SG133602A1 - Pyrrolo [2,3-d] pyrimidine compounds for treating transplant rejection - Google Patents
Pyrrolo [2,3-d] pyrimidine compounds for treating transplant rejectionInfo
- Publication number
- SG133602A1 SG133602A1 SG200704529-7A SG2007045297A SG133602A1 SG 133602 A1 SG133602 A1 SG 133602A1 SG 2007045297 A SG2007045297 A SG 2007045297A SG 133602 A1 SG133602 A1 SG 133602A1
- Authority
- SG
- Singapore
- Prior art keywords
- pyrrolo
- transplant rejection
- pyrimidine compounds
- treating transplant
- treating
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US53118003P | 2003-12-17 | 2003-12-17 |
Publications (1)
Publication Number | Publication Date |
---|---|
SG133602A1 true SG133602A1 (en) | 2007-07-30 |
Family
ID=34710208
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG200704529-7A SG133602A1 (en) | 2003-12-17 | 2004-12-06 | Pyrrolo [2,3-d] pyrimidine compounds for treating transplant rejection |
Country Status (17)
Country | Link |
---|---|
US (1) | US20050159433A1 (ko) |
EP (1) | EP1734967A2 (ko) |
JP (1) | JP2007514729A (ko) |
KR (1) | KR20060096153A (ko) |
CN (1) | CN1893952A (ko) |
AU (1) | AU2004305317A1 (ko) |
BR (1) | BRPI0417803A (ko) |
CA (1) | CA2549485A1 (ko) |
CO (1) | CO5700767A2 (ko) |
IL (1) | IL175812A0 (ko) |
MX (1) | MXPA06007002A (ko) |
NO (1) | NO20062292L (ko) |
RU (1) | RU2006120956A (ko) |
SG (1) | SG133602A1 (ko) |
TW (1) | TW200529853A (ko) |
WO (1) | WO2005060972A2 (ko) |
ZA (1) | ZA200604888B (ko) |
Families Citing this family (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001042246A2 (en) | 1999-12-10 | 2001-06-14 | Pfizer Products Inc. | PYRROLO[2,3-d]PYRIMIDINE COMPOUNDS |
EP1572213A1 (en) | 2002-11-26 | 2005-09-14 | Pfizer Products Inc. | Method of treatment of transplant rejection |
AR054416A1 (es) | 2004-12-22 | 2007-06-27 | Incyte Corp | Pirrolo [2,3-b]piridin-4-il-aminas y pirrolo [2,3-b]pirimidin-4-il-aminas como inhibidores de las quinasas janus. composiciones farmaceuticas. |
EP1910358A2 (en) | 2005-07-14 | 2008-04-16 | Astellas Pharma Inc. | Heterocyclic janus kinase 3 inhibitors |
EP2251341A1 (en) | 2005-07-14 | 2010-11-17 | Astellas Pharma Inc. | Heterocyclic Janus kinase 3 inhibitors |
US20070149506A1 (en) | 2005-09-22 | 2007-06-28 | Arvanitis Argyrios G | Azepine inhibitors of Janus kinases |
TWI468162B (zh) | 2005-12-13 | 2015-01-11 | 英塞特公司 | 作為傑納斯激酶(JANUS KINASE)抑制劑之經雜芳基取代之吡咯并〔2,3-b〕吡啶及吡咯并〔2,3-b〕嘧啶 |
GB0605691D0 (en) * | 2006-03-21 | 2006-05-03 | Novartis Ag | Organic Compounds |
US8513270B2 (en) | 2006-12-22 | 2013-08-20 | Incyte Corporation | Substituted heterocycles as Janus kinase inhibitors |
SG10201509887UA (en) | 2007-06-13 | 2016-01-28 | Incyte Corp | Salts of the janus kinase inhibitor (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclopentylpropanenitrile |
CL2008001709A1 (es) | 2007-06-13 | 2008-11-03 | Incyte Corp | Compuestos derivados de pirrolo [2,3-b]pirimidina, moduladores de quinasas jak; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como cancer, psoriasis, artritis reumatoide, entre otras. |
ES2602577T3 (es) | 2008-03-11 | 2017-02-21 | Incyte Holdings Corporation | Derivados de azetidina y ciclobutano como inhibidores de JAK |
RU2493157C2 (ru) * | 2008-08-20 | 2013-09-20 | Пфайзер Инк. | ПРОИЗВОДНЫЕ ПИРРОЛО[2,3-d]ПИРИМИДИНА |
EP2421867B1 (en) | 2009-04-20 | 2015-09-02 | Auspex Pharmaceuticals, Llc | Piperidine inhibitors of janus kinase 3 |
SG176111A1 (en) | 2009-05-22 | 2011-12-29 | Incyte Corp | 3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]octane- or heptane-nitrile as jak inhibitors |
EA025520B1 (ru) | 2009-05-22 | 2017-01-30 | Инсайт Холдингс Корпорейшн | N-(ГЕТЕРО)АРИЛПИРРОЛИДИНОВЫЕ ПРОИЗВОДНЫЕ ПИРАЗОЛ-4-ИЛ-ПИРРОЛО[2,3-d]ПИРИМИДИНОВ И ПИРРОЛ-3-ИЛ-ПИРРОЛО[2,3-d]ПИРИМИДИНОВ В КАЧЕСТВЕ ИНГИБИТОРОВ ЯНУС-КИНАЗЫ |
CN102574857B (zh) | 2009-07-08 | 2015-06-10 | 利奥制药有限公司 | 作为jak受体和蛋白酪氨酸激酶抑制剂的杂环化合物 |
WO2011028685A1 (en) | 2009-09-01 | 2011-03-10 | Incyte Corporation | Heterocyclic derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors |
US8486902B2 (en) | 2009-10-09 | 2013-07-16 | Incyte Corporation | Hydroxyl, keto, and glucuronide derivatives of 3-(4-(7H-pyrrolo[2,3-d] pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile |
EP2338888A1 (en) | 2009-12-24 | 2011-06-29 | Almirall, S.A. | Imidazopyridine derivatives as JAK inhibitors |
MX347851B (es) | 2010-03-10 | 2017-05-16 | Incyte Corp | Derivados de piperidin-4-il azetidina como inhibidores de janus cinasa 1 (jak1). |
EP2574168B9 (en) | 2010-05-21 | 2016-10-05 | Incyte Holdings Corporation | Topical formulation for a jak inhibitor |
WO2012068450A1 (en) | 2010-11-19 | 2012-05-24 | Incyte Corporation | Cyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as jak inhibitors |
US9034884B2 (en) | 2010-11-19 | 2015-05-19 | Incyte Corporation | Heterocyclic-substituted pyrrolopyridines and pyrrolopyrimidines as JAK inhibitors |
CN103298817A (zh) * | 2011-01-07 | 2013-09-11 | 利奥制药有限公司 | 作为蛋白酪氨酸激酶抑制剂的新磺酰胺哌嗪衍生物及其药物用途 |
AU2012219395B2 (en) | 2011-02-18 | 2017-05-25 | Incyte Corporation | mTOR/JAK inhibitor combination therapy |
EP2688890B1 (en) | 2011-03-22 | 2017-08-30 | Advinus Therapeutics Limited | Substituted fused tricyclic compounds, compositions and medicinal applications thereof |
CA2839767A1 (en) | 2011-06-20 | 2012-12-27 | Incyte Corporation | Azetidinyl phenyl, pyridyl or pyrazinyl carboxamide derivatives as jak inhibitors |
WO2013023119A1 (en) | 2011-08-10 | 2013-02-14 | Novartis Pharma Ag | JAK P13K/mTOR COMBINATION THERAPY |
TW201313721A (zh) | 2011-08-18 | 2013-04-01 | Incyte Corp | 作為jak抑制劑之環己基氮雜環丁烷衍生物 |
UA111854C2 (uk) | 2011-09-07 | 2016-06-24 | Інсайт Холдінгс Корпорейшн | Способи і проміжні сполуки для отримання інгібіторів jak |
US9193733B2 (en) | 2012-05-18 | 2015-11-24 | Incyte Holdings Corporation | Piperidinylcyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as JAK inhibitors |
US9593115B2 (en) | 2012-09-21 | 2017-03-14 | Advinus Therapeutics Ltd. | Substituted fused tricyclic compounds, compositions, and medicinal applications thereof |
BR112015010663B1 (pt) | 2012-11-15 | 2022-12-06 | Incyte Holdings Corporation | Formas de dosagem oral de liberação sustentada, e uso de ruxolitinib ou de sal farmaceuticamente aceitável do mesmo |
CN103896826B (zh) * | 2012-12-26 | 2016-08-03 | 上海朴颐化学科技有限公司 | 氮保护的(3r,4r)-3-甲氨基-4-甲基哌啶的不对称合成方法、相关中间体及原料制备方法 |
WO2014102826A1 (en) * | 2012-12-28 | 2014-07-03 | Glenmark Pharmaceuticals Limited; | The present invention relates to process for the preparation of tofacitinib and intermediates thereof. |
CN105189509B (zh) | 2013-03-06 | 2017-12-19 | 因赛特公司 | 用于制备jak抑制剂的方法及中间体 |
RS60469B1 (sr) | 2013-08-07 | 2020-07-31 | Incyte Corp | Dozni oblici sa produženim oslobađanjem za jak1 inhibitor |
WO2015184305A1 (en) | 2014-05-30 | 2015-12-03 | Incyte Corporation | TREATMENT OF CHRONIC NEUTROPHILIC LEUKEMIA (CNL) AND ATYPICAL CHRONIC MYELOID LEUKEMIA (aCML) BY INHIBITORS OF JAK1 |
CN104059016A (zh) * | 2014-06-20 | 2014-09-24 | 湖南天地恒一制药有限公司 | 制备托法替布的中间体及所述中间体的制备方法 |
US10596161B2 (en) | 2017-12-08 | 2020-03-24 | Incyte Corporation | Low dose combination therapy for treatment of myeloproliferative neoplasms |
WO2019152374A1 (en) | 2018-01-30 | 2019-08-08 | Incyte Corporation | Processes for preparing (1 -(3-fluoro-2-(trifluoromethyl)isonicotinyl)piperidine-4-one) |
MX2022012285A (es) | 2018-03-30 | 2023-08-15 | Incyte Corp | Tratamiento de la hidradenitis supurativa mediante el uso de inhibidores de actividad de la cinasa janus (jak). |
US11833155B2 (en) | 2020-06-03 | 2023-12-05 | Incyte Corporation | Combination therapy for treatment of myeloproliferative neoplasms |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US53782A (en) * | 1866-04-10 | Improvement in nut-machines | ||
WO2001042246A2 (en) * | 1999-12-10 | 2001-06-14 | Pfizer Products Inc. | PYRROLO[2,3-d]PYRIMIDINE COMPOUNDS |
EP1572213A1 (en) * | 2002-11-26 | 2005-09-14 | Pfizer Products Inc. | Method of treatment of transplant rejection |
-
2004
- 2004-12-06 AU AU2004305317A patent/AU2004305317A1/en not_active Abandoned
- 2004-12-06 BR BRPI0417803-3A patent/BRPI0417803A/pt not_active IP Right Cessation
- 2004-12-06 SG SG200704529-7A patent/SG133602A1/en unknown
- 2004-12-06 JP JP2006544578A patent/JP2007514729A/ja active Pending
- 2004-12-06 KR KR1020067011842A patent/KR20060096153A/ko not_active Application Discontinuation
- 2004-12-06 WO PCT/IB2004/004034 patent/WO2005060972A2/en active Application Filing
- 2004-12-06 MX MXPA06007002A patent/MXPA06007002A/es unknown
- 2004-12-06 CN CNA2004800377587A patent/CN1893952A/zh active Pending
- 2004-12-06 RU RU2006120956/04A patent/RU2006120956A/ru not_active Application Discontinuation
- 2004-12-06 EP EP04801340A patent/EP1734967A2/en not_active Withdrawn
- 2004-12-06 CA CA002549485A patent/CA2549485A1/en not_active Abandoned
- 2004-12-13 US US11/011,474 patent/US20050159433A1/en not_active Abandoned
- 2004-12-16 TW TW093139167A patent/TW200529853A/zh unknown
-
2006
- 2006-05-19 NO NO20062292A patent/NO20062292L/no not_active Application Discontinuation
- 2006-05-22 IL IL175812A patent/IL175812A0/en unknown
- 2006-06-09 CO CO06056308A patent/CO5700767A2/es not_active Application Discontinuation
- 2006-06-13 ZA ZA200604888A patent/ZA200604888B/en unknown
Also Published As
Publication number | Publication date |
---|---|
KR20060096153A (ko) | 2006-09-07 |
CO5700767A2 (es) | 2006-11-30 |
BRPI0417803A (pt) | 2007-04-10 |
US20050159433A1 (en) | 2005-07-21 |
AU2004305317A1 (en) | 2005-07-07 |
IL175812A0 (en) | 2008-04-13 |
CA2549485A1 (en) | 2005-07-07 |
JP2007514729A (ja) | 2007-06-07 |
MXPA06007002A (es) | 2006-08-31 |
EP1734967A2 (en) | 2006-12-27 |
NO20062292L (no) | 2006-06-14 |
WO2005060972A2 (en) | 2005-07-07 |
RU2006120956A (ru) | 2008-01-27 |
CN1893952A (zh) | 2007-01-10 |
TW200529853A (en) | 2005-09-16 |
WO2005060972A3 (en) | 2005-10-20 |
ZA200604888B (en) | 2007-11-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL175812A0 (en) | Pyrrolo [2,3-d] pyrimidine compounds for treating transplant rejection | |
EP1599482A4 (en) | PYRAZOLO1,5-A PYRIMIDINE DERIVATIVES | |
IL182099A0 (en) | Piperidinylamino-thieno[2,3-d] pyrimidine compounds | |
IL152771A0 (en) | PYRROLO(2,3-d) PYRIMIDINE COMPOUNDS AS IMMUNOSUPPRESSIVE AGENTS | |
AP2002002543A0 (en) | Pyrrolo Ä2,3-dÜ pyrimidine compounds | |
ZA200705279B (en) | Processes for preparing pyrazolo[3,4-d]pyrimidine ethers | |
IL175813A0 (en) | PYRIDO [2,3-d] PYRIMIDINE-2,4-DIAMINES AS PDE 2 INHIBITORS | |
HK1099286A1 (en) | 5,7-diaminopyrazolo [4,3-d] pyrimidines with pde-5 inhibiting activity | |
PL1699795T3 (pl) | Podstawione pochodne 8’-piry(mi)dynylo-dihydrospiro-[cykloalkiloamino]-pirymido[1,2-a]pirymidyn-6-onu | |
HK1100081A1 (en) | Process for preparing substituted pyrimidines | |
PL379009A1 (pl) | Pochodne pirazolo [1,5-a] [1,3,5] triazyny jako ligandy receptora kanabinoidowego | |
IL170680A0 (en) | 8 - SUBSTITUTED - 6,7,8,9 -TETRAHYDROPYRIMIDO [1,2-a] PYRIMIDIN - 4 - ONE DERIVATIVES | |
EP1653969A4 (en) | PYRROLO 1,2-B PYRIDAZINE DERIVATIVES | |
PL375316A1 (en) | Process for preparing certain pyrrolotriazine compounds | |
IL169879A0 (en) | Process for preparing pyrrolotriazine derivatives | |
ZA200507192B (en) | Substituted 8-perfluoroalkyl-6,7,8,9-tetrahydropyrimido [1,2-A] pyrimidin-4-one derivatives | |
IL174196A0 (en) | 6-halogeno-[1,2,4]triazolo[1,5-a]pyrimidines for combating animal pests | |
IL173445A (en) | 6-(1,1-difluoroalkyl)-4-aminopicolinates for use as herbicides | |
PT1578731E (pt) | Processo para a preparação de compostos pirimidina | |
PL1678182T3 (pl) | Sposób wytwarzania podstawionych 5-aminopirazolo[4,3-e]-1,2,4-triazolo-[1,5-c]pirymidyn | |
GB2424883B (en) | Process for preparing pyrrolo[2, 1-c] [1,4] benzodiazepine hybrids | |
TWI372760B (en) | A pyrazolo[1,5-a]pyrimidine compound | |
IL176471A0 (en) | Process for the preparation of triazolopyrimidines | |
GB2425309B (en) | C2-fluoro pyrrolo[2,1-c][1,4]benzodiazepine dimers | |
IL181900A0 (en) | 7-aminomethyl-1,2,4-triazolo[1,5-a] pyrimidine compounds and their use for controlling pathogenic fungi |