SI2252300T1 - Uporaba 2,4-pirimidindiaminov za zdravljenje ateroskleroze - Google Patents

Uporaba 2,4-pirimidindiaminov za zdravljenje ateroskleroze

Info

Publication number
SI2252300T1
SI2252300T1 SI200931588A SI200931588A SI2252300T1 SI 2252300 T1 SI2252300 T1 SI 2252300T1 SI 200931588 A SI200931588 A SI 200931588A SI 200931588 A SI200931588 A SI 200931588A SI 2252300 T1 SI2252300 T1 SI 2252300T1
Authority
SI
Slovenia
Prior art keywords
pyrimidinediamines
atherosclerosis
treatment
Prior art date
Application number
SI200931588A
Other languages
English (en)
Inventor
Esteban Masuda
Jochen Schmitz
Original Assignee
Rigel Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rigel Pharmaceuticals, Inc. filed Critical Rigel Pharmaceuticals, Inc.
Publication of SI2252300T1 publication Critical patent/SI2252300T1/sl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
SI200931588A 2008-02-22 2009-02-20 Uporaba 2,4-pirimidindiaminov za zdravljenje ateroskleroze SI2252300T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3090308P 2008-02-22 2008-02-22
PCT/US2009/034718 WO2009105675A1 (en) 2008-02-22 2009-02-20 Use of 2,4-pyrimidinediamines for the treatment of atherosclerosis
EP09711944.0A EP2252300B1 (en) 2008-02-22 2009-02-20 Use of 2,4-pyrimidinediamines for the treatment of atherosclerosis

Publications (1)

Publication Number Publication Date
SI2252300T1 true SI2252300T1 (sl) 2017-04-26

Family

ID=40559977

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200931588A SI2252300T1 (sl) 2008-02-22 2009-02-20 Uporaba 2,4-pirimidindiaminov za zdravljenje ateroskleroze

Country Status (21)

Country Link
US (1) US8530466B2 (sl)
EP (1) EP2252300B1 (sl)
JP (1) JP5586482B2 (sl)
KR (1) KR101614555B1 (sl)
CN (1) CN102014917A (sl)
AU (1) AU2009215430B2 (sl)
BR (1) BRPI0907724B8 (sl)
CA (1) CA2715962C (sl)
CY (1) CY1118655T1 (sl)
DK (1) DK2252300T3 (sl)
ES (1) ES2610880T3 (sl)
HK (1) HK1150555A1 (sl)
HR (1) HRP20170050T1 (sl)
HU (1) HUE030307T2 (sl)
LT (1) LT2252300T (sl)
MX (1) MX2010009159A (sl)
PL (1) PL2252300T3 (sl)
PT (1) PT2252300T (sl)
RU (1) RU2490015C2 (sl)
SI (1) SI2252300T1 (sl)
WO (1) WO2009105675A1 (sl)

Families Citing this family (21)

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US8338439B2 (en) 2008-06-27 2012-12-25 Celgene Avilomics Research, Inc. 2,4-disubstituted pyrimidines useful as kinase inhibitors
CA2986640C (en) 2008-06-27 2019-03-26 Celgene Avilomics Research, Inc. Heteroaryl compounds and uses thereof
US11351168B1 (en) 2008-06-27 2022-06-07 Celgene Car Llc 2,4-disubstituted pyrimidines useful as kinase inhibitors
MX2012007402A (es) 2009-12-23 2012-08-23 Takeda Pharmaceutical Pirrolidinonas heteroaromaticas fusionadas como inhibidores de tirosina cinasa esplenica (syk).
MX2012013274A (es) 2010-05-21 2013-05-28 Chemilia Ab Novedosos derivados de la pirimidina.
KR20130099040A (ko) 2010-08-10 2013-09-05 셀진 아빌로믹스 리서치, 인코포레이티드 Ｂｔｋ 억제제의 베실레이트 염
US8975249B2 (en) 2010-11-01 2015-03-10 Celgene Avilomics Research, Inc. Heterocyclic compounds and uses thereof
EP2635285B1 (en) 2010-11-01 2017-05-03 Celgene Avilomics Research, Inc. Heteroaryl compounds and uses thereof
US8796255B2 (en) 2010-11-10 2014-08-05 Celgene Avilomics Research, Inc Mutant-selective EGFR inhibitors and uses thereof
US9006241B2 (en) 2011-03-24 2015-04-14 Noviga Research Ab Pyrimidine derivatives
US9056873B2 (en) 2011-06-22 2015-06-16 Takeda Pharmaceutical Company Limited Substituted 6-aza-isoindolin-1-one derivatives
AU2012288632B2 (en) 2011-07-28 2017-08-17 Rigel Pharmaceuticals, Inc. New (trimethoxyphenylamino)pyrimidinyl formulations
CA2853498A1 (en) 2011-10-28 2013-05-02 Celgene Avilomics Research, Inc. Methods of treating a bruton's tyrosine kinase disease or disorder
EP2825041B1 (en) 2012-03-15 2021-04-21 Celgene CAR LLC Solid forms of an epidermal growth factor receptor kinase inhibitor
RS57901B1 (sr) 2012-03-15 2019-01-31 Celgene Car Llc Soli inhibitora kinaze receptora epidermalnog faktora rasta
EP2935226A4 (en) 2012-12-21 2016-11-02 Celgene Avilomics Res Inc HETEROARYL COMPOUNDS AND USES THEREOF
PE20151274A1 (es) 2013-02-08 2015-09-12 Celgene Avilomics Res Inc Inhibidores de erk y sus usos
US9492471B2 (en) 2013-08-27 2016-11-15 Celgene Avilomics Research, Inc. Methods of treating a disease or disorder associated with Bruton'S Tyrosine Kinase
US9415049B2 (en) 2013-12-20 2016-08-16 Celgene Avilomics Research, Inc. Heteroaryl compounds and uses thereof
JP7118642B2 (ja) 2014-08-08 2022-08-16 アリ リサーチ ソシエタ ア レスポンサビリタ リミタータ センプリフィカタ 炎症性およびアレルギー性病変の治療に用いるための脂肪酸とパルミトイルエタノールアミドの混合物
ES2741785T3 (es) 2014-08-13 2020-02-12 Celgene Car Llc Formas y composiciones de un inhibidor de ERK

Family Cites Families (18)

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Publication number Priority date Publication date Assignee Title
JP2983636B2 (ja) * 1993-10-01 1999-11-29 ノバルティス アクチェンゲゼルシャフト 薬理学的に活性なピリジン誘導体及びその製造方法
CN1142817A (zh) * 1993-10-12 1997-02-12 杜邦麦克制药有限公司 1n-烷基-n-芳基嘧啶胺及其衍生物
JP2002523497A (ja) * 1998-08-29 2002-07-30 アストラゼネカ・アクチエボラーグ ピリミジン化合物
GB9828511D0 (en) * 1998-12-24 1999-02-17 Zeneca Ltd Chemical compounds
JP4510442B2 (ja) * 2001-06-26 2010-07-21 ブリストル−マイヤーズ スクイブ カンパニー ＴＮＦ−α発現のＮ−ヘテロ環インヒビター
EP1470122B1 (en) 2002-01-23 2007-12-19 Bayer Pharmaceuticals Corporation Rho-kinase inhibitors
EP1483260A1 (de) * 2002-03-11 2004-12-08 Schering Aktiengesellschaft Cdk inhibitorische 2-heteroaryl-pyrimidine, deren herstellung und verwendung als arzneimittel
US7288547B2 (en) 2002-03-11 2007-10-30 Schering Ag CDK-inhibitory 2-heteroaryl-pyrimidines, their production and use as pharmaceutical agents
GB0321710D0 (en) 2003-09-16 2003-10-15 Novartis Ag Organic compounds
TW200517057A (en) * 2003-09-22 2005-06-01 Basf Ag Fungicidal mixtures
AU2005281735A1 (en) * 2004-09-10 2006-03-16 Nycomed Gmbh Ciclesonide and syk inhibitor combination and methods of use thereof
ES2337496T3 (es) * 2005-01-19 2010-04-26 Rigel Pharmaceuticals, Inc. Profarmacos de compuestos de 2,4-pirimidindiamina y sus usos.
DE102005016634A1 (de) * 2005-04-12 2006-10-19 Merck Patent Gmbh Neuartige Aza-Hetercyclen als Kinase-Inhibitoren
WO2007008541A2 (en) 2005-07-08 2007-01-18 Kalypsys, Inc. Cellular cholesterol absorption modifiers
AU2006309013B2 (en) * 2005-11-01 2012-06-28 Impact Biomedicines, Inc. Bi-aryl meta-pyrimidine inhibitors of kinases
EP2032543A1 (en) 2006-06-15 2009-03-11 Boehringer Ingelheim International GmbH 2-anilino-4-aminoalkyleneaminopyrimidines
EP2043651A2 (en) * 2006-07-05 2009-04-08 Exelixis, Inc. Methods of using igf1r and abl kinase modulators
CA2693594A1 (en) * 2007-07-17 2009-01-22 Rigel Pharmaceuticals, Inc. Cyclic amine substituted pyrimidinediamines as pkc inhibitors

Also Published As

Publication number Publication date
US20110046126A1 (en) 2011-02-24
LT2252300T (lt) 2017-02-10
CA2715962A1 (en) 2009-08-27
ES2610880T3 (es) 2017-05-03
CY1118655T1 (el) 2017-07-12
JP5586482B2 (ja) 2014-09-10
MX2010009159A (es) 2010-09-14
HUE030307T2 (en) 2017-04-28
US8530466B2 (en) 2013-09-10
AU2009215430B2 (en) 2015-02-12
PT2252300T (pt) 2017-01-06
AU2009215430A1 (en) 2009-08-27
EP2252300A1 (en) 2010-11-24
JP2011513230A (ja) 2011-04-28
HK1150555A1 (zh) 2012-01-06
BRPI0907724B8 (pt) 2021-05-25
BRPI0907724B1 (pt) 2019-12-17
RU2490015C2 (ru) 2013-08-20
KR101614555B1 (ko) 2016-04-21
WO2009105675A1 (en) 2009-08-27
KR20100126422A (ko) 2010-12-01
PL2252300T3 (pl) 2017-04-28
CA2715962C (en) 2017-03-07
CN102014917A (zh) 2011-04-13
DK2252300T3 (en) 2017-02-06
HRP20170050T1 (hr) 2017-03-10
RU2010138899A (ru) 2012-03-27
BRPI0907724A2 (pt) 2017-06-13
EP2252300B1 (en) 2016-10-19

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