SI2776065T1 - Kombinacijske terapije z uporabo molekul, ki vežejo anti-Pseudomonas Psl in PcrV - Google Patents
Kombinacijske terapije z uporabo molekul, ki vežejo anti-Pseudomonas Psl in PcrVInfo
- Publication number
- SI2776065T1 SI2776065T1 SI201231834T SI201231834T SI2776065T1 SI 2776065 T1 SI2776065 T1 SI 2776065T1 SI 201231834 T SI201231834 T SI 201231834T SI 201231834 T SI201231834 T SI 201231834T SI 2776065 T1 SI2776065 T1 SI 2776065T1
- Authority
- SI
- Slovenia
- Prior art keywords
- binding molecules
- combination therapies
- pseudomonas psl
- pcrv binding
- pcrv
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
- C07K16/1214—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Pseudomonadaceae (F)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/40—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum bacterial
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161556645P | 2011-11-07 | 2011-11-07 | |
US201261625299P | 2012-04-17 | 2012-04-17 | |
US201261697585P | 2012-09-06 | 2012-09-06 | |
PCT/US2012/063722 WO2013070615A1 (en) | 2011-11-07 | 2012-11-06 | Combination therapies using anti- pseudomonas psl and pcrv binding molecules |
EP12847479.8A EP2776065B1 (en) | 2011-11-07 | 2012-11-06 | Combination therapies using anti- pseudomonas psl and pcrv binding molecules |
Publications (1)
Publication Number | Publication Date |
---|---|
SI2776065T1 true SI2776065T1 (sl) | 2020-10-30 |
Family
ID=48290482
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI201231834T SI2776065T1 (sl) | 2011-11-07 | 2012-11-06 | Kombinacijske terapije z uporabo molekul, ki vežejo anti-Pseudomonas Psl in PcrV |
Country Status (22)
Country | Link |
---|---|
US (3) | US10597439B2 (sl) |
EP (1) | EP2776065B1 (sl) |
JP (1) | JP6182152B2 (sl) |
KR (1) | KR102184343B1 (sl) |
CN (1) | CN104136042B (sl) |
AU (3) | AU2012336028A1 (sl) |
BR (1) | BR112014011028B1 (sl) |
CA (2) | CA2854817C (sl) |
CY (1) | CY1123552T1 (sl) |
DK (1) | DK2776065T3 (sl) |
ES (1) | ES2859323T3 (sl) |
HK (1) | HK1201453A1 (sl) |
HR (1) | HRP20201370T1 (sl) |
HU (1) | HUE050985T2 (sl) |
LT (1) | LT2776065T (sl) |
MX (1) | MX2014005566A (sl) |
PL (1) | PL2776065T3 (sl) |
PT (1) | PT2776065T (sl) |
RS (1) | RS60920B1 (sl) |
RU (1) | RU2687588C2 (sl) |
SI (1) | SI2776065T1 (sl) |
WO (1) | WO2013070615A1 (sl) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2012267732A1 (en) | 2011-06-10 | 2014-01-09 | Medimmune Limited | Anti-Pseudomonas Psl binding molecules and uses thereof |
CA2854817C (en) | 2011-11-07 | 2022-08-16 | Medimmune, Llc | Combination therapies using anti-pseudomonas psl and pcrv binding molecules |
SG11201404532XA (en) * | 2012-03-02 | 2014-08-28 | Ablynx Nv | Pseudomonas aeruginosa pcrv binding single variable domain antibodies |
EP2917236A2 (en) * | 2012-11-06 | 2015-09-16 | MedImmune, LLC | Combination therapies using anti-pseudomonas psl and pcrv binding molecules |
WO2014186358A2 (en) * | 2013-05-14 | 2014-11-20 | Antonio Digiandomenico | Synthetic oligosaccharide subunits of the psl exoplysaccharide of pseudomonas aeruginosa and uses therof |
WO2015171504A1 (en) * | 2014-05-05 | 2015-11-12 | Medimmune, Llc | Multi-specific anti-pseudomonas psl and pcrv binding molecules and uses thereof |
TWI719938B (zh) | 2014-06-19 | 2021-03-01 | 美商麥迪紐有限責任公司 | 多重細菌感染之治療 |
KR20180020142A (ko) | 2015-05-01 | 2018-02-27 | 인히브릭스 엘피 | Iii형 분비계 표적화 분자 |
AU2016313653A1 (en) * | 2015-08-24 | 2018-04-12 | Medimmune, Llc | MrkA polypeptides, antibodies, and uses thereof |
EP3383884A4 (en) * | 2015-11-30 | 2019-07-31 | Medimmune Limited | PROCESS FOR PREVENTING OR TREATING NOSOCOMIAL PNEUMONIA |
KR20230093338A (ko) * | 2016-05-05 | 2023-06-27 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | 슈도모나스 에루지노사에 대해 사용하기 위한 dna 항체 작제물 |
MX2021015156A (es) | 2019-06-11 | 2022-01-18 | Regeneron Pharma | Anticuerpos anti-pcrv que se unen a pcrv, composiciones que comprenden anticuerpos anti-pcrv, y metodos de uso de estos. |
BR112021026788A2 (pt) * | 2019-07-09 | 2022-05-10 | Staidson Beijing Biopharmaceuticals Co Ltd | Anticorpos que reconhecem especificamente pcrv de pseudomonas e usos dos mesmos |
KR20210095781A (ko) | 2020-01-24 | 2021-08-03 | 주식회사 에이프릴바이오 | 항원결합 단편 및 생리활성 이펙터 모이어티로 구성된 융합 컨스트럭트를 포함하는 다중결합항체 및 이를 포함하는 약학조성물 |
WO2021244421A1 (en) * | 2020-06-01 | 2021-12-09 | Staidson (Beijing) Biopharmaceuticals Co., Ltd. | Antibodies specifically recognizing pseudomonas pcrv and uses thereof |
EP4192856A1 (en) * | 2020-08-07 | 2023-06-14 | Beijing SoloBio Genetechnology Company Ltd. | Antibodies specifically recognizing pseudomonas psl and uses thereof |
FR3114970B1 (fr) | 2020-10-08 | 2023-06-30 | Univ Tours | Combinaison d’anticorps inhalés avec des agents immunomodulateurs pour le traitement ou la prévention d’inféctions respiratoires |
KR20230109703A (ko) * | 2020-11-18 | 2023-07-20 | 베이징 솔로바이오 진테크놀로지 컴퍼니 리미티드 | 슈도모나스 pcrv 및 psl을 특이적으로 식별하는 항체 결합을 포함하는 항체 조합 및 이중특이성 항체 |
WO2023141611A2 (en) * | 2022-01-21 | 2023-07-27 | Lyvgen Biopharma Holdings Limited | Multi-specific antibodies in uses thereof in avidity receptor crosslinking and immune modulation |
WO2024003103A1 (en) | 2022-06-29 | 2024-01-04 | Astrazeneca Ab | Anti-pcrv and psl bispecific antibodies for treatment of bronchiectasis |
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WO2015171504A1 (en) * | 2014-05-05 | 2015-11-12 | Medimmune, Llc | Multi-specific anti-pseudomonas psl and pcrv binding molecules and uses thereof |
TWI719938B (zh) * | 2014-06-19 | 2021-03-01 | 美商麥迪紐有限責任公司 | 多重細菌感染之治療 |
EP3383884A4 (en) * | 2015-11-30 | 2019-07-31 | Medimmune Limited | PROCESS FOR PREVENTING OR TREATING NOSOCOMIAL PNEUMONIA |
KR20230093338A (ko) * | 2016-05-05 | 2023-06-27 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | 슈도모나스 에루지노사에 대해 사용하기 위한 dna 항체 작제물 |
MX2021015156A (es) * | 2019-06-11 | 2022-01-18 | Regeneron Pharma | Anticuerpos anti-pcrv que se unen a pcrv, composiciones que comprenden anticuerpos anti-pcrv, y metodos de uso de estos. |
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2012
- 2012-11-06 CA CA2854817A patent/CA2854817C/en active Active
- 2012-11-06 HU HUE12847479A patent/HUE050985T2/hu unknown
- 2012-11-06 MX MX2014005566A patent/MX2014005566A/es active IP Right Grant
- 2012-11-06 CA CA3161431A patent/CA3161431A1/en active Pending
- 2012-11-06 SI SI201231834T patent/SI2776065T1/sl unknown
- 2012-11-06 RS RS20201211A patent/RS60920B1/sr unknown
- 2012-11-06 LT LTEP12847479.8T patent/LT2776065T/lt unknown
- 2012-11-06 AU AU2012336028A patent/AU2012336028A1/en not_active Abandoned
- 2012-11-06 DK DK12847479.8T patent/DK2776065T3/da active
- 2012-11-06 WO PCT/US2012/063722 patent/WO2013070615A1/en active Application Filing
- 2012-11-06 US US14/356,500 patent/US10597439B2/en active Active
- 2012-11-06 ES ES12847479T patent/ES2859323T3/es active Active
- 2012-11-06 JP JP2014540196A patent/JP6182152B2/ja active Active
- 2012-11-06 CN CN201280054651.8A patent/CN104136042B/zh active Active
- 2012-11-06 EP EP12847479.8A patent/EP2776065B1/en active Active
- 2012-11-06 PT PT128474798T patent/PT2776065T/pt unknown
- 2012-11-06 BR BR112014011028-0A patent/BR112014011028B1/pt active IP Right Grant
- 2012-11-06 RU RU2014122990A patent/RU2687588C2/ru active
- 2012-11-06 PL PL12847479T patent/PL2776065T3/pl unknown
- 2012-11-06 KR KR1020147015274A patent/KR102184343B1/ko active IP Right Grant
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2015
- 2015-02-27 HK HK15101962.5A patent/HK1201453A1/xx unknown
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2017
- 2017-08-25 AU AU2017219081A patent/AU2017219081B9/en active Active
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2019
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2020
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2021
- 2021-11-15 US US17/454,837 patent/US20220177554A1/en active Pending
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