SG11202012625PA - N-substituted tetrahydrothienopyridine derivatives and uses thereof - Google Patents

N-substituted tetrahydrothienopyridine derivatives and uses thereof

Info

Publication number
SG11202012625PA
SG11202012625PA SG11202012625PA SG11202012625PA SG11202012625PA SG 11202012625P A SG11202012625P A SG 11202012625PA SG 11202012625P A SG11202012625P A SG 11202012625PA SG 11202012625P A SG11202012625P A SG 11202012625PA SG 11202012625P A SG11202012625P A SG 11202012625PA
Authority
SG
Singapore
Prior art keywords
substituted
tetrahydrothienopyridine derivatives
derivatives
substituted tetrahydrothienopyridine
tetrahydrothienopyridine
Prior art date
Application number
SG11202012625PA
Other languages
English (en)
Inventor
Cyrille Kounde
Wei Lin Sandra Sim
Oliver Simon
Gang Wang
Hui Quan Yeo
Bryan Ks Yeung
Fumiaki Yokokawa
Bin Zou
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of SG11202012625PA publication Critical patent/SG11202012625PA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/22Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
    • C07C311/29Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SG11202012625PA 2018-06-19 2019-06-18 N-substituted tetrahydrothienopyridine derivatives and uses thereof SG11202012625PA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862687068P 2018-06-19 2018-06-19
PCT/IB2019/055121 WO2019244047A1 (en) 2018-06-19 2019-06-18 N-substituted tetrahydrothienopyridine derivatives and uses thereof

Publications (1)

Publication Number Publication Date
SG11202012625PA true SG11202012625PA (en) 2021-01-28

Family

ID=67841114

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202012625PA SG11202012625PA (en) 2018-06-19 2019-06-18 N-substituted tetrahydrothienopyridine derivatives and uses thereof

Country Status (23)

Country Link
US (1) US12012417B2 (es)
EP (2) EP4169925A3 (es)
JP (1) JP7328260B2 (es)
KR (1) KR20210022645A (es)
CN (1) CN112313237A (es)
AU (1) AU2019291488B2 (es)
BR (1) BR112020025696A2 (es)
CA (1) CA3100957A1 (es)
CL (1) CL2020003248A1 (es)
CR (1) CR20200618A (es)
CU (1) CU20200100A7 (es)
EA (1) EA202190046A1 (es)
EC (1) ECSP20080995A (es)
ES (1) ES2941946T3 (es)
IL (1) IL279441B2 (es)
JO (1) JOP20200326A1 (es)
MA (1) MA52976A (es)
MX (1) MX2020013852A (es)
PE (1) PE20210097A1 (es)
PH (1) PH12020552185A1 (es)
SA (1) SA520420809B1 (es)
SG (1) SG11202012625PA (es)
WO (1) WO2019244047A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11466024B2 (en) * 2017-08-01 2022-10-11 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Bicylic compound acting as an inhibitor
KR20210022645A (ko) 2018-06-19 2021-03-03 노파르티스 아게 N-치환된 테트라히드로티에노피리딘 유도체 및 이의 용도
USD1006154S1 (en) * 2023-06-27 2023-11-28 Qiongfang Mao Cable crossover attachment

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4656A (en) 1846-07-24 Improvement in potato-plows
US5807A (en) 1848-09-26 Brake fob cabs
US6344A (en) 1849-04-17 Driving-bobbin
US498178A (en) 1893-05-23 William valentine leonard
US54472A (en) 1866-05-01 Improved blacking-brush
US8766A (en) 1852-02-24 Appabatus for lightening vessels
US5807876A (en) 1996-04-23 1998-09-15 Vertex Pharmaceuticals Incorporated Inhibitors of IMPDH enzyme
US6054472A (en) 1996-04-23 2000-04-25 Vertex Pharmaceuticals, Incorporated Inhibitors of IMPDH enzyme
CZ298463B6 (cs) 1996-04-23 2007-10-10 Vertex Pharmaceuticals Incorporated Deriváty mocoviny pro použití jako inhibitory IMPDH enzymu a farmaceutické prostredky, které je obsahují
WO1998040381A1 (en) 1997-03-14 1998-09-17 Vertex Pharmaceuticals Incorporated Inhibitors of impdh enzyme
EE200100492A (et) 1999-03-19 2002-12-16 Vertex Pharmaceuticals Incorporated Ensüümi IMPDH inhibiitorid
GB0114185D0 (en) 2001-06-12 2001-08-01 Protherics Molecular Design Lt Compounds
AU2002318146B2 (en) 2001-05-21 2007-05-10 Monsanto Technology Llc Pesticide concentrates containing etheramine surfactants
US20030232994A1 (en) 2001-10-04 2003-12-18 Shao-Po Lu Bicyclic thiophene derivatives and combinatorial libraries thereof
JP2006502175A (ja) 2002-09-12 2006-01-19 メルク エンド カムパニー インコーポレーテッド 糖尿病及び関連疾患を治療する方法
US7138529B2 (en) 2003-04-16 2006-11-21 Hoffmann-La Roche Inc. Substituted 3-cyanothiophene acetamides as glucagon receptor antagonists
GB0324653D0 (en) 2003-10-22 2003-11-26 Syngenta Participations Ag Fungicides
NZ550513A (en) 2004-05-28 2009-10-30 4Sc Ag Tetrahydropyridothiophenes
CA2575563A1 (en) 2004-08-12 2006-02-23 Wyeth Combination therapy for diabetes, obesity, and cardiovascular diseases using gdf-8 inhibitors
WO2006084869A1 (en) 2005-02-09 2006-08-17 Nycomed Gmbh Tetrahydropyridothiophenes for the treatment of proliferative diseases such as cancer
AU2006212179A1 (en) 2005-02-11 2006-08-17 4Sc Ag Tetrahydropyridothiophenes as antripoliferative agents for the treatment of cancer
AP2007004245A0 (en) 2005-05-13 2007-12-31 Virochem Pharma Inc Compounds and methods for the treatment or prevention of flavivirus infections
CA2609003A1 (en) 2005-05-25 2006-11-30 Nycomed Gmbh Tetrahydropyridothiophenes for use in the treatment of cancer
JP2008542243A (ja) 2005-05-25 2008-11-27 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規のテトラヒドロピリドチオフェン
US7932391B2 (en) 2005-09-08 2011-04-26 Zhejiang Hauhai Pharmaceutical Co., Ltd. Method for the preparation of clopidogrel and its analogues of methyl-tetrahydrothieno[3,2-C]pyridine acetate
JP2010500395A (ja) 2006-08-16 2010-01-07 4エスツェー アクチェンゲゼルシャフト 癌治療のためのテトラヒドロピリドチオフェン誘導体
CA2660604A1 (en) 2006-08-16 2008-02-21 4Sc Ag Tetrahydrobenzothiophene derivatives
WO2008067222A1 (en) 2006-11-28 2008-06-05 Kalypsys, Inc. Heterocyclic modulators of tgr5
EP2219646A4 (en) 2007-12-21 2010-12-22 Univ Rochester METHOD FOR MODIFYING THE LIFETIME OF EUKARYOTIC ORGANISMS
MX2011008988A (es) * 2009-02-27 2011-12-16 Siga Technologies Inc Derivados de tienopiridina para el tratamiento y prevencion de infecciones por el virus del dengue.
US20130129677A1 (en) 2009-02-27 2013-05-23 Siga Technologies, Inc. Thienopyridine Derivatives for the Treatment and Prevention of Dengue Virus Infections
JP5701655B2 (ja) * 2011-03-29 2015-04-15 奈良県 植物精油中のトロポロン類及び/又はフェノール類の金属錯体化方法
KR20140070631A (ko) 2011-09-30 2014-06-10 키네타, 인크. 항바이러스 화합물
EP3325473A4 (en) 2015-07-22 2019-06-26 The Royal Institution for the Advancement of Learning / McGill University Compounds and uses thereof in the treatment of cancer and other medical disorders
CN108689987A (zh) * 2017-04-05 2018-10-23 浙江海正药业股份有限公司 一种磺胺类衍生物及其制备方法和用途
WO2018215316A1 (en) 2017-05-22 2018-11-29 Janssen Pharmaceuticals, Inc. Substituted indoline derivatives as dengue viral replication inhibitors
US11466024B2 (en) 2017-08-01 2022-10-11 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Bicylic compound acting as an inhibitor
CN108191885B (zh) * 2018-01-29 2020-08-04 华东师范大学 一类哌啶并噻吩类小分子有机化合物及其应用
KR20210022645A (ko) 2018-06-19 2021-03-03 노파르티스 아게 N-치환된 테트라히드로티에노피리딘 유도체 및 이의 용도

Also Published As

Publication number Publication date
IL279441A (en) 2021-01-31
EP3810613A1 (en) 2021-04-28
EP3810613B1 (en) 2023-01-11
CL2020003248A1 (es) 2021-07-09
EA202190046A1 (ru) 2021-03-24
WO2019244047A1 (en) 2019-12-26
AU2019291488A1 (en) 2021-02-04
JOP20200326A1 (ar) 2020-12-14
AU2019291488B2 (en) 2022-02-24
MX2020013852A (es) 2021-05-27
JP2021529159A (ja) 2021-10-28
BR112020025696A2 (pt) 2021-03-16
CU20200100A7 (es) 2021-08-06
CR20200618A (es) 2021-01-21
ECSP20080995A (es) 2021-02-26
US20220073535A1 (en) 2022-03-10
KR20210022645A (ko) 2021-03-03
MA52976A (fr) 2021-04-28
PH12020552185A1 (en) 2021-06-07
EP4169925A3 (en) 2023-06-14
PE20210097A1 (es) 2021-01-12
ES2941946T3 (es) 2023-05-26
SA520420809B1 (ar) 2022-08-17
JP7328260B2 (ja) 2023-08-16
US12012417B2 (en) 2024-06-18
CN112313237A (zh) 2021-02-02
EP4169925A2 (en) 2023-04-26
CA3100957A1 (en) 2019-12-26
IL279441B2 (en) 2023-06-01

Similar Documents

Publication Publication Date Title
ZA202001340B (en) Heterocyclic compound and use thereof
IL278171A (en) Glucose-dependent insulin polypeptide and its uses
IL283533A (en) Pentatein derivatives and their uses
IL270616B (en) Nitrogen-substituted indoles
IL279441A (en) History of N-converted tetrahydrothinopyridines and their uses
EP3802495A4 (en) HETEROCYCLIC DERIVATIVES AND THEIR USE
SG11202008543RA (en) Pyrrolidineamide derivatives and uses thereof
GB2577419B (en) Lipo-glycopeptide cleavable derivatives and uses thereof
SG11202010985TA (en) Heterocyclic derivatives and use thereof
EP3686204A4 (en) THIENODIAZEPIN DERIVATIVES AND THEIR USES
IL287026A (en) Heterocyclic compounds and their uses
IL282527A (en) 5-Azaindazole history and their use
IL278973A (en) New benzodiazepine histories and uses
IL276912A (en) Heterocyclic compound and its use
PT3796975T (pt) Derivados de sulfonilaminobenzamida
IL267937A (en) Amide compounds and their use
IL282526A (en) 5-Azaindazole history and their use
SG11202103533UA (en) Alkoxybenzaldehyde derivatives and precursors thereof
EP3568137A4 (en) HETEROCYCLIC COMPOUNDS AND USE OF SUCH COMPOUNDS
EP4028502A4 (en) N-ACYL-TYROSINE DERIVATIVES AND THEIR USES
IL284843A (en) Carbamate derivatives and their uses
ZA201908398B (en) N-substituted indole derivatives
HUE064420T2 (hu) Dipeptidil-ketoamid-meta-metoxifenil-származékok és alkalmazásuk