SI2041138T1 - Pirolotriazin kinazni inhibitorji - Google Patents

Pirolotriazin kinazni inhibitorji

Info

Publication number
SI2041138T1
SI2041138T1 SI200731488T SI200731488T SI2041138T1 SI 2041138 T1 SI2041138 T1 SI 2041138T1 SI 200731488 T SI200731488 T SI 200731488T SI 200731488 T SI200731488 T SI 200731488T SI 2041138 T1 SI2041138 T1 SI 2041138T1
Authority
SI
Slovenia
Prior art keywords
kinase inhibitors
pyrrolotriazine kinase
pyrrolotriazine
inhibitors
kinase
Prior art date
Application number
SI200731488T
Other languages
English (en)
Inventor
Harold Mastalerz
Mark D. Wittman
Kurt Zimmermann
Mark G. Saulnier
Upender Velaparthi
Dolatrai M. Vyas
Guifen Zhang
Walter Lewis Johnson
David B. Frennesson
Xiaopeng Sang
Peiying Liu
David R. Langley
Original Assignee
Bristol-Myers Squibb Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol-Myers Squibb Company filed Critical Bristol-Myers Squibb Company
Publication of SI2041138T1 publication Critical patent/SI2041138T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
SI200731488T 2006-07-07 2007-07-03 Pirolotriazin kinazni inhibitorji SI2041138T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US81917106P 2006-07-07 2006-07-07
PCT/US2007/072697 WO2008005956A2 (en) 2006-07-07 2007-07-03 Pyrrolotriazine kinase inhibitors
EP07799265.9A EP2041138B1 (en) 2006-07-07 2007-07-03 Pyrrolotriazine kinase inhibitors

Publications (1)

Publication Number Publication Date
SI2041138T1 true SI2041138T1 (sl) 2014-08-29

Family

ID=38671050

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200731488T SI2041138T1 (sl) 2006-07-07 2007-07-03 Pirolotriazin kinazni inhibitorji

Country Status (26)

Country Link
US (4) US7534792B2 (sl)
EP (1) EP2041138B1 (sl)
JP (1) JP5185930B2 (sl)
KR (1) KR101443400B1 (sl)
CN (1) CN101511835B (sl)
AR (1) AR061873A1 (sl)
AU (1) AU2007269163B2 (sl)
BR (1) BRPI0714359A2 (sl)
CA (1) CA2657594C (sl)
CL (1) CL2007001995A1 (sl)
CO (1) CO6220940A2 (sl)
DK (1) DK2041138T3 (sl)
EA (1) EA018322B1 (sl)
ES (1) ES2493566T3 (sl)
HR (1) HRP20140688T1 (sl)
IL (1) IL196033A0 (sl)
MX (1) MX2008016517A (sl)
NO (1) NO342385B1 (sl)
NZ (1) NZ574189A (sl)
PE (1) PE20080677A1 (sl)
PL (1) PL2041138T3 (sl)
PT (1) PT2041138E (sl)
SI (1) SI2041138T1 (sl)
TW (1) TWI393722B (sl)
WO (1) WO2008005956A2 (sl)
ZA (1) ZA200900109B (sl)

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US8492328B2 (en) * 2007-05-17 2013-07-23 Bristol-Myers Squibb Company Biomarkers and methods for determining sensitivity to insulin growth factor-1 receptor modulators
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US20100240657A1 (en) * 2007-07-02 2010-09-23 Boehringer Ingelheim International Gmbh Chemical compounds
US8212031B2 (en) 2008-03-06 2012-07-03 Bristol-Myers Squibb Company Pyrrolotriazine kinase inhibitors
BRPI0920608A2 (pt) 2008-09-29 2019-09-24 Boehringer Ingelheim Int compostos quimicos
US8445676B2 (en) * 2008-10-08 2013-05-21 Bristol-Myers Squibb Company Pyrrolotriazine kinase inhibitors
EP2376491B1 (en) 2008-12-19 2015-03-04 Cephalon, Inc. Pyrrolotriazines as alk and jak2 inhibitors
EP2494070A2 (en) 2009-10-30 2012-09-05 Bristol-Myers Squibb Company Methods for treating cancer in patients having igf-1r inhibitor resistance
WO2011083391A2 (en) 2010-01-05 2011-07-14 Pfizer Inc. Biomarkers for anti-igf-ir cancer therapy
US8691981B2 (en) 2010-02-03 2014-04-08 Bristol-Myers Squibb Company Crystalline forms of (S)-1-(4-(5-cyclopropyl-1H-pyrazol-3-ylamino)pyrrolo[1,2-f][1,2,4]triazin-2-yl)-N-(6-fluoropyridin-3-yl)-2-methylpyrrolidine-2-carboxamide
JP5093527B2 (ja) * 2010-02-10 2012-12-12 日本電気株式会社 複合光導波路、波長可変フィルタ、波長可変レーザ、および光集積回路
JP5871897B2 (ja) 2010-03-26 2016-03-01 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ピリジルトリアゾール
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US8710055B2 (en) 2010-12-21 2014-04-29 Boehringer Ingelheim International Gmbh Triazolylphenyl sulfonamides as serine/threonine kinase inhibitors
CN102584828B (zh) * 2011-01-14 2016-01-27 上海艾力斯医药科技有限公司 吡咯烷[3，4-d]嘧啶衍生物、制备方法及其应用
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CN103450204B (zh) 2012-05-31 2016-08-17 中国科学院上海药物研究所 吡咯[2，1-f][1，2，4]并三嗪类化合物，其制备方法及用途
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WO2014160521A1 (en) 2013-03-15 2014-10-02 Blueprint Medicines Corporation Piperazine derivatives and their use as kit modulators
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TWI672141B (zh) 2014-02-20 2019-09-21 美商醫科泰生技 投予ｒｏｓ１突變癌細胞之分子
CN104974163B (zh) * 2014-04-14 2017-11-07 广东东阳光药业有限公司 取代的杂芳基化合物及其组合物和用途
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CN107207471B (zh) 2014-12-02 2020-06-26 伊尼塔公司 用于治疗神经母细胞瘤的组合
CN108026102A (zh) 2015-07-24 2018-05-11 蓝印药品公司 可用于治疗与kit和pdgfr相关的病症的化合物
JP7061068B2 (ja) 2015-12-18 2022-04-27 イグナイタ インコーポレイテッド 癌治療のための併用薬
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Also Published As

Publication number Publication date
AR061873A1 (es) 2008-09-24
EP2041138B1 (en) 2014-06-25
CN101511835A (zh) 2009-08-19
BRPI0714359A2 (pt) 2013-02-26
IL196033A0 (en) 2009-09-01
US20080009497A1 (en) 2008-01-10
EP2041138A2 (en) 2009-04-01
US20110124623A1 (en) 2011-05-26
TW200813059A (en) 2008-03-16
CN101511835B (zh) 2013-11-27
NO342385B1 (no) 2018-05-14
US8592579B2 (en) 2013-11-26
KR20090027764A (ko) 2009-03-17
CA2657594C (en) 2012-01-17
CA2657594A1 (en) 2008-01-10
KR101443400B1 (ko) 2014-10-02
EA200900152A1 (ru) 2009-06-30
WO2008005956A3 (en) 2008-03-06
PT2041138E (pt) 2014-10-07
CL2007001995A1 (es) 2008-01-25
PE20080677A1 (es) 2008-06-26
US8263765B2 (en) 2012-09-11
NO20090025L (no) 2009-02-02
ES2493566T3 (es) 2014-09-12
JP2009542814A (ja) 2009-12-03
AU2007269163B2 (en) 2011-07-28
CO6220940A2 (es) 2010-11-19
US7534792B2 (en) 2009-05-19
US20120302747A1 (en) 2012-11-29
ZA200900109B (en) 2010-03-31
NZ574189A (en) 2011-03-31
US20090239838A1 (en) 2009-09-24
WO2008005956A2 (en) 2008-01-10
TWI393722B (zh) 2013-04-21
HRP20140688T1 (hr) 2014-10-24
DK2041138T3 (da) 2014-08-11
MX2008016517A (es) 2009-01-19
JP5185930B2 (ja) 2013-04-17
EA018322B1 (ru) 2013-07-30
PL2041138T3 (pl) 2014-11-28
AU2007269163A1 (en) 2008-01-10
US7879855B2 (en) 2011-02-01

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