SI2139484T1 - Postopki za zdravljenje raka s pirido pirimidin PI3K alfa inhibitorji - Google Patents
Postopki za zdravljenje raka s pirido pirimidin PI3K alfa inhibitorjiInfo
- Publication number
- SI2139484T1 SI2139484T1 SI200831004T SI200831004T SI2139484T1 SI 2139484 T1 SI2139484 T1 SI 2139484T1 SI 200831004 T SI200831004 T SI 200831004T SI 200831004 T SI200831004 T SI 200831004T SI 2139484 T1 SI2139484 T1 SI 2139484T1
- Authority
- SI
- Slovenia
- Prior art keywords
- methods
- treating cancer
- pi3k alpha
- pyridopyrimidinone
- inhibitors
- Prior art date
Links
- IAAQUOVTPAMQCR-UHFFFAOYSA-N 1h-pyrido[3,2-d]pyrimidin-2-one Chemical compound C1=CC=C2NC(=O)N=CC2=N1 IAAQUOVTPAMQCR-UHFFFAOYSA-N 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/282—Platinum compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US92289907P | 2007-04-10 | 2007-04-10 | |
EP08742677.1A EP2139484B9 (en) | 2007-04-10 | 2008-04-09 | Methods of treating cancer using pyridopyrimidinone inhibitors of pi3k alpha |
PCT/US2008/004573 WO2008124161A1 (en) | 2007-04-10 | 2008-04-09 | Methods of treating cancer using pyridopyrimidinone inhibitors of pi3k alpha |
Publications (1)
Publication Number | Publication Date |
---|---|
SI2139484T1 true SI2139484T1 (sl) | 2013-10-30 |
Family
ID=39627802
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI200831004T SI2139484T1 (sl) | 2007-04-10 | 2008-04-09 | Postopki za zdravljenje raka s pirido pirimidin PI3K alfa inhibitorji |
Country Status (32)
Country | Link |
---|---|
US (1) | US8513266B2 (sl) |
EP (1) | EP2139484B9 (sl) |
JP (3) | JP2010523670A (sl) |
KR (1) | KR101626435B1 (sl) |
CN (2) | CN101715345A (sl) |
AU (1) | AU2008236562B2 (sl) |
BR (1) | BRPI0810206A2 (sl) |
CA (1) | CA2683641C (sl) |
CO (1) | CO6251254A2 (sl) |
CR (1) | CR11100A (sl) |
DK (1) | DK2139484T3 (sl) |
DO (1) | DOP2009000243A (sl) |
EA (1) | EA020022B1 (sl) |
EC (1) | ECSP099724A (sl) |
ES (1) | ES2430614T3 (sl) |
HK (1) | HK1139863A1 (sl) |
HN (1) | HN2009003002A (sl) |
HR (1) | HRP20130688T1 (sl) |
IL (1) | IL201284A (sl) |
MA (1) | MA31358B1 (sl) |
ME (1) | ME00936B (sl) |
MX (1) | MX2009010930A (sl) |
MY (1) | MY150697A (sl) |
NZ (1) | NZ580110A (sl) |
PL (1) | PL2139484T3 (sl) |
PT (1) | PT2139484E (sl) |
RS (1) | RS52939B (sl) |
SI (1) | SI2139484T1 (sl) |
TN (1) | TN2009000400A1 (sl) |
UA (1) | UA100979C2 (sl) |
WO (1) | WO2008124161A1 (sl) |
ZA (1) | ZA200906764B (sl) |
Families Citing this family (43)
Publication number | Priority date | Publication date | Assignee | Title |
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TW200726767A (en) * | 2005-07-04 | 2007-07-16 | Astrazeneca Ab | Chemical compounds 2 |
PL1940839T3 (pl) * | 2005-10-07 | 2013-12-31 | Exelixis Inc | Pirydopirymidynonowe inhibitory PI3Kalfa |
DK1931645T3 (da) * | 2005-10-07 | 2014-09-29 | Exelixis Inc | N-(3-aminoquinoxalin-2-yl)-sulfonamidderivater og deres anvendelse som inhibitorer af phosphatidylinositol-3-kinase |
CN101528231A (zh) | 2006-08-16 | 2009-09-09 | 埃克塞利希斯股份有限公司 | 在癌症的治疗中使用pi3k和mek调控剂 |
US8188113B2 (en) * | 2006-09-14 | 2012-05-29 | Deciphera Pharmaceuticals, Inc. | Dihydropyridopyrimidinyl, dihydronaphthyidinyl and related compounds useful as kinase inhibitors for the treatment of proliferative diseases |
SA08280783B1 (ar) * | 2007-01-11 | 2011-04-24 | استرازينيكا ايه بي | مشتقات بيريدوبيريميدين كمثبطات pde4 |
DK2139484T3 (da) | 2007-04-10 | 2013-10-21 | Exelixis Inc | Fremgangsmåder til behandling af cancer ved brug af pyridopyrimidinon-inhibitorer af PI3K-alfa |
UA98141C2 (ru) * | 2007-04-11 | 2012-04-25 | Экселиксис, Инк. | Способы лечения с применением хинаксолиновых ингибиторов pi3k-альфа |
TW201020245A (en) | 2008-08-20 | 2010-06-01 | Schering Corp | Ethynyl-substituted pyridine and pyrimidine derivatives and their use in treating viral infections |
EP2326628A1 (en) | 2008-08-20 | 2011-06-01 | Schering Corporation | Azo-substituted pyridine and pyrimidine derivatives and their use in treating viral infections |
EP2326627A1 (en) | 2008-08-20 | 2011-06-01 | Schering Corporation | Substituted pyridine and pyrimidine derivatives and their use in treating viral infections |
TW201020238A (en) * | 2008-08-20 | 2010-06-01 | Schering Corp | Ethenyl-substituted pyridine and pyrimidine derivatives and their use in treating viral infections |
WO2011100319A1 (en) | 2010-02-09 | 2011-08-18 | Exelixis, Inc. | Methods of treating cancer using pyridopyrimidinone inhibitors of pi3k and mtor in combination with autophagy inhibitors |
WO2012027536A1 (en) * | 2010-08-26 | 2012-03-01 | Bristol-Myers Squibb Company | Combination of anti-ctla4 antibody with braf inhibitors for the synergistic treatment of proliferative diseases |
AU2011302196B2 (en) | 2010-09-14 | 2016-04-28 | Exelixis, Inc. | Inhibitors of PI3K-delta and methods of their use and manufacture |
WO2012065019A2 (en) | 2010-11-12 | 2012-05-18 | Exelixis, Inc. | Pyridopyrimidinone inhibitors of p13k alpha |
WO2012158960A2 (en) * | 2011-05-17 | 2012-11-22 | H. Lee Moffitt Cancer Center & Research Institute, Inc. | Melanocortin 1 receptor ligands and methods of use |
TW201306842A (zh) * | 2011-06-15 | 2013-02-16 | Exelixis Inc | 使用pi3k/mtor吡啶並嘧啶酮抑制劑及苯達莫司汀及/或利妥昔單抗治療惡性血液疾病之組合療法 |
WO2013015833A2 (en) * | 2011-07-28 | 2013-01-31 | Genentech, Inc | Pik3ca h1047r knock-in non-human animal breast cancer model |
WO2013056067A1 (en) * | 2011-10-13 | 2013-04-18 | Exelixis, Inc. | Compounds for use in the treatment of basal cell carcinoma |
AU2012332486A1 (en) | 2011-11-01 | 2014-06-19 | Arthur Decillis | N- (3- { [ (3- { [2-chloro-5- (methoxy) phenyl] amino} quinoxalin- 2 -yl) amino] sulfonyl} phe nyl) - 2 -methylalaninamide as phosphatidylinositol 3 - kinase inhibitor for the treatment of lymphoproliferative malignancies |
WO2013071264A1 (en) * | 2011-11-11 | 2013-05-16 | Intellikine, Llc | Combination of kinase inhibitors and uses thereof |
CA2860051A1 (en) | 2011-12-27 | 2013-07-04 | Kadmon Corporation, Llc | Methods for treatment of breast cancer nonresponsive to trastuzumab |
US8461179B1 (en) | 2012-06-07 | 2013-06-11 | Deciphera Pharmaceuticals, Llc | Dihydronaphthyridines and related compounds useful as kinase inhibitors for the treatment of proliferative diseases |
EP2872161B1 (en) | 2012-06-26 | 2020-12-16 | Del Mar Pharmaceuticals | Dianhydrogalactitol for use in treating tyrosine-kinase-inhibitor-resistant malignancies in patients with genetic polymorphisms or ahi1 dysregulations or mutations |
US8980259B2 (en) * | 2012-07-20 | 2015-03-17 | Novartis Ag | Combination therapy |
KR102112885B1 (ko) | 2012-08-07 | 2020-05-19 | 노파르티스 아게 | B-raf 억제제, egfr 억제제 및 임의로 pi3k-알파 억제제를 포함하는 제약 조합물 |
EP2983674A4 (en) | 2013-04-08 | 2017-05-10 | Dennis M. Brown | Therapeutic benefit of suboptimally administered chemical compounds |
US9950194B2 (en) | 2014-09-09 | 2018-04-24 | Mevion Medical Systems, Inc. | Patient positioning system |
KR20220110859A (ko) | 2016-03-04 | 2022-08-09 | 다이호야쿠힌고교 가부시키가이샤 | 악성 종양 치료용 제제 및 조성물 |
US11883404B2 (en) | 2016-03-04 | 2024-01-30 | Taiho Pharmaceuticals Co., Ltd. | Preparation and composition for treatment of malignant tumors |
UA124804C2 (uk) * | 2016-08-15 | 2021-11-24 | Пфайзер Інк. | Піридопіримідинонові інгібітори cdk2/4/6 |
JP7027699B2 (ja) * | 2017-05-09 | 2022-03-02 | 住友ゴム工業株式会社 | タイヤトレッドおよびタイヤ |
US11833151B2 (en) | 2018-03-19 | 2023-12-05 | Taiho Pharmaceutical Co., Ltd. | Pharmaceutical composition including sodium alkyl sulfate |
WO2021030405A1 (en) | 2019-08-12 | 2021-02-18 | Deciphera Pharmaceuticals, Llc | Ripretinib for treating gastrointestinal stromal tumors |
KR20220045189A (ko) | 2019-08-12 | 2022-04-12 | 데시페라 파마슈티칼스, 엘엘씨. | 위장관 기질 종양을 치료하는 방법 |
BR112022011372A2 (pt) * | 2019-12-10 | 2022-08-23 | Univ Indiana Trustees | Inibidores de interação de proteína a de replicação (rpa)-dna |
EP4084779A1 (en) | 2019-12-30 | 2022-11-09 | Deciphera Pharmaceuticals, LLC | Compositions of 1-(4-bromo-5-(1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl)-3-phenylurea |
CA3163053A1 (en) | 2019-12-30 | 2021-07-08 | Michael D. Kaufman | Amorphous kinase inhibitor formulations and methods of use thereof |
KR102195221B1 (ko) | 2019-12-31 | 2020-12-24 | 서울대학교산학협력단 | 포스파티딜이노시톨 3-키나아제 억제제 및 프로그램화 세포 사멸 단백질 1 억제제를 포함하는, 삼중음성 유방암의 방사선 병용 치료용 약학적 조성물 |
CN111358952B (zh) * | 2020-04-15 | 2022-03-15 | 中山大学肿瘤防治中心(中山大学附属肿瘤医院、中山大学肿瘤研究所) | 一种抗肿瘤药物组合物及其制剂和应用 |
WO2023092104A1 (en) * | 2021-11-18 | 2023-05-25 | Onconova Therapeutics, Inc. | Methods and compositions for treating cancer |
US11779572B1 (en) | 2022-09-02 | 2023-10-10 | Deciphera Pharmaceuticals, Llc | Methods of treating gastrointestinal stromal tumors |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7019002B2 (en) | 2001-12-11 | 2006-03-28 | Pharmacia & Upjohn, S.P.A. | Pyridopyrimidinones derivatives as telomerase inhibitors |
EP1521747B1 (en) * | 2002-07-15 | 2018-09-05 | Symphony Evolution, Inc. | Receptor-type kinase modulators and methods of use |
WO2005082903A1 (en) | 2004-02-18 | 2005-09-09 | Warner-Lambert Company Llc | 2-(pyridin-3-ylamino)-pyrido[2,3-d]pyrimidin-7-ones |
DE602005002562T2 (de) * | 2004-05-04 | 2008-01-31 | Warner-Lambert Company Llc | Pyrrolylsubstituierte pyridoä2,3-düpyrimidin-7-one und derivate davon als therapeutische mittel |
JP5216958B2 (ja) * | 2005-07-06 | 2013-06-19 | 株式会社三和技術総合研究所 | 漏洩電流検出装置及び漏洩電流検出方法 |
PL1940839T3 (pl) * | 2005-10-07 | 2013-12-31 | Exelixis Inc | Pirydopirymidynonowe inhibitory PI3Kalfa |
DK1931645T3 (da) | 2005-10-07 | 2014-09-29 | Exelixis Inc | N-(3-aminoquinoxalin-2-yl)-sulfonamidderivater og deres anvendelse som inhibitorer af phosphatidylinositol-3-kinase |
CA2624965A1 (en) | 2005-10-07 | 2007-04-19 | Exelixis, Inc. | Pyridopyrimidinone inhibitors of pi3k.alpha. |
CN101528231A (zh) | 2006-08-16 | 2009-09-09 | 埃克塞利希斯股份有限公司 | 在癌症的治疗中使用pi3k和mek调控剂 |
AP2710A (en) * | 2006-09-15 | 2013-07-30 | Pfizer Prod Inc | Pyrido (2, 3-D) Pyrimidinone compounds and their use as P13 inhibitors |
DK2139484T3 (da) | 2007-04-10 | 2013-10-21 | Exelixis Inc | Fremgangsmåder til behandling af cancer ved brug af pyridopyrimidinon-inhibitorer af PI3K-alfa |
CA2683784A1 (en) | 2007-04-11 | 2008-10-23 | Exelixis, Inc. | Pyrido[2,3-d]pyrimidin-7-one compounds as inhibitors of pi3k-alpha for the treatment of cancer |
UA98141C2 (ru) | 2007-04-11 | 2012-04-25 | Экселиксис, Инк. | Способы лечения с применением хинаксолиновых ингибиторов pi3k-альфа |
AU2008239596B2 (en) | 2007-04-11 | 2013-08-15 | Exelixis, Inc. | Pyrido [2,3-D] pyrimidin-7-one compounds as inhibitors of PI3K-alpha for the treatment of cancer |
TW201018685A (en) | 2008-09-30 | 2010-05-16 | Exelixis Inc | Pyridopyrimidinone inhibitors of PI3Kα and mTOR |
-
2008
- 2008-04-09 DK DK08742677.1T patent/DK2139484T3/da active
- 2008-04-09 JP JP2010503045A patent/JP2010523670A/ja active Pending
- 2008-04-09 PL PL08742677T patent/PL2139484T3/pl unknown
- 2008-04-09 AU AU2008236562A patent/AU2008236562B2/en not_active Ceased
- 2008-04-09 RS RS20130384A patent/RS52939B/en unknown
- 2008-04-09 CA CA2683641A patent/CA2683641C/en not_active Expired - Fee Related
- 2008-04-09 MY MYPI20094214 patent/MY150697A/en unknown
- 2008-04-09 CN CN200880018725A patent/CN101715345A/zh active Pending
- 2008-04-09 BR BRPI0810206-6A2A patent/BRPI0810206A2/pt not_active IP Right Cessation
- 2008-04-09 UA UAA200911419A patent/UA100979C2/ru unknown
- 2008-04-09 PT PT87426771T patent/PT2139484E/pt unknown
- 2008-04-09 KR KR1020097023351A patent/KR101626435B1/ko active IP Right Grant
- 2008-04-09 MX MX2009010930A patent/MX2009010930A/es active IP Right Grant
- 2008-04-09 ES ES08742677T patent/ES2430614T3/es active Active
- 2008-04-09 US US12/595,219 patent/US8513266B2/en active Active
- 2008-04-09 EP EP08742677.1A patent/EP2139484B9/en active Active
- 2008-04-09 CN CN201210032620.4A patent/CN102727498B/zh not_active Expired - Fee Related
- 2008-04-09 NZ NZ580110A patent/NZ580110A/en not_active IP Right Cessation
- 2008-04-09 SI SI200831004T patent/SI2139484T1/sl unknown
- 2008-04-09 EA EA200970932A patent/EA020022B1/ru not_active IP Right Cessation
- 2008-04-09 WO PCT/US2008/004573 patent/WO2008124161A1/en active Application Filing
- 2008-04-09 ME MEP-2009-303A patent/ME00936B/me unknown
-
2009
- 2009-09-29 ZA ZA200906764A patent/ZA200906764B/xx unknown
- 2009-09-30 TN TNP2009000400A patent/TN2009000400A1/fr unknown
- 2009-10-01 IL IL201284A patent/IL201284A/en active IP Right Grant
- 2009-10-09 HN HN2009003002A patent/HN2009003002A/es unknown
- 2009-10-09 DO DO2009000243A patent/DOP2009000243A/es unknown
- 2009-11-02 MA MA32318A patent/MA31358B1/fr unknown
- 2009-11-09 CO CO09126924A patent/CO6251254A2/es not_active Application Discontinuation
- 2009-11-09 CR CR11100A patent/CR11100A/es unknown
- 2009-11-09 EC EC2009009724A patent/ECSP099724A/es unknown
-
2010
- 2010-07-05 HK HK10106503.5A patent/HK1139863A1/xx not_active IP Right Cessation
-
2013
- 2013-07-22 HR HRP20130688AT patent/HRP20130688T1/hr unknown
- 2013-09-19 JP JP2013194611A patent/JP2014034576A/ja active Pending
-
2014
- 2014-03-24 JP JP2014059561A patent/JP2014139217A/ja active Pending
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