SG11201811230RA - Compositions and methods for reducing ocular neovascularization - Google Patents
Compositions and methods for reducing ocular neovascularizationInfo
- Publication number
- SG11201811230RA SG11201811230RA SG11201811230RA SG11201811230RA SG11201811230RA SG 11201811230R A SG11201811230R A SG 11201811230RA SG 11201811230R A SG11201811230R A SG 11201811230RA SG 11201811230R A SG11201811230R A SG 11201811230RA SG 11201811230R A SG11201811230R A SG 11201811230RA
- Authority
- SG
- Singapore
- Prior art keywords
- international
- suite
- pct
- methods
- menlo park
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, ***e
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0075—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the delivery route, e.g. oral, subcutaneous
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
Abstract
INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization 1111111111 0111011110111110101111111 011111111101111111111111110111111111 International Bureau (10) International Publication Number (43) International Publication Date .....0\"\"\" WO 2017/218981 A2 21 December 2017 (21.12.2017) WIP0 I PCT (51) (21) International Application Number: (22) International Filing Date: (25) Filing Language: (26) Publication Language: (30) (71) (72) Inventors: BLUMENKRANZ, Mark; (74) International Patent Classification: (81) Designated States A61K 48/00 (2006.01) Cl 2N 15/861 (2006.01) PCT/US2017/038012 16 June 2017 (16.06.2017) English English Priority Data: 62/351,231 16 June 2016 (16.06.2016) US (84) Designated States Applicant: ADVERUM BIOTECHNOLOGIES, INC. [US/US]; 1035 O'Brien Drive, Suite A, Menlo Park, CA 94025 (US). 1035 O'Brien Dri- ye, Suite A, Menlo Park, CA 94025 (US). GASMI, Mehdi; 1035 O'Brien Drive, Suite A, Menlo Park, CA 94025 (US). Agent: YIN, Eva F. et al.; Wilson Sonsini Goodrich & Rosati, 650 Page Mill Road, Palo Alto, CA 94304-1050 (US). (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). — = = Title: COMPOSITIONS AND METHODS FOR REDUCING OCULAR NEOVASCULARIZATION : The present disclosure provides pharmaceutical compositions and methods thereof neovascularization, such as having a nucleic acid sequence that encodes an anti-VEGF agent. (54) FIG. 1 for the prevention or treatment of composition comprising a rAAV = \ \• \ \,, , k , ,,. ,, ' , •,„N•k \ , % ‘ • ' = = = = - = = ei 11 GC C:r GC 11 ei IN ,-1 (57) 0 ocular ei vector AMD, in a subject, by administering to the subject a pharmaceutical [Continued on next page] WO 2017/218981 A2 MIMMOMMIONMEMIHMOIMMOIIIMEHMIE Published: — without international search report and to upon receipt of that report (Rule 48.2(g)) be republished
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662351231P | 2016-06-16 | 2016-06-16 | |
PCT/US2017/038012 WO2017218981A2 (en) | 2016-06-16 | 2017-06-16 | Compositions and methods for reducing ocular neovascularization |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201811230RA true SG11201811230RA (en) | 2019-01-30 |
Family
ID=60664289
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201811230RA SG11201811230RA (en) | 2016-06-16 | 2017-06-16 | Compositions and methods for reducing ocular neovascularization |
Country Status (17)
Country | Link |
---|---|
US (2) | US20190100582A1 (en) |
EP (2) | EP4083203A1 (en) |
JP (3) | JP6990667B2 (en) |
KR (2) | KR102622823B1 (en) |
AU (2) | AU2017286680B2 (en) |
CA (1) | CA3027740A1 (en) |
DK (1) | DK3472317T3 (en) |
ES (1) | ES2916344T3 (en) |
HR (1) | HRP20220612T1 (en) |
HU (1) | HUE059424T2 (en) |
LT (1) | LT3472317T (en) |
PL (1) | PL3472317T3 (en) |
PT (1) | PT3472317T (en) |
RS (1) | RS63282B1 (en) |
SG (1) | SG11201811230RA (en) |
SI (1) | SI3472317T1 (en) |
WO (1) | WO2017218981A2 (en) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10000741B2 (en) | 2014-03-17 | 2018-06-19 | Adverum Biotechnologies, Inc. | Compositions and methods for enhanced gene expression in cone cells |
US9840553B2 (en) | 2014-06-28 | 2017-12-12 | Kodiak Sciences Inc. | Dual PDGF/VEGF antagonists |
JP7095994B2 (en) | 2015-03-02 | 2022-07-05 | アドヴェラム バイオテクノロジーズ, インコーポレイテッド | Compositions and Methods for Intravitreal Delivery of Polynucleotides to the Retinal Pyramids |
WO2017117464A1 (en) | 2015-12-30 | 2017-07-06 | Kodiak Sciences Inc. | Antibodies and conjugates thereof |
JP7343903B2 (en) | 2017-03-17 | 2023-09-13 | アドヴェラム バイオテクノロジーズ, インコーポレイテッド | Compositions and methods for enhancing gene expression |
KR20200090927A (en) | 2017-12-19 | 2020-07-29 | 아카우오스, 인크. | AAV-mediated delivery of therapeutic antibodies to the inner ear |
CN111989397A (en) * | 2018-03-30 | 2020-11-24 | 藤堂具纪 | Oncolytic virus with inhibited swelling development |
WO2021050094A1 (en) * | 2019-09-11 | 2021-03-18 | Adverum Biotechnologies, Inc. | Methods of treating ocular neovascular diseases using aav2 variants encoding aflibercept |
JP2022552262A (en) * | 2019-10-07 | 2022-12-15 | リジェネックスバイオ インコーポレイテッド | Adeno-associated virus vector pharmaceutical compositions and methods |
AU2020364071A1 (en) | 2019-10-10 | 2022-05-26 | Kodiak Sciences Inc. | Methods of treating an eye disorder |
WO2021163451A1 (en) * | 2020-02-14 | 2021-08-19 | Asklepios Biopharmaceutical, Inc. | Method of treating gene therapy associated toxicity with antibiotics |
CN115869425A (en) * | 2022-12-12 | 2023-03-31 | 北京生物制品研究所有限责任公司 | AAV ophthalmic injection and preparation method and application thereof |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK0694042T3 (en) | 1993-03-25 | 2005-02-14 | Merck & Co Inc | Vascular endothelial cell growth factor inhibitor |
WO2010040772A2 (en) * | 2008-10-07 | 2010-04-15 | Bracco Research Sa | Targeting construct comprising anti-polymer antibody and liposomes or microvesicles binding to the same |
US8663624B2 (en) * | 2010-10-06 | 2014-03-04 | The Regents Of The University Of California | Adeno-associated virus virions with variant capsid and methods of use thereof |
SG10202110919YA (en) * | 2011-04-22 | 2021-11-29 | Univ California | Adeno-associated virus virions with variant capsid and methods of use thereof |
TWI775096B (en) * | 2012-05-15 | 2022-08-21 | 澳大利亞商艾佛蘭屈澳洲私營有限公司 | Treatment of amd using aav sflt-1 |
US10000741B2 (en) * | 2014-03-17 | 2018-06-19 | Adverum Biotechnologies, Inc. | Compositions and methods for enhanced gene expression in cone cells |
EP3570895A1 (en) * | 2017-01-17 | 2019-11-27 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods of expressing a polynucleotide of interest in the cone photoreceptors |
-
2017
- 2017-06-16 PT PT178142287T patent/PT3472317T/en unknown
- 2017-06-16 CA CA3027740A patent/CA3027740A1/en active Pending
- 2017-06-16 SG SG11201811230RA patent/SG11201811230RA/en unknown
- 2017-06-16 JP JP2018565844A patent/JP6990667B2/en active Active
- 2017-06-16 LT LTEPPCT/US2017/038012T patent/LT3472317T/en unknown
- 2017-06-16 DK DK17814228.7T patent/DK3472317T3/en active
- 2017-06-16 EP EP22154859.7A patent/EP4083203A1/en active Pending
- 2017-06-16 HR HRP20220612TT patent/HRP20220612T1/en unknown
- 2017-06-16 KR KR1020227041433A patent/KR102622823B1/en active IP Right Grant
- 2017-06-16 PL PL17814228.7T patent/PL3472317T3/en unknown
- 2017-06-16 SI SI201731153T patent/SI3472317T1/en unknown
- 2017-06-16 AU AU2017286680A patent/AU2017286680B2/en active Active
- 2017-06-16 KR KR1020197001022A patent/KR20190038536A/en active IP Right Grant
- 2017-06-16 WO PCT/US2017/038012 patent/WO2017218981A2/en unknown
- 2017-06-16 HU HUE17814228A patent/HUE059424T2/en unknown
- 2017-06-16 EP EP17814228.7A patent/EP3472317B1/en active Active
- 2017-06-16 ES ES17814228T patent/ES2916344T3/en active Active
- 2017-06-16 RS RS20220484A patent/RS63282B1/en unknown
-
2018
- 2018-12-12 US US16/218,350 patent/US20190100582A1/en not_active Abandoned
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2021
- 2021-12-06 JP JP2021197648A patent/JP7384447B2/en active Active
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2022
- 2022-10-12 US US18/046,112 patent/US20230322911A1/en active Pending
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2023
- 2023-04-13 AU AU2023202277A patent/AU2023202277A1/en active Pending
- 2023-10-05 JP JP2023173614A patent/JP2023171953A/en active Pending
Also Published As
Publication number | Publication date |
---|---|
EP3472317A4 (en) | 2020-02-26 |
EP3472317A2 (en) | 2019-04-24 |
AU2017286680B2 (en) | 2023-01-19 |
AU2023202277A1 (en) | 2023-05-11 |
CA3027740A1 (en) | 2017-12-21 |
US20230322911A1 (en) | 2023-10-12 |
DK3472317T3 (en) | 2022-05-23 |
JP7384447B2 (en) | 2023-11-21 |
EP3472317B1 (en) | 2022-03-16 |
SI3472317T1 (en) | 2022-08-31 |
WO2017218981A3 (en) | 2018-02-15 |
ES2916344T3 (en) | 2022-06-30 |
JP6990667B2 (en) | 2022-02-03 |
LT3472317T (en) | 2022-06-27 |
PL3472317T3 (en) | 2022-08-08 |
RS63282B1 (en) | 2022-06-30 |
KR20220162881A (en) | 2022-12-08 |
KR20190038536A (en) | 2019-04-08 |
JP2019521989A (en) | 2019-08-08 |
EP4083203A1 (en) | 2022-11-02 |
HUE059424T2 (en) | 2022-11-28 |
JP2022028928A (en) | 2022-02-16 |
AU2017286680A1 (en) | 2019-01-31 |
US20190100582A1 (en) | 2019-04-04 |
JP2023171953A (en) | 2023-12-05 |
WO2017218981A2 (en) | 2017-12-21 |
HRP20220612T1 (en) | 2022-07-22 |
PT3472317T (en) | 2022-06-27 |
KR102622823B1 (en) | 2024-01-10 |
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