PT2428576E - Oxidorredutases para a redução estereosseletiva de compostos ceto - Google Patents
Oxidorredutases para a redução estereosseletiva de compostos ceto Download PDFInfo
- Publication number
- PT2428576E PT2428576E PT111897088T PT11189708T PT2428576E PT 2428576 E PT2428576 E PT 2428576E PT 111897088 T PT111897088 T PT 111897088T PT 11189708 T PT11189708 T PT 11189708T PT 2428576 E PT2428576 E PT 2428576E
- Authority
- PT
- Portugal
- Prior art keywords
- oxidoreductases
- stereo
- selective reduction
- keto compounds
- keto
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/62—Carboxylic acid esters
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/42—Hydroxy-carboxylic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AT0126105A AT502395B1 (de) | 2005-07-27 | 2005-07-27 | Oxidoreduktasen zur stereoselektiven reduktion von ketoverbindungen |
Publications (1)
Publication Number | Publication Date |
---|---|
PT2428576E true PT2428576E (pt) | 2015-04-30 |
Family
ID=37216025
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT111897088T PT2428576E (pt) | 2005-07-27 | 2006-07-20 | Oxidorredutases para a redução estereosseletiva de compostos ceto |
PT111897039T PT2428574E (pt) | 2005-07-27 | 2006-07-20 | Oxidorredutases para a redução estereosseletiva de compostos ceto |
PT111897013T PT2426209E (pt) | 2005-07-27 | 2006-07-20 | Oxidorredutases para a redução estereosseletiva decompostos ceto |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT111897039T PT2428574E (pt) | 2005-07-27 | 2006-07-20 | Oxidorredutases para a redução estereosseletiva de compostos ceto |
PT111897013T PT2426209E (pt) | 2005-07-27 | 2006-07-20 | Oxidorredutases para a redução estereosseletiva decompostos ceto |
Country Status (16)
Country | Link |
---|---|
US (2) | US20090311762A1 (pt) |
EP (5) | EP1907556A1 (pt) |
JP (1) | JP2009502148A (pt) |
KR (2) | KR101354546B1 (pt) |
CN (1) | CN101273137A (pt) |
AT (1) | AT502395B1 (pt) |
AU (1) | AU2006274252B2 (pt) |
CA (5) | CA2821719C (pt) |
DK (3) | DK2428576T3 (pt) |
ES (3) | ES2525549T3 (pt) |
HU (1) | HUE024985T2 (pt) |
PL (3) | PL2426209T3 (pt) |
PT (3) | PT2428576E (pt) |
SI (3) | SI2428576T1 (pt) |
WO (1) | WO2007012428A1 (pt) |
ZA (1) | ZA200800732B (pt) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AT501928B1 (de) | 2004-10-27 | 2010-09-15 | Iep Gmbh | Verfahren zur herstellung von chiralen alkoholen |
CN101528917B (zh) * | 2006-10-02 | 2015-07-29 | 科德克希思公司 | 用于制备立体异构纯的他汀类及其合成中间体的组合物和方法 |
JP2010517574A (ja) | 2007-02-08 | 2010-05-27 | コデクシス, インコーポレイテッド | ケトレダクターゼおよびその使用 |
JP2010536385A (ja) | 2007-08-24 | 2010-12-02 | コデクシス, インコーポレイテッド | (r)−3−ヒドロキシチオランの立体選択的生成のための改善されたケトレダクターゼポリペプチド |
JP5973131B2 (ja) | 2007-09-13 | 2016-08-23 | コデクシス, インコーポレイテッド | アセトフェノンの還元のためのケトレダクターゼポリペプチド |
TWI601825B (zh) * | 2007-09-27 | 2017-10-11 | Iep有限公司 | 對映異構選擇性酶催化還原中間產物之方法 |
KR20100061571A (ko) | 2007-09-28 | 2010-06-07 | 코덱시스, 인코포레이티드 | 케토리덕타제 폴리펩티드 및 이의 용도 |
WO2009046153A1 (en) | 2007-10-01 | 2009-04-09 | Codexis, Inc. | Ketoreductase polypeptides for the production of azetidinone |
SI2329013T1 (sl) | 2008-08-27 | 2016-03-31 | Codexis, Inc. | Polipeptidi ketoreduktaze za proizvodnjo 3-aril-3-hidroksipropanamina iz 3-aril-3-ketopropanamina |
US8288141B2 (en) | 2008-08-27 | 2012-10-16 | Codexis, Inc. | Ketoreductase polypeptides for the production of 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine |
US8273554B2 (en) | 2008-08-29 | 2012-09-25 | Codexis, Inc. | Ketoreductase polypeptides for the stereoselective production of (4S)-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one |
EP2226386A1 (de) | 2009-03-05 | 2010-09-08 | IEP GmbH | Verfahren zur stereoselektiven enzymatischen Reduktion von Ketoverbindungen |
CN102803233B (zh) | 2009-06-22 | 2017-03-01 | 爱思开生物制药株式会社 | 制备氨基甲酸(r)‑1‑芳基‑2‑四唑基‑乙酯的方法 |
EP2467473B1 (en) | 2009-08-19 | 2016-03-23 | Codexis, Inc. | Ketoreductase polypeptides for the preparation of phenylephrine |
US8404461B2 (en) | 2009-10-15 | 2013-03-26 | SK Biopharmaceutical Co. Ltd. | Method for preparation of carbamic acid (R)-1-aryl-2-tetrazolyl-ethyl ester |
JP2013511498A (ja) * | 2009-11-24 | 2013-04-04 | ビーエーエスエフ ソシエタス・ヨーロピア | 水性生体変換混合物からのアルカノールの単離方法 |
EP2566497B1 (en) | 2010-05-04 | 2015-07-29 | Codexis, Inc. | Biocatalysts for ezetimibe synthesis |
BR112014031474A2 (pt) | 2012-06-18 | 2017-08-01 | Laboratorio Chimico Int S P A | processo para preparar um composto, uso de uma oxidoredutase, uso de uma oxidoredutase e composto |
WO2014086702A2 (de) * | 2012-12-03 | 2014-06-12 | Basf Se | Enzymatische reduktion von hydroxymethylfurfuralen |
DE102013104418B4 (de) | 2013-04-30 | 2018-09-27 | Cambrex Iep Gmbh | Biokatalytisches Verfahren für die Herstellung von (R)-3-Chinuclidinol |
CA2958211C (en) * | 2014-08-25 | 2023-09-26 | Hli Cellular Therapeutics, Llc | Extracellular matrix compositions |
CN108441433B (zh) * | 2018-03-31 | 2021-08-20 | 湖南科技大学 | 胶红酵母nq1及在制备手性醇中的应用 |
CN108753851B (zh) * | 2018-05-28 | 2022-05-20 | 中国科学院成都生物研究所 | 羰基还原酶生物催化生产手性1,2-二醇类化合物 |
US20230002795A1 (en) * | 2019-06-13 | 2023-01-05 | Asymchem Laboratories (Tianjin) Co., Ltd. | Ketoreductase mutant and method for producing chiral alcohols |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH03127998A (ja) | 1989-10-13 | 1991-05-31 | Taunzu:Kk | 尿素の定量法 |
DE4014573C1 (pt) | 1990-05-07 | 1991-10-10 | Forschungszentrum Juelich Gmbh, 5170 Juelich, De | |
US5200355A (en) | 1990-12-10 | 1993-04-06 | Samsung Electronics Co., Ltd. | Method for manufacturing a mask read only memory device |
US5385833A (en) | 1992-02-26 | 1995-01-31 | The Scripps Research Institute | Pseudomonas sp. ATCC No. 49794 alcohol dehydrogenase |
US5523223A (en) | 1992-03-13 | 1996-06-04 | Forschungszentrum Julich Gmbh | Ketoester reductase for conversion of keto acid esters to optically active hydroxy acid esters |
JP3574682B2 (ja) * | 1993-09-24 | 2004-10-06 | ダイセル化学工業株式会社 | 新規な酵素、該酵素を製造する方法、該酵素をコードするdna、該dnaを含む形質転換体、該酵素による光学活性アルコール等の製造方法 |
US5523233A (en) * | 1995-05-03 | 1996-06-04 | Merck & Co., Inc. | Enzymatic hydrolysis of 3,3-diethyl-4-[(4-carboxy)phenoxy]-2-azetidinone esters |
DE19610984A1 (de) | 1996-03-21 | 1997-09-25 | Boehringer Mannheim Gmbh | Alkohol-Dehydrogenase und deren Verwendung zur enzymatischen Herstellung chiraler Hydroxyverbindungen |
JP4753273B2 (ja) * | 1999-07-21 | 2011-08-24 | 株式会社カネカ | 光学活性ピリジンエタノール誘導体の製造方法 |
TWI275645B (en) * | 2000-02-16 | 2007-03-11 | Daicel Chemical Industries Ltd. | (R)-2-octanol dehydrogenases, methods for producing the enzymes, DNA encoding the enzymes, and methods for producing alcohols using the enzymes |
DE10037101A1 (de) * | 2000-07-27 | 2002-02-07 | Degussa | Rekombinant hergestellte Enzyme mit verbesserter NAD(H)-Akzeptanz |
DE10119274A1 (de) * | 2001-04-20 | 2002-10-31 | Juelich Enzyme Products Gmbh | Enzymatisches Verfahren zur enantioselektiven Reduktion von Ketoverbindungen |
AU2003214111A1 (en) * | 2002-03-18 | 2003-09-29 | Ciba Specialty Chemicals Holding Inc. | Alcohol dehydrogenases with high solvent and temperature stability |
DE10218689A1 (de) * | 2002-04-26 | 2003-11-20 | Degussa | ADH aus Rhodococcus erythropolis |
DE10300335B4 (de) | 2003-01-09 | 2008-06-26 | Iep Gmbh | Oxidoreduktase |
US20050037946A1 (en) * | 2003-01-13 | 2005-02-17 | Millennium Pharmaceuticals, Inc. | Methods and compositions for treating cardiovascular disease using 1722, 10280, 59917, 85553, 10653, 9235, 21668, 17794, 2210, 6169, 10102, 21061, 17662, 1468, 12282, 6350, 9035, 1820, 23652, 7301, 8925, 8701, 3533, 9462, 9123, 12788, 17729, 65552, 1261, 21476, 33770, 9380, 2569654, 33556, 53656, 44143, 32612, 10671, 261, 44570, 41922, 2552, 2417, 19319, 43969, 8921, 8993, 955, 32345, 966, 1920, 17318, 1510, 14180, 26005, 554, 16408, 42028, 112091, 13886, 13942, 1673, 54946 or 2419 |
DE10327454A1 (de) * | 2003-06-18 | 2005-01-20 | Juelich Enzyme Products Gmbh | Oxidoreduktase aus Pichia capsulata |
JP2007502111A (ja) * | 2003-08-11 | 2007-02-08 | コデクシス, インコーポレイテッド | 4−置換3−ヒドロキシ酪酸誘導体およびビシナルなシアノ,ヒドロキシ置換カルボン酸エステルの生成のための酵素的プロセス |
EP1654354A1 (en) * | 2003-08-11 | 2006-05-10 | Codexis, Inc. | Improved ketoreductase polypeptides and related polynucleotides |
JP2005095022A (ja) * | 2003-09-22 | 2005-04-14 | Daicel Chem Ind Ltd | 光学活性アルコールの製造方法 |
EP1731618A1 (en) | 2005-06-07 | 2006-12-13 | Prodotti Chimici E Alimentari Spa | Process for the selective oxydation of colic acid |
AT503486B1 (de) * | 2006-04-11 | 2008-05-15 | Iep Gmbh | Verfahren zur enantioselektiven reduktion von steroiden |
-
2005
- 2005-07-27 AT AT0126105A patent/AT502395B1/de not_active IP Right Cessation
-
2006
- 2006-07-20 SI SI200631899T patent/SI2428576T1/sl unknown
- 2006-07-20 PT PT111897088T patent/PT2428576E/pt unknown
- 2006-07-20 JP JP2008523190A patent/JP2009502148A/ja active Pending
- 2006-07-20 US US11/996,968 patent/US20090311762A1/en not_active Abandoned
- 2006-07-20 ES ES11189701.3T patent/ES2525549T3/es active Active
- 2006-07-20 EP EP06776315A patent/EP1907556A1/de not_active Withdrawn
- 2006-07-20 CA CA2821719A patent/CA2821719C/en active Active
- 2006-07-20 EP EP11189703.9A patent/EP2428574B1/de not_active Not-in-force
- 2006-07-20 PT PT111897039T patent/PT2428574E/pt unknown
- 2006-07-20 EP EP11189707A patent/EP2428575A1/de not_active Withdrawn
- 2006-07-20 CA CA2821720A patent/CA2821720C/en active Active
- 2006-07-20 PT PT111897013T patent/PT2426209E/pt unknown
- 2006-07-20 DK DK11189708T patent/DK2428576T3/en active
- 2006-07-20 WO PCT/EP2006/007150 patent/WO2007012428A1/de active Application Filing
- 2006-07-20 EP EP11189708.8A patent/EP2428576B1/de active Active
- 2006-07-20 PL PL11189701T patent/PL2426209T3/pl unknown
- 2006-07-20 ZA ZA200800732A patent/ZA200800732B/xx unknown
- 2006-07-20 AU AU2006274252A patent/AU2006274252B2/en not_active Ceased
- 2006-07-20 HU HUE11189708A patent/HUE024985T2/hu unknown
- 2006-07-20 CA CA2625834A patent/CA2625834C/en active Active
- 2006-07-20 ES ES11189708.8T patent/ES2534657T3/es active Active
- 2006-07-20 PL PL11189703T patent/PL2428574T3/pl unknown
- 2006-07-20 SI SI200631878T patent/SI2426209T1/sl unknown
- 2006-07-20 ES ES11189703.9T patent/ES2524167T3/es active Active
- 2006-07-20 EP EP11189701.3A patent/EP2426209B1/de not_active Not-in-force
- 2006-07-20 CN CNA2006800356804A patent/CN101273137A/zh active Pending
- 2006-07-20 DK DK11189701.3T patent/DK2426209T3/da active
- 2006-07-20 CA CA2869218A patent/CA2869218C/en active Active
- 2006-07-20 SI SI200631849T patent/SI2428574T1/sl unknown
- 2006-07-20 CA CA2821717A patent/CA2821717C/en active Active
- 2006-07-20 DK DK11189703.9T patent/DK2428574T3/da active
- 2006-07-20 PL PL11189708T patent/PL2428576T3/pl unknown
- 2006-07-20 KR KR1020137022212A patent/KR101354546B1/ko active IP Right Grant
-
2008
- 2008-02-26 KR KR1020087004580A patent/KR101341392B1/ko active IP Right Grant
-
2011
- 2011-10-25 US US13/280,876 patent/US9040265B2/en not_active Expired - Fee Related
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