RS64058B9 - 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof - Google Patents

3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof

Info

Publication number
RS64058B9
RS64058B9 RS20230203A RSP20230203A RS64058B9 RS 64058 B9 RS64058 B9 RS 64058B9 RS 20230203 A RS20230203 A RS 20230203A RS P20230203 A RSP20230203 A RS P20230203A RS 64058 B9 RS64058 B9 RS 64058B9
Authority
RS
Serbia
Prior art keywords
oxoisoindolin
piperidine
dione derivatives
dione
derivatives
Prior art date
Application number
RS20230203A
Other languages
Serbian (sr)
Inventor
Rohan Eric John Beckwith
Simone Bonazzi
Artiom Cernijenko
Aleem Fazal
Ritesh Bhanudasji Tichkule
Michael Scott Visser
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of RS64058B1 publication Critical patent/RS64058B1/en
Publication of RS64058B9 publication Critical patent/RS64058B9/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
RS20230203A 2017-08-23 2018-08-23 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof RS64058B9 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762549225P 2017-08-23 2017-08-23
EP18772885.2A EP3672949B9 (en) 2017-08-23 2018-08-23 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof
PCT/IB2018/056400 WO2019038717A1 (en) 2017-08-23 2018-08-23 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof

Publications (2)

Publication Number Publication Date
RS64058B1 RS64058B1 (en) 2023-04-28
RS64058B9 true RS64058B9 (en) 2023-08-31

Family

ID=63638171

Family Applications (1)

Application Number Title Priority Date Filing Date
RS20230203A RS64058B9 (en) 2017-08-23 2018-08-23 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof

Country Status (37)

Country Link
US (5) US10414755B2 (en)
EP (2) EP3672949B9 (en)
JP (1) JP7386787B2 (en)
KR (1) KR20200044038A (en)
CN (1) CN111051298B (en)
AR (1) AR112529A1 (en)
AU (3) AU2018319577B2 (en)
BR (1) BR112020003373B1 (en)
CA (1) CA3072694A1 (en)
CL (1) CL2020000427A1 (en)
CO (1) CO2020001860A2 (en)
CR (1) CR20200081A (en)
CU (1) CU20200014A7 (en)
DK (1) DK3672949T5 (en)
DO (1) DOP2020000037A (en)
EA (1) EA202090553A1 (en)
EC (1) ECSP20013248A (en)
ES (1) ES2940448T3 (en)
FI (1) FI3672949T3 (en)
HR (1) HRP20230244T1 (en)
HU (1) HUE061895T2 (en)
IL (1) IL272748B2 (en)
JO (1) JOP20200042A1 (en)
LT (1) LT3672949T (en)
MA (1) MA49952B1 (en)
MX (1) MX2020002060A (en)
PH (1) PH12020500125A1 (en)
PL (1) PL3672949T3 (en)
PT (1) PT3672949T (en)
RS (1) RS64058B9 (en)
SA (1) SA520411325B1 (en)
SG (1) SG11202000490PA (en)
SI (1) SI3672949T1 (en)
TW (1) TWI793151B (en)
UY (1) UY37854A (en)
WO (1) WO2019038717A1 (en)
ZA (1) ZA202000208B (en)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017197055A1 (en) * 2016-05-10 2017-11-16 C4 Therapeutics, Inc. Heterocyclic degronimers for target protein degradation
TWI793151B (en) 2017-08-23 2023-02-21 瑞士商諾華公司 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof
CN112262134B (en) * 2018-04-13 2024-05-24 阿尔维纳斯运营股份有限公司 Cerebulin ligands and bifunctional compounds comprising same
AR116109A1 (en) * 2018-07-10 2021-03-31 Novartis Ag DERIVATIVES OF 3- (5-AMINO-1-OXOISOINDOLIN-2-IL) PIPERIDINE-2,6-DIONA AND USES OF THE SAME
CR20210001A (en) * 2018-07-10 2021-04-19 Novartis Ag 3-(5-hydroxy-1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and their use in the treatment of ikaros family zinc finger 2 (ikzf2)-dependent diseases
KR20210106437A (en) * 2018-12-20 2021-08-30 노파르티스 아게 Dosage regimens and pharmaceutical combinations comprising 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives
US20220144807A1 (en) * 2019-02-15 2022-05-12 Novartis Ag 3-(1-oxo-5-(piperidin-4-yl)isoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof
EP3924055B1 (en) 2019-02-15 2024-04-03 Novartis AG Substituted 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof
CN113677664A (en) * 2019-04-12 2021-11-19 C4医药公司 Tricyclic degradants of IKAROS and AIOLOS
WO2020219742A1 (en) 2019-04-24 2020-10-29 Novartis Ag Compositions and methods for selective protein degradation
CN114502540A (en) 2019-05-31 2022-05-13 医肯纳肿瘤学公司 TEAD inhibitors and uses thereof
JP2022534426A (en) 2019-05-31 2022-07-29 イケナ オンコロジー， インコーポレイテッド TEAD inhibitors and uses thereof
KR20220092920A (en) * 2019-10-30 2022-07-04 다나-파버 캔서 인스티튜트 인크. Helios small molecule degrading agent and method of use
CN110862395B (en) * 2019-11-13 2020-09-29 株洲千金药业股份有限公司 Preparation method of raw material compound for preparing tadalafil important impurities
JP2023503052A (en) * 2019-11-19 2023-01-26 ブリストル－マイヤーズ スクイブ カンパニー Compounds Useful as Inhibitors of Helios Protein
TW202140441A (en) * 2020-03-23 2021-11-01 美商必治妥美雅史谷比公司 Substituted oxoisoindoline compounds
EP4144728A4 (en) * 2020-04-30 2023-08-23 Shanghaitech University Heterocycle and glutarimide skeleton-based compound and applications thereof
CN115916199A (en) 2020-06-23 2023-04-04 诺华股份有限公司 Dosing regimens comprising 3- (1-oxoisoindolin-2-yl) piperidine-2, 6-dione derivatives
US20230357193A1 (en) * 2020-07-09 2023-11-09 Sichuan Haisco Pharmaceutical Co., Ltd. Compound capable of inhibiting and degrading androgen receptors, and pharmaceutical compositions and pharmaceutical uses thereof
US20230271940A1 (en) * 2020-08-03 2023-08-31 Novartis Ag Heteroaryl substituted 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof
CN116583509A (en) * 2020-10-07 2023-08-11 上海睿跃生物科技有限公司 Compounds and methods for treating cancer
JP2023545396A (en) * 2020-10-16 2023-10-30 ダナ－ファーバー キャンサー インスティテュート，インコーポレイテッド Helios' piperidinyl low molecule decomposer and how to use it
WO2022120355A1 (en) * 2020-12-02 2022-06-09 Ikena Oncology, Inc. Tead degraders and uses thereof
UY39671A (en) * 2021-03-15 2022-10-31 Novartis Ag Pyrazolopyridine derivatives and their uses.
US11718601B2 (en) 2021-04-06 2023-08-08 Bristol-Myers Squibb Company Pyridinyl substituted oxoisoindoline compounds
AU2022264584A1 (en) * 2021-04-29 2023-11-02 Dana-Farber Cancer Institute, Inc. Substituted 2-(2,6-dioxopiperidin-3-yl)-5-(1-piperidin-4-yl)isoindoline-1,3-dione derivatives and uses thereof
WO2023283425A1 (en) 2021-07-09 2023-01-12 Plexium, Inc. Aryl compounds and pharmaceutical compositions that modulate ikzf2
AR126718A1 (en) 2021-08-06 2023-11-08 Celgene Corp COMPOSITIONS AND METHODS FOR THE SELECTIVE DEGRADATION OF ENGINEERED PROTEINS
EP4385985A1 (en) * 2021-08-11 2024-06-19 Xizang Haisco Pharmaceutical Co., Ltd. Heterocyclic derivative, and composition and pharmaceutical use thereof
WO2023076983A1 (en) 2021-10-28 2023-05-04 Gilead Sciences, Inc. Pyridizin-3(2h)-one derivatives
CA3235986A1 (en) 2021-10-29 2023-05-04 Gilead Science, Inc. Cd73 compounds
AU2022419982A1 (en) 2021-12-22 2024-06-06 Gilead Sciences, Inc. Ikaros zinc finger family degraders and uses thereof
AU2022417491A1 (en) 2021-12-22 2024-05-23 Gilead Sciences, Inc. Ikaros zinc finger family degraders and uses thereof
TW202340168A (en) 2022-01-28 2023-10-16 美商基利科學股份有限公司 Parp7 inhibitors
CN116640122A (en) * 2022-02-16 2023-08-25 苏州国匡医药科技有限公司 IKZF 2 Degradation agent, pharmaceutical composition containing degradation agent and application of degradation agent
TW202346277A (en) 2022-03-17 2023-12-01 美商基利科學股份有限公司 Ikaros zinc finger family degraders and uses thereof
TW202345797A (en) * 2022-03-25 2023-12-01 美商昂科皮治療公司亦以普羅提歐凡治療公司名稱營業 Bicyclic heteroaryl-containing compounds as ikzf2 degraders
WO2023183540A1 (en) * 2022-03-25 2023-09-28 Regents Of The University Of Michigan Ikzf2 degraders and uses thereof
WO2023201012A1 (en) * 2022-04-15 2023-10-19 Regents Of The University Of Michigan Ikzf2 degraders and uses thereof
TW202400138A (en) 2022-04-21 2024-01-01 美商基利科學股份有限公司 Kras g12d modulating compounds
WO2024006929A1 (en) 2022-07-01 2024-01-04 Gilead Sciences, Inc. Cd73 compounds
CN117881668A (en) * 2022-08-10 2024-04-12 标新生物医药科技(上海)有限公司 Compound based on isoindoline substituted glutarimide skeleton and application thereof
WO2024059107A1 (en) * 2022-09-14 2024-03-21 President And Fellows Of Harvard College Ikzf2 and ck1-alpha degrading compounds and uses thereof
WO2024120438A1 (en) * 2022-12-07 2024-06-13 杭州格博生物医药有限公司 Solid dispersion, preparation method therefor, and use thereof

Family Cites Families (92)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5114946A (en) 1987-06-12 1992-05-19 American Cyanamid Company Transdermal delivery of pharmaceuticals
US4818541A (en) 1987-08-19 1989-04-04 Schering Corporation Transdermal delivery of enantiomers of phenylpropanolamine
US7196170B2 (en) 1992-09-14 2007-03-27 The General Hospital Corporation Aiolos, Helios, Daedalos and Ikaros: genes, polypeptides, regulatory elements and uses thereof
US5262564A (en) 1992-10-30 1993-11-16 Octamer, Inc. Sulfinic acid adducts of organo nitroso compounds useful as retroviral inactivating agents anti-retroviral agents and anti-tumor agents
DE69740140D1 (en) 1996-07-24 2011-04-14 Celgene Corp Substituted 2- (2,6-dioxopiperidin-3-yl) -phthalimides and oxoisoindolines and methods for reducing TNF-alpha levels
WO2002044372A2 (en) 2000-12-01 2002-06-06 Parker Hughes Institute Nucleotide and protein sequence of helios 3 and methods of use
US7902179B2 (en) 2001-04-26 2011-03-08 Ajinomoto Co., Inc. Heterocyclic compounds
WO2003014315A2 (en) 2001-08-06 2003-02-20 The Children's Medical Center Corporation Synthesis and anti-tumor activity of nitrogen substituted thalidomide analogs
US20050203142A1 (en) 2002-10-24 2005-09-15 Zeldis Jerome B. Methods of using and compositions comprising immunomodulatory compounds for treatment, modification and management of pain
US20040087558A1 (en) 2002-10-24 2004-05-06 Zeldis Jerome B. Methods of using and compositions comprising selective cytokine inhibitory drugs for treatment, modification and management of pain
US7612096B2 (en) 2003-10-23 2009-11-03 Celgene Corporation Methods for treatment, modification and management of radiculopathy using 1-oxo-2-(2,6-dioxopiperidin-3yl)-4-aminoisoindoline
US20070161696A1 (en) 2004-04-23 2007-07-12 Zeldis Jerome B Methods of using and compositions comprising selective cytokine inhibitory drugs for treatment, modification and management of pain
CA2579291C (en) * 2004-09-03 2011-11-29 Celgene Corporation Processes for the preparation of substituted 2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolines
JP4731867B2 (en) 2004-10-01 2011-07-27 国立大学法人三重大学 Method for inducing CD8 positive cytotoxic T lymphocytes
JP5775245B2 (en) 2004-12-01 2015-09-09 セルジーン コーポレイション Methods and compositions using immunomodulatory compounds for the treatment of immunodeficiency disorders
US20090215036A1 (en) 2004-12-10 2009-08-27 Bayer Healthcare Ag Genetic Alterations Useful For The Response Prediction of Malignant Neoplasia to Taxane-Based Medical Treatments
US20070128636A1 (en) 2005-12-05 2007-06-07 Baker Joffre B Predictors Of Patient Response To Treatment With EGFR Inhibitors
CN101374941A (en) 2005-12-29 2009-02-25 人类起源公司 Improved composition for collecting and preserving placental stem cells and methods of using the composition
EP2004625B1 (en) 2006-03-22 2009-12-30 Vertex Pharmaceuticals Incorporated C-met protein kinase inhibitors for the treatment of proliferative disorders
US20070269827A1 (en) 2006-05-18 2007-11-22 Oklahoma Medical Research Foundation Predicting and Diagnosing Patients With Autoimmune Disease
KR101342035B1 (en) 2006-06-20 2013-12-16 한국과학기술연구원 Biomaker and screening method of drug having nephyrotoxicity and side effects using thereof
US8877780B2 (en) 2006-08-30 2014-11-04 Celgene Corporation 5-substituted isoindoline compounds
JP2009092508A (en) 2007-10-09 2009-04-30 Norihiro Nishimoto Method for predicting effect of rheumatic therapeutic agent
EP2227558A1 (en) 2007-11-30 2010-09-15 GlaxoSmithKline Biologicals SA Method for classifying cancer patients as responder or non-responder to immunotherapy
KR100957051B1 (en) 2007-12-28 2010-05-13 한국과학기술연구원 Marker genes based on nitrofurantoin treatment for screening of drug inducing pulmonary toxicity and screening method using thereof
GB2456390A (en) 2008-01-15 2009-07-22 Glaxo Group Ltd Bipolar disorder treatments
WO2009094592A2 (en) 2008-01-23 2009-07-30 Perlegen Sciences, Inc. Genetic basis of alzheimer's disease and diagnosis and treatment thereof
US20090307180A1 (en) 2008-03-19 2009-12-10 Brandon Colby Genetic analysis
US20110229498A1 (en) 2008-05-08 2011-09-22 The Johns Hopkins University Compositions and methods for modulating an immune response
EP2177615A1 (en) 2008-10-10 2010-04-21 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Method for a genome wide identification of expression regulatory sequences and use of genes and molecules derived thereof for the diagnosis and therapy of metabolic and/or tumorous diseases
US20100204265A1 (en) 2009-02-09 2010-08-12 Genelabs Technologies, Inc. Certain Nitrogen Containing Bicyclic Chemical Entities for Treating Viral Infections
US9212177B2 (en) 2009-08-05 2015-12-15 Versitech Limited Antiviral compounds and methods of making and using thereof
CN102596946B (en) 2009-08-05 2015-06-17 港大科桥有限公司 Antiviral compounds and methods of making and using thereof
EP2494076B1 (en) 2009-10-26 2017-11-22 Abbott Molecular Inc. Detection of chromosomal abnormalities associated with prognosis of non small cell lung cancer
AU2011253481A1 (en) 2010-05-12 2013-01-10 Steven E. Schutzer Diagnostic markers for neuropsychiatric disease
US20120149715A1 (en) 2010-05-28 2012-06-14 Yi Tsun Richard Kao Compounds and methods for the treatment of viral infections
WO2011151941A1 (en) 2010-06-04 2011-12-08 国立大学法人東京大学 Composition having activity of inducing proliferation or accumulation of regulatory t cell
WO2012021867A2 (en) 2010-08-13 2012-02-16 The Johns Hopkins University A comprehensive methylome map of myeloid and lymphoid commitment from hematopoietic progenitors
WO2012054509A2 (en) 2010-10-22 2012-04-26 Dana-Farber Cancer Institute, Inc. Discovery of regulatory t cells programmed to suppress an immune response
CA2838275C (en) 2011-06-06 2021-08-10 University Of Iowa Research Foundation Methods for inhibiting muscle atrophy
EP2723362A1 (en) 2011-06-21 2014-04-30 Innate Pharma NKp46-MEDIATED NK CELL TUNING
US9910039B2 (en) 2011-07-01 2018-03-06 Beckman Coulter, Inc. Regulatory T cells and methods of identifying, obtaining and using to treat immuno-based disorders
CN103797120B (en) 2011-09-16 2017-04-12 上海长海医院 Prostate cancer biomarkers, therapeutic targets and uses thereof
CA2892588A1 (en) 2011-12-01 2013-06-06 School Corporation, Azabu Veterinary Medicine Educational Institution Human-derived bacteria that induce proliferation or accumulation of regulatory t cells
US9481866B2 (en) 2011-12-16 2016-11-01 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods of producing T cell populations enriched for stable regulatory T-cells
IN2014CN04935A (en) 2011-12-31 2015-09-18 Moni Abraham Kuriakose
EP3366768B1 (en) 2012-03-02 2020-07-08 The Regents of The University of California Expansion of alloantigen-reactive regulatory t cells
GB201207297D0 (en) 2012-04-26 2012-06-06 Senzagen Ab Analytical methods and arrays for use in the same
GB201213571D0 (en) 2012-07-31 2012-09-12 Univ Leuven Kath Growth factor cocktail to enhnce osteogenic differentiayion of mesenchymal
EP2682750A1 (en) 2012-07-02 2014-01-08 Sotio a.s. In vitro method for the diagnosis and surveillance of cancer
AU2013329372B2 (en) 2012-10-08 2018-07-12 St. Jude Children's Research Hospital Therapies based on control of regulatory T cell stability and function via a Neuropilin-1:Semaphorin axis
US20160007893A1 (en) 2013-02-06 2016-01-14 Loxbridge Research Llp Systems and methods for early disease detection and real-time disease monitoring
CA2906752A1 (en) 2013-03-14 2014-09-25 Children's Medical Center Corporation Compositions and methods for reprogramming hematopoietic stem cell lineages
WO2014151764A2 (en) 2013-03-15 2014-09-25 Veracyte, Inc. Methods and compositions for classification of samples
US20160122821A1 (en) 2013-06-10 2016-05-05 Suregene, Llc Genetic markers of antipsychotic response
GB2532672A (en) 2013-09-09 2016-05-25 Scripps Research Inst Methods and systems for analysis of organ transplantation
US10927412B2 (en) 2013-10-01 2021-02-23 The Regents Of The University Of California Endometriosis classifier
UY35790A (en) 2013-10-21 2015-05-29 Teva Pharma GENETIC MARKERS THAT PREACH THE RESPONSE TO THE GLATIRAMER ACETATE
WO2015109212A1 (en) 2014-01-17 2015-07-23 Pfizer Inc. Anti-il-2 antibodies and compositions and uses thereof
WO2015107196A1 (en) 2014-01-20 2015-07-23 Institut Curie Use of thalidomide or analogs thereof for preventing neurologic disorders induced by brain irradiation
AU2015247817C1 (en) * 2014-04-14 2022-02-10 Arvinas Operations, Inc. Imide-based modulators of proteolysis and associated methods of use
US20160058872A1 (en) * 2014-04-14 2016-03-03 Arvinas, Inc. Imide-based modulators of proteolysis and associated methods of use
EP3227464B1 (en) 2014-12-05 2022-04-20 Foundation Medicine, Inc. Multigene analysis of tumor samples
EP3034620A1 (en) 2014-12-17 2016-06-22 Diaxonhit Compositions and methods for diagnosing thyroid cancer
WO2016103269A1 (en) 2014-12-23 2016-06-30 Ramot At Tel-Aviv University Ltd. Populations of neural progenitor cells and methods of producing and using same
AU2016209321B2 (en) 2015-01-20 2019-05-09 Boehringer Ingelheim Animal Health USA Inc. Anthelmintic compounds, compositions and method of using thereof
EP3050570A1 (en) 2015-01-31 2016-08-03 Neurovision Pharma GmbH Pharmaceutical composition consisting of a combination of G-CSF with GM-CSF
WO2016140974A1 (en) 2015-03-01 2016-09-09 Novena Therapeutics Inc. Process for measuring tumor response to an initial oncology treatment
KR102055491B1 (en) 2015-05-22 2019-12-12 바이오테릭스, 인코포레이티드 Compounds, Compositions, Methods, and Uses That Target Proteins
US10338077B2 (en) 2015-06-02 2019-07-02 Celgene Corporation Methods for determining drug efficacy for treatment of cancer ration of cereblon associated proteins
EP3302548A4 (en) 2015-06-03 2019-01-02 Dana Farber Cancer Institute, Inc. Methods to induce conversion of regulatory t cells into effector t cells for cancer immunotherapy
WO2016209806A1 (en) 2015-06-22 2016-12-29 President And Fellows Of Harvard College Induction of lamina propria regulatory t cells
WO2017042337A1 (en) 2015-09-09 2017-03-16 Max-Delbrück-Centrum Für Molekulare Medizin In Der Helmhotz-Gemeinschaft Short-chain fatty acids for use in the treatment of cardiovascular disease
US20180250369A1 (en) 2015-09-11 2018-09-06 Ventria Bioscience, Inc. Lactoferrin compositions and methods for modulation of t cell subtypes and treatment of autoimmune diseases
US10954300B2 (en) 2015-09-28 2021-03-23 The Trustees Of Columbia University In The City Of New York Use of pentoxifylline with immune checkpoint-blockade therapies for the treatment of melanoma
AU2016330967B2 (en) 2015-09-30 2021-03-25 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Thalidomide analogs and methods of use
WO2017075478A2 (en) 2015-10-28 2017-05-04 The Broad Institute Inc. Compositions and methods for evaluating and modulating immune responses by use of immune cell gene signatures
WO2017075451A1 (en) 2015-10-28 2017-05-04 The Broad Institute Inc. Compositions and methods for evaluating and modulating immune responses by detecting and targeting pou2af1
WO2017075465A1 (en) 2015-10-28 2017-05-04 The Broad Institute Inc. Compositions and methods for evaluating and modulating immune responses by detecting and targeting gata3
EP3384013A4 (en) 2015-12-04 2019-07-10 The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. Antigen-specific t cells for inducing immune tolerance
EP4049665A1 (en) 2016-03-15 2022-08-31 Children's Medical Center Corporation Methods and compositions relating to hematopoietic stem cell expansion
WO2017176958A1 (en) 2016-04-06 2017-10-12 The Regents Of The University Of Michigan Monofunctional intermediates for ligand-dependent target protein degradation
EP3452101A2 (en) 2016-05-04 2019-03-13 CureVac AG Rna encoding a therapeutic protein
WO2017197056A1 (en) 2016-05-10 2017-11-16 C4 Therapeutics, Inc. Bromodomain targeting degronimers for target protein degradation
WO2017197051A1 (en) 2016-05-10 2017-11-16 C4 Therapeutics, Inc. Amine-linked c3-glutarimide degronimers for target protein degradation
AU2017341723B2 (en) 2016-10-11 2021-12-16 Arvinas Operations, Inc. Compounds and methods for the targeted degradation of androgen receptor
WO2018118598A1 (en) 2016-12-23 2018-06-28 Arvinas, Inc. Compounds and methods for the targeted degradation of fetal liver kinase polypeptides
BR112019012878A2 (en) 2016-12-23 2019-11-26 Arvinas Operations Inc compounds and methods for target degradation of rapidly accelerated fibrosarcoma polypeptides
US11191741B2 (en) 2016-12-24 2021-12-07 Arvinas Operations, Inc. Compounds and methods for the targeted degradation of enhancer of zeste homolog 2 polypeptide
KR20230140606A (en) 2017-01-26 2023-10-06 아비나스 오퍼레이션스, 인코포레이티드 Modulators of estrogen receptor proteolysis and associated methods of use
CN106932576A (en) 2017-03-22 2017-07-07 山东大学深圳研究院 A kind of detection method of the immune suppression function of people's regulatory T cells
TWI793151B (en) 2017-08-23 2023-02-21 瑞士商諾華公司 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof

Also Published As

Publication number Publication date
SG11202000490PA (en) 2020-03-30
MA49952A (en) 2021-04-28
BR112020003373A2 (en) 2020-08-25
US20190062309A1 (en) 2019-02-28
PH12020500125A1 (en) 2020-09-14
TW201920143A (en) 2019-06-01
DK3672949T3 (en) 2023-03-27
LT3672949T (en) 2023-04-11
US11053218B2 (en) 2021-07-06
AU2020277231A1 (en) 2020-12-24
US10640489B2 (en) 2020-05-05
US20200231569A1 (en) 2020-07-23
EP3672949B1 (en) 2022-12-21
UY37854A (en) 2019-03-29
US10647701B2 (en) 2020-05-12
AU2018319577B2 (en) 2020-10-15
AR112529A1 (en) 2019-11-06
AU2022231670A1 (en) 2022-10-06
PT3672949T (en) 2023-03-16
US10414755B2 (en) 2019-09-17
CL2020000427A1 (en) 2020-08-28
HRP20230244T1 (en) 2023-04-14
RU2020111556A (en) 2021-09-23
MA49952B1 (en) 2023-03-31
ZA202000208B (en) 2021-07-28
US20210309638A1 (en) 2021-10-07
DOP2020000037A (en) 2020-08-15
FI3672949T3 (en) 2023-03-23
US20190359594A1 (en) 2019-11-28
WO2019038717A1 (en) 2019-02-28
JP2020531498A (en) 2020-11-05
EP4183782A1 (en) 2023-05-24
KR20200044038A (en) 2020-04-28
MX2020002060A (en) 2020-07-13
AU2018319577A1 (en) 2020-02-06
CN111051298A (en) 2020-04-21
SA520411325B1 (en) 2022-06-13
EA202090553A1 (en) 2020-06-08
IL272748A (en) 2020-04-30
CU20200014A7 (en) 2020-11-30
ECSP20013248A (en) 2020-05-29
CN111051298B (en) 2023-06-27
CO2020001860A2 (en) 2020-05-29
ES2940448T3 (en) 2023-05-08
JP7386787B2 (en) 2023-11-27
JOP20200042A1 (en) 2020-02-20
CA3072694A1 (en) 2019-02-28
IL272748B2 (en) 2023-02-01
RU2020111556A3 (en) 2021-12-17
US20190367483A1 (en) 2019-12-05
SI3672949T1 (en) 2023-04-28
EP3672949B9 (en) 2023-04-05
BR112020003373B1 (en) 2022-08-09
IL272748B (en) 2022-10-01
HUE061895T2 (en) 2023-08-28
PL3672949T3 (en) 2023-05-08
CR20200081A (en) 2020-05-14
TWI793151B (en) 2023-02-21
DK3672949T5 (en) 2023-05-01
RS64058B1 (en) 2023-04-28
EP3672949A1 (en) 2020-07-01

Similar Documents

Publication Publication Date Title
IL272748A (en) 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof
HK1254654A1 (en) 4,6-pyrimidinylene derivatives and uses thereof
IL254124A0 (en) Novel 3-indol substituted derivatives, pharmaceutical compositions and methods for use
EP3623366A4 (en) Novel piperidine-2,6-dione derivative and use thereof
IL283148A (en) Dosing regimen and pharmaceutical combination comprising 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives
IL273571A (en) Aztreonam derivatives and uses thereof
IL261643B (en) Piperidine derivatives, their preparation and use
IL260497B (en) 3-(carboxymethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives
IL260488B (en) 8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives
IL260495B (en) 3-(carboxyethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives
EP3833343C0 (en) Heterocyclic flavone derivatives, compositions, and methods related thereto
EP3546449A4 (en) Piperidine-2,6-diketone derivative and treatment for crohn's disease
IL248773B (en) 1,6-naphthyridine-4,5-dione derivatives and pharmaceutical compositions comprising them
IL259597A (en) Cycling therapy using 3-(5-amino-2-methyl-4-oxo-4h-quinazolin-3-yl)-piperidine-2,6-dione
GB2590189B (en) Lycorine derivative, and pharmaceutical composition and use thereof
EP3199526A4 (en) Intermediate for use in synthesizing paroxetine, preparation method for the intermediate, and uses thereof
HK1252415A1 (en) Pharmaceutical compositions comprising 3-(5-amino-2-methyl-4-oxo-4h-quinazolin-3-yl)-piperidine-2,6-dione
EP3386988A4 (en) Novel dihydropyranopyrimidinone derivatives, and use thereof
IL262597B (en) Piperidinyl derivatives, their preparation and use
EP3788031C0 (en) Dipeptidyl ketoamide meta-methoxyphenyl derivatives and uses thereof
TH1501006617A (en) synthesis 3-(5amino-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione