DK3329909T3 - Fenfluramin til anvendelse i behandling af dravet syndrom - Google Patents

Fenfluramin til anvendelse i behandling af dravet syndrom Download PDF

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Publication number
DK3329909T3
DK3329909T3 DK18152406.7T DK18152406T DK3329909T3 DK 3329909 T3 DK3329909 T3 DK 3329909T3 DK 18152406 T DK18152406 T DK 18152406T DK 3329909 T3 DK3329909 T3 DK 3329909T3
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Denmark
Prior art keywords
fenfluramine
treatment
syndrome
drug
drug syndrome
Prior art date
Application number
DK18152406.7T
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English (en)
Inventor
Berten Ceulemans
Lieven Lagae
Original Assignee
Katholieke Univ Leuven Ku Leuven Research & Development
Univ Hospital Antwerp
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Application filed by Katholieke Univ Leuven Ku Leuven Research & Development, Univ Hospital Antwerp filed Critical Katholieke Univ Leuven Ku Leuven Research & Development
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A61K31/36—Compounds containing methylenedioxyphenyl groups, e.g. sesamin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyridine Compounds (AREA)
DK18152406.7T 2013-05-03 2014-05-01 Fenfluramin til anvendelse i behandling af dravet syndrom DK3329909T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13/887,014 US9549909B2 (en) 2013-05-03 2013-05-03 Method for the treatment of dravet syndrome
EP14724037.8A EP2991637B1 (en) 2013-05-03 2014-05-01 Fenfluramine for use in the treatment of dravet syndrome

Publications (1)

Publication Number Publication Date
DK3329909T3 true DK3329909T3 (da) 2021-04-19

Family

ID=50729472

Family Applications (2)

Application Number Title Priority Date Filing Date
DK14724037.8T DK2991637T3 (da) 2013-05-03 2014-05-01 Fenfluramin til anvendelse i behandling af dravets syndrom
DK18152406.7T DK3329909T3 (da) 2013-05-03 2014-05-01 Fenfluramin til anvendelse i behandling af dravet syndrom

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK14724037.8T DK2991637T3 (da) 2013-05-03 2014-05-01 Fenfluramin til anvendelse i behandling af dravets syndrom

Country Status (17)

Country Link
US (13) US9549909B2 (da)
EP (2) EP3329909B1 (da)
JP (3) JP6441313B2 (da)
AU (4) AU2014261329B2 (da)
BR (1) BR112015027282A8 (da)
CA (1) CA2909335C (da)
CY (1) CY1124298T1 (da)
DK (2) DK2991637T3 (da)
ES (2) ES2666657T3 (da)
HR (1) HRP20210819T1 (da)
HU (1) HUE054577T2 (da)
LT (1) LT3329909T (da)
NO (1) NO3092234T3 (da)
PL (2) PL3329909T3 (da)
PT (2) PT2991637T (da)
SI (1) SI3329909T1 (da)
WO (1) WO2014177676A1 (da)

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Publication number Publication date
US20170151214A1 (en) 2017-06-01
US20210121479A1 (en) 2021-04-29
US9603815B2 (en) 2017-03-28
LT3329909T (lt) 2021-07-12
US20170151259A1 (en) 2017-06-01
PL3329909T3 (pl) 2021-10-11
DK2991637T3 (da) 2018-05-07
PT3329909T (pt) 2021-05-14
AU2019203832A1 (en) 2019-06-20
US20170151213A1 (en) 2017-06-01
US20140343161A1 (en) 2014-11-20
AU2019203448A1 (en) 2019-06-06
BR112015027282A2 (pt) 2017-07-25
AU2014261329A1 (en) 2015-11-05
CY1124298T1 (el) 2022-07-22
AU2020267264A1 (en) 2020-12-17
JP6966584B2 (ja) 2021-11-17
PT2991637T (pt) 2018-04-24
HRP20210819T1 (hr) 2021-08-20
US9603814B2 (en) 2017-03-28
JP6655156B2 (ja) 2020-02-26
ES2666657T3 (es) 2018-05-07
BR112015027282A8 (pt) 2019-12-24
EP3329909A1 (en) 2018-06-06
JP2020063309A (ja) 2020-04-23
US20160136114A1 (en) 2016-05-19
US20170151257A1 (en) 2017-06-01
AU2014261329B2 (en) 2019-02-21
JP6441313B2 (ja) 2018-12-19
US10478441B2 (en) 2019-11-19
AU2019203832B2 (en) 2020-10-15
NO3092234T3 (da) 2018-07-14
WO2014177676A1 (en) 2014-11-06
US20140343162A1 (en) 2014-11-20
US20200030341A1 (en) 2020-01-30
EP2991637B1 (en) 2018-03-07
US20140329908A1 (en) 2014-11-06
US20170151194A1 (en) 2017-06-01
US20140343044A1 (en) 2014-11-20
JP2019048862A (ja) 2019-03-28
US9610260B2 (en) 2017-04-04
HUE054577T2 (hu) 2021-09-28
CA2909335A1 (en) 2014-11-06
AU2019203448B2 (en) 2020-08-06
CA2909335C (en) 2021-05-18
EP2991637A1 (en) 2016-03-09
JP2016518387A (ja) 2016-06-23
ES2863929T3 (es) 2021-10-13
US9549909B2 (en) 2017-01-24
US20220160727A1 (en) 2022-05-26
SI3329909T1 (sl) 2021-08-31
EP3329909B1 (en) 2021-03-17
US10478442B2 (en) 2019-11-19
PL2991637T3 (pl) 2018-07-31

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