SI2429574T1 - Sestavki in metode za zdravljenje hematoloških rakov, ki ciljajo interakcijo SIRP - CD47 - Google Patents
Sestavki in metode za zdravljenje hematoloških rakov, ki ciljajo interakcijo SIRP - CD47Info
- Publication number
- SI2429574T1 SI2429574T1 SI201030950T SI201030950T SI2429574T1 SI 2429574 T1 SI2429574 T1 SI 2429574T1 SI 201030950 T SI201030950 T SI 201030950T SI 201030950 T SI201030950 T SI 201030950T SI 2429574 T1 SI2429574 T1 SI 2429574T1
- Authority
- SI
- Slovenia
- Prior art keywords
- sirp
- interaction
- compositions
- methods
- hematologic cancers
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Pathology (AREA)
- Wood Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Engineering & Computer Science (AREA)
- Hospice & Palliative Care (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Hematology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US17855309P | 2009-05-15 | 2009-05-15 | |
EP10774475.7A EP2429574B1 (en) | 2009-05-15 | 2010-05-14 | Compositions and methods for treating hematologic cancers targeting the sirp - cd47 interaction |
PCT/CA2010/000743 WO2010130053A1 (en) | 2009-05-15 | 2010-05-14 | COMPOSITIONS AND METHODS FOR TREATING HEMATOLOGIC CANCERS TARGETING THE SIRPα - CD47 INTERACTION |
Publications (1)
Publication Number | Publication Date |
---|---|
SI2429574T1 true SI2429574T1 (sl) | 2015-10-30 |
Family
ID=43084582
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI201030950T SI2429574T1 (sl) | 2009-05-15 | 2010-05-14 | Sestavki in metode za zdravljenje hematoloških rakov, ki ciljajo interakcijo SIRP - CD47 |
Country Status (14)
Country | Link |
---|---|
US (3) | US10907209B2 (sl) |
EP (3) | EP4311863A3 (sl) |
JP (6) | JP6091891B2 (sl) |
CN (2) | CN107252476A (sl) |
AU (1) | AU2010246872B2 (sl) |
CA (2) | CA2983972C (sl) |
DK (2) | DK2429574T3 (sl) |
ES (1) | ES2539141T3 (sl) |
FI (1) | FI2995315T3 (sl) |
HR (1) | HRP20150553T1 (sl) |
PL (2) | PL2429574T3 (sl) |
PT (2) | PT2995315T (sl) |
SI (1) | SI2429574T1 (sl) |
WO (1) | WO2010130053A1 (sl) |
Families Citing this family (53)
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ES2740823T3 (es) | 2008-01-15 | 2020-02-06 | Univ Leland Stanford Junior | Métodos para manipular fagocitosis mediada por CD47 |
AU2010246872B2 (en) * | 2009-05-15 | 2015-01-22 | The Hospital For Sick Children | Compositions and methods for treating hematologic cancers targeting the SIRPalpha - CD47 interaction |
CN104136037B (zh) * | 2012-01-17 | 2018-02-23 | 小利兰·斯坦福大学托管委员会 | 高亲和力SIRP‑α试剂 |
EP2806883B1 (en) | 2012-01-25 | 2019-04-24 | DNAtrix, Inc. | Biomarkers and combination therapies using oncolytic virus and immunomodulation |
CN102643347A (zh) * | 2012-03-29 | 2012-08-22 | 中国人民解放军第四军医大学 | 一种白血病干细胞靶向可溶性蛋白TrxHis-hSIRPα |
CN103804495A (zh) * | 2012-11-07 | 2014-05-21 | 深圳大学 | 抗肿瘤基因工程二价类抗体及其制备方法及抗肿瘤基因工程药物 |
HUE058790T2 (hu) * | 2012-12-17 | 2022-09-28 | Pf Argentum Ip Holdings Llc | CD47+ beteg sejtek kezelése SIRP-alfa-Fc fúziókkal |
WO2014121093A1 (en) | 2013-01-31 | 2014-08-07 | Thomas Jefferson University | Fusion proteins that facilitate cancer cell destruction |
DK3311824T3 (da) | 2013-02-05 | 2020-04-14 | Univ Leland Stanford Junior | Cd47 målrettede terapier til behandlingen af infektionssygdomme |
CN103665165B (zh) * | 2013-08-28 | 2016-02-24 | 江苏匡亚生物医药科技有限公司 | 一种靶向人CD47-SIRPα信号通路的双特异性抗体及其制备方法和用途 |
EP3122783B1 (en) * | 2014-03-24 | 2019-09-04 | Immuneonco Biopharmaceuticals (Shanghai) Co., Ltd. | Novel recombinant bi-functional fusion proteins, preparation and use thereof |
TWI702228B (zh) * | 2014-08-08 | 2020-08-21 | 美商Alx腫瘤技術股份有限公司 | 信號調節蛋白α(signal-regulatory protein α, SIRP-α)變體構築物及其用途 |
EP3643727A1 (en) | 2014-08-15 | 2020-04-29 | Merck Patent GmbH | Sirp-alpha immunoglobulin fusion proteins |
EP3012271A1 (en) | 2014-10-24 | 2016-04-27 | Effimune | Method and compositions for inducing differentiation of myeloid derived suppressor cell to treat cancer and infectious diseases |
CN106146670B (zh) * | 2015-04-24 | 2019-01-15 | 宜明昂科生物医药技术(上海)有限公司 | 一种新的重组双功能融合蛋白及其制备和应用 |
RS62151B1 (sr) * | 2015-08-07 | 2021-08-31 | Alx Oncology Inc | Konstrukti koji sadrže sirp-alfa domen ili njegovu varijantu |
NZ741324A (en) | 2015-09-21 | 2021-09-24 | Erasmus Univ Medical Center | Anti-cd47 antibodies and methods of use |
EP4186927A1 (en) | 2015-10-21 | 2023-05-31 | Ose Immunotherapeutics | Methods and compositions for modifying macrophage polarization into pro-inflammatory cells to treat cancer |
CN107149682B (zh) * | 2016-03-04 | 2022-01-04 | 复旦大学 | 一种靶向cd47的免疫检查点抑制剂药物组合物及其制备方法 |
KR102355240B1 (ko) | 2016-04-14 | 2022-01-25 | 오제 이뮈노테라프틱스 | 신규한 항-SIRPa 항체 및 이들의 치료학적 적용 방법 |
US20190091290A1 (en) * | 2016-04-15 | 2019-03-28 | Trillium Therapeutics Inc. | Macrophage stimulation in cd47 blockade therapy |
WO2017197495A1 (en) * | 2016-05-19 | 2017-11-23 | Adaerata, Limited Partnership | Methods of preventing or treating slamf7 positive and slamf7 negative cancers |
CN110087673A (zh) | 2016-07-19 | 2019-08-02 | 梯瓦制药澳大利亚股份有限公司 | 抗cd47联合治疗 |
US11446315B2 (en) | 2016-11-03 | 2022-09-20 | Pf Argentum Ip Holdings Llc | Enhancement of CD47 blockade therapy by proteasome inhibitors |
WO2018081898A1 (en) | 2016-11-03 | 2018-05-11 | Trillium Therapeutics Inc. | Improvements in cd47 blockade therapy by hdac inhibitors |
CN110325549B (zh) | 2016-12-09 | 2024-03-08 | 艾利妥 | 抗SIRPα抗体及其使用方法 |
US11299530B2 (en) | 2017-01-05 | 2022-04-12 | Kahr Medical Ltd. | SIRP alpha-CD70 fusion protein and methods of use thereof |
WO2018127916A1 (en) | 2017-01-05 | 2018-07-12 | Kahr Medical Ltd. | A pd1-cd70 fusion protein and methods of use thereof |
KR102597943B1 (ko) | 2017-01-05 | 2023-11-06 | 카 메디컬 리미티드 | Pd1-41bbl 융합 단백질 및 이의 이용 방법 |
IL267862B2 (en) | 2017-01-05 | 2024-05-01 | Kahr Medical Ltd | SIRPalpha-41BBL conjugate protein and methods of using it |
PL3658589T3 (pl) | 2017-07-26 | 2024-03-18 | Forty Seven, Inc. | Przeciwciała anty-sirp-alfa i powiązane sposoby |
NZ761568A (en) | 2017-08-02 | 2022-11-25 | Phanes Therapeutics Inc | Anti-cd47 antibodies and uses thereof |
WO2019073080A1 (en) | 2017-10-13 | 2019-04-18 | Ose Immunotherapeutics | ANTI-SIRPA MODIFIED ANTIBODIES AND USES THEREOF |
US11771764B2 (en) | 2017-11-06 | 2023-10-03 | Pfizer Inc. | CD47 blockade with radiation therapy |
CN108484774B (zh) * | 2018-03-09 | 2021-11-05 | 上海高菲生物科技有限公司 | 一种SIRPα融合蛋白及其制备方法和用途 |
BR112020017709A2 (pt) | 2018-03-13 | 2020-12-29 | Ose Immunotherapeutics | Anticorpo anti-sirpa humana, fragmento de ligação a antígeno do mesmo ou anticorpo modificado do mesmo, composição farmacêutica, uso de um polipeptídeo, métodos para preparar um anticorpo anti-sirpa humana v1, para aumentar a apresentação cruzada de um antígeno e para avaliar a probabilidade de eficácia de um tratamento, método in vitro ou ex vivo para avaliar a probabilidade de eficácia de um tratamento, e, combinação de compostos |
CN110386984B (zh) * | 2018-04-17 | 2022-04-22 | 杭州尚健生物技术有限公司 | 结合cd47蛋白的融合蛋白及其应用 |
WO2019226973A1 (en) | 2018-05-25 | 2019-11-28 | Alector Llc | Anti-sirpa antibodies and methods of use thereof |
CN108872569A (zh) * | 2018-06-19 | 2018-11-23 | 浠思(上海)生物技术有限公司 | 利用HTRF一步法筛选CD47/SIRP alpha阻断剂的方法 |
WO2020047326A2 (en) * | 2018-08-31 | 2020-03-05 | ALX Oncology Inc. | Decoy polypeptides |
US11613564B2 (en) | 2019-05-31 | 2023-03-28 | ALX Oncology Inc. | Methods of treating cancer |
EP4197559A4 (en) * | 2020-08-14 | 2024-04-24 | Korea Inst Sci & Tech | ARNSI/IMMUNOMODULATING PROTEIN COMPLEX WITH ANTI-CANCER ACTIVITY |
KR102557016B1 (ko) * | 2020-09-22 | 2023-07-20 | 비피진 주식회사 | 암 치료를 위한 cd47 바인더 및 리포좀 복합체 |
KR102398032B1 (ko) * | 2020-09-22 | 2022-05-19 | 비피진 주식회사 | 암 치료를 위한 5''-뉴클레오티다아제 변이체 |
WO2022130016A1 (en) | 2020-12-18 | 2022-06-23 | Instil Bio (Uk) Limited | Tumor infiltrating lymphocytes and anti-cd47 therapeutics |
CA3217814A1 (en) | 2021-04-27 | 2022-11-03 | Pfizer Inc. | Enhancement of cd47 blockade therapy with dhfr inhibitors |
KR20240027677A (ko) | 2021-06-04 | 2024-03-04 | 베링거 인겔하임 인터내셔날 게엠베하 | 항-sirp-알파 항체 |
CN117915938A (zh) * | 2021-06-30 | 2024-04-19 | 俄亥俄州国家创新基金会 | 用于与抗cd47-sirpα治疗剂组合抑制二氢乳清酸脱氢酶的方法和组合物 |
KR20240045260A (ko) * | 2021-08-05 | 2024-04-05 | 이뮤노스 테라퓨틱스 아게 | Hla 융합 단백질을 포함하는 복합 치료제 |
WO2023073580A1 (en) | 2021-10-29 | 2023-05-04 | Pfizer Inc. | Enhancement of cd47 blockade with taxanes for cd47+ cancer therapy |
WO2023079438A1 (en) | 2021-11-08 | 2023-05-11 | Pfizer Inc. | Enhancement of cd47 blockade therapy with anti-vegf agents |
WO2023228044A1 (en) | 2022-05-25 | 2023-11-30 | Pfizer Inc. | Dosing regimens of sirp alpha fusion proteins for treatment of cancer |
WO2024040151A1 (en) | 2022-08-18 | 2024-02-22 | Pfizer Inc. | Sirp alpha fusion protein and anti-cd38 antibody combination therapies |
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JP2007008895A (ja) * | 2005-07-04 | 2007-01-18 | Chugai Pharmaceut Co Ltd | 抗cd47抗体とインテグリンリガンドとの併用 |
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US8377448B2 (en) * | 2006-05-15 | 2013-02-19 | The Board Of Trustees Of The Leland Standford Junior University | CD47 related compositions and methods for treating immunological diseases and disorders |
EP2573112A1 (en) * | 2007-10-11 | 2013-03-27 | The Hospital For Sick Children | Modulation of sirpa - cd47 interaction for increasing human hematopoietic stem cell engraftment and compounds therefor |
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ES2796085T3 (es) | 2008-01-15 | 2020-11-25 | Univ Leland Stanford Junior | Marcadores de células madre de leucemia mieloide aguda |
ES2740823T3 (es) | 2008-01-15 | 2020-02-06 | Univ Leland Stanford Junior | Métodos para manipular fagocitosis mediada por CD47 |
EP2111869A1 (en) | 2008-04-23 | 2009-10-28 | Stichting Sanquin Bloedvoorziening | Compositions and methods to enhance the immune system |
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AU2010246872B2 (en) * | 2009-05-15 | 2015-01-22 | The Hospital For Sick Children | Compositions and methods for treating hematologic cancers targeting the SIRPalpha - CD47 interaction |
LT3789038T (lt) | 2010-05-14 | 2022-12-12 | The Board Of Trustees Of The Leland Stanford Junior University | Humanizuoti ir chimeriniai monokloniniai antikūnai prieš cd47 |
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2010
- 2010-05-14 AU AU2010246872A patent/AU2010246872B2/en active Active
- 2010-05-14 EP EP23214532.6A patent/EP4311863A3/en active Pending
- 2010-05-14 CN CN201710476053.4A patent/CN107252476A/zh active Pending
- 2010-05-14 CA CA2983972A patent/CA2983972C/en active Active
- 2010-05-14 DK DK10774475.7T patent/DK2429574T3/da active
- 2010-05-14 SI SI201030950T patent/SI2429574T1/sl unknown
- 2010-05-14 PT PT151601697T patent/PT2995315T/pt unknown
- 2010-05-14 CA CA2761438A patent/CA2761438C/en active Active
- 2010-05-14 PL PL10774475T patent/PL2429574T3/pl unknown
- 2010-05-14 EP EP15160169.7A patent/EP2995315B1/en active Active
- 2010-05-14 US US13/320,629 patent/US10907209B2/en active Active
- 2010-05-14 FI FIEP15160169.7T patent/FI2995315T3/fi active
- 2010-05-14 PL PL15160169.7T patent/PL2995315T3/pl unknown
- 2010-05-14 WO PCT/CA2010/000743 patent/WO2010130053A1/en active Application Filing
- 2010-05-14 JP JP2012510083A patent/JP6091891B2/ja active Active
- 2010-05-14 ES ES10774475.7T patent/ES2539141T3/es active Active
- 2010-05-14 PT PT107744757T patent/PT2429574E/pt unknown
- 2010-05-14 EP EP10774475.7A patent/EP2429574B1/en active Active
- 2010-05-14 CN CN2010800213987A patent/CN102596233A/zh active Pending
- 2010-05-14 DK DK15160169.7T patent/DK2995315T3/da active
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2015
- 2015-05-25 HR HRP20150553TT patent/HRP20150553T1/hr unknown
- 2015-08-17 JP JP2015160462A patent/JP6254124B2/ja active Active
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2017
- 2017-11-14 JP JP2017218996A patent/JP6410911B2/ja active Active
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2018
- 2018-08-30 US US16/118,038 patent/US20190093174A1/en not_active Abandoned
- 2018-09-25 JP JP2018178322A patent/JP2019011347A/ja active Pending
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2020
- 2020-06-01 JP JP2020095230A patent/JP2020143146A/ja active Pending
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2022
- 2022-09-20 JP JP2022148798A patent/JP2022180495A/ja active Pending
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2023
- 2023-11-22 US US18/518,353 patent/US20240084399A1/en active Pending
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