SI1004582T1 - - Google Patents

Info

Publication number: SI1004582T1
Authority: SI; Slovenia
Prior art keywords: phenyl; deriv; substd; opt; furyl
Prior art date: 1993-10-22

Application number

SI9430476T

Other languages

English (en)

Inventor

Thomas Michael Bare

Timothy Wayne Davenport

James Roy Empfield

Kinney Jeffrey Alan Mc

Richard Bruce Sparks

Original Assignee

Astrazeneca Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-10-22

Filing date

1994-10-20

Publication date

2005-08-31

1993-10-22 Priority claimed from GB939321854A external-priority patent/GB9321854D0/en

1994-08-25 Priority claimed from GB9417171A external-priority patent/GB9417171D0/en

1994-10-20 Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab

2005-08-31 Publication of SI1004582T1 publication Critical patent/SI1004582T1/xx

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Diabetes (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Emergency Medicine (AREA)
Hematology (AREA)
Obesity (AREA)
Endocrinology (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Cardiology (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Pain & Pain Management (AREA)
Heart & Thoracic Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Quinoline Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Saccharide Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

SI9430476T 1993-10-22 1994-10-20 SI1004582T1 (hu)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GB939321854A GB9321854D0 (en)	1993-10-22	1993-10-22	Pyridazino quinoline compounds
GB9417171A GB9417171D0 (en)	1994-08-25	1994-08-25	Pyridazino quinoline compounds
EP00101917A EP1004582B1 (en)	1993-10-22	1994-10-20	Pyridazino quinoline compounds

Publications (1)

Publication Number	Publication Date
SI1004582T1 true SI1004582T1 (hu)	2005-08-31

Family

ID=26303731

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
SI9430476T SI1004582T1 (hu)	1993-10-22	1994-10-20
SI9430314T SI0724583T1 (en)	1993-10-22	1994-10-20	Pyridazino quinoline compounds

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
SI9430314T SI0724583T1 (en)	1993-10-22	1994-10-20	Pyridazino quinoline compounds

Country Status (30)

Country	Link
US (3)	US5744471A (hu)
EP (2)	EP0724583B1 (hu)
JP (1)	JP3583132B2 (hu)
KR (1)	KR100261209B1 (hu)
CN (1)	CN1053189C (hu)
AT (2)	ATE295846T1 (hu)
AU (2)	AU688393B2 (hu)
CA (1)	CA2171332A1 (hu)
CZ (1)	CZ292311B6 (hu)
DE (2)	DE69434380T2 (hu)
DK (2)	DK0724583T3 (hu)
ES (2)	ES2241513T3 (hu)
FI (2)	FI113865B (hu)
GB (1)	GB9420590D0 (hu)
GR (1)	GR3035080T3 (hu)
HK (1)	HK1013997A1 (hu)
HU (1)	HUT74161A (hu)
IL (1)	IL111266A (hu)
MY (2)	MY124316A (hu)
NO (1)	NO306995B1 (hu)
NZ (2)	NZ275472A (hu)
PL (1)	PL180679B1 (hu)
PT (2)	PT724583E (hu)
RU (1)	RU2168511C2 (hu)
SG (2)	SG59971A1 (hu)
SI (2)	SI1004582T1 (hu)
SK (1)	SK282491B6 (hu)
TW (1)	TW406082B (hu)
UA (1)	UA60291C2 (hu)
WO (1)	WO1995011244A1 (hu)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL111266A (en) *	1993-10-22	2002-03-10	Zeneca Ltd	2-HETEROARYL OR 2-ARYLPYRIDAZINO [4,5-b] QUINOLINE - 1, 10 - DIONES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
GB9422894D0 (en) *	1994-11-12	1995-01-04	Zeneca Ltd	Pyridazino quinoline compounds
US6214826B1 (en)	1994-11-12	2001-04-10	Zeneca Limited	Pyridazino quinoline compounds
GB9507318D0 (en) *	1995-04-07	1995-05-31	Zeneca Ltd	Alpha substituted pyridazino quinoline compounds
JP2003519147A (ja) *	1999-12-23	2003-06-17	アストラゼネカ・アクチエボラーグ	痛みの処置のための化合物および方法
EP1577311A1 (en) *	1999-12-23	2005-09-21	AstraZeneca AB	Salts of a pyridazino aquinoline derivative and use for the treatment of pain
US6787547B2 (en)	1999-12-23	2004-09-07	Astrazeneca Ab	Compound and method for the treatment of pain
WO2001047927A1 (en) *	1999-12-23	2001-07-05	Astrazeneca Ab	Compound and method for the treatment of pain
US6730675B2 (en)	1999-12-23	2004-05-04	Astrazeneca Ab	Compounds and methods for the treatment of pain
EP1244663B1 (en) *	1999-12-23	2004-08-25	AstraZeneca AB	Compounds and methods for the treatment of pain
US6943165B2 (en) *	1999-12-23	2005-09-13	Astrazeneca Ab	Compound and method for the treatment of pain
JP2003518500A (ja) *	1999-12-23	2003-06-10	アストラゼネカ・アクチエボラーグ	痛みの処置のための方法および組成物
US20030176435A1 (en) *	2002-12-17	2003-09-18	Brown Dean Gordon	Compounds and methods for the treatment of pain
JP2003519146A (ja) *	1999-12-23	2003-06-17	アストラゼネカ・アクチエボラーグ	痛みの処置のための方法および組成物
BR0016646A (pt) *	1999-12-23	2002-10-08	Astrazeneca Ab	Método para tratar um paciente que sofre de dor, e, composição farmacêutica
WO2001047926A1 (en) *	1999-12-23	2001-07-05	Astrazeneca Ab	Compounds and methods for the treatment of pain
US6403818B1 (en)	2000-02-28	2002-06-11	Eisai Co., Ltd.	Process for producing α-hydroxy-carbonyl compound
EP1325005A1 (en) *	2000-09-29	2003-07-09	AstraZeneca AB	1,2,5,10-tetrahydropyridazino 4,5-b]quinoline-1,10-diones and their use for the treatment of pain
JP2004509964A (ja)	2000-09-29	2004-04-02	アストラゼネカ・アクチエボラーグ	７−クロロ−４−ヒドロキシ−２−（２−ピリジルエチル）−１，２，５，１０−テトラヒドロピリダジノ［４，５−ｂ］キノリン−１，１０−ジオン及び疼痛治療のためのその使用
DE60119949T2 (de)	2000-09-29	2007-04-26	Astrazeneca Ab	1,2,5,10-TETRAHYDROPYRIDAZINOi4,5-BöCHINOLIN-1,10-DIONE UND IHRE ANWENDUNG IN DER BEHANDLUNG VON SCHMERZEN
EP1325004A1 (en)	2000-09-29	2003-07-09	AstraZeneca AB	1,2,5,10-tetrahydropyridazino[4,5-b]quinoline-1,10-diones and their use for the treatment of pain
US20100074949A1 (en)	2008-08-13	2010-03-25	William Rowe	Pharmaceutical composition and administration thereof
MXPA03010870A (es)	2001-05-31	2004-02-27	Sanofi Synthelabo	Derivados de aminoquinolina y aminopiridina y su uso como ligandos de a3 de adenosina.
US8592421B2 (en)	2003-08-04	2013-11-26	Valery Khazhmuratovich Zhilov	Cyclic bioisosters of purine system derivatives and a pharmaceutical composition based thereon
US8354427B2 (en)	2004-06-24	2013-01-15	Vertex Pharmaceutical Incorporated	Modulators of ATP-binding cassette transporters
CA2571949C (en)	2004-06-24	2015-05-12	Vertex Pharmaceuticals Incorporated	Modulators of atp-binding cassette transporters
AU2006331614A1 (en) *	2005-12-24	2007-07-05	Vertex Pharmaceuticals Incorporated	Quinolin- 4 - one derivatives as modulators of ABC transporters
HUE049976T2 (hu)	2005-12-28	2020-11-30	Vertex Pharma	N-[2,4-bisz(1,1-dimetil-etil)-5-hidroxi-fenil]-1,4-dihidro-4-oxo-kinolin-3-karboxamid amorf alakjának gyógyászati kompozíciói
KR101852173B1 (ko)	2009-03-20	2018-04-27	버텍스 파마슈티칼스 인코포레이티드	낭성 섬유증 막횡단 전도도 조절자의 조정자의 제조 방법
US8802700B2 (en)	2010-12-10	2014-08-12	Vertex Pharmaceuticals Incorporated	Modulators of ATP-Binding Cassette transporters
MX2014010253A (es)	2012-02-27	2014-11-12	Vertex Pharma	Composicion farmaceutica y administraciones de la misma.
JP6746569B2 (ja)	2014-10-07	2020-08-26	バーテックスファーマシューティカルズインコーポレイテッドＶｅｒｔｅｘＰｈａｒｍａｃｅｕｔｉｃａｌｓＩｎｃｏｒｐｏｒａｔｅｄ	嚢胞性線維症膜貫通コンダクタンス制御因子のモジュレーターの共結晶

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9109972D0 (en) *	1991-05-09	1991-07-03	Ici Plc	Therapeutic compounds
GB9208511D0 (en) *	1991-05-09	1992-06-03	Ici Plc	Compounds
IL111266A (en) *	1993-10-22	2002-03-10	Zeneca Ltd	2-HETEROARYL OR 2-ARYLPYRIDAZINO [4,5-b] QUINOLINE - 1, 10 - DIONES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
GB9422894D0 (en) *	1994-11-12	1995-01-04	Zeneca Ltd	Pyridazino quinoline compounds
GB9507318D0 (en) *	1995-04-07	1995-05-31	Zeneca Ltd	Alpha substituted pyridazino quinoline compounds

1994
- 1994-10-12 IL IL11126694A patent/IL111266A/xx not_active IP Right Cessation
- 1994-10-12 GB GB9420590A patent/GB9420590D0/en active Pending
- 1994-10-20 PT PT94930275T patent/PT724583E/pt unknown
- 1994-10-20 JP JP51152195A patent/JP3583132B2/ja not_active Expired - Fee Related
- 1994-10-20 ES ES00101917T patent/ES2241513T3/es not_active Expired - Lifetime
- 1994-10-20 US US08/637,641 patent/US5744471A/en not_active Expired - Fee Related
- 1994-10-20 DK DK94930275T patent/DK0724583T3/da active
- 1994-10-20 SI SI9430476T patent/SI1004582T1/xx unknown
- 1994-10-20 ES ES94930275T patent/ES2154686T3/es not_active Expired - Lifetime
- 1994-10-20 DE DE69434380T patent/DE69434380T2/de not_active Expired - Fee Related
- 1994-10-20 RU RU96109470/04A patent/RU2168511C2/ru not_active IP Right Cessation
- 1994-10-20 AT AT00101917T patent/ATE295846T1/de not_active IP Right Cessation
- 1994-10-20 EP EP94930275A patent/EP0724583B1/en not_active Expired - Lifetime
- 1994-10-20 AU AU79440/94A patent/AU688393B2/en not_active Ceased
- 1994-10-20 PL PL94314041A patent/PL180679B1/pl not_active IP Right Cessation
- 1994-10-20 DE DE69426422T patent/DE69426422T2/de not_active Expired - Fee Related
- 1994-10-20 NZ NZ275472A patent/NZ275472A/en not_active IP Right Cessation
- 1994-10-20 SK SK504-96A patent/SK282491B6/sk not_active IP Right Cessation
- 1994-10-20 PT PT00101917T patent/PT1004582E/pt unknown
- 1994-10-20 SG SG1996007261A patent/SG59971A1/en unknown
- 1994-10-20 CZ CZ19961138A patent/CZ292311B6/cs not_active IP Right Cessation
- 1994-10-20 EP EP00101917A patent/EP1004582B1/en not_active Expired - Lifetime
- 1994-10-20 CN CN94194578A patent/CN1053189C/zh not_active Expired - Fee Related
- 1994-10-20 AT AT94930275T patent/ATE198072T1/de not_active IP Right Cessation
- 1994-10-20 MY MYPI94002796A patent/MY124316A/en unknown
- 1994-10-20 CA CA002171332A patent/CA2171332A1/en not_active Abandoned
- 1994-10-20 SG SG9900943A patent/SG92630A1/en unknown
- 1994-10-20 DK DK00101917T patent/DK1004582T3/da active
- 1994-10-20 KR KR1019960702011A patent/KR100261209B1/ko not_active IP Right Cessation
- 1994-10-20 NZ NZ329303A patent/NZ329303A/xx not_active IP Right Cessation
- 1994-10-20 MY MYPI98002508A patent/MY132875A/en unknown
- 1994-10-20 WO PCT/GB1994/002295 patent/WO1995011244A1/en active IP Right Grant
- 1994-10-20 SI SI9430314T patent/SI0724583T1/xx unknown
- 1994-10-20 UA UA96041567A patent/UA60291C2/uk unknown
- 1994-10-20 HU HU9600889A patent/HUT74161A/hu unknown
- 1994-11-18 TW TW083110721A patent/TW406082B/zh not_active IP Right Cessation
1996
- 1996-04-18 FI FI961696A patent/FI113865B/fi active
- 1996-04-19 NO NO961584A patent/NO306995B1/no not_active IP Right Cessation
1997
- 1997-03-03 FI FI970907A patent/FI114916B/fi active IP Right Grant
1998
- 1998-03-19 US US09/044,109 patent/US6232313B1/en not_active Expired - Fee Related
- 1998-05-27 AU AU68999/98A patent/AU721139B2/en not_active Ceased
- 1998-12-24 HK HK98115415A patent/HK1013997A1/xx not_active IP Right Cessation
1999
- 1999-12-06 US US09/455,096 patent/US6103721A/en not_active Expired - Fee Related
2000
- 2000-12-14 GR GR20000402690T patent/GR3035080T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
EP1004582A3 (en)	2000-08-30
AU6899998A (en)	1998-07-30
IL111266A0 (en)	1994-12-29
HK1013997A1 (en)	1999-09-17
SK50496A3 (en)	1997-03-05
AU721139B2 (en)	2000-06-22
CA2171332A1 (en)	1995-04-27
CZ113896A3 (en)	1996-09-11
DE69426422T2 (de)	2001-05-10
FI961696A (fi)	1996-04-18
PT724583E (pt)	2001-03-30
DK1004582T3 (da)	2005-08-15
EP1004582B1 (en)	2005-05-18
PL314041A1 (en)	1996-08-05
HUT74161A (en)	1996-11-28
GR3035080T3 (en)	2001-03-30
NZ275472A (en)	1998-03-25
HU9600889D0 (en)	1996-06-28
DE69426422D1 (de)	2001-01-18
ES2154686T3 (es)	2001-04-16
FI961696A0 (fi)	1996-04-18
UA60291C2 (uk)	2003-10-15
EP0724583B1 (en)	2000-12-13
DK0724583T3 (da)	2001-03-05
CZ292311B6 (cs)	2003-09-17
NZ329303A (en)	2000-01-28
EP1004582A2 (en)	2000-05-31
GB9420590D0 (en)	1994-11-30
DE69434380D1 (de)	2005-06-23
IL111266A (en)	2002-03-10
KR100261209B1 (ko)	2000-09-01
MY124316A (en)	2006-06-30
AU688393B2 (en)	1998-03-12
US6232313B1 (en)	2001-05-15
DE69434380T2 (de)	2006-05-04
PL180679B1 (en)	2001-03-30
MY132875A (en)	2007-10-31
ES2241513T3 (es)	2005-11-01
SG92630A1 (en)	2002-11-19
FI970907A (fi)	1997-03-03
FI970907A0 (fi)	1997-03-03
CN1053189C (zh)	2000-06-07
US5744471A (en)	1998-04-28
CN1138332A (zh)	1996-12-18
NO961584L (no)	1996-04-19
SI0724583T1 (en)	2001-04-30
SG59971A1 (en)	1999-02-22
RU2168511C2 (ru)	2001-06-10
JPH09504519A (ja)	1997-05-06
AU7944094A (en)	1995-05-08
EP0724583A1 (en)	1996-08-07
FI114916B (fi)	2005-01-31
SK282491B6 (sk)	2002-02-05
US6103721A (en)	2000-08-15
WO1995011244A1 (en)	1995-04-27
PT1004582E (pt)	2005-09-30
TW406082B (en)	2000-09-21
JP3583132B2 (ja)	2004-10-27
NO306995B1 (no)	2000-01-24
FI113865B (fi)	2004-06-30
ATE295846T1 (de)	2005-06-15
NO961584D0 (no)	1996-04-19
ATE198072T1 (de)	2000-12-15

Publication	Publication Date	Title
SI1004582T1 (hu)	2005-08-31
PL328310A1 (en)	1999-01-18	Derivatives of quinazoline
ATE101181T1 (de)	1994-02-15	Anti-krebs-verbindungen.
DE69217312D1 (de)	1997-03-20	Tricyclische Heterocyclen als PGE2-Antagonisten
ATE182891T1 (de)	1999-08-15	Indazolderivate
DE69207182D1 (en)	1996-02-08	Antitumor anthracenderivate
DE69316392D1 (de)	1998-02-19	Azanoradamantane
ES2063177T3 (es)	1995-01-01	Antagonistas de calcio.
ZA928684B (en)	1994-05-11	Benzimidazole anthelmintic agents
HUP9903545A2 (hu)	2000-02-28	Helyettesített triciklusos vegyületek, eljárás előállításukra és a vegyületeket tartalmazó gyógyászati készítmények