SI1515717T1 - Kalcijeve soli statinov, izvedenih iz indola - Google Patents

Kalcijeve soli statinov, izvedenih iz indola

Info

Publication number
SI1515717T1
SI1515717T1 SI200331474T SI200331474T SI1515717T1 SI 1515717 T1 SI1515717 T1 SI 1515717T1 SI 200331474 T SI200331474 T SI 200331474T SI 200331474 T SI200331474 T SI 200331474T SI 1515717 T1 SI1515717 T1 SI 1515717T1
Authority
SI
Slovenia
Prior art keywords
alkyl
calcium
calcium salts
present
aralkyl
Prior art date
Application number
SI200331474T
Other languages
English (en)
Inventor
Guang-Pei Chen
Prasad Koteswara Kapa
Paul Allen Sutton
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of SI1515717T1 publication Critical patent/SI1515717T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an alkyl or cycloalkyl radical attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
SI200331474T 2002-06-13 2003-06-12 Kalcijeve soli statinov, izvedenih iz indola SI1515717T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US38831802P 2002-06-13 2002-06-13
PCT/EP2003/006195 WO2003105837A1 (en) 2002-06-13 2003-06-12 Calcium salts of indole derived statins
EP03740234A EP1515717B8 (en) 2002-06-13 2003-06-12 Calcium salts of indole derived statins

Publications (1)

Publication Number Publication Date
SI1515717T1 true SI1515717T1 (sl) 2009-02-28

Family

ID=29736457

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200331474T SI1515717T1 (sl) 2002-06-13 2003-06-12 Kalcijeve soli statinov, izvedenih iz indola

Country Status (13)

Country Link
US (2) US20060035941A1 (sl)
EP (1) EP1515717B8 (sl)
JP (1) JP2005532362A (sl)
AT (1) ATE409476T1 (sl)
AU (1) AU2003276960A1 (sl)
CA (1) CA2486557A1 (sl)
CY (1) CY1108675T1 (sl)
DE (1) DE60323835D1 (sl)
DK (1) DK1515717T3 (sl)
ES (1) ES2315510T3 (sl)
PT (1) PT1515717E (sl)
SI (1) SI1515717T1 (sl)
WO (1) WO2003105837A1 (sl)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1752448A3 (en) * 2003-06-18 2007-03-14 Teva Pharmaceutical Industries, Inc. Fluvastatin sodium crystal form lxxix, processes for preparing it, compositions containing it and methods of using it
US20090042979A1 (en) * 2004-08-06 2009-02-12 Transform Pharmaceuticals Inc. Novel Statin Pharmaceutical Compositions and Related Methods of Treatment
EP1786414A4 (en) * 2004-08-06 2008-04-09 Transform Pharmaceuticals Inc NEW PHARMACEUTICAL STATIN COMPOSITIONS AND RELEVANT TREATMENT PROCEDURES
JP2008516890A (ja) * 2004-08-06 2008-05-22 トランスフオーム・フアーマシユーチカルズ・インコーポレーテツド 新規なフェノフィブラート製剤および関連治療方法

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0044801B1 (de) * 1980-07-17 1984-02-15 Josef Dr. Klosa Nichthygroskopische Salze der 4-Hydroxybuttersäure, Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung pharmazeutischer Mittel
ZA814854B (en) * 1980-07-17 1982-07-28 J Klosa Nonhygroscopic salts of 4-hydroxybutryric acid, methods of their production and pharmaceutical preparations containing these salts
JPS643178B2 (sl) * 1980-07-28 1989-01-19 Abbott Lab
US5354772A (en) * 1982-11-22 1994-10-11 Sandoz Pharm. Corp. Indole analogs of mevalonolactone and derivatives thereof
JPS63101320A (ja) * 1986-10-17 1988-05-06 Dainippon Pharmaceut Co Ltd バルプロ酸カルシウム製剤
DE3709230A1 (de) * 1987-03-20 1988-10-06 Desitin Arzneimittel Gmbh Neues calciumsalz der valproinsaeure
US5189164A (en) * 1989-05-22 1993-02-23 Sandoz Ltd. Processes for the synthesis of syn-(E)-3,5-dihydroxy-7-substituted hept-6-enoic and heptanoic acids and derivatives and intermediates thereof
FI94339C (fi) * 1989-07-21 1995-08-25 Warner Lambert Co Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi
HU9203780D0 (en) * 1991-12-12 1993-03-29 Sandoz Ag Stabilized pharmaceutical products of hmg-coa reductase inhibitor and method for producing them
US5777552A (en) * 1995-08-02 1998-07-07 Sentrol, Inc. Curtain door alarm
EP1011660A1 (en) * 1997-07-14 2000-06-28 Inter-Health Nutraceuticals Incorporated Hydroxycitric acid compositions, pharmaceutical and dietary supplements and food products made therefrom, and methods for their use in reducing body weight
AU3380899A (en) * 1998-04-01 1999-10-18 Ganeden Biotech, Inc. Methods for reducing cholesterol using (bacillus coagulans) spores, systems and compositions
SI20070A (sl) * 1998-09-18 2000-04-30 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Nove soli inhibitorjev HMG-CoA reduktaze
EP1163203A1 (en) * 1999-03-08 2001-12-19 Merck & Co., Inc. Crystalline hydrated dihydroxy open-acid simvastatin calcium salt
ES2349364T3 (es) * 1999-11-17 2010-12-30 Teva Pharmaceutical Industries, Ltd. Procedimiento para la preparación de una forma polimórfica de atorvastatina cálcica.
GB0003305D0 (en) * 2000-02-15 2000-04-05 Zeneca Ltd Pyrimidine derivatives
US6242003B1 (en) * 2000-04-13 2001-06-05 Novartis Ag Organic compounds
IL152580A0 (en) * 2000-05-26 2003-05-29 Ciba Sc Holding Ag Process for the preparation of indole derivatives and intermediates of the process
WO2001093860A1 (en) * 2000-06-09 2001-12-13 Lek Pharmaceuticals D.D. Stabilized pharmaceutically effective composition and pharmaceutical formulation comprising the same
NZ523557A (en) * 2000-07-19 2004-12-24 Novartis Ag Calcium salt of valsartan
US6858643B2 (en) * 2000-10-31 2005-02-22 Ciba Specialty Chemicals Corporation Crystalline forms of Fluvastatin sodium
US6777552B2 (en) * 2001-08-16 2004-08-17 Teva Pharmaceutical Industries, Ltd. Processes for preparing calcium salt forms of statins
US6777443B2 (en) * 2001-05-15 2004-08-17 Novartis Ag Dipeptide derivatives
US6686642B2 (en) * 2001-06-11 2004-02-03 Hewlett-Packard Development Company, L.P. Multi-level integrated circuit for wide-gap substrate bonding
US6869970B2 (en) * 2002-02-04 2005-03-22 Novartis Ag Crystalline salt forms of valsartan
GB0210234D0 (en) * 2002-05-03 2002-06-12 Novartis Ag Process for the manufacture of organic compounds
US6859970B2 (en) * 2002-07-18 2005-03-01 Matsushita Electric Corporation Of America Agitator for vacuum cleaner/extractor
EA013500B1 (ru) * 2003-04-11 2010-06-30 Лек Фармасьютиклз Д.Д. Способ получения аморфной кальциевой соли аторвастатина

Also Published As

Publication number Publication date
CA2486557A1 (en) 2003-12-24
EP1515717B1 (en) 2008-10-01
EP1515717B8 (en) 2009-12-16
PT1515717E (pt) 2009-02-20
ES2315510T3 (es) 2009-04-01
EP1515717A1 (en) 2005-03-23
ATE409476T1 (de) 2008-10-15
US20100249204A1 (en) 2010-09-30
US20060035941A1 (en) 2006-02-16
DE60323835D1 (de) 2008-11-13
JP2005532362A (ja) 2005-10-27
WO2003105837A1 (en) 2003-12-24
CY1108675T1 (el) 2014-04-09
AU2003276960A1 (en) 2003-12-31
DK1515717T3 (da) 2009-02-09

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