SG11202010855XA - Technique for regulating jak-stat pathway to allow cell differentiation, dedifferentiation, and rejuvenation, and applications of technique - Google Patents
Technique for regulating jak-stat pathway to allow cell differentiation, dedifferentiation, and rejuvenation, and applications of techniqueInfo
- Publication number
- SG11202010855XA SG11202010855XA SG11202010855XA SG11202010855XA SG11202010855XA SG 11202010855X A SG11202010855X A SG 11202010855XA SG 11202010855X A SG11202010855X A SG 11202010855XA SG 11202010855X A SG11202010855X A SG 11202010855XA SG 11202010855X A SG11202010855X A SG 11202010855XA
- Authority
- SG
- Singapore
- Prior art keywords
- technique
- dedifferentiation
- rejuvenation
- applications
- cell differentiation
- Prior art date
Links
- 230000004163 JAK-STAT signaling pathway Effects 0.000 title 1
- 230000007348 cell dedifferentiation Effects 0.000 title 1
- 230000024245 cell differentiation Effects 0.000 title 1
- 230000001105 regulatory effect Effects 0.000 title 1
- 230000003716 rejuvenation Effects 0.000 title 1
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CN201810407253.9A CN110423719B (zh) | 2018-05-01 | 2018-05-01 | 调控Jak-Stat通路使细胞分化、去分化、年轻化的技术及其应用 |
PCT/CN2019/085186 WO2019210851A1 (fr) | 2018-05-01 | 2019-04-30 | Technique de régulation de la voie jak-stat pour permettre la différenciation, la dédifférenciation et la régénération cellulaires, et applications de la technique |
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EP (1) | EP3789482A4 (fr) |
JP (1) | JP2021522859A (fr) |
CN (3) | CN117887659A (fr) |
AU (1) | AU2019263863B2 (fr) |
CA (1) | CA3098924A1 (fr) |
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CN110423721B (zh) * | 2018-05-01 | 2024-02-27 | 云南济慈再生医学研究院有限公司 | 一种年轻化的修复型成纤维细胞的制备方法及其应用 |
CN117887659A (zh) * | 2018-05-01 | 2024-04-16 | 云南济慈再生医学研究院有限公司 | 一种促进靶细胞向神经细胞分化的方法 |
CN111041027B (zh) * | 2019-12-19 | 2022-10-28 | 广东省农业科学院动物卫生研究所 | 一种Atg12基因敲除细胞系构建方法及其应用 |
CN111269887B (zh) * | 2020-02-28 | 2021-11-16 | 上海市东方医院(同济大学附属东方医院) | 一种人多能干细胞向外胚层分化的方法 |
CN111778289A (zh) * | 2020-07-27 | 2020-10-16 | 扬州大学 | 一种利用CRISPR-Cas9靶向敲除鸡Bmp4基因的方法 |
CN111944810B (zh) * | 2020-07-29 | 2022-05-27 | 中国农业大学 | 靶向敲除TNFα基因的sgRNA和敲除TNFα基因的猪胚胎成纤维细胞系及其应用 |
CN112022848B (zh) * | 2020-08-13 | 2022-02-22 | 中南大学湘雅二医院 | 索拉非尼在治疗1型糖尿病中的应用 |
CN112662621B (zh) * | 2020-12-31 | 2022-12-27 | 中国人民解放军总医院 | 一种逆转间充质干细胞衰老的方法及应用 |
CN112626010B (zh) * | 2021-01-12 | 2022-05-17 | 北京大学口腔医学院 | Cdc20在间充质干细胞成骨向分化中的应用 |
WO2023061484A1 (fr) * | 2021-10-14 | 2023-04-20 | 北京干细胞与再生医学研究院 | Cellule non pluripotente régénérée, son procédé de préparation et son utilisation |
CN114196676B (zh) * | 2021-11-29 | 2023-07-18 | 中国农业科学院北京畜牧兽医研究所 | Itga2基因在调控猪米色脂肪形成中的应用 |
CN114958918B (zh) * | 2022-06-24 | 2023-08-25 | 中国农业科学院哈尔滨兽医研究所(中国动物卫生与流行病学中心哈尔滨分中心) | 猪nlrp6基因启动子区的双荧光素酶报告基因载体 |
CN117660335A (zh) * | 2023-12-14 | 2024-03-08 | 广州百康细胞生命科技有限公司 | 一种使用化学重编辑法将体细胞转化成免疫细胞的方法 |
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AU2003274748A1 (en) * | 2002-11-08 | 2004-06-07 | Reprocell Inc. | Expansion agents for stem cells |
CN1769447A (zh) * | 2004-11-05 | 2006-05-10 | 重庆医科大学 | 抑制慢性粒细胞白血病中stat5活性的诱骗寡核苷酸及其应用 |
EP1693466A1 (fr) * | 2005-02-16 | 2006-08-23 | Eppendorf Array Technologies SA | Methode et trousse permettant l'etablissement de profils de tumeurs apres analyse de marqueurs biologiques incluant des facteurs de transcription |
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WO2008110491A2 (fr) * | 2007-03-09 | 2008-09-18 | University Of Basel | Chimiothérapie de maladies néoplasiques à l'aide de combinaisons de rapamycine et de composés modulant la voie mtor, individuellement ou en combinaison avec la chaleur |
JP2008261764A (ja) * | 2007-04-13 | 2008-10-30 | Kyowa Hakko Kogyo Co Ltd | キナーゼ阻害物質の測定方法 |
WO2009026106A1 (fr) * | 2007-08-16 | 2009-02-26 | The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services | Procédés favorisant la prolifération et la survie des cellules souches |
WO2010069008A1 (fr) * | 2008-12-19 | 2010-06-24 | Griffith University | Cellule à compétence germinale dérivée de tissu adulte |
ES2685171T3 (es) * | 2010-06-14 | 2018-10-05 | The Scripps Research Institute | Reprogramación de células a un nuevo destino |
WO2014013014A1 (fr) * | 2012-07-18 | 2014-01-23 | Fundació Privada Centre De Regulació Genòmica (Crg) | Inhibiteurs de jak pour l'activation de populations de cellules souches épidermiques |
WO2015056804A1 (fr) * | 2013-10-17 | 2015-04-23 | 国立大学法人京都大学 | Procédé efficace pour l'établissement de cellules souches pluripotentes induites |
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US20180291378A1 (en) * | 2015-05-07 | 2018-10-11 | The Trustees Of Columbia University In The City Of New York | Methods and compositions for promoting hair growth |
EP3380102A4 (fr) * | 2015-11-25 | 2019-05-08 | The Methodist Hospital System | Extension de télomères et agents anti-inflammatoires pour régénération cellulaire |
ES2921257T3 (es) * | 2016-06-20 | 2022-08-22 | Daegu Gyeongbuk Medical Innovation Found | Nuevo derivado de imidazopiridina, procedimiento para prepararlo y composición farmacéutica que contiene el mismo como ingrediente activo para prevenir o tratar el cáncer |
TW201819625A (zh) * | 2016-08-23 | 2018-06-01 | 中央研究院 | 製備誘導型間質幹細胞及增進間質幹細胞之特質的方法及其應用 |
CN108060119B (zh) * | 2016-11-07 | 2021-07-09 | 云南济慈再生医学研究院有限公司 | 小分子化合物组合及利用该小分子化合物组合诱导分化的细胞制备血管平滑肌细胞的方法 |
CN108060120B (zh) * | 2016-11-07 | 2022-11-04 | 云南济慈再生医学研究院有限公司 | 用于分化的细胞重编程的小分子化合物组合、试剂盒及应用 |
CN108060123B (zh) * | 2016-11-07 | 2021-07-09 | 云南济慈再生医学研究院有限公司 | 一种用于体细胞去分化的靶点调控***、试剂盒及应用 |
CN108070549A (zh) * | 2016-11-07 | 2018-05-25 | 昆明学院 | 小分子化合物组合及利用该小分子化合物组合诱导分化的细胞制备血管内皮细胞的方法 |
CN108060126B (zh) * | 2016-11-07 | 2020-09-08 | 云南济慈再生医学研究院有限公司 | 一种诱导分化的细胞制备间充质干细胞的方法及调控靶点的组合 |
CN108060121B (zh) * | 2016-11-07 | 2021-05-28 | 惠州市正多实业有限公司 | 小分子化合物组合及利用该小分子化合物组合诱导分化的细胞制备成骨细胞的方法 |
CN108300686B (zh) * | 2017-01-13 | 2022-08-26 | 云南美颜美龄生物科技有限公司 | 用于预防、延缓或逆转细胞、组织、器官、机体衰老的小分子化合物/组合,产品及其用途 |
CN110423721B (zh) * | 2018-05-01 | 2024-02-27 | 云南济慈再生医学研究院有限公司 | 一种年轻化的修复型成纤维细胞的制备方法及其应用 |
CN117887659A (zh) * | 2018-05-01 | 2024-04-16 | 云南济慈再生医学研究院有限公司 | 一种促进靶细胞向神经细胞分化的方法 |
WO2019213796A1 (fr) * | 2018-05-05 | 2019-11-14 | The Regents Of The University Of California | Cellules souches mésenchymateuses régénérées induites et leurs procédés d'utilisation |
TW202302846A (zh) * | 2021-04-16 | 2023-01-16 | 中國大陸商杭州啟函生物科技有限公司 | 用於細胞工程化的安全港基因座 |
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- 2018-05-01 CN CN202410157679.9A patent/CN118006541A/zh active Pending
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US20210205369A1 (en) | 2021-07-08 |
CN110423719B (zh) | 2024-02-27 |
CN118006541A (zh) | 2024-05-10 |
AU2019263863A1 (en) | 2020-11-26 |
JP2021522859A (ja) | 2021-09-02 |
CN117887659A (zh) | 2024-04-16 |
EP3789482A1 (fr) | 2021-03-10 |
CA3098924A1 (fr) | 2019-11-07 |
CN110423719A (zh) | 2019-11-08 |
WO2019210851A1 (fr) | 2019-11-07 |
EP3789482A4 (fr) | 2022-01-05 |
AU2019263863B2 (en) | 2023-03-30 |
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