SI2428574T1 - Oksidoreduktaze za stereoselektivno redukcijo keto spojin - Google Patents

Oksidoreduktaze za stereoselektivno redukcijo keto spojin

Info

Publication number
SI2428574T1
SI2428574T1 SI200631849T SI200631849T SI2428574T1 SI 2428574 T1 SI2428574 T1 SI 2428574T1 SI 200631849 T SI200631849 T SI 200631849T SI 200631849 T SI200631849 T SI 200631849T SI 2428574 T1 SI2428574 T1 SI 2428574T1
Authority
SI
Slovenia
Prior art keywords
oxidoreductases
stereo
selective reduction
keto compounds
keto
Prior art date
Application number
SI200631849T
Other languages
English (en)
Inventor
Antje Tschentscher
Antje Gupta
Maria Dupont
Original Assignee
Cambrex Iep Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cambrex Iep Gmbh filed Critical Cambrex Iep Gmbh
Publication of SI2428574T1 publication Critical patent/SI2428574T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
SI200631849T 2005-07-27 2006-07-20 Oksidoreduktaze za stereoselektivno redukcijo keto spojin SI2428574T1 (sl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AT0126105A AT502395B1 (de) 2005-07-27 2005-07-27 Oxidoreduktasen zur stereoselektiven reduktion von ketoverbindungen
EP11189703.9A EP2428574B1 (de) 2005-07-27 2006-07-20 Oxidoreduktasen zur stereoselektiven Reduktion von Ketoverbindungen

Publications (1)

Publication Number Publication Date
SI2428574T1 true SI2428574T1 (sl) 2014-12-31

Family

ID=37216025

Family Applications (3)

Application Number Title Priority Date Filing Date
SI200631899T SI2428576T1 (sl) 2005-07-27 2006-07-20 Oksidoreduktaze za stereoselektivno redukcijo keto spojin
SI200631878T SI2426209T1 (sl) 2005-07-27 2006-07-20 Oksidoreduktaze za stereoselektivno redukcijo keto spojin
SI200631849T SI2428574T1 (sl) 2005-07-27 2006-07-20 Oksidoreduktaze za stereoselektivno redukcijo keto spojin

Family Applications Before (2)

Application Number Title Priority Date Filing Date
SI200631899T SI2428576T1 (sl) 2005-07-27 2006-07-20 Oksidoreduktaze za stereoselektivno redukcijo keto spojin
SI200631878T SI2426209T1 (sl) 2005-07-27 2006-07-20 Oksidoreduktaze za stereoselektivno redukcijo keto spojin

Country Status (16)

Country Link
US (2) US20090311762A1 (sl)
EP (5) EP1907556A1 (sl)
JP (1) JP2009502148A (sl)
KR (2) KR101354546B1 (sl)
CN (1) CN101273137A (sl)
AT (1) AT502395B1 (sl)
AU (1) AU2006274252B2 (sl)
CA (5) CA2821719C (sl)
DK (3) DK2428576T3 (sl)
ES (3) ES2525549T3 (sl)
HU (1) HUE024985T2 (sl)
PL (3) PL2426209T3 (sl)
PT (3) PT2428576E (sl)
SI (3) SI2428576T1 (sl)
WO (1) WO2007012428A1 (sl)
ZA (1) ZA200800732B (sl)

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JP2010517574A (ja) 2007-02-08 2010-05-27 コデクシス， インコーポレイテッド ケトレダクターゼおよびその使用
JP2010536385A (ja) 2007-08-24 2010-12-02 コデクシス， インコーポレイテッド （ｒ）−３−ヒドロキシチオランの立体選択的生成のための改善されたケトレダクターゼポリペプチド
JP5973131B2 (ja) 2007-09-13 2016-08-23 コデクシス， インコーポレイテッド アセトフェノンの還元のためのケトレダクターゼポリペプチド
TWI601825B (zh) * 2007-09-27 2017-10-11 Ｉｅｐ有限公司 對映異構選擇性酶催化還原中間產物之方法
KR20100061571A (ko) 2007-09-28 2010-06-07 코덱시스, 인코포레이티드 케토리덕타제 폴리펩티드 및 이의 용도
WO2009046153A1 (en) 2007-10-01 2009-04-09 Codexis, Inc. Ketoreductase polypeptides for the production of azetidinone
SI2329013T1 (sl) 2008-08-27 2016-03-31 Codexis, Inc. Polipeptidi ketoreduktaze za proizvodnjo 3-aril-3-hidroksipropanamina iz 3-aril-3-ketopropanamina
US8288141B2 (en) 2008-08-27 2012-10-16 Codexis, Inc. Ketoreductase polypeptides for the production of 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine
US8273554B2 (en) 2008-08-29 2012-09-25 Codexis, Inc. Ketoreductase polypeptides for the stereoselective production of (4S)-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one
EP2226386A1 (de) 2009-03-05 2010-09-08 IEP GmbH Verfahren zur stereoselektiven enzymatischen Reduktion von Ketoverbindungen
CN102803233B (zh) 2009-06-22 2017-03-01 爱思开生物制药株式会社 制备氨基甲酸(r)‑1‑芳基‑2‑四唑基‑乙酯的方法
EP2467473B1 (en) 2009-08-19 2016-03-23 Codexis, Inc. Ketoreductase polypeptides for the preparation of phenylephrine
US8404461B2 (en) 2009-10-15 2013-03-26 SK Biopharmaceutical Co. Ltd. Method for preparation of carbamic acid (R)-1-aryl-2-tetrazolyl-ethyl ester
JP2013511498A (ja) * 2009-11-24 2013-04-04 ビーエーエスエフ ソシエタス・ヨーロピア 水性生体変換混合物からのアルカノールの単離方法
EP2566497B1 (en) 2010-05-04 2015-07-29 Codexis, Inc. Biocatalysts for ezetimibe synthesis
BR112014031474A2 (pt) 2012-06-18 2017-08-01 Laboratorio Chimico Int S P A processo para preparar um composto, uso de uma oxidoredutase, uso de uma oxidoredutase e composto
WO2014086702A2 (de) * 2012-12-03 2014-06-12 Basf Se Enzymatische reduktion von hydroxymethylfurfuralen
DE102013104418B4 (de) 2013-04-30 2018-09-27 Cambrex Iep Gmbh Biokatalytisches Verfahren für die Herstellung von (R)-3-Chinuclidinol
CA2958211C (en) * 2014-08-25 2023-09-26 Hli Cellular Therapeutics, Llc Extracellular matrix compositions
CN108441433B (zh) * 2018-03-31 2021-08-20 湖南科技大学 胶红酵母nq1及在制备手性醇中的应用
CN108753851B (zh) * 2018-05-28 2022-05-20 中国科学院成都生物研究所 羰基还原酶生物催化生产手性1,2-二醇类化合物
US20230002795A1 (en) * 2019-06-13 2023-01-05 Asymchem Laboratories (Tianjin) Co., Ltd. Ketoreductase mutant and method for producing chiral alcohols

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Also Published As

Publication number Publication date
PL2426209T3 (pl) 2015-04-30
AU2006274252A1 (en) 2007-02-01
US20090311762A1 (en) 2009-12-17
KR101354546B1 (ko) 2014-01-22
PL2428576T3 (pl) 2015-07-31
KR20130110223A (ko) 2013-10-08
ES2524167T3 (es) 2014-12-04
PL2428574T3 (pl) 2015-03-31
CA2821720C (en) 2015-11-24
CA2625834C (en) 2013-08-27
EP2426209A1 (de) 2012-03-07
CN101273137A (zh) 2008-09-24
DK2428574T3 (da) 2014-10-27
AT502395A4 (de) 2007-03-15
DK2428576T3 (en) 2015-03-09
WO2007012428A1 (de) 2007-02-01
CA2625834A1 (en) 2007-02-01
ES2525549T3 (es) 2014-12-26
KR20080036617A (ko) 2008-04-28
US20140017743A1 (en) 2014-01-16
PT2426209E (pt) 2014-12-16
EP1907556A1 (de) 2008-04-09
ZA200800732B (en) 2009-05-27
DK2426209T3 (da) 2014-11-10
EP2428576A1 (de) 2012-03-14
CA2821717A1 (en) 2007-02-01
US9040265B2 (en) 2015-05-26
AT502395B1 (de) 2007-03-15
CA2821719C (en) 2017-06-27
HUE024985T2 (hu) 2016-02-29
EP2428574B1 (de) 2014-09-24
SI2428576T1 (sl) 2015-04-30
AU2006274252B2 (en) 2012-12-13
EP2428574A1 (de) 2012-03-14
EP2428576B1 (de) 2015-01-14
CA2821719A1 (en) 2007-02-01
CA2869218C (en) 2017-06-27
PT2428574E (pt) 2014-11-26
EP2426209B1 (de) 2014-10-15
CA2821720A1 (en) 2007-02-01
JP2009502148A (ja) 2009-01-29
ES2534657T3 (es) 2015-04-27
SI2426209T1 (sl) 2015-02-27
EP2428575A1 (de) 2012-03-14
KR101341392B1 (ko) 2013-12-20
CA2869218A1 (en) 2007-02-01
PT2428576E (pt) 2015-04-30
CA2821717C (en) 2017-06-27

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