SI2089343T1 - Klik kemija za proizvodnjo poročevalskih molekul - Google Patents

Klik kemija za proizvodnjo poročevalskih molekul

Info

Publication number
SI2089343T1
SI2089343T1 SI200730721T SI200730721T SI2089343T1 SI 2089343 T1 SI2089343 T1 SI 2089343T1 SI 200730721 T SI200730721 T SI 200730721T SI 200730721 T SI200730721 T SI 200730721T SI 2089343 T1 SI2089343 T1 SI 2089343T1
Authority
SI
Slovenia
Prior art keywords
reporter molecules
production
click chemistry
methods
relates
Prior art date
Application number
SI200730721T
Other languages
English (en)
Inventor
Thomas Carell
Anja Schwogler
Original Assignee
Baseclick Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baseclick Gmbh filed Critical Baseclick Gmbh
Publication of SI2089343T1 publication Critical patent/SI2089343T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/14—Pyrrolo-pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
SI200730721T 2006-10-31 2007-10-31 Klik kemija za proizvodnjo poročevalskih molekul SI2089343T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US85557406P 2006-10-31 2006-10-31
PCT/EP2007/009474 WO2008052775A2 (en) 2006-10-31 2007-10-31 Click chemistry for the production of reporter molecules
EP07819506A EP2089343B1 (en) 2006-10-31 2007-10-31 Click chemistry for the production of reporter molecules

Publications (1)

Publication Number Publication Date
SI2089343T1 true SI2089343T1 (sl) 2011-10-28

Family

ID=39344631

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200730721T SI2089343T1 (sl) 2006-10-31 2007-10-31 Klik kemija za proizvodnjo poročevalskih molekul

Country Status (14)

Country Link
US (1) US8193335B2 (sl)
EP (1) EP2089343B1 (sl)
JP (1) JP5646172B2 (sl)
CN (1) CN101605743A (sl)
AT (1) ATE515488T1 (sl)
AU (1) AU2007315190B2 (sl)
CA (1) CA2667136A1 (sl)
DK (1) DK2089343T3 (sl)
ES (1) ES2369299T3 (sl)
HR (1) HRP20110554T1 (sl)
PL (1) PL2089343T3 (sl)
PT (1) PT2089343E (sl)
SI (1) SI2089343T1 (sl)
WO (1) WO2008052775A2 (sl)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101335218B1 (ko) 2005-05-02 2013-12-12 바스프 에스이 분석물의 감응성 검출을 위한 신규한 표지화 전략
TWI406952B (zh) * 2005-05-02 2013-09-01 Basf Ag 分析物之敏感偵測的新標記策略
CA2667136A1 (en) 2006-10-31 2008-05-08 Baseclick Gmbh Click chemistry for the production of reporter molecules
WO2008106485A2 (en) 2007-02-27 2008-09-04 Trustees Of Tufts College Tissue-engineered silk organs
ES2527125T3 (es) 2007-05-29 2015-01-20 Trustees Of Tufts College Método para la gelificación de fibroína de seda usando sonicación
US8618297B2 (en) 2008-07-25 2013-12-31 Basf Se Azide substituted naphthylene or rylene imide derivatives and their use as reagents in click-reactions
WO2010039548A2 (en) * 2008-09-23 2010-04-08 Alnylam Pharmaceuticals, Inc. Chemical modifications of monomers and oligonucleotides with cycloaddition
US9150910B2 (en) 2008-11-17 2015-10-06 Headway Technologies, Inc. Methods and compositions in particle-based detection of target molecules using linking molecules
WO2010056579A1 (en) 2008-11-17 2010-05-20 Magic Technologies, Inc. Methods and compositions in particle-based detection of target molecules using covalent bond forming reactive pairs
JP5569768B2 (ja) * 2008-12-02 2014-08-13 国立大学法人九州大学 ヌクレオシド三リン酸誘導体、核酸プローブ、マルチラベル化核酸プローブおよび標的核酸の検出方法
EP2239053A1 (en) 2009-04-09 2010-10-13 baseclick GmbH Click chemistry on heterogeneous catalysts
US9074302B2 (en) 2009-09-28 2015-07-07 Trustees Of Tufts College Methods of making drawn silk fibers
CN102010508B (zh) * 2010-10-19 2012-10-03 北京大学 一种阳离子聚合物及其制备方法和应用
EP2629836B1 (en) 2010-10-19 2018-09-12 Trustees Of Tufts College Silk fibroin-based microneedles and methods of making the same
EP2675917B1 (en) 2011-02-16 2017-09-13 Headway Technologies, Inc. Methods and compositions for the target-localized anchoring of detectable label
WO2012145652A1 (en) 2011-04-20 2012-10-26 Trustees Of Tufts College Dynamic silk coatings for implantable devices
WO2013033705A2 (en) 2011-09-01 2013-03-07 Case Western Reserve University Non-natural nucleosides as theranostic agents
US9200121B2 (en) * 2012-04-12 2015-12-01 The Hong Kong University Of Science And Technology Thermosetting poly(siloxane-diphenylbutadiyne) with readily tunable glass transition temperature and high thermal stability
US9480752B2 (en) 2012-07-10 2016-11-01 Baseclick Gmbh Anandamide-modified nucleic acid molecules
CA2891966A1 (en) 2012-12-20 2014-06-26 Sirna Therapeutics, Inc. Post-synthetic orthogonal amidation plus metal catalyzed azide-alkyne cycloaddition click chemistry on sirna
WO2015012912A2 (en) * 2013-04-22 2015-01-29 Northwestern University Alkyne phosphoramidites and preparation of spherical nucleic acid constructs
WO2015026663A1 (en) * 2013-08-19 2015-02-26 University Of Houston Phosphorescent reporters
WO2015088990A1 (en) 2013-12-09 2015-06-18 Durect Corporation Pharmaceutically active agent complexes, polymer complexes, and compositions and methods involving the same
CA2968424A1 (en) * 2014-11-20 2016-05-26 Stratos Genomics, Inc. Nucleoside phosphoroamidate esters and derivatives thereof, use and synthesis thereof
US10487103B2 (en) 2015-03-24 2019-11-26 Gifu University Oligonucleotide derivative, oligonucleotide construct using the same, and methods for producing them
EP3472376A4 (en) 2016-06-16 2019-12-18 Richard Edward Watts DIRECTED AND RECORDED COMBINATORY SYNTHESIS OF OLIGONUCLEOTIDES OF CODED PROBE MOLECULES
EP3619340A4 (en) 2017-05-02 2021-01-20 Haystack Sciences Corporation MOLECULES FOR THE VERIFICATION OF OLIGONUCLEOTIDE DIRECTED COMBINATIONAL SYNTHESIS AND METHOD OF MANUFACTURING AND USING THEREOF
CN109490523A (zh) * 2018-10-22 2019-03-19 北京纳晶生物科技有限公司 用于标记的纳米材料、核酸探针及核酸与纳米材料偶联的方法
CN112305227A (zh) * 2019-07-31 2021-02-02 深圳市帝迈生物技术有限公司 自交联蛋白、配体组合物、制备方法、试剂盒及***
CN111018930A (zh) * 2019-12-06 2020-04-17 深圳大学 Tpe-2’-脱氧核苷、荧光凝胶及其制备方法与应用

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2209754A (en) 1987-09-17 1989-05-24 Thomas Lee Mattson Polyaldehydic polynucleotides in use as probes,their preparation and use
AU636110B2 (en) * 1988-06-08 1993-04-22 Nichols Institute Diagnostics Assays utilizing sensitizer-induced production of detectable signal
US5723289A (en) 1990-06-11 1998-03-03 Nexstar Pharmaceuticals, Inc. Parallel selex
US5843650A (en) 1995-05-01 1998-12-01 Segev; David Nucleic acid detection and amplification by chemical linkage of oligonucleotides
CA2277159A1 (en) * 1997-01-08 1998-07-16 Wolfgang Pieken Bioconjugation of macromolecules
US7427678B2 (en) * 1998-01-08 2008-09-23 Sigma-Aldrich Co. Method for immobilizing oligonucleotides employing the cycloaddition bioconjugation method
US7205105B2 (en) * 1999-12-08 2007-04-17 Epoch Biosciences, Inc. Real-time linear detection probes: sensitive 5′-minor groove binder-containing probes for PCR analysis
US6727356B1 (en) 1999-12-08 2004-04-27 Epoch Pharmaceuticals, Inc. Fluorescent quenching detection reagents and methods
DE10013600A1 (de) * 2000-03-18 2002-01-10 Aventis Res & Tech Gmbh & Co Reaktive Monomere für die Oligonucleotid- und Polynucleotidsynthese, modifizierte Oligonucleotide und Polynucleotiden und ein Verfahren zu deren Herstellung
AU2003225799A1 (en) 2002-03-03 2003-09-29 Activx Biosciences, Inc. Tethered activity-based probes and uses thereof
WO2003101972A1 (en) 2002-05-30 2003-12-11 The Scripps Research Institute Copper-catalysed ligation of azides and acetylenes
US20050032081A1 (en) * 2002-12-13 2005-02-10 Jingyue Ju Biomolecular coupling methods using 1,3-dipolar cycloaddition chemistry
KR100540509B1 (ko) * 2004-01-07 2006-01-11 학교법인 포항공과대학교 수화젤레이터로 사용되는 2'-데옥시우리딘 유도체
CA2562285A1 (en) * 2004-04-08 2006-03-16 Nimblegen Systems, Inc. Comparative genomic resequencing
KR20080000620A (ko) 2005-04-27 2008-01-02 지멘스 메디컬 솔루션즈 유에스에이, 인크. 분자 이미징 프로브를 합성하기 위한 클릭 화학 방법
TWI406952B (zh) * 2005-05-02 2013-09-01 Basf Ag 分析物之敏感偵測的新標記策略
WO2007050811A2 (en) 2005-10-27 2007-05-03 The President And Fellows Of Harvard College Methods and compositions for labeling nucleic acids
CA2667136A1 (en) 2006-10-31 2008-05-08 Baseclick Gmbh Click chemistry for the production of reporter molecules

Also Published As

Publication number Publication date
US8193335B2 (en) 2012-06-05
WO2008052775A2 (en) 2008-05-08
JP5646172B2 (ja) 2014-12-24
CN101605743A (zh) 2009-12-16
HRP20110554T1 (hr) 2011-09-30
JP2010508015A (ja) 2010-03-18
WO2008052775A3 (en) 2009-01-15
ATE515488T1 (de) 2011-07-15
AU2007315190B2 (en) 2012-05-31
US20100081137A1 (en) 2010-04-01
ES2369299T3 (es) 2011-11-29
DK2089343T3 (da) 2011-10-24
EP2089343B1 (en) 2011-07-06
PL2089343T3 (pl) 2011-12-30
CA2667136A1 (en) 2008-05-08
AU2007315190A1 (en) 2008-05-08
EP2089343A2 (en) 2009-08-19
PT2089343E (pt) 2011-09-06

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