ATE252104T1 - Verfahren und gerät zur herstellung von 1ss, 10ss-epoxy-13-dimethylamino-guaia-3(4)-en-6,12- lid- hydrochlorid - Google Patents

Verfahren und gerät zur herstellung von 1ss, 10ss-epoxy-13-dimethylamino-guaia-3(4)-en-6,12- lid- hydrochlorid

Info

Publication number
ATE252104T1
ATE252104T1 AT97947981T AT97947981T ATE252104T1 AT E252104 T1 ATE252104 T1 AT E252104T1 AT 97947981 T AT97947981 T AT 97947981T AT 97947981 T AT97947981 T AT 97947981T AT E252104 T1 ATE252104 T1 AT E252104T1
Authority
AT
Austria
Prior art keywords
hydrochloride
production
waste material
walls
separation
Prior art date
Application number
AT97947981T
Other languages
English (en)
Inventor
Sergazy Mynzhasarovic Adekenov
Original Assignee
Tovarischestvo S Ogranichennoi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tovarischestvo S Ogranichennoi filed Critical Tovarischestvo S Ogranichennoi
Application granted granted Critical
Publication of ATE252104T1 publication Critical patent/ATE252104T1/de

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/02—Solvent extraction of solids
    • B01D11/0215—Solid material in other stationary receptacles
    • B01D11/0223—Moving bed of solid material
    • B01D11/0226—Moving bed of solid material with the general transport direction of the solids parallel to the rotation axis of the conveyor, e.g. worm
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Extraction Or Liquid Replacement (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT97947981T 1996-12-20 1997-12-19 Verfahren und gerät zur herstellung von 1ss, 10ss-epoxy-13-dimethylamino-guaia-3(4)-en-6,12- lid- hydrochlorid ATE252104T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KZ960995 1996-12-20
KZ970397 1997-04-26
PCT/KZ1997/000006 WO1998028303A1 (en) 1996-12-20 1997-12-19 METHOD AND DEVICE FOR PRODUCTION OF LYOPHILIZED HYDROCHLORIDE-1β,10β-EPOXY-13-DIMETHYLAMINO-GUAIA-3(4)-EN-6,12-OLIDE

Publications (1)

Publication Number Publication Date
ATE252104T1 true ATE252104T1 (de) 2003-11-15

Family

ID=26639596

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97947981T ATE252104T1 (de) 1996-12-20 1997-12-19 Verfahren und gerät zur herstellung von 1ss, 10ss-epoxy-13-dimethylamino-guaia-3(4)-en-6,12- lid- hydrochlorid

Country Status (6)

Country Link
EP (1) EP0946565B1 (de)
JP (2) JP2001505548A (de)
CN (1) CN1095845C (de)
AT (1) ATE252104T1 (de)
DE (1) DE69725604T2 (de)
WO (1) WO1998028303A1 (de)

Families Citing this family (36)

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US5994388A (en) 1997-03-18 1999-11-30 The Children's Medical Center Corporation Cytochalasin and isoindolinone derivatives as inhibitors of angiogenesis
CA2397558A1 (en) 2000-02-24 2001-08-30 Janssen Pharmaceutica N.V. Dosing regimen
DE60322686D1 (de) * 2002-03-20 2008-09-18 Matsushita Electric Ind Co Ltd Extraktionsvorrichtung
DE10326152A1 (de) * 2003-06-06 2005-01-05 Aventis Pharma Deutschland Gmbh Verfahren und Vorrichtung zur quantitativen Analyse von Lösungen und Dispersionen mittels Nahinfrarot-Spektroskopie
US20050003422A1 (en) 2003-07-01 2005-01-06 Mitch Reponi Methods for assessing and treating cancer
DE102004037002B4 (de) * 2004-07-30 2006-06-14 Chemieanlagenbau Chemnitz Gmbh Verfahren zur Herstellung von Dimethylaminoarglabin-Hydrochlorid
ES2403060T3 (es) 2004-11-05 2013-05-13 Janssen Pharmaceutica Nv Uso terapéutico de inhibidores de la farnesiltransferasa y métodos de control de la eficacia de los mismos.
US20060281788A1 (en) 2005-06-10 2006-12-14 Baumann Christian A Synergistic modulation of flt3 kinase using a flt3 inhibitor and a farnesyl transferase inhibitor
US7414050B2 (en) 2006-04-20 2008-08-19 Janssen Pharmaceutica, N.V. Inhibitors of c-fms kinase
US8697716B2 (en) 2006-04-20 2014-04-15 Janssen Pharmaceutica Nv Method of inhibiting C-KIT kinase
CA2649739C (en) 2006-04-20 2015-09-01 Janssen Pharmaceutica N.V. Inhibitors of c-fms kinase
GEP20115246B (en) * 2006-09-19 2011-06-27 Sergazy Adekenov Method for production of hydrochloride 1(10) beta-epoxy-13-dimethylamino-5,7 alpha,6,11 beta (h)-guaia-3(4)-en-6,12-olide, lyophilized antitumor preparation “arglabin”
JO3240B1 (ar) 2007-10-17 2018-03-08 Janssen Pharmaceutica Nv c-fms مثبطات كيناز
CN102190663B (zh) * 2010-03-02 2013-11-13 石药集团中奇制药技术（石家庄）有限公司 一种二甲氨基阿格拉宾盐酸盐晶型
CN102190662B (zh) * 2010-03-02 2014-06-25 石药集团中奇制药技术（石家庄）有限公司 一种二甲氨基阿格拉宾盐酸盐的制备方法
CN102372723B (zh) * 2010-08-19 2014-03-26 石药集团中奇制药技术（石家庄）有限公司 一种从多花蒿中提取阿格拉宾的方法
JOP20180012A1 (ar) 2012-08-07 2019-01-30 Janssen Pharmaceutica Nv عملية السلفنة باستخدام نونافلوروبوتانيسولفونيل فلوريد
EP2882757B1 (de) 2012-08-07 2016-10-05 Janssen Pharmaceutica, N.V. Verfahren zur herstellung heterocyclischer esterderivate
CN102850372A (zh) * 2012-10-15 2013-01-02 河北医科大学 一种蓍草倍半萜内酯化合物及其提取方法和应用
CN103833766B (zh) * 2012-11-23 2016-12-21 天津尚德药缘科技股份有限公司 阿格拉滨二甲胺富马酸盐及其在药物制备中的用途
HUE049620T2 (hu) 2015-08-17 2020-09-28 Kura Oncology Inc Módszerek rákos páciensek kezelésére farneziltranszferáz inhibitorokkal
CN105251236B (zh) * 2015-11-02 2018-01-16 济宁金百特生物机械有限公司 逆流提取装置
WO2017184968A1 (en) 2016-04-22 2017-10-26 Kura Oncology, Inc. Methods of selecting cancer patients for treatment with farnesyltransferase inhibitors
ES2863730T3 (es) 2016-11-03 2021-10-11 Kura Oncology Inc Inhibidores de la farnesiltransferasa para uso en el tratamiento del cáncer
US9956215B1 (en) 2017-02-21 2018-05-01 Kura Oncology, Inc. Methods of treating cancer with farnesyltransferase inhibitors
CA3053795A1 (en) 2017-02-21 2018-08-30 Kura Oncology, Inc. Methods of treating cancer with farnesyltransferase inhibitors
US10806730B2 (en) 2017-08-07 2020-10-20 Kura Oncology, Inc. Methods of treating cancer with farnesyltransferase inhibitors
EP3664804A4 (de) 2017-08-07 2021-04-14 Kura Oncology, Inc. Verfahren zur behandlung von krebs mit farnesyltransferase-inhibitoren
WO2019113269A1 (en) 2017-12-08 2019-06-13 Kura Oncology, Inc. Methods of treating cancer patients with farnesyltransferase inhibitors
CA3117968A1 (en) 2018-11-01 2020-05-07 Kura Oncology, Inc. Methods of treating cancer with farnesyltransferase inhibitors
WO2020132437A1 (en) 2018-12-21 2020-06-25 Kura Oncology, Inc. Therapies for squamous cell carcinomas
WO2020180663A1 (en) 2019-03-01 2020-09-10 Kura Oncology, Inc. Methods of treating cancer with farnesyltransferase inhibitors
WO2020190604A1 (en) 2019-03-15 2020-09-24 Kura Oncology, Inc. Methods of treating cancer patients with farnesyltransferase inhibitors
WO2020205486A1 (en) 2019-03-29 2020-10-08 Kura Oncology, Inc. Methods of treating squamous cell carcinomas with farnesyltransferase inhibitors
US20220168296A1 (en) 2019-04-01 2022-06-02 Kura Oncology, Inc. Methods of treating cancer with farnesyltransferase inhibitors
US20220305001A1 (en) 2019-05-02 2022-09-29 Kura Oncology, Inc. Methods of treating acute myeloid leukemia with farnesyltransferase inhibitors

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1627208A1 (ru) * 1988-05-24 1991-02-15 Всесоюзный научно-исследовательский институт консервной и овощесушильной промышленности Секционный лопастной экстрактор дл сухого растительного сырь

Also Published As

Publication number Publication date
EP0946565A1 (de) 1999-10-06
DE69725604D1 (de) 2003-11-20
JP2001505548A (ja) 2001-04-24
CN1245501A (zh) 2000-02-23
DE69725604T2 (de) 2005-03-03
WO1998028303A1 (en) 1998-07-02
CN1095845C (zh) 2002-12-11
EP0946565B1 (de) 2003-10-15
JP2007137890A (ja) 2007-06-07

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