SI1675956T1 - Minimalno zaporedje dna, ki deluje kot izolirni element kromatina in njegova uporaba pri ekspresiji proteinov - Google Patents

Minimalno zaporedje dna, ki deluje kot izolirni element kromatina in njegova uporaba pri ekspresiji proteinov

Info

Publication number
SI1675956T1
SI1675956T1 SI200431541T SI200431541T SI1675956T1 SI 1675956 T1 SI1675956 T1 SI 1675956T1 SI 200431541 T SI200431541 T SI 200431541T SI 200431541 T SI200431541 T SI 200431541T SI 1675956 T1 SI1675956 T1 SI 1675956T1
Authority
SI
Slovenia
Prior art keywords
dna sequence
protein expression
chromatin insulator
minimal dna
sequence acting
Prior art date
Application number
SI200431541T
Other languages
English (en)
Inventor
Philippe Chatellard
Markus Imhof
Original Assignee
Merck Serono Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Serono Sa filed Critical Merck Serono Sa
Publication of SI1675956T1 publication Critical patent/SI1675956T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/465—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from birds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
SI200431541T 2003-10-21 2004-10-20 Minimalno zaporedje dna, ki deluje kot izolirni element kromatina in njegova uporaba pri ekspresiji proteinov SI1675956T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP03103890 2003-10-21
EP04791263A EP1675956B1 (en) 2003-10-21 2004-10-20 Minimal dna sequence acting as a chromatin insulator and its use in protein expression
PCT/EP2004/052591 WO2005040384A1 (en) 2003-10-21 2004-10-20 Minimal dna sequence acting as a chromatin insulator and its use in protein expression

Publications (1)

Publication Number Publication Date
SI1675956T1 true SI1675956T1 (sl) 2010-12-31

Family

ID=34486337

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200431541T SI1675956T1 (sl) 2003-10-21 2004-10-20 Minimalno zaporedje dna, ki deluje kot izolirni element kromatina in njegova uporaba pri ekspresiji proteinov

Country Status (17)

Country Link
US (1) US8133699B2 (sl)
EP (1) EP1675956B1 (sl)
JP (1) JP4745972B2 (sl)
AT (1) ATE484591T1 (sl)
AU (1) AU2004284243B2 (sl)
CA (1) CA2541523A1 (sl)
CY (1) CY1110868T1 (sl)
DE (1) DE602004029598D1 (sl)
DK (1) DK1675956T3 (sl)
ES (1) ES2354160T3 (sl)
HR (1) HRP20100560T1 (sl)
IL (1) IL175021A (sl)
NO (1) NO338767B1 (sl)
PL (1) PL1675956T3 (sl)
PT (1) PT1675956E (sl)
SI (1) SI1675956T1 (sl)
WO (1) WO2005040384A1 (sl)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1395669T3 (da) 2001-01-26 2009-11-16 Selexis Sa Matriks bindingsregioner og fremgangsmåder til anvendelse af disse
CN100429315C (zh) * 2003-03-11 2008-10-29 雪兰诺实验室有限公司 含有mcmv ie2启动子的表达载体
JP5074030B2 (ja) * 2003-05-13 2012-11-14 メルク セローノ ソシエテ アノニム Ｉｌ−１８結合タンパク質の活性変異体とその医学的応用
AU2004284220B2 (en) 2003-10-24 2010-10-14 Selexis S.A. High efficiency gene transfer and expression in mammalian cells by a multiple transfection procedure of matrix attachment region sequences
PT1689777E (pt) 2003-11-05 2007-05-31 Ares Trading Sa Processo para a purificação da proteína de ligação a il-18
RS50531B (sr) * 2004-03-01 2010-05-07 Ares Trading S.A. Upotreba podloge za ćelijsku kulturu bez sadržaja seruma za produkciju il-18bp u ćelijama sisara
EP1761552B1 (en) 2004-06-29 2008-09-17 Ares Trading S.A. Process for the purification of il-18 binding protein
CA2609060C (en) * 2005-06-03 2014-07-15 Urs Weber Production of recombinant il-18 binding protein
JP5091127B2 (ja) 2005-06-10 2012-12-05 アレス トレーディング ソシエテ アノニム Ｉｌ−１８結合タンパク質の精製のための方法
EP1760092A1 (en) * 2005-08-26 2007-03-07 Applied Research Systems ARS Holding N.V. System for screening cells for high expression of a protein of interest
FR2919616A1 (fr) * 2007-08-02 2009-02-06 Ecole Norm Superieure Lyon Polynucleotides insulateurs derives de l'element d4z4 et leurs utilisations en transgenese
CN103620034B (zh) 2011-04-13 2016-12-14 加拿大国家研究委员会 具有来自IFNα2的SAR元件的表达***
CA2857755A1 (en) * 2011-12-21 2013-06-27 Danisco Us Inc. Improving fungal gene expression using insulator dna sequences
CN113151179A (zh) 2012-07-31 2021-07-23 阿格克斯治疗有限公司 Hla g修饰的细胞及方法
KR101591823B1 (ko) * 2013-12-27 2016-02-04 재단법인 목암생명공학연구소 증가된 유전자 발현능을 갖는 발현벡터
AU2016343887B2 (en) * 2015-10-28 2023-04-06 Sangamo Therapeutics, Inc. Liver-specific constructs, factor VIII expression cassettes and methods of use thereof
WO2017075395A1 (en) * 2015-10-28 2017-05-04 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Tumor-specific adenovirus vectors and therapeutic uses
CN106754817B (zh) * 2016-11-03 2021-02-05 山西省生物研究院有限公司 一种重组自分泌运动因子的表达方法
EP3672986A1 (en) 2017-08-22 2020-07-01 Sanabio, LLC Soluble interferon receptors and uses thereof

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5859205A (en) * 1989-12-21 1999-01-12 Celltech Limited Humanised antibodies
US6113898A (en) * 1995-06-07 2000-09-05 Idec Pharmaceuticals Corporation Human B7.1-specific primatized antibodies and transfectomas expressing said antibodies
US6432700B1 (en) * 1997-03-03 2002-08-13 Cell Genesys, Inc. Adenovirus vectors containing heterologous transcription regulatory elements and methods of using same
US6194152B1 (en) * 1997-08-20 2001-02-27 Dendreon Corporation Prostate tumor polynucleotide compositions and methods of detection thereof
WO2000023606A1 (en) * 1998-10-22 2000-04-27 Medical College Of Georgia Institute, Inc. Long terminal repeat, enhancer, and insulator sequences for use in recombinant vectors
WO2001002553A2 (en) * 1999-06-30 2001-01-11 The Government Of The United States Of America As Represented By The Secretary, Department Of Health And Human Services Dna binding protein and sequence as insulators having specific enhancer blocking activity for regulation of gene expression
CN100429315C (zh) 2003-03-11 2008-10-29 雪兰诺实验室有限公司 含有mcmv ie2启动子的表达载体
JP5074030B2 (ja) 2003-05-13 2012-11-14 メルク セローノ ソシエテ アノニム Ｉｌ−１８結合タンパク質の活性変異体とその医学的応用
PT1689777E (pt) 2003-11-05 2007-05-31 Ares Trading Sa Processo para a purificação da proteína de ligação a il-18
RS50531B (sr) 2004-03-01 2010-05-07 Ares Trading S.A. Upotreba podloge za ćelijsku kulturu bez sadržaja seruma za produkciju il-18bp u ćelijama sisara
EP1761552B1 (en) 2004-06-29 2008-09-17 Ares Trading S.A. Process for the purification of il-18 binding protein
CA2609060C (en) 2005-06-03 2014-07-15 Urs Weber Production of recombinant il-18 binding protein
JP5091127B2 (ja) 2005-06-10 2012-12-05 アレス トレーディング ソシエテ アノニム Ｉｌ−１８結合タンパク質の精製のための方法

Also Published As

Publication number Publication date
CY1110868T1 (el) 2015-06-10
WO2005040384A1 (en) 2005-05-06
DK1675956T3 (da) 2010-11-22
NO338767B1 (no) 2016-10-17
CA2541523A1 (en) 2005-05-06
EP1675956B1 (en) 2010-10-13
IL175021A0 (en) 2006-08-20
PT1675956E (pt) 2010-11-04
ES2354160T3 (es) 2011-03-10
US20070134761A1 (en) 2007-06-14
HRP20100560T1 (hr) 2010-11-30
IL175021A (en) 2011-07-31
AU2004284243B2 (en) 2010-11-04
PL1675956T3 (pl) 2011-06-30
JP2007508833A (ja) 2007-04-12
EP1675956A1 (en) 2006-07-05
JP4745972B2 (ja) 2011-08-10
US8133699B2 (en) 2012-03-13
ATE484591T1 (de) 2010-10-15
NO20062315L (no) 2006-07-18
AU2004284243A1 (en) 2005-05-06
DE602004029598D1 (de) 2010-11-25

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