SI2623498T1 - Natrijeva sol 6-fluoro-3-hidroksi-2-pirazinkarboksamida - Google Patents
Natrijeva sol 6-fluoro-3-hidroksi-2-pirazinkarboksamidaInfo
- Publication number
- SI2623498T1 SI2623498T1 SI201130722T SI201130722T SI2623498T1 SI 2623498 T1 SI2623498 T1 SI 2623498T1 SI 201130722 T SI201130722 T SI 201130722T SI 201130722 T SI201130722 T SI 201130722T SI 2623498 T1 SI2623498 T1 SI 2623498T1
- Authority
- SI
- Slovenia
- Prior art keywords
- fluoro
- hydroxy
- sodium salt
- pyrazine carboxamide
- pyrazine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Virology (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2010221682 | 2010-09-30 | ||
| PCT/JP2011/072333 WO2012043700A1 (ja) | 2010-09-30 | 2011-09-29 | ６－フルオロ－３－ヒドロキシ－２－ピラジンカルボキサミドのナトリウム塩 |
| EP11829253.1A EP2623498B1 (en) | 2010-09-30 | 2011-09-29 | Sodium salt of 6-fluoro-3-hydroxy-2-pyrazine carboxamide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI2623498T1 true SI2623498T1 (sl) | 2016-03-31 |
Family
ID=45893139
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI201130722T SI2623498T1 (sl) | 2010-09-30 | 2011-09-29 | Natrijeva sol 6-fluoro-3-hidroksi-2-pirazinkarboksamida |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US20130274472A1 (sl) |
| EP (1) | EP2623498B1 (sl) |
| JP (1) | JPWO2012043700A1 (sl) |
| CN (1) | CN103209966B (sl) |
| CY (1) | CY1117041T1 (sl) |
| DK (1) | DK2623498T3 (sl) |
| ES (1) | ES2554630T3 (sl) |
| HK (1) | HK1183015A1 (sl) |
| HR (1) | HRP20151263T1 (sl) |
| HU (1) | HUE026872T2 (sl) |
| MY (1) | MY161429A (sl) |
| PH (1) | PH12015501649A1 (sl) |
| PL (1) | PL2623498T3 (sl) |
| PT (1) | PT2623498E (sl) |
| RS (1) | RS54408B1 (sl) |
| SG (1) | SG189161A1 (sl) |
| SI (1) | SI2623498T1 (sl) |
| SM (1) | SMT201600072B (sl) |
| TW (1) | TWI552998B (sl) |
| WO (1) | WO2012043700A1 (sl) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8778398B2 (en) | 2008-11-04 | 2014-07-15 | Jazz Pharmaceuticals, Inc. | Immediate release formulations and dosage forms of gamma-hydroxybutyrate |
| WO2011119839A1 (en) | 2010-03-24 | 2011-09-29 | Jazz Pharmaceuticals, Inc. | Controlled release dosage forms for high dose, water soluble and hygroscopic drug substances |
| SG188662A1 (en) | 2010-09-30 | 2013-05-31 | Toyama Chemical Co Ltd | Meglumine salt of 6-fluoro-3-hydroxy-2-pyrazine carboxamide |
| US9809589B2 (en) * | 2012-12-22 | 2017-11-07 | Kbp Biosciences Co., Ltd. | Crystal form of compound used as mineralocorticoid receptor antagonist and preparation method therefor |
| JP6487051B2 (ja) * | 2014-12-30 | 2019-03-20 | サムヤン バイオファーマシューティカルズ コーポレイションＳａｍｙａｎｇ Ｂｉｏｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｃｏｒｐｏｒａｔｉｏｎ | ポリマーナノ粒子の凍結乾燥物、及びその製造方法 |
| US10398662B1 (en) | 2015-02-18 | 2019-09-03 | Jazz Pharma Ireland Limited | GHB formulation and method for its manufacture |
| TW201808291A (zh) * | 2016-06-30 | 2018-03-16 | 富山化學工業股份有限公司 | 冷凍乾燥製劑之製造方法 |
| US11602512B1 (en) | 2016-07-22 | 2023-03-14 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US11602513B1 (en) | 2016-07-22 | 2023-03-14 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| UY37341A (es) | 2016-07-22 | 2017-11-30 | Flamel Ireland Ltd | Formulaciones de gamma-hidroxibutirato de liberación modificada con farmacocinética mejorada |
| US11986451B1 (en) | 2016-07-22 | 2024-05-21 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US11504347B1 (en) | 2016-07-22 | 2022-11-22 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US20180263936A1 (en) | 2017-03-17 | 2018-09-20 | Jazz Pharmaceuticals Ireland Limited | Gamma-hydroxybutyrate compositions and their use for the treatment of disorders |
| WO2019131223A1 (ja) | 2017-12-28 | 2019-07-04 | 富士フイルム富山化学株式会社 | 凍結乾燥製剤の製造方法 |
| EP3883549A1 (en) | 2018-11-19 | 2021-09-29 | Jazz Pharmaceuticals Ireland Limited | Alcohol-resistant drug formulations |
| JP2022522270A (ja) | 2019-03-01 | 2022-04-15 | フラメル アイルランド リミテッド | 食事摂取状態における改善された薬物動態を有するガンマ－ヒドロキシ酪酸塩組成物 |
| CN111249229B (zh) * | 2020-03-10 | 2023-05-02 | 北京阜康仁生物制药科技有限公司 | 一种稳定的法匹拉韦注射液及其制备方法 |
| TR202017792A2 (tr) * | 2020-11-06 | 2021-01-21 | Aroma Ilac Sanayi Ltd Sti | 6-floro-3-hidroksi-2-pirazinkarboksamid etken maddesi veya sodyum tuzunu içeren liyofilizasyon tekniğiyle üretilen yeni bir farmasötik kompozisyon |
| CN113750105A (zh) * | 2020-12-11 | 2021-12-07 | 山东大学 | 一种法匹拉韦药用结合物及在制备抗病毒药物制剂中的应用 |
| CN112574130B (zh) * | 2020-12-11 | 2021-10-15 | 山东大学 | 一种法匹拉韦药物共晶及其制备方法和应用 |
| US20240041866A1 (en) | 2020-12-18 | 2024-02-08 | Fujifilm Toyama Chemical Co., Ltd. | Pharmaceutical composition |
| WO2022131112A1 (ja) | 2020-12-18 | 2022-06-23 | 富士フイルム富山化学株式会社 | 医薬組成物 |
| WO2023033683A1 (ru) * | 2021-09-06 | 2023-03-09 | Общество С Ограниченной Ответственностью "Промомед Рус" | Противовирусная фармацевтическая композиция, содержащая фавипиравир и аминокислоту |
| US11779557B1 (en) | 2022-02-07 | 2023-10-10 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US11583510B1 (en) | 2022-02-07 | 2023-02-21 | Flamel Ireland Limited | Methods of administering gamma hydroxybutyrate formulations after a high-fat meal |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3413406B2 (ja) | 1998-01-07 | 2003-06-03 | 明治製菓株式会社 | 結晶学的に安定な非晶質セファロスポリンの組成物とその製造方法 |
| PL200955B1 (pl) | 1998-08-20 | 2009-02-27 | Toyama Chemical Co Ltd | Przeciwwirusowa kompozycja farmaceutyczna i jej zastosowanie oraz zawierająca azot heterocykliczna pochodna karboksamidu |
| DK1295890T3 (da) | 2000-02-16 | 2005-05-17 | Toyama Chemical Co Ltd | Hidtil ukendte pyrazinderivater eller salte deraf, farmaceutiske præparater, der indeholder derivaterne eller saltene, og mellemprodukter til fremstilling af begge |
| BRPI0807597B8 (pt) | 2007-02-16 | 2021-05-25 | Fujifilm Toyama Chemical Co Ltd | composição farmacêutica, e, uso de um derivado de pirazina ou um sal do mesmo e um ou mais inibidor(es) de neuraminidase em combinação |
| JP5174365B2 (ja) * | 2007-03-23 | 2013-04-03 | 第一三共株式会社 | キノロン含有凍結乾燥製剤の製造方法 |
| JP2008231064A (ja) | 2007-03-23 | 2008-10-02 | Nippon Shokubai Co Ltd | カルバゾイルアルキル（メタ）アクリレートの製造方法 |
| NZ584157A (en) * | 2007-09-27 | 2012-04-27 | Toyama Chemical Co Ltd | Organic amine salt of 6-fluoro-3-hydroxy-2-pyrazinecarbonitrile and method for producing the same |
| SI2407166T1 (sl) | 2009-03-13 | 2013-12-31 | Toyama Chemical Co., Ltd. | Tableta in granuliran praĺ ek, vsebujoäśa 6-fluoro-3-hidroksi-2-pirazinkarboksamid |
| SG188662A1 (en) | 2010-09-30 | 2013-05-31 | Toyama Chemical Co Ltd | Meglumine salt of 6-fluoro-3-hydroxy-2-pyrazine carboxamide |
-
2011
- 2011-09-29 EP EP11829253.1A patent/EP2623498B1/en active Active
- 2011-09-29 JP JP2012536536A patent/JPWO2012043700A1/ja active Pending
- 2011-09-29 RS RS20150767A patent/RS54408B1/en unknown
- 2011-09-29 PL PL11829253T patent/PL2623498T3/pl unknown
- 2011-09-29 CN CN201180055060.8A patent/CN103209966B/zh active Active
- 2011-09-29 MY MYPI2013001093A patent/MY161429A/en unknown
- 2011-09-29 DK DK11829253.1T patent/DK2623498T3/en active
- 2011-09-29 ES ES11829253.1T patent/ES2554630T3/es active Active
- 2011-09-29 TW TW100135298A patent/TWI552998B/zh active
- 2011-09-29 HU HUE11829253A patent/HUE026872T2/en unknown
- 2011-09-29 WO PCT/JP2011/072333 patent/WO2012043700A1/ja active Application Filing
- 2011-09-29 US US13/876,998 patent/US20130274472A1/en not_active Abandoned
- 2011-09-29 SG SG2013023437A patent/SG189161A1/en unknown
- 2011-09-29 PT PT118292531T patent/PT2623498E/pt unknown
- 2011-09-29 SI SI201130722T patent/SI2623498T1/sl unknown
-
2013
- 2013-09-02 HK HK13110207.3A patent/HK1183015A1/xx unknown
-
2014
- 2014-10-16 US US14/515,673 patent/US9096547B2/en active Active
-
2015
- 2015-06-08 US US14/733,199 patent/US20150266831A1/en not_active Abandoned
- 2015-07-24 PH PH12015501649A patent/PH12015501649A1/en unknown
- 2015-11-24 HR HRP20151263TT patent/HRP20151263T1/hr unknown
- 2015-12-09 CY CY20151101124T patent/CY1117041T1/el unknown
-
2016
- 2016-03-14 SM SM201600072T patent/SMT201600072B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20150038713A1 (en) | 2015-02-05 |
| US20150266831A1 (en) | 2015-09-24 |
| WO2012043700A1 (ja) | 2012-04-05 |
| CN103209966B (zh) | 2015-06-10 |
| EP2623498A4 (en) | 2014-03-26 |
| EP2623498B1 (en) | 2015-11-18 |
| EP2623498A1 (en) | 2013-08-07 |
| HK1183015A1 (en) | 2013-12-13 |
| ES2554630T3 (es) | 2015-12-22 |
| PT2623498E (pt) | 2016-02-02 |
| HUE026872T2 (en) | 2016-07-28 |
| CN103209966A (zh) | 2013-07-17 |
| CY1117041T1 (el) | 2017-04-05 |
| PH12015501649B1 (en) | 2015-10-05 |
| DK2623498T3 (en) | 2016-02-22 |
| SG189161A1 (en) | 2013-05-31 |
| US20130274472A1 (en) | 2013-10-17 |
| RS54408B1 (en) | 2016-04-28 |
| TWI552998B (zh) | 2016-10-11 |
| PL2623498T3 (pl) | 2016-05-31 |
| TW201219375A (en) | 2012-05-16 |
| PH12015501649A1 (en) | 2015-10-05 |
| SMT201600072B (it) | 2016-04-29 |
| JPWO2012043700A1 (ja) | 2014-02-24 |
| US9096547B2 (en) | 2015-08-04 |
| MY161429A (en) | 2017-04-14 |
| HRP20151263T1 (hr) | 2015-12-18 |
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