SG11201909967QA - Formulations for extending lifespan and healthspan - Google Patents

Formulations for extending lifespan and healthspan

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Publication number
SG11201909967QA
SG11201909967QA SG11201909967QA SG11201909967QA SG 11201909967Q A SG11201909967Q A SG 11201909967QA SG 11201909967Q A SG11201909967Q A SG 11201909967QA SG 11201909967Q A SG11201909967Q A SG 11201909967QA
Authority
SG
Singapore
Prior art keywords
blvd
redwood
international
novato
rule
Prior art date
Application number
Inventor
Brian Kennedy
Gordon Lithgow
Thomas Weldon
Daniel Edgar
Mark Lucanic
Original Assignee
The Buck Institute For Res On Aging
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Filing date
Publication date
Application filed by The Buck Institute For Res On Aging filed Critical The Buck Institute For Res On Aging
Publication of SG11201909967QA publication Critical patent/SG11201909967QA/en

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    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Birds (AREA)
  • Animal Husbandry (AREA)
  • Zoology (AREA)
  • Dermatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nutrition Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mycology (AREA)
  • Emergency Medicine (AREA)
  • Physiology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Management, Administration, Business Operations System, And Electronic Commerce (AREA)
  • Fodder In General (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 01 November 2018 (01.11.2018) WIPO I PCT ~~ll~~~~~~~~ 011101010VIIIOH olo oi olo iimo oo1 mom ow (10) International Publication Number WO 2018/200736 A2 (51) International Patent Classification: A61K 31/4745 (2006.01) A61K 31/19 (2006.01) (21) International Application Number: PCT/US2018/029455 (22) International Filing Date: 25 April 2018 (25.04.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/489,884 25 April 2017 (25.04.2017) US 62/646,734 22 March 2018 (22.03.2018) US (71) Applicant: THE BUCK INSTITUTE FOR RESEARCH ON AGING [US/US]; 8001 Redwood Blvd., Novato, CA 94945 (US). (72) Inventors: KENNEDY, Brian; 8001 Redwood Blvd., No- vato, CA 94945 (US). LITHGOW, Gordon, J.; 8001 Redwood Blvd., Novato, CA 94945 (US). WELDON, Thomas; 8001 Redwood Blvd., Novato, CA 94945 (US). EDGAR, Daniel; 8001 Redwood Blvd., Novato, CA 94945 (US). LUCANIC, Mark; 8001 Redwood Blvd., Novato, CA 94945 (US). (74) Agent: MCNAMARA, Laurie, K.; Wilson Sonsini Goodrich & Rosati, 650 Page Mill Road, Palo Alto, CA 94304 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). = (54) Title: FORMULATIONS FOR EXTENDING LIFESPAN AND HEALTHSPAN 8/ 2007 36 A2 Fig. 11A 1-1 (57) : Described herein are compositions for delaying onset or delaying progression of frailty, reversing aging phenotype, © extending healthspan, compressing morbidity, increasing lifespan and reducing formation of senescent cells. C [Continued on next page] WO 2018/200736 A2 MIDIOHOMMIEFIEHIMMEllilIMIONEEDIS Declarations under Rule 4.17: as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(11)) as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) Published: without international search report and to be republished upon receipt of that report (Rule 48.2(g))
SG11201909967Q 2017-04-25 2018-04-25 Formulations for extending lifespan and healthspan SG11201909967QA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762489884P 2017-04-25 2017-04-25
US201862646734P 2018-03-22 2018-03-22
PCT/US2018/029455 WO2018200736A2 (en) 2017-04-25 2018-04-25 Formulations for extending lifespan and healthspan

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US (2) US20200188327A1 (en)
EP (1) EP3615029A4 (en)
JP (2) JP2020517689A (en)
KR (2) KR102643567B1 (en)
CN (2) CN110913847A (en)
AU (2) AU2018260646A1 (en)
BR (1) BR112019022455A2 (en)
CA (1) CA3061381A1 (en)
IL (1) IL308093A (en)
SG (2) SG10202107237SA (en)
WO (1) WO2018200736A2 (en)

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JP7499259B2 (en) 2018-09-25 2024-06-13 ポンス デ レオン ヘルス デジグネイテッド アクティビティ カンパニー Process for producing calcium alpha-ketoglutarate
WO2020086733A1 (en) * 2018-10-24 2020-04-30 Ponce De Leon Health Designated Activity Company Nicotinamide riboside compositions for healthspan extension
WO2020252014A1 (en) * 2019-06-10 2020-12-17 Ponce De Leon Health, Inc. Sustained-release compositions of alpha-ketoglutarate
CA3142781A1 (en) * 2019-06-10 2020-12-17 Buck Institute For Research On Aging Methods and compositions for altering senescence associated secretory phenotype
CN113018288A (en) * 2019-12-25 2021-06-25 同济大学 Use of alpha-ketoglutaric acid in the manufacture of a medicament
WO2021155341A1 (en) * 2020-02-01 2021-08-05 Ageless Sciences, Inc. Compositions and methods for treating aging-related disorders
CA3188646A1 (en) * 2020-07-02 2022-01-06 Ponce De Leon Health Designated Activity Company Compositions and methods for treating crp-mediated diseases
CN113244182A (en) * 2021-04-30 2021-08-13 雅本化学股份有限公司 Alpha-ketoglutarate calcium vitamin C effervescent tablet and preparation method thereof
WO2023212104A1 (en) * 2022-04-27 2023-11-02 The Regents Of The University Of California Methods and agents for preventing skeletal aging, osteoporosis and obesity
WO2024039646A1 (en) * 2022-08-15 2024-02-22 Mayo Foundation For Medical Education And Research Methods and materials for using and assessing anti-senescence treatments within mammals

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6451341B1 (en) * 1990-02-05 2002-09-17 Thomas J. Slaga Time release formulation of vitamins, minerals and other beneficial supplements
US20030190381A1 (en) * 2001-02-02 2003-10-09 Bland Jeffrey S. Medical composition for balancing bodily processes
WO2006066244A2 (en) * 2004-12-17 2006-06-22 Cash Alan B Method for extending lifespan and delaying the onset of age-related disease
US20070135376A1 (en) * 2005-06-20 2007-06-14 Accera, Inc. Method to reduce oxidative damage and improve mitochondrial efficiency
PL226695B1 (en) * 2006-07-03 2017-08-31 Danuta Kruszewska Agent for preventing and/or inhibiting the colonization of Helicobater pylori and its application
AU2008271307B2 (en) * 2007-07-02 2013-10-24 Protista Biotechnology Ab New use of known pharmacologically active chemical compounds
EP2033623A1 (en) * 2007-09-07 2009-03-11 Cutech S.R.L. Compositions comprising ornithine ketoglutarate (OKG)
DE102009016119A1 (en) * 2009-04-03 2010-10-14 Evonik Degussa Gmbh Nutritional supplement containing alpha-keto acids to support diabetes therapy
EP2965763B8 (en) * 2009-04-10 2018-08-15 Haiyan Qi Anti-aging agents
CN102740870B (en) * 2009-06-12 2016-06-29 基因雷克斯制药有限公司 Japan's Herba Diclipterae Chinensis organic extract purposes in preparation is used for treatment or prophylaxis of hypertension medicine
FR2953139B1 (en) * 2009-11-27 2012-04-13 Servier Lab PHARMACEUTICAL COMPOSITION COMPRISING STRONTIUM SALT, VITAMIN D AND CYCLODEXTRIN
RU2013151085A (en) * 2011-04-18 2015-05-27 Нестек С.А. NUTRITIONAL COMPOSITIONS CONTAINING α-HYDROXYSIOCAPRIC ACID (α-HICA), AND METHODS OF USE
CN106163513A (en) * 2014-02-12 2016-11-23 加利福尼亚大学董事会 For treating compositions and the method for old and feeble and age-related disease and symptom
EP3160460B1 (en) * 2014-06-30 2020-08-05 The Regents of the University of California Ketobutyrate compounds and compositions for treating age-related symptoms and diseases
AU2015296098B2 (en) * 2014-07-29 2019-06-27 Shenzhen Hightide Biopharmaceutical, Ltd. Berberine salts, ursodeoxycholic salts and combinations, methods of preparation and application thereof

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