SG11202000490PA - 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof - Google Patents

3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof

Info

Publication number
SG11202000490PA
SG11202000490PA SG11202000490PA SG11202000490PA SG11202000490PA SG 11202000490P A SG11202000490P A SG 11202000490PA SG 11202000490P A SG11202000490P A SG 11202000490PA SG 11202000490P A SG11202000490P A SG 11202000490PA SG 11202000490P A SG11202000490P A SG 11202000490PA
Authority
SG
Singapore
Prior art keywords
oxoisoindolin
piperidine
dione derivatives
dione
derivatives
Prior art date
Application number
SG11202000490PA
Inventor
Rohan Eric John Beckwith
Simone Bonazzi
Artiom Cernijenko
Aleem Fazal
Ritesh Bhanudasji Tichkule
Michael Scott Visser
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of SG11202000490PA publication Critical patent/SG11202000490PA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
SG11202000490PA 2017-08-23 2018-08-23 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof SG11202000490PA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762549225P 2017-08-23 2017-08-23
PCT/IB2018/056400 WO2019038717A1 (en) 2017-08-23 2018-08-23 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof

Publications (1)

Publication Number Publication Date
SG11202000490PA true SG11202000490PA (en) 2020-03-30

Family

ID=63638171

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202000490PA SG11202000490PA (en) 2017-08-23 2018-08-23 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof

Country Status (37)

Country Link
US (5) US10414755B2 (en)
EP (2) EP4183782A1 (en)
JP (1) JP7386787B2 (en)
KR (1) KR20200044038A (en)
CN (1) CN111051298B (en)
AR (1) AR112529A1 (en)
AU (3) AU2018319577B2 (en)
BR (1) BR112020003373B1 (en)
CA (1) CA3072694A1 (en)
CL (1) CL2020000427A1 (en)
CO (1) CO2020001860A2 (en)
CR (1) CR20200081A (en)
CU (1) CU20200014A7 (en)
DK (1) DK3672949T5 (en)
DO (1) DOP2020000037A (en)
EA (1) EA202090553A1 (en)
EC (1) ECSP20013248A (en)
ES (1) ES2940448T3 (en)
FI (1) FI3672949T3 (en)
HR (1) HRP20230244T1 (en)
HU (1) HUE061895T2 (en)
IL (1) IL272748B2 (en)
JO (1) JOP20200042A1 (en)
LT (1) LT3672949T (en)
MA (1) MA49952B1 (en)
MX (1) MX2020002060A (en)
PH (1) PH12020500125A1 (en)
PL (1) PL3672949T3 (en)
PT (1) PT3672949T (en)
RS (1) RS64058B9 (en)
SA (1) SA520411325B1 (en)
SG (1) SG11202000490PA (en)
SI (1) SI3672949T1 (en)
TW (1) TWI793151B (en)
UY (1) UY37854A (en)
WO (1) WO2019038717A1 (en)
ZA (1) ZA202000208B (en)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017197055A1 (en) 2016-05-10 2017-11-16 C4 Therapeutics, Inc. Heterocyclic degronimers for target protein degradation
TWI793151B (en) 2017-08-23 2023-02-21 瑞士商諾華公司 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof
JP2021521192A (en) * 2018-04-13 2021-08-26 アルビナス・オペレーションズ・インコーポレイテッドＡｒｖｉｎａｓ Ｏｐｅｒａｔｉｏｎｓ， Ｉｎｃ． Celebron ligand and a bifunctional compound containing the ligand
RS64759B1 (en) * 2018-07-10 2023-11-30 Novartis Ag 3-(5-hydroxy-1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and their use in the treatment of ikaros family zinc finger 2 (ikzf2)-dependent diseases
AR116109A1 (en) 2018-07-10 2021-03-31 Novartis Ag DERIVATIVES OF 3- (5-AMINO-1-OXOISOINDOLIN-2-IL) PIPERIDINE-2,6-DIONA AND USES OF THE SAME
AU2019402189B2 (en) 2018-12-20 2023-04-13 Novartis Ag Dosing regimen and pharmaceutical combination comprising 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives
AU2020222346B2 (en) * 2019-02-15 2021-12-09 Novartis Ag Substituted 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof
EA202192019A1 (en) * 2019-02-15 2021-11-02 Новартис Аг DERIVATIVES OF 3- (1-OXO-5- (PIPERIDIN-4-YL) ISOINDOLIN-2-YL) PIPERIDINE-2,6-DIONE AND ROUTES OF THEIR APPLICATION
CA3130469A1 (en) 2019-04-12 2020-10-15 C4 Therapeutics, Inc. Tricyclic degraders of ikaros and aiolos
WO2020219742A1 (en) 2019-04-24 2020-10-29 Novartis Ag Compositions and methods for selective protein degradation
TW202108571A (en) 2019-05-31 2021-03-01 美商醫肯納腫瘤學公司 Tead inhibitors and uses thereof
JP2022534425A (en) 2019-05-31 2022-07-29 イケナ オンコロジー， インコーポレイテッド TEAD inhibitors and uses thereof
CN114650868A (en) * 2019-10-30 2022-06-21 达纳-法伯癌症研究公司 Small molecule degradation agent of HELIOS and use method thereof
CN110862395B (en) * 2019-11-13 2020-09-29 株洲千金药业股份有限公司 Preparation method of raw material compound for preparing tadalafil important impurities
KR20220103753A (en) 2019-11-19 2022-07-22 브리스톨-마이어스 스큅 컴퍼니 Compounds useful as inhibitors of helios proteins
TW202140441A (en) * 2020-03-23 2021-11-01 美商必治妥美雅史谷比公司 Substituted oxoisoindoline compounds
AU2021262334B2 (en) * 2020-04-30 2023-12-14 Shanghaitech University Heterocycle and glutarimide skeleton-based compounds and applications thereof
WO2021260528A1 (en) 2020-06-23 2021-12-30 Novartis Ag Dosing regimen comprising 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives
WO2022007903A1 (en) * 2020-07-09 2022-01-13 四川海思科制药有限公司 Compound capable of inhibiting and degrading androgen receptors, and pharmaceutical compositions and pharmaceutical uses thereof
CN116134027A (en) * 2020-08-03 2023-05-16 诺华股份有限公司 Heteroaryl-substituted 3- (1-oxo-isoindolin-2-yl) piperidine-2, 6-dione derivatives and uses thereof
US20240050428A1 (en) * 2020-10-07 2024-02-15 Cullgen (Shanghai), Inc. Compounds and methods of treating cancers
CR20230143A (en) * 2020-10-16 2023-07-28 Neomorph Inc Piperidinyl small molecule degraders of helios and methods of use
WO2022120355A1 (en) * 2020-12-02 2022-06-09 Ikena Oncology, Inc. Tead degraders and uses thereof
UY39671A (en) * 2021-03-15 2022-10-31 Novartis Ag Pyrazolopyridine derivatives and their uses.
BR112023020077A2 (en) 2021-04-06 2023-11-14 Bristol Myers Squibb Co OXOISOINDOLINE COMPOUNDS REPLACED BY PYRIDINYL
AU2022264584A1 (en) * 2021-04-29 2023-11-02 Dana-Farber Cancer Institute, Inc. Substituted 2-(2,6-dioxopiperidin-3-yl)-5-(1-piperidin-4-yl)isoindoline-1,3-dione derivatives and uses thereof
CA3226162A1 (en) 2021-07-09 2023-01-12 Plexium, Inc. Aryl compounds and pharmaceutical compositions that modulate ikzf2
AU2022324621A1 (en) 2021-08-06 2024-01-18 Celgene Corporation Compositions and methods for selective degradation of engineered proteins
WO2023016518A1 (en) * 2021-08-11 2023-02-16 四川海思科制药有限公司 Heterocyclic derivative, and composition and pharmaceutical use thereof
TW202330504A (en) 2021-10-28 2023-08-01 美商基利科學股份有限公司 Pyridizin-3(2h)-one derivatives
US11919869B2 (en) 2021-10-29 2024-03-05 Gilead Sciences, Inc. CD73 compounds
US20240124412A1 (en) 2021-12-22 2024-04-18 Gilead Sciences, Inc. Ikaros zinc finger family degraders and uses thereof
WO2023122615A1 (en) 2021-12-22 2023-06-29 Gilead Sciences, Inc. Ikaros zinc finger family degraders and uses thereof
TW202340168A (en) 2022-01-28 2023-10-16 美商基利科學股份有限公司 Parp7 inhibitors
CN116640122A (en) * 2022-02-16 2023-08-25 苏州国匡医药科技有限公司 IKZF 2 Degradation agent, pharmaceutical composition containing degradation agent and application of degradation agent
WO2023178181A1 (en) 2022-03-17 2023-09-21 Gilead Sciences, Inc. Ikaros zinc finger family degraders and uses thereof
TW202341988A (en) * 2022-03-25 2023-11-01 密西根大學董事會 Ikzf2 degraders and uses thereof
TW202345797A (en) * 2022-03-25 2023-12-01 美商昂科皮治療公司亦以普羅提歐凡治療公司名稱營業 Bicyclic heteroaryl-containing compounds as ikzf2 degraders
WO2023201012A1 (en) * 2022-04-15 2023-10-19 Regents Of The University Of Michigan Ikzf2 degraders and uses thereof
TW202400138A (en) 2022-04-21 2024-01-01 美商基利科學股份有限公司 Kras g12d modulating compounds
WO2024006929A1 (en) 2022-07-01 2024-01-04 Gilead Sciences, Inc. Cd73 compounds
WO2024032689A1 (en) * 2022-08-10 2024-02-15 标新生物医药科技(上海)有限公司 Compound based on isoindoline-substituted glutarimide backbone and use thereof
WO2024059107A1 (en) * 2022-09-14 2024-03-21 President And Fellows Of Harvard College Ikzf2 and ck1-alpha degrading compounds and uses thereof

Family Cites Families (92)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5114946A (en) 1987-06-12 1992-05-19 American Cyanamid Company Transdermal delivery of pharmaceuticals
US4818541A (en) 1987-08-19 1989-04-04 Schering Corporation Transdermal delivery of enantiomers of phenylpropanolamine
US7196170B2 (en) 1992-09-14 2007-03-27 The General Hospital Corporation Aiolos, Helios, Daedalos and Ikaros: genes, polypeptides, regulatory elements and uses thereof
US5262564A (en) 1992-10-30 1993-11-16 Octamer, Inc. Sulfinic acid adducts of organo nitroso compounds useful as retroviral inactivating agents anti-retroviral agents and anti-tumor agents
ES2529190T3 (en) * 1996-07-24 2015-02-17 Celgene Corporation 2- (2,6-Dioxopiperidin-3-yl) -amino-substituted phthalimides to reduce TNF-alpha levels
WO2002044372A2 (en) 2000-12-01 2002-06-06 Parker Hughes Institute Nucleotide and protein sequence of helios 3 and methods of use
US7902179B2 (en) * 2001-04-26 2011-03-08 Ajinomoto Co., Inc. Heterocyclic compounds
NZ531294A (en) 2001-08-06 2005-11-25 Childrens Medical Center Synthesis and anti-tumor activity of nitrogen substituted thalidomide analogs
US20050203142A1 (en) 2002-10-24 2005-09-15 Zeldis Jerome B. Methods of using and compositions comprising immunomodulatory compounds for treatment, modification and management of pain
US20040087558A1 (en) 2002-10-24 2004-05-06 Zeldis Jerome B. Methods of using and compositions comprising selective cytokine inhibitory drugs for treatment, modification and management of pain
US7612096B2 (en) 2003-10-23 2009-11-03 Celgene Corporation Methods for treatment, modification and management of radiculopathy using 1-oxo-2-(2,6-dioxopiperidin-3yl)-4-aminoisoindoline
US20070161696A1 (en) 2004-04-23 2007-07-12 Zeldis Jerome B Methods of using and compositions comprising selective cytokine inhibitory drugs for treatment, modification and management of pain
ZA200702382B (en) * 2004-09-03 2008-08-27 Celgene Corp Processes for the preparation of substituted 2-(2,6-dioxoplperidin-3-yl)-1-oxoisoindolines
JP4731867B2 (en) 2004-10-01 2011-07-27 国立大学法人三重大学 Method for inducing CD8 positive cytotoxic T lymphocytes
EP1924250B1 (en) 2004-12-01 2017-01-04 Celgene Corporation Methods and compositions comprising immunomodulatory compounds for use for the treatment of immunodeficiency disorders
JP2008524986A (en) 2004-12-10 2008-07-17 バイエル・ヘルスケア・アクチェンゲゼルシャフト Genetic changes useful for predicting malignant tumor response to taxane-based drug therapy
WO2007067500A2 (en) 2005-12-05 2007-06-14 Genomic Health, Inc. Predictors of patient response to treatment with egfr inhibitors
KR20080097190A (en) 2005-12-29 2008-11-04 안트로제네시스 코포레이션 Improved composition for collecting and preserving placental stem cells and methods of using the composition
CN101479255B (en) 2006-03-22 2013-05-01 沃泰克斯药物股份有限公司 C-MET protein kinase inhibitors for the treatment of proliferative disorders
US20070269827A1 (en) 2006-05-18 2007-11-22 Oklahoma Medical Research Foundation Predicting and Diagnosing Patients With Autoimmune Disease
KR101342035B1 (en) 2006-06-20 2013-12-16 한국과학기술연구원 Biomaker and screening method of drug having nephyrotoxicity and side effects using thereof
US8877780B2 (en) * 2006-08-30 2014-11-04 Celgene Corporation 5-substituted isoindoline compounds
JP2009092508A (en) 2007-10-09 2009-04-30 Norihiro Nishimoto Method for predicting effect of rheumatic therapeutic agent
EP2227558A1 (en) 2007-11-30 2010-09-15 GlaxoSmithKline Biologicals SA Method for classifying cancer patients as responder or non-responder to immunotherapy
KR100957051B1 (en) 2007-12-28 2010-05-13 한국과학기술연구원 Marker genes based on nitrofurantoin treatment for screening of drug inducing pulmonary toxicity and screening method using thereof
GB2456390A (en) 2008-01-15 2009-07-22 Glaxo Group Ltd Bipolar disorder treatments
WO2009094592A2 (en) 2008-01-23 2009-07-30 Perlegen Sciences, Inc. Genetic basis of alzheimer's disease and diagnosis and treatment thereof
AU2009226083A1 (en) 2008-03-19 2009-09-24 Existence Genetics Llc Genetic analysis
US20110229498A1 (en) 2008-05-08 2011-09-22 The Johns Hopkins University Compositions and methods for modulating an immune response
EP2177615A1 (en) 2008-10-10 2010-04-21 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Method for a genome wide identification of expression regulatory sequences and use of genes and molecules derived thereof for the diagnosis and therapy of metabolic and/or tumorous diseases
US20100204265A1 (en) 2009-02-09 2010-08-12 Genelabs Technologies, Inc. Certain Nitrogen Containing Bicyclic Chemical Entities for Treating Viral Infections
US9212177B2 (en) 2009-08-05 2015-12-15 Versitech Limited Antiviral compounds and methods of making and using thereof
KR20120092567A (en) 2009-08-05 2012-08-21 벌시테크 리미티드 Antiviral compounds and methods of making and using thereof cross reference to related applications
EP2494076B1 (en) 2009-10-26 2017-11-22 Abbott Molecular Inc. Detection of chromosomal abnormalities associated with prognosis of non small cell lung cancer
WO2011142827A2 (en) 2010-05-12 2011-11-17 Schutzer Steven E Diagnostic markers for neuropsychiatric disease
US20120142701A1 (en) 2010-05-28 2012-06-07 The University Of Hong Kong Compounds and methods for the treatment of proliferative diseases
WO2011151941A1 (en) 2010-06-04 2011-12-08 国立大学法人東京大学 Composition having activity of inducing proliferation or accumulation of regulatory t cell
US20130281304A1 (en) 2010-08-13 2013-10-24 Andrew P. Feinberg Comprehensive Methylome Map of Myeloid and Lymphoid Commitment from Hematopoietic Proenitors
WO2012054509A2 (en) 2010-10-22 2012-04-26 Dana-Farber Cancer Institute, Inc. Discovery of regulatory t cells programmed to suppress an immune response
EP3520793B1 (en) 2011-06-06 2023-03-29 University of Iowa Research Foundation Substances and compostions for use in methods of inhibiting muscle atrophy
WO2012175613A1 (en) 2011-06-21 2012-12-27 Innate Pharma NKp46-MEDIATED NK CELL TUNING
CA2840424C (en) 2011-07-01 2022-02-01 Beckman Coulter, Inc. Regulatory t cells and methods of identifying, obtaining and using to treat immuno-based disorders
CN103797120B (en) 2011-09-16 2017-04-12 上海长海医院 Prostate cancer biomarkers, therapeutic targets and uses thereof
CN116942833A (en) 2011-12-01 2023-10-27 国立大学法人 东京大学 Human bacteria inducing proliferation or accumulation of regulatory T cells
US9481866B2 (en) 2011-12-16 2016-11-01 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods of producing T cell populations enriched for stable regulatory T-cells
WO2013098797A2 (en) 2011-12-31 2013-07-04 Kuriakose Moni Abraham Diagnostic tests for predicting prognosis, recurrence, resistance or sensitivity to therapy and metastatic status in cancer
US9801911B2 (en) 2012-03-02 2017-10-31 The Regents Of The University Of California Expansion of alloantigen-reactive regulatory T cells
GB201207297D0 (en) 2012-04-26 2012-06-06 Senzagen Ab Analytical methods and arrays for use in the same
GB201213571D0 (en) 2012-07-31 2012-09-12 Univ Leuven Kath Growth factor cocktail to enhnce osteogenic differentiayion of mesenchymal
EP2682750A1 (en) 2012-07-02 2014-01-08 Sotio a.s. In vitro method for the diagnosis and surveillance of cancer
EP2903692B1 (en) 2012-10-08 2019-12-25 St. Jude Children's Research Hospital Therapies based on control of regulatory t cell stability and function via a neuropilin-1:semaphorin axis
EP2953524B1 (en) 2013-02-06 2018-08-01 Freenome Holdings Inc. Systems and methods for early disease detection and real-time disease monitoring
WO2014153115A2 (en) 2013-03-14 2014-09-25 Children's Medical Center Corporation Compositions and methods for reprogramming hematopoietic stem cell lineages
EP2971164B1 (en) 2013-03-15 2023-07-26 Veracyte, Inc. Methods and compositions for classification of samples
US20160122821A1 (en) 2013-06-10 2016-05-05 Suregene, Llc Genetic markers of antipsychotic response
GB2532672A (en) 2013-09-09 2016-05-25 Scripps Research Inst Methods and systems for analysis of organ transplantation
WO2015050875A1 (en) 2013-10-01 2015-04-09 The Regents Of The University Of California Endometriosis classifier
UY35790A (en) 2013-10-21 2015-05-29 Teva Pharma GENETIC MARKERS THAT PREACH THE RESPONSE TO THE GLATIRAMER ACETATE
WO2015109212A1 (en) 2014-01-17 2015-07-23 Pfizer Inc. Anti-il-2 antibodies and compositions and uses thereof
WO2015107196A1 (en) 2014-01-20 2015-07-23 Institut Curie Use of thalidomide or analogs thereof for preventing neurologic disorders induced by brain irradiation
US20160058872A1 (en) * 2014-04-14 2016-03-03 Arvinas, Inc. Imide-based modulators of proteolysis and associated methods of use
KR20210132233A (en) * 2014-04-14 2021-11-03 아비나스 오퍼레이션스, 인코포레이티드 Imide-based modulators of proteolysis and associated methods of use
CA2967447A1 (en) 2014-12-05 2016-06-09 Foundation Medicine, Inc. Multigene analysis of tumor samples
EP3034620A1 (en) 2014-12-17 2016-06-22 Diaxonhit Compositions and methods for diagnosing thyroid cancer
WO2016103269A1 (en) 2014-12-23 2016-06-30 Ramot At Tel-Aviv University Ltd. Populations of neural progenitor cells and methods of producing and using same
CA2973873A1 (en) 2015-01-20 2016-07-28 Merial, Inc. Anthelmintic compounds, compositions and method of using thereof
EP3050570A1 (en) 2015-01-31 2016-08-03 Neurovision Pharma GmbH Pharmaceutical composition consisting of a combination of G-CSF with GM-CSF
WO2016140974A1 (en) 2015-03-01 2016-09-09 Novena Therapeutics Inc. Process for measuring tumor response to an initial oncology treatment
CN107787320B (en) 2015-05-22 2020-12-04 拜欧赛里克斯公司 Protein targeting compounds, compositions, methods and uses thereof
US10338077B2 (en) 2015-06-02 2019-07-02 Celgene Corporation Methods for determining drug efficacy for treatment of cancer ration of cereblon associated proteins
EP3302548A4 (en) 2015-06-03 2019-01-02 Dana Farber Cancer Institute, Inc. Methods to induce conversion of regulatory t cells into effector t cells for cancer immunotherapy
US20180193391A1 (en) 2015-06-22 2018-07-12 President And Fellows Of Harvard College Induction of lamina propria regulatory t cells
WO2017042337A1 (en) 2015-09-09 2017-03-16 Max-Delbrück-Centrum Für Molekulare Medizin In Der Helmhotz-Gemeinschaft Short-chain fatty acids for use in the treatment of cardiovascular disease
WO2017044979A2 (en) 2015-09-11 2017-03-16 Ventria Bioscience Inc. Lactoferrin compositions and methods for modulation of t cell subtypes and treatment of autoimmune diseases
US10954300B2 (en) 2015-09-28 2021-03-23 The Trustees Of Columbia University In The City Of New York Use of pentoxifylline with immune checkpoint-blockade therapies for the treatment of melanoma
CA3000661C (en) 2015-09-30 2024-04-02 Nigel H. Greig Thalidomide analogs and methods of use
EP3368689B1 (en) 2015-10-28 2020-06-17 The Broad Institute, Inc. Composition for modulating immune responses by use of immune cell gene signature
WO2017075451A1 (en) 2015-10-28 2017-05-04 The Broad Institute Inc. Compositions and methods for evaluating and modulating immune responses by detecting and targeting pou2af1
WO2017075465A1 (en) 2015-10-28 2017-05-04 The Broad Institute Inc. Compositions and methods for evaluating and modulating immune responses by detecting and targeting gata3
WO2017095525A1 (en) 2015-12-04 2017-06-08 David Scott Antigen-specific t cells for inducing immune tolerance
EP3429603B1 (en) 2016-03-15 2021-12-29 Children's Medical Center Corporation Methods and compositions relating to hematopoietic stem cell expansion
US10759808B2 (en) 2016-04-06 2020-09-01 The Regents Of The University Of Michigan Monofunctional intermediates for ligand-dependent target protein degradation
EP3452101A2 (en) 2016-05-04 2019-03-13 CureVac AG Rna encoding a therapeutic protein
WO2017197051A1 (en) 2016-05-10 2017-11-16 C4 Therapeutics, Inc. Amine-linked c3-glutarimide degronimers for target protein degradation
WO2017197056A1 (en) 2016-05-10 2017-11-16 C4 Therapeutics, Inc. Bromodomain targeting degronimers for target protein degradation
KR102173463B1 (en) 2016-10-11 2020-11-04 아비나스 오퍼레이션스, 인코포레이티드 Compounds and methods for the targeted degradation of androgen receptor
EP3559006A4 (en) 2016-12-23 2021-03-03 Arvinas Operations, Inc. Compounds and methods for the targeted degradation of fetal liver kinase polypeptides
MX2019007649A (en) 2016-12-23 2019-09-10 Arvinas Operations Inc Compounds and methods for the targeted degradation of rapidly accelerated fibrosarcoma polypeptides.
US11191741B2 (en) 2016-12-24 2021-12-07 Arvinas Operations, Inc. Compounds and methods for the targeted degradation of enhancer of zeste homolog 2 polypeptide
CN117551089A (en) 2017-01-26 2024-02-13 阿尔维纳斯运营股份有限公司 Estrogen receptor proteolytic modulators and related methods of use
CN106932576A (en) 2017-03-22 2017-07-07 山东大学深圳研究院 A kind of detection method of the immune suppression function of people's regulatory T cells
TWI793151B (en) 2017-08-23 2023-02-21 瑞士商諾華公司 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof

Also Published As

Publication number Publication date
CN111051298A (en) 2020-04-21
IL272748B (en) 2022-10-01
DOP2020000037A (en) 2020-08-15
HUE061895T2 (en) 2023-08-28
BR112020003373A2 (en) 2020-08-25
AU2022231670A1 (en) 2022-10-06
CN111051298B (en) 2023-06-27
SI3672949T1 (en) 2023-04-28
AU2018319577B2 (en) 2020-10-15
US10647701B2 (en) 2020-05-12
EP4183782A1 (en) 2023-05-24
PL3672949T3 (en) 2023-05-08
BR112020003373B1 (en) 2022-08-09
EP3672949A1 (en) 2020-07-01
RS64058B9 (en) 2023-08-31
CO2020001860A2 (en) 2020-05-29
PH12020500125A1 (en) 2020-09-14
CA3072694A1 (en) 2019-02-28
MA49952B1 (en) 2023-03-31
US20190062309A1 (en) 2019-02-28
US20210309638A1 (en) 2021-10-07
US20200231569A1 (en) 2020-07-23
ES2940448T3 (en) 2023-05-08
LT3672949T (en) 2023-04-11
US20190359594A1 (en) 2019-11-28
JOP20200042A1 (en) 2020-02-20
AU2020277231A1 (en) 2020-12-24
WO2019038717A1 (en) 2019-02-28
EA202090553A1 (en) 2020-06-08
RU2020111556A (en) 2021-09-23
EP3672949B1 (en) 2022-12-21
RS64058B1 (en) 2023-04-28
CU20200014A7 (en) 2020-11-30
AU2018319577A1 (en) 2020-02-06
DK3672949T3 (en) 2023-03-27
TWI793151B (en) 2023-02-21
US11053218B2 (en) 2021-07-06
SA520411325B1 (en) 2022-06-13
MX2020002060A (en) 2020-07-13
ECSP20013248A (en) 2020-05-29
EP3672949B9 (en) 2023-04-05
IL272748A (en) 2020-04-30
US10414755B2 (en) 2019-09-17
US10640489B2 (en) 2020-05-05
UY37854A (en) 2019-03-29
AR112529A1 (en) 2019-11-06
CR20200081A (en) 2020-05-14
JP2020531498A (en) 2020-11-05
RU2020111556A3 (en) 2021-12-17
US20190367483A1 (en) 2019-12-05
FI3672949T3 (en) 2023-03-23
PT3672949T (en) 2023-03-16
MA49952A (en) 2021-04-28
TW201920143A (en) 2019-06-01
KR20200044038A (en) 2020-04-28
ZA202000208B (en) 2021-07-28
IL272748B2 (en) 2023-02-01
JP7386787B2 (en) 2023-11-27
CL2020000427A1 (en) 2020-08-28
DK3672949T5 (en) 2023-05-01
HRP20230244T1 (en) 2023-04-14

Similar Documents

Publication Publication Date Title
IL272748A (en) 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof
HK1254654A1 (en) 4,6-pyrimidinylene derivatives and uses thereof
HK1243999A1 (en) Novel 3-indol substituted derivatives, pharmaceutical compositions and methods for use
EP3623366A4 (en) Novel piperidine-2,6-dione derivative and use thereof
IL283148A (en) Dosing regimen and pharmaceutical combination comprising 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives
IL273571A (en) Aztreonam derivatives and uses thereof
IL261643B (en) Piperidine derivatives, their preparation and use
IL260497B (en) 3-(carboxymethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives
IL260495B (en) 3-(carboxyethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives
EP3546449A4 (en) Piperidine-2,6-diketone derivative and treatment for crohn's disease
IL248773B (en) 1,6-naphthyridine-4,5-dione derivatives and pharmaceutical compositions comprising them
GB2590189B (en) Lycorine derivative, and pharmaceutical composition and use thereof
EP3199526A4 (en) Intermediate for use in synthesizing paroxetine, preparation method for the intermediate, and uses thereof
HK1252415A1 (en) Pharmaceutical compositions comprising 3-(5-amino-2-methyl-4-oxo-4h-quinazolin-3-yl)-piperidine-2,6-dione
PL3386988T3 (en) Novel dihydropyranopyrimidinone derivatives, and use thereof
IL262597B (en) Piperidinyl derivatives, their preparation and use
ZA201904654B (en) Benzimidazole derivatives, preparation methods and uses thereof
EP3788031C0 (en) Dipeptidyl ketoamide meta-methoxyphenyl derivatives and uses thereof
TH1501006617A (en) synthesis 3-(5amino-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione