SI1010694T1 - Spiroimidazoline derivatives and their use as alpha2-adrenergic antagonists and monoamines-reuptake blockers - Google Patents

Spiroimidazoline derivatives and their use as alpha2-adrenergic antagonists and monoamines-reuptake blockers

Info

Publication number: SI1010694T1
Authority: SI; Slovenia
Prior art keywords: derivatives; spiroimidazoline; alpha2; monoamines; adrenergic antagonists
Prior art date: 1998-12-18

Application number

SI9930368T

Other languages

English (en)

Slovenian (sl)

Inventor

Alex Cordi

Mark Millan

Adrian Newman-Tancredi

Mauricette Brocco

Original Assignee

Les Laboratoires Servier

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-12-18

Filing date

1999-12-17

Publication date

2003-12-31

1999-12-17 Application filed by Les Laboratoires Servier filed Critical Les Laboratoires Servier

2003-12-31 Publication of SI1010694T1 publication Critical patent/SI1010694T1/xx

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Psychiatry (AREA)
Endocrinology (AREA)
Pain & Pain Management (AREA)
Reproductive Health (AREA)
Epidemiology (AREA)
Diabetes (AREA)
Hospice & Palliative Care (AREA)
Psychology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Child & Adolescent Psychology (AREA)
Gynecology & Obstetrics (AREA)
Hematology (AREA)
Obesity (AREA)
Addiction (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

SI9930368T 1998-12-18 1999-12-17 Spiroimidazoline derivatives and their use as alpha2-adrenergic antagonists and monoamines-reuptake blockers SI1010694T1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR9816000A FR2787450B1 (fr)	1998-12-18	1998-12-18	Nouveaux derives spiroimidazoliniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
EP99403189A EP1010694B1 (fr)	1998-12-18	1999-12-17	Dérivés spiroimidazoliniques et leur utilisation comme antagonistes alpha2-adrénergiques et bloqueurs de la recapture de monoamines

Publications (1)

Publication Number	Publication Date
SI1010694T1 true SI1010694T1 (en)	2003-12-31

Family

ID=9534134

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SI9930368T SI1010694T1 (en)	1998-12-18	1999-12-17	Spiroimidazoline derivatives and their use as alpha2-adrenergic antagonists and monoamines-reuptake blockers

Country Status (22)

Country	Link
US (1)	US6172097B1 (xx)
EP (1)	EP1010694B1 (xx)
JP (1)	JP3457241B2 (xx)
KR (1)	KR100472522B1 (xx)
CN (1)	CN1149201C (xx)
AT (1)	ATE246680T1 (xx)
AU (1)	AU760373B2 (xx)
BR (1)	BR9905904A (xx)
CA (1)	CA2292920C (xx)
DE (1)	DE69910156T2 (xx)
DK (1)	DK1010694T3 (xx)
EA (1)	EA002979B1 (xx)
ES (1)	ES2205741T3 (xx)
FR (1)	FR2787450B1 (xx)
HK (1)	HK1029117A1 (xx)
HU (1)	HU225820B1 (xx)
NO (1)	NO314402B1 (xx)
NZ (1)	NZ501890A (xx)
PL (1)	PL202368B1 (xx)
PT (1)	PT1010694E (xx)
SI (1)	SI1010694T1 (xx)
ZA (1)	ZA997735B (xx)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6638981B2 (en)	2001-08-17	2003-10-28	Epicept Corporation	Topical compositions and methods for treating pain
CA2716080C (en)	2008-02-20	2016-12-13	Targia Pharmaceuticals	Cns pharmaceutical compositions and methods of use

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6294185B1 (en) *	1993-03-12	2001-09-25	Auburn University	Monomeric and polymeric cyclic amine and N-halamine compounds
FR2707982B1 (fr) *	1993-07-20	1995-09-01	Adir	Nouveaux dérivés de benzospiroalcène, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
FR2709306B1 (fr) *	1993-07-20	1995-10-20	Adir	Nouveaux dérivés de benzospiroalcène, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
FR2707981B1 (fr) *	1993-07-20	1995-09-01	Adir	Nouveaux dérivés de benzospiroalcène, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.

1998
- 1998-12-18 FR FR9816000A patent/FR2787450B1/fr not_active Expired - Fee Related
1999
- 1999-12-16 JP JP35716799A patent/JP3457241B2/ja not_active Expired - Fee Related
- 1999-12-17 CN CNB991278305A patent/CN1149201C/zh not_active Expired - Fee Related
- 1999-12-17 NZ NZ501890A patent/NZ501890A/xx not_active IP Right Cessation
- 1999-12-17 US US09/465,619 patent/US6172097B1/en not_active Expired - Fee Related
- 1999-12-17 PT PT99403189T patent/PT1010694E/pt unknown
- 1999-12-17 HU HU9904629A patent/HU225820B1/hu not_active IP Right Cessation
- 1999-12-17 EA EA199901049A patent/EA002979B1/ru not_active IP Right Cessation
- 1999-12-17 CA CA002292920A patent/CA2292920C/fr not_active Expired - Fee Related
- 1999-12-17 DK DK99403189T patent/DK1010694T3/da active
- 1999-12-17 PL PL337265A patent/PL202368B1/pl not_active IP Right Cessation
- 1999-12-17 SI SI9930368T patent/SI1010694T1/xx unknown
- 1999-12-17 ES ES99403189T patent/ES2205741T3/es not_active Expired - Lifetime
- 1999-12-17 EP EP99403189A patent/EP1010694B1/fr not_active Expired - Lifetime
- 1999-12-17 ZA ZA9907735A patent/ZA997735B/xx unknown
- 1999-12-17 NO NO19996285A patent/NO314402B1/no not_active IP Right Cessation
- 1999-12-17 DE DE69910156T patent/DE69910156T2/de not_active Expired - Lifetime
- 1999-12-17 AT AT99403189T patent/ATE246680T1/de not_active IP Right Cessation
- 1999-12-17 BR BR9905904-5A patent/BR9905904A/pt not_active Application Discontinuation
- 1999-12-17 AU AU65291/99A patent/AU760373B2/en not_active Ceased
- 1999-12-18 KR KR10-1999-0058931A patent/KR100472522B1/ko not_active IP Right Cessation
2000
- 2000-12-28 HK HK00108451A patent/HK1029117A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
KR100472522B1 (ko)	2005-03-07
AU760373B2 (en)	2003-05-15
ATE246680T1 (de)	2003-08-15
AU6529199A (en)	2000-06-22
BR9905904A (pt)	2000-08-29
HU225820B1 (en)	2007-10-29
EA199901049A3 (ru)	2000-08-28
DE69910156T2 (de)	2004-06-09
HUP9904629A2 (hu)	2000-08-28
NO996285D0 (no)	1999-12-17
NO996285L (no)	2000-06-19
EP1010694A3 (fr)	2000-07-26
JP3457241B2 (ja)	2003-10-14
CA2292920C (fr)	2004-01-27
HU9904629D0 (en)	2000-02-28
CN1149201C (zh)	2004-05-12
NZ501890A (en)	2001-03-30
KR20000067830A (ko)	2000-11-25
ZA997735B (en)	2000-06-19
PL337265A1 (en)	2000-06-19
DE69910156D1 (de)	2003-09-11
HK1029117A1 (en)	2001-03-23
EA002979B1 (ru)	2002-12-26
JP2000178257A (ja)	2000-06-27
US6172097B1 (en)	2001-01-09
HUP9904629A3 (en)	2000-12-28
CA2292920A1 (fr)	2000-06-18
ES2205741T3 (es)	2004-05-01
EP1010694B1 (fr)	2003-08-06
CN1264704A (zh)	2000-08-30
EA199901049A2 (ru)	2000-08-28
EP1010694A2 (fr)	2000-06-21
PL202368B1 (pl)	2009-06-30
NO314402B1 (no)	2003-03-17
FR2787450A1 (fr)	2000-06-23
DK1010694T3 (da)	2003-11-24
PT1010694E (pt)	2003-10-31
FR2787450B1 (fr)	2001-01-26

Publication	Publication Date	Title
CA2414018A1 (en)	2001-12-13	2-aminocarbonyl-9h-purine derivatives
EP0902007A4 (en)	1999-10-13	CHALCON DERIVATIVES AND MEDICINES THAT CONTAIN THEM
WO2001032130A3 (en)	2002-03-14	Phenyl amine carboxylic acid compounds and compositions for delivering active agents
AUPR213700A0 (en)	2001-01-25	Antiviral agents
WO2001009103A3 (en)	2001-05-31	Imidazole antiproliferative agents
DK1029853T3 (da)	2004-05-24	Heteroaromatiske bicykliske derivativer, der er egnede som anticancermidler
MXPA03008215A (es)	2004-01-29	Inhibidores de integrina alfa v beta 6.
CA2119662A1 (fr)	1994-09-25	Nouveaux derives bicycliques azotes, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
HU9801950D0 (en)	1998-10-28	2-(arylphenyl)-amino-imidazoline derivatives
SI1010693T1 (en)	2004-02-29	Imidazoline derivatives, preparation and pharmaceutical compositions containing them
EP1553096A4 (en)	2008-05-28	pyrazole
WO2003066594A3 (de)	2003-11-27	3-alkanoylamino-propionsäure-derivate als inhibitoren des integrins avss6
IL127177A (en)	2003-10-31	ANTIPYSYCHOTIC 5-(1, 3, 4, 4a, 5, 9b-HEXAHYDRO-PYRIDO (3, 4-b) INDOL-2-YLALKYL) PYRIMIDIN-4-ONE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
SI1010694T1 (en)	2003-12-31	Spiroimidazoline derivatives and their use as alpha2-adrenergic antagonists and monoamines-reuptake blockers
AU2983792A (en)	1993-06-10	Diaminomethyleneamino substituted substituted phenyl thiazoles
MXPA04001442A (es)	2004-05-27	Derivados de m-aminofenol y agentes colorantes que contienen estos compuestos.
AU4084889A (en)	1990-03-08	Antihypertensive 3-piperidinyl-indazole derivatives
EP1227098A4 (en)	2003-04-09	TRIAZOLPURINE DERIVATIVES, MEDICINAL COMPOSITIONS CONTAINING THEM AND MEANS THAT SHOW AFFINITY TO THE ADENOSINE A3 RECEPTOR
HUT65376A (en)	1994-05-02	Process for preparing n,n',n-trisubstituted 5-(diamino-methylene)-1,3-dioxane-4,6-diones and pharmaceutical compositions containing them as active ingredient
AP2001002179A0 (en)	2002-11-30	2-Aminocarbonyl-9h-purine derivatives.
AU1528292A (en)	1992-11-12	New urea derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same
HUP9903036A2 (hu)	2000-03-28	Mappia foetidából izolált kamptotecinvázas vegyületek, alkalmazásuk új gyógyszerekben szintonokként, valamint terápiás szerekként