SG11202001847WA - Cyclic di-nucleotides as stimulator of interferon genes modulators - Google Patents
Cyclic di-nucleotides as stimulator of interferon genes modulatorsInfo
- Publication number
- SG11202001847WA SG11202001847WA SG11202001847WA SG11202001847WA SG11202001847WA SG 11202001847W A SG11202001847W A SG 11202001847WA SG 11202001847W A SG11202001847W A SG 11202001847WA SG 11202001847W A SG11202001847W A SG 11202001847WA SG 11202001847W A SG11202001847W A SG 11202001847WA
- Authority
- SG
- Singapore
- Prior art keywords
- stimulator
- modulators
- nucleotides
- cyclic
- interferon genes
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7084—Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
- C07H19/213—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids containing cyclic phosphate
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H23/00—Compounds containing boron, silicon, or a metal, e.g. chelates, vitamin B12
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762552148P | 2017-08-30 | 2017-08-30 | |
| US201862660565P | 2018-04-20 | 2018-04-20 | |
| PCT/IB2018/056658 WO2019043634A2 (en) | 2017-08-30 | 2018-08-30 | CYCLIC DI-NUCLEOTIDES AS STIMULATORS OF INTERFERON GENE MODULATORS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11202001847WA true SG11202001847WA (en) | 2020-03-30 |
Family
ID=65527221
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11202001847WA SG11202001847WA (en) | 2017-08-30 | 2018-08-30 | Cyclic di-nucleotides as stimulator of interferon genes modulators |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US11773132B2 (ru) |
| EP (1) | EP3692048A4 (ru) |
| JP (1) | JP7311514B2 (ru) |
| KR (1) | KR20200058411A (ru) |
| CN (1) | CN111263767B (ru) |
| AU (1) | AU2018323053A1 (ru) |
| BR (1) | BR112020004047A2 (ru) |
| CA (1) | CA3073919A1 (ru) |
| IL (1) | IL272928A (ru) |
| MX (1) | MX2020002303A (ru) |
| RU (1) | RU2020112502A (ru) |
| SG (1) | SG11202001847WA (ru) |
| TW (1) | TWI808092B (ru) |
| WO (1) | WO2019043634A2 (ru) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT3429596T (pt) | 2016-03-18 | 2022-11-25 | Immune Sensor Llc | Compostos de dinucleotídeos cíclicos e métodos de utilização |
| JOP20170192A1 (ar) | 2016-12-01 | 2019-01-30 | Takeda Pharmaceuticals Co | داي نوكليوتيد حلقي |
| CA3053568A1 (en) | 2017-02-21 | 2018-08-30 | Board Of Regents, The University Of Texas System | Cyclic dinucleotides as agonists of stimulator of interferon gene dependent signalling |
| CN111263767B (zh) | 2017-08-30 | 2023-07-18 | 北京轩义医药科技有限公司 | 作为干扰素基因调节剂的刺激剂的环状二核苷酸 |
| SG11202004113VA (en) | 2017-11-10 | 2020-06-29 | Takeda Pharmaceuticals Co | Sting modulator compounds, and methods of making and using |
| EP3762397B1 (en) * | 2018-03-08 | 2024-05-01 | Bristol-Myers Squibb Company | Cyclic dinucleotides as anticancer agents |
| CN112512531B (zh) | 2018-06-01 | 2024-04-09 | 卫材R&D管理有限公司 | 用于膀胱癌的治疗的方法 |
| EP3868773A4 (en) * | 2018-10-12 | 2022-07-13 | Shanghai Jemincare Pharmaceuticals Co., Ltd. | CYCLIC DINUCLEOTIDE COMPOUND AND ITS APPLICATIONS |
| CN114206898A (zh) * | 2019-07-25 | 2022-03-18 | 百济神州有限公司 | 作为sting激动剂的环状二核苷酸 |
| KR20220167275A (ko) | 2020-04-10 | 2022-12-20 | 오노 야꾸힝 고교 가부시키가이샤 | 암 치료 방법 |
| CN111592570B (zh) * | 2020-05-15 | 2022-04-29 | 清华大学 | 新型sting激动剂及其制备方法和应用 |
| JP2023546278A (ja) * | 2020-10-20 | 2023-11-01 | タイリガンド バイオサイエンス（シャンハイ）リミテッド | 多機能環状ジヌクレオチド及びその使用 |
| KR102466750B1 (ko) * | 2020-10-23 | 2022-11-15 | 아주대학교산학협력단 | 인돌리진 유도체를 유효성분으로 포함하는 인터페론 유전자 자극제 조성물 |
| CA3197167A1 (en) | 2020-11-09 | 2022-05-12 | He Xu | Antibody drug conjugates |
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| US5376645A (en) | 1990-01-23 | 1994-12-27 | University Of Kansas | Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof |
| GB9518953D0 (en) | 1995-09-15 | 1995-11-15 | Pfizer Ltd | Pharmaceutical formulations |
| WO2000035296A1 (en) | 1996-11-27 | 2000-06-22 | Wm. Wrigley Jr. Company | Improved release of medicament active agents from a chewing gum coating |
| GB9711643D0 (en) | 1997-06-05 | 1997-07-30 | Janssen Pharmaceutica Nv | Glass thermoplastic systems |
| JP4727992B2 (ja) | 2002-11-15 | 2011-07-20 | ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド | 癌転移および癌転移に伴なう骨量減少を予防および処置するための方法 |
| US20060167241A1 (en) | 2003-07-15 | 2006-07-27 | Mitsui Chemicals, Inc. | Method for synthesizing cyclic bisdinucleoside |
| US8367716B2 (en) * | 2003-07-28 | 2013-02-05 | Karaolis David K R | Method for attentuating virulence of microbial pathogens and for inhibiting microbial biofilm formation |
| WO2005087238A2 (en) | 2004-03-15 | 2005-09-22 | Karaolis David K R | Method for stimulating the immune, inflammatory or neuroprotective response |
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| JP5547656B2 (ja) | 2008-01-15 | 2014-07-16 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | Ｃｄ４７によって媒介される食作用を操作するための方法 |
| EP2111869A1 (en) | 2008-04-23 | 2009-10-28 | Stichting Sanquin Bloedvoorziening | Compositions and methods to enhance the immune system |
| WO2009133560A1 (en) | 2008-04-29 | 2009-11-05 | Smart Assays | Non-hydrolyzable and permeable cyclic bis-[nucleotide monophosphate] derivatives and uses thereof |
| DK2403528T3 (en) | 2009-03-02 | 2016-05-23 | Aduro Biotech Holdings Europ B V | ANTIBODIES AGAINST A proliferation-inducing ligand (April) |
| CN103080134B (zh) | 2010-08-20 | 2015-11-25 | 诺华股份有限公司 | 表皮生长因子受体3(her3)的抗体 |
| CN105008381B (zh) | 2012-12-13 | 2018-08-07 | 艾杜罗生物科技公司 | 包含具有确定立体化学的环嘌呤二核苷酸的组合物及其制备和使用方法 |
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| CA2908154C (en) | 2013-04-29 | 2023-11-28 | Memorial Sloan Kettering Cancer Center | Compositions and methods for altering second messenger signaling |
| US9549944B2 (en) | 2013-05-18 | 2017-01-24 | Aduro Biotech, Inc. | Compositions and methods for inhibiting “stimulator of interferon gene”—dependent signalling |
| JP6453855B2 (ja) | 2013-05-18 | 2019-01-16 | アドゥロ バイオテック，インク． | 「インターフェロン遺伝子の刺激因子」依存性シグナル伝達を活性化するための組成物及び方法 |
| EP3060056A4 (en) | 2013-10-21 | 2017-10-18 | Drexel University | Use of sting agonists to treat chronic hepatitis b virus infection |
| US10092644B2 (en) | 2013-11-22 | 2018-10-09 | Brock University | Use of fluorinated cyclic dinucleotides as oral vaccine adjuvants |
| KR20170015353A (ko) | 2014-06-04 | 2017-02-08 | 글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 | Ｓｔｉｎｇ의 조절제로서 사이클릭 디뉴클레오타이드 |
| WO2016096577A1 (en) | 2014-12-16 | 2016-06-23 | Invivogen | Combined use of a chemotherapeutic agent and a cyclic dinucleotide for cancer treatment |
| CN107148424B (zh) * | 2014-12-16 | 2021-01-08 | 凯拉治疗股份公司 | 用于诱导细胞因子的环状二核苷酸 |
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| US10106574B2 (en) | 2015-08-13 | 2018-10-23 | Merck Sharp & Dohme Corp. | Cyclic di-nucleotide compounds as sting agonists |
| KR20180066241A (ko) | 2015-10-28 | 2018-06-18 | 아두로 바이오테크, 인코포레이티드 | “인터페론 유전자의 자극제”-의존성 신호전달을 활성화시키기 위한 조성물 및 방법 |
| ES2863225T3 (es) * | 2015-12-03 | 2021-10-11 | Glaxosmithkline Ip Dev Ltd | Dinucleótidos cíclicos purinos como moduladores del sting |
| US20180369268A1 (en) | 2015-12-16 | 2018-12-27 | Aduro Biotech, Inc. | Methods for identifying inhibitors of "stimulator of interferon gene"- dependent interferon production |
| WO2017123657A1 (en) | 2016-01-11 | 2017-07-20 | Gary Glick | Cyclic dinucleotides for treating conditions associated with sting activity such as cancer |
| KR20180097751A (ko) | 2016-01-11 | 2018-08-31 | 인네이트 튜머 이뮤니티, 인코포레이티드 | Sting 활성과 연관된 상태 예컨대 암의 치료를 위한 시클릭 디뉴클레오티드 |
| PT3429596T (pt) * | 2016-03-18 | 2022-11-25 | Immune Sensor Llc | Compostos de dinucleotídeos cíclicos e métodos de utilização |
| WO2017186711A1 (en) * | 2016-04-25 | 2017-11-02 | Invivogen | Novel complexes of immunostimulatory compounds, and uses thereof |
| EP3507367A4 (en) | 2016-07-05 | 2020-03-25 | Aduro BioTech, Inc. | CYCLIC DINUCLEOTID COMPOUNDS WITH INCLUDED NUCLEIC ACIDS AND USES THEREOF |
| US20190345191A1 (en) | 2016-08-31 | 2019-11-14 | Innate Tumor Immunity, Inc. | Cyclic dinucleotide analogs for treating conditions associated with sting (stimulator of interferon genes) activity |
| US10537590B2 (en) | 2016-09-30 | 2020-01-21 | Boehringer Ingelheim International Gmbh | Cyclic dinucleotide compounds |
| US11001605B2 (en) * | 2016-10-07 | 2021-05-11 | Biolog Life Science Institute Gmbh & Co. Kg | Cyclic dinucleotides containing benzimidazole, method for the production of same, and use of same to activate stimulator of interferon genes (sting)-dependent signaling pathways |
| JOP20170188A1 (ar) * | 2016-11-25 | 2019-01-30 | Janssen Biotech Inc | ثنائي النوكليوتيدات الحلقية كمنبهات ستينغ (sting) |
| JOP20170192A1 (ar) | 2016-12-01 | 2019-01-30 | Takeda Pharmaceuticals Co | داي نوكليوتيد حلقي |
| US20200113924A1 (en) | 2016-12-20 | 2020-04-16 | Merck Sharp & Dohme Corp. | Cyclic dinucleotide sting agonists for cancer treatment |
| CN110167566A (zh) * | 2016-12-21 | 2019-08-23 | 弗莱德哈钦森癌症研究中心 | 治疗实体瘤细胞和逃避变体的支架 |
| EP3573718B1 (en) * | 2017-01-27 | 2022-06-01 | Janssen Biotech, Inc. | Cyclic dinucleotides as sting agonists |
| ES2891326T3 (es) | 2017-01-27 | 2022-01-27 | Janssen Biotech Inc | Dinucleótidos cíclicos como agonistas de la STING |
| CN111263767B (zh) | 2017-08-30 | 2023-07-18 | 北京轩义医药科技有限公司 | 作为干扰素基因调节剂的刺激剂的环状二核苷酸 |
| EP3868773A4 (en) * | 2018-10-12 | 2022-07-13 | Shanghai Jemincare Pharmaceuticals Co., Ltd. | CYCLIC DINUCLEOTIDE COMPOUND AND ITS APPLICATIONS |
-
2018
- 2018-08-30 CN CN201880056293.1A patent/CN111263767B/zh active Active
- 2018-08-30 KR KR1020207008457A patent/KR20200058411A/ko not_active Application Discontinuation
- 2018-08-30 US US16/643,127 patent/US11773132B2/en active Active
- 2018-08-30 SG SG11202001847WA patent/SG11202001847WA/en unknown
- 2018-08-30 JP JP2020533876A patent/JP7311514B2/ja active Active
- 2018-08-30 CA CA3073919A patent/CA3073919A1/en not_active Abandoned
- 2018-08-30 MX MX2020002303A patent/MX2020002303A/es unknown
- 2018-08-30 AU AU2018323053A patent/AU2018323053A1/en not_active Abandoned
- 2018-08-30 EP EP18850228.0A patent/EP3692048A4/en active Pending
- 2018-08-30 WO PCT/IB2018/056658 patent/WO2019043634A2/en unknown
- 2018-08-30 BR BR112020004047-9A patent/BR112020004047A2/pt not_active IP Right Cessation
- 2018-08-30 TW TW107130419A patent/TWI808092B/zh active
- 2018-08-30 RU RU2020112502A patent/RU2020112502A/ru unknown
-
2020
- 2020-02-26 IL IL272928A patent/IL272928A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20200331957A1 (en) | 2020-10-22 |
| WO2019043634A3 (en) | 2019-04-11 |
| US11773132B2 (en) | 2023-10-03 |
| JP7311514B2 (ja) | 2023-07-19 |
| CN111263767A (zh) | 2020-06-09 |
| AU2018323053A1 (en) | 2020-03-19 |
| WO2019043634A2 (en) | 2019-03-07 |
| JP2020532585A (ja) | 2020-11-12 |
| EP3692048A4 (en) | 2021-10-20 |
| RU2020112502A (ru) | 2021-10-01 |
| TW201919650A (zh) | 2019-06-01 |
| TWI808092B (zh) | 2023-07-11 |
| BR112020004047A2 (pt) | 2020-09-01 |
| EP3692048A2 (en) | 2020-08-12 |
| IL272928A (en) | 2020-04-30 |
| MX2020002303A (es) | 2020-09-10 |
| RU2020112502A3 (ru) | 2021-10-08 |
| KR20200058411A (ko) | 2020-05-27 |
| CA3073919A1 (en) | 2019-03-07 |
| CN111263767B (zh) | 2023-07-18 |
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