SI2021335T1 - Heterocikliäśne spojine kot zaviralci c-fms kinaze - Google Patents
Heterocikliäśne spojine kot zaviralci c-fms kinazeInfo
- Publication number
- SI2021335T1 SI2021335T1 SI200730671T SI200730671T SI2021335T1 SI 2021335 T1 SI2021335 T1 SI 2021335T1 SI 200730671 T SI200730671 T SI 200730671T SI 200730671 T SI200730671 T SI 200730671T SI 2021335 T1 SI2021335 T1 SI 2021335T1
- Authority
- SI
- Slovenia
- Prior art keywords
- inhibitors
- heterocyclic compounds
- fms kinase
- fms
- kinase
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US79369706P | 2006-04-20 | 2006-04-20 | |
US88353907P | 2007-01-05 | 2007-01-05 | |
EP07760833A EP2021335B1 (en) | 2006-04-20 | 2007-04-18 | Heterocyclic compounds as inhibitors of c-fms kinase |
PCT/US2007/066860 WO2007124316A1 (en) | 2006-04-20 | 2007-04-18 | Heterocyclic compounds as inhibitors of c-fms kinase |
Publications (1)
Publication Number | Publication Date |
---|---|
SI2021335T1 true SI2021335T1 (sl) | 2011-09-30 |
Family
ID=38353368
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI200730671T SI2021335T1 (sl) | 2006-04-20 | 2007-04-18 | Heterocikliäśne spojine kot zaviralci c-fms kinaze |
Country Status (17)
Country | Link |
---|---|
US (6) | US7414050B2 (sl) |
EP (1) | EP2021335B1 (sl) |
JP (1) | JP5089681B2 (sl) |
KR (1) | KR101367645B1 (sl) |
AR (1) | AR060608A1 (sl) |
AT (1) | ATE510832T1 (sl) |
AU (1) | AU2007240437B2 (sl) |
CA (1) | CA2649736C (sl) |
CY (1) | CY1111749T1 (sl) |
DK (1) | DK2021335T3 (sl) |
MX (1) | MX2008013533A (sl) |
NZ (1) | NZ572073A (sl) |
PL (1) | PL2021335T3 (sl) |
PT (1) | PT2021335E (sl) |
SI (1) | SI2021335T1 (sl) |
TW (1) | TW200811162A (sl) |
WO (1) | WO2007124316A1 (sl) |
Families Citing this family (25)
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US20020171789A1 (en) * | 1995-12-04 | 2002-11-21 | Minolta Co., Ltd. | Layered type reflective full-color liquid crystal display element and display device having the element |
US20060281788A1 (en) * | 2005-06-10 | 2006-12-14 | Baumann Christian A | Synergistic modulation of flt3 kinase using a flt3 inhibitor and a farnesyl transferase inhibitor |
ES2572263T3 (es) | 2005-10-25 | 2016-05-31 | Shionogi & Co | Derivados de dihidrooxazina y tetrahidropirimidina como inhibidores de BACE 1 |
PE20080074A1 (es) | 2006-04-20 | 2008-02-11 | Janssen Pharmaceutica Nv | Derivados de amida como agentes inhibidores de la quinasa c-fms |
WO2007124369A2 (en) * | 2006-04-20 | 2007-11-01 | Janssen Pharmaceutica N.V. | Method of inhibiting c kit kinase |
US8697716B2 (en) | 2006-04-20 | 2014-04-15 | Janssen Pharmaceutica Nv | Method of inhibiting C-KIT kinase |
EP2687516A1 (en) * | 2006-04-20 | 2014-01-22 | Janssen Pharmaceutica N.V. | Inhibitors of C-FMS Kinase |
DK2021335T3 (da) | 2006-04-20 | 2011-09-05 | Janssen Pharmaceutica Nv | Heterocykliske forbindelser som C-FMS-kinasehæmmere |
JP5383483B2 (ja) | 2007-04-24 | 2014-01-08 | 塩野義製薬株式会社 | アルツハイマー症治療用医薬組成物 |
ES2476605T3 (es) | 2007-04-24 | 2014-07-15 | Shionogi & Co., Ltd. | Derivados de aminohidrotiazina sustituidos con grupos cíclicos |
JO3240B1 (ar) * | 2007-10-17 | 2018-03-08 | Janssen Pharmaceutica Nv | c-fms مثبطات كيناز |
CN102119161B (zh) | 2008-06-13 | 2015-07-08 | 盐野义制药株式会社 | 具有β分泌酶抑制作用的含硫杂环衍生物 |
EP2360155A4 (en) * | 2008-10-22 | 2012-06-20 | Shionogi & Co | 2-AMINOPYRIDIN-4-ON AND 2-AMINOPYRIDINE DERIVATIVE WITH BACE1-HEMDERING EFFECT |
UA110467C2 (uk) | 2009-12-11 | 2016-01-12 | Шионогі Енд Ко., Лтд. | Похідні оксазину |
WO2012057248A1 (ja) | 2010-10-29 | 2012-05-03 | 塩野義製薬株式会社 | ナフチリジン誘導体 |
US9018219B2 (en) | 2010-10-29 | 2015-04-28 | Shionogi & Co., Ltd. | Fused aminodihydropyrimidine derivative |
TW201247635A (en) | 2011-04-26 | 2012-12-01 | Shionogi & Co | Oxazine derivatives and a pharmaceutical composition for inhibiting BAC1 containing them |
MX358311B (es) * | 2012-04-17 | 2018-08-14 | Fujifilm Corp | Compuesto heterociclico que contiene nitrogeno o sal del mismo. |
JOP20180012A1 (ar) | 2012-08-07 | 2019-01-30 | Janssen Pharmaceutica Nv | عملية السلفنة باستخدام نونافلوروبوتانيسولفونيل فلوريد |
IN2015DN00659A (sl) | 2012-08-07 | 2015-06-26 | Janssen Pharmaceutica Nv | |
EP2912035A4 (en) | 2012-10-24 | 2016-06-15 | Shionogi & Co | DERIVATIVES OF DIHYDROOXAZINE OR OXAZEPINE HAVING BACE1 INHIBITING ACTIVITY |
CN106674084B (zh) * | 2016-12-20 | 2019-03-01 | 山东轩德医药科技有限公司 | 一种2-异丙基氧基-5-甲基-4-(哌啶-4-基)苯胺二盐酸盐的制备方法 |
CN109776509B (zh) * | 2018-01-30 | 2023-07-07 | 成都麻沸散医药科技有限公司 | 一种n-取代咪唑甲酸酯类衍生物及其用途 |
WO2021144360A1 (en) | 2020-01-17 | 2021-07-22 | F. Hoffmann-La Roche Ag | Small molecule csf-1r inhibitors in therapeutic and cosmetic uses |
CN111646945A (zh) * | 2020-05-29 | 2020-09-11 | 凯美克(上海)医药科技有限公司 | 一种4-溴-2-硝基-1h-咪唑的合成方法 |
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KR19990007865A (ko) | 1995-04-19 | 1999-01-25 | 스피겔알렌제이 | 약물 방출용 피복 스텐트 |
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JP2009534403A (ja) | 2009-09-24 |
CA2649736C (en) | 2013-11-26 |
CY1111749T1 (el) | 2015-10-07 |
KR101367645B1 (ko) | 2014-02-27 |
PT2021335E (pt) | 2011-07-25 |
US8481564B2 (en) | 2013-07-09 |
US7973035B2 (en) | 2011-07-05 |
TW200811162A (en) | 2008-03-01 |
CA2649736A1 (en) | 2007-11-01 |
US20070249593A1 (en) | 2007-10-25 |
NZ572073A (en) | 2011-09-30 |
AU2007240437B2 (en) | 2012-12-06 |
US8759347B2 (en) | 2014-06-24 |
US20080275031A1 (en) | 2008-11-06 |
DK2021335T3 (da) | 2011-09-05 |
AR060608A1 (es) | 2008-07-02 |
MX2008013533A (es) | 2009-01-15 |
WO2007124316A1 (en) | 2007-11-01 |
US20110195960A1 (en) | 2011-08-11 |
AU2007240437A1 (en) | 2007-11-01 |
US9296726B2 (en) | 2016-03-29 |
JP5089681B2 (ja) | 2012-12-05 |
ATE510832T1 (de) | 2011-06-15 |
US7414050B2 (en) | 2008-08-19 |
KR20090008371A (ko) | 2009-01-21 |
EP2021335A1 (en) | 2009-02-11 |
PL2021335T3 (pl) | 2011-10-31 |
US20130281475A1 (en) | 2013-10-24 |
US8895584B2 (en) | 2014-11-25 |
US20140243382A1 (en) | 2014-08-28 |
US20150051196A1 (en) | 2015-02-19 |
EP2021335B1 (en) | 2011-05-25 |
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