-01 | 2018-01-10 | Gw Res Ltd | Parenteral formulations |
SG11201900975XA (en) | 2016-08-24 | 2019-03-28 | Zogenix International Ltd | Formulation for inhibiting formation of 5-ht 2b agonists and methods of using same |
GB2553139A (en) | 2016-08-25 | 2018-02-28 | Gw Res Ltd | Use of cannabinoids in the treatment of multiple myeloma |
US20180092864A1 (en) * | 2016-09-30 | 2018-04-05 | Zogenix International Limited | Compositions and methods for treating seizure disorders |
MX2019005779A (es) * | 2016-11-22 | 2019-08-22 | Ovid Therapeutics Inc | Metodos para tratar trastornos del desarrollo y/o trastornos convulsivos con flupirtina. |
GB2557921A (en) | 2016-12-16 | 2018-07-04 | Gw Res Ltd | Use of cannabinoids in the treatment of angelman syndrome |
GB2559774B (en) | 2017-02-17 | 2021-09-29 | Gw Res Ltd | Oral cannabinoid formulations |
US10765646B2 (en) | 2017-04-13 | 2020-09-08 | Ovid Therapeutics Inc. | Methods of treating developmental encephalopathies |
US20200170965A1 (en) * | 2017-05-09 | 2020-06-04 | Zogenix International Limited | Methods of treating doose syndrome using fenfluramine |
EP4303321A3 (en) | 2017-08-25 | 2024-07-24 | Stoke Therapeutics, Inc. | Antisense oligomers for treatment of conditions and diseases |
US20190125697A1 (en) * | 2017-09-26 | 2019-05-02 | Zogenix International Limited | Method of reduction in convulsive seizure frequency |
US20190091179A1 (en) | 2017-09-26 | 2019-03-28 | Zogenix International Limited | Congnitive function with fenfluramine |
US10682317B2 (en) | 2017-09-26 | 2020-06-16 | Zogenix International Limited | Ketogenic diet compatible fenfluramine formulation |
WO2019067413A1 (en) * | 2017-09-26 | 2019-04-04 | Zogenix International Limited | USE OF A FENFLURAMINE FORMULATION TO REDUCE THE NUMBER AND FREQUENCIES OF CONVULSIVE CRISES IN PATIENT POPULATIONS |
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GB2569961B (en) | 2018-01-03 | 2021-12-22 | Gw Res Ltd | Pharmaceutical |
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JP2021530481A (ja) * | 2018-07-10 | 2021-11-11 | ゾゲニクス インターナショナル リミテッド | 肺高血圧症を有さない患者においててんかんまたはてんかん性脳症を処置するために使用するためのフェンフルラミン |
BR112021001135A2 (pt) * | 2018-07-27 | 2021-04-20 | Xenon Pharmaceuticals Inc. | compostos e composições farmacêuticas para tratar epilepsia ou transtorno convulsivo epiléptico |
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CN111944835B (zh) * | 2019-05-14 | 2022-03-29 | 南通大学 | 一种突变型gabrg2转基因斑马鱼癫痫模型的构建方法及应用 |
CA3151422A1 (en) * | 2019-08-30 | 2021-03-04 | Research Institute At Nationwide Children's Hospital | Copper-atsm for treating neurodegenerative disorders associated with mitochondrial dysfunction |
AU2020351305A1 (en) * | 2019-09-17 | 2022-03-24 | Zogenix International Limited | Methods of treating epileptic patients with fenfluramine |
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GB202002754D0 (en) | 2020-02-27 | 2020-04-15 | Gw Res Ltd | Methods of treating tuberous sclerosis complex with cannabidiol and everolimus |
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US9549909B2 (en) | 2013-05-03 | 2017-01-24 | The Katholieke Universiteit Leuven | Method for the treatment of dravet syndrome |
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SG11201900975XA (en) | 2016-08-24 | 2019-03-28 | Zogenix International Ltd | Formulation for inhibiting formation of 5-ht 2b agonists and methods of using same |
US20180092864A1 (en) | 2016-09-30 | 2018-04-05 | Zogenix International Limited | Compositions and methods for treating seizure disorders |
US20200170965A1 (en) | 2017-05-09 | 2020-06-04 | Zogenix International Limited | Methods of treating doose syndrome using fenfluramine |
-
2013
- 2013-05-03 US US13/887,014 patent/US9549909B2/en active Active
-
2014
- 2014-05-01 ES ES14724037.8T patent/ES2666657T3/es active Active
- 2014-05-01 AU AU2014261329A patent/AU2014261329B2/en active Active
- 2014-05-01 BR BR112015027282A patent/BR112015027282A8/pt not_active Application Discontinuation
- 2014-05-01 HU HUE18152406A patent/HUE054577T2/hu unknown
- 2014-05-01 SI SI201431811T patent/SI3329909T1/sl unknown
- 2014-05-01 DK DK18152406.7T patent/DK3329909T3/da active
- 2014-05-01 WO PCT/EP2014/058954 patent/WO2014177676A1/en active Application Filing
- 2014-05-01 DK DK14724037.8T patent/DK2991637T3/en active
- 2014-05-01 EP EP14724037.8A patent/EP2991637B1/en not_active Revoked
- 2014-05-01 PL PL18152406T patent/PL3329909T3/pl unknown
- 2014-05-01 PL PL14724037T patent/PL2991637T3/pl unknown
- 2014-05-01 PT PT181524067T patent/PT3329909T/pt unknown
- 2014-05-01 ES ES18152406T patent/ES2863929T3/es active Active
- 2014-05-01 PT PT147240378T patent/PT2991637T/pt unknown
- 2014-05-01 EP EP18152406.7A patent/EP3329909B1/en active Active
- 2014-05-01 JP JP2016511083A patent/JP6441313B2/ja active Active
- 2014-05-01 CA CA2909335A patent/CA2909335C/en active Active
- 2014-05-01 LT LTEP18152406.7T patent/LT3329909T/lt unknown
- 2014-07-30 US US14/447,303 patent/US9603814B2/en active Active
- 2014-07-30 US US14/447,253 patent/US9610260B2/en active Active
- 2014-07-30 US US14/447,369 patent/US20140343044A1/en not_active Abandoned
- 2014-12-03 NO NO14819206A patent/NO3092234T3/no unknown
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2016
- 2016-01-21 US US15/003,161 patent/US9603815B2/en active Active
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2017
- 2017-02-10 US US15/429,516 patent/US10478441B2/en active Active
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2018
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2019
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- 2019-05-31 AU AU2019203832A patent/AU2019203832B2/en active Active
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2020
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2021
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2022
- 2022-02-08 US US17/667,136 patent/US20220160727A1/en active Pending
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