SG11201909243TA - New bicyclic pyrazole derivatives - Google Patents

New bicyclic pyrazole derivatives

Info

Publication number
SG11201909243TA
SG11201909243TA SG11201909243TA SG11201909243TA SG 11201909243T A SG11201909243T A SG 11201909243TA SG 11201909243T A SG11201909243T A SG 11201909243TA SG 11201909243T A SG11201909243T A SG 11201909243TA
Authority
SG
Singapore
Prior art keywords
international
compounds
str
pct
bicyclic pyrazole
Prior art date
Application number
Inventor
Nils Griebenow
Wei Zhuang
Daniel Kulke
Adeline Köhler
Thomas Ilg
Claudia Welz
Hans-Georg Schwarz
Ulrich Görgens
Walter Hübsch
Johannes Köbberling
Original Assignee
Bayer Animal Health Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Animal Health Gmbh filed Critical Bayer Animal Health Gmbh
Publication of SG11201909243TA publication Critical patent/SG11201909243TA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D513/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics

Abstract

1 O 71. (I) It-- R2 N—N O 0 (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 01 November 2018 (01.11.2018) WIPO I PCT mu °million °nolo Oil mo Ho O II111110uOIIIIII IE (10) International Publication Number WO 2018/197401 Al (51) International Patent Classification: CO7D 513/00 (2006.01) A61K 31/429 (2006.01) A61P 31/00 (2006.01) (21) International Application Number: PCT/EP2018/060313 (22) International Filing Date: 23 April 2018 (23.04.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 17168558.9 27 April 2017 (27.04.2017) EP (71) Applicant: BAYER ANIMAL HEALTH GMBH [DE/DE]; Kaiser-Wilhelm-Allee 10, 51373 Leverkusen (DE). (72) Inventors: GRIEBENOW, Nils; Kurftirstenstr. 39, 41541 Dormagen (DE). ZHUANG, Wei; StauffenbergstraBe 13, 40789 Monheim (DE). KULKE, Daniel; Dillinger Str. 13, 51375 Leverkusen (DE). KOHLER, Adeline; Heimchen- weg 9, 40764 Langenfeld (DE). ILG, Thomas; Plotzenseer Strasse 16, 40789 Monheim (DE). WELZ, Claudia; An der Ziegelei 14, 40593 Diisseldorf (DE). SCHWARZ, Hans- Georg; Auf dem Beerenkamp 82b, 46282 Dorsten (DE). GORGENS, Ulrich; Fester Str.37, 40882 Ratingen (DE). HUBSCH, Walter; Wildsteig 22, 42113 Wuppertal (DE). KOBBERLING, Johannes; Azalienstr. 30, 41466 Neuss (DE). (74) Agent: BIP PATENTS; Alfred-Nobel-Str. 10, 40789 Mon- heim am Rhein NRW (DE). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(ii)) Published: with international search report (Art. 21(3)) (54) Title: NEW BICYCLIC PYRAZOLE DERIVATIVES 1-1 (57) : The present invention covers bicyclic pyrazole compounds of general formula (I) : in which G, A, R 1 , R , R 2 3 , and Q are as defined herein, methods of preparing said compounds, intermedi- ate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compo- sitions for the treatment, control and/or prevention of diseases, in particular of helminth infections, as a sole agent or in combination with other active ingredients.
SG11201909243T 2017-04-27 2018-04-23 New bicyclic pyrazole derivatives SG11201909243TA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP17168558 2017-04-27
PCT/EP2018/060313 WO2018197401A1 (en) 2017-04-27 2018-04-23 New bicyclic pyrazole derivatives

Publications (1)

Publication Number Publication Date
SG11201909243TA true SG11201909243TA (en) 2019-11-28

Family

ID=58638808

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201909243T SG11201909243TA (en) 2017-04-27 2018-04-23 New bicyclic pyrazole derivatives

Country Status (17)

Country Link
US (1) US11130768B2 (en)
EP (1) EP3585791A1 (en)
JP (1) JP7261747B2 (en)
KR (1) KR102596307B1 (en)
CN (1) CN110536892B (en)
AU (1) AU2018257582B2 (en)
BR (1) BR112019022383A2 (en)
CA (1) CA3061406A1 (en)
CL (1) CL2019003078A1 (en)
CO (1) CO2019011877A2 (en)
DO (1) DOP2019000275A (en)
MX (1) MX2019012803A (en)
SG (1) SG11201909243TA (en)
TW (1) TWI780147B (en)
UY (1) UY37705A (en)
WO (1) WO2018197401A1 (en)
ZA (1) ZA201907834B (en)

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CA3122106A1 (en) 2018-12-18 2020-06-25 Elanco Tiergesundheit Ag Bicyclic derivatives
SG11202109786UA (en) * 2019-03-19 2021-10-28 Boehringer Ingelheim Animal Health Usa Inc Anthelmintic aza-benzothiophene and aza-benzofuran compounds
WO2020247747A1 (en) 2019-06-07 2020-12-10 Elanco Tiergesundheit Ag Bicyclic derivatives for treating endoparasites
US11964977B2 (en) 2020-05-29 2024-04-23 Boehringer Ingelheim Animal Health USA Inc. Anthelmintic heterocyclic compounds
JP2023553269A (en) 2020-11-18 2023-12-21 エランコ・ティアゲゾンタイト・アーゲー N-(2,3-dihydro-1,4-benzoxazin-4-yl)-3-isopropyl-7-(2,3,5-trifluorophenyl)benzo- for treating dog heartworm infections Thiophene-2-carboxamide derivatives and similar compounds
TW202237600A (en) 2020-12-04 2022-10-01 瑞士商禮藍動物保健股份有限公司 Bicyclic derivatives
US20230159543A1 (en) 2021-11-01 2023-05-25 Boehringer Ingelheim Vetmedica Gmbh Anthelmintic pyrrolopyridazine compounds

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Also Published As

Publication number Publication date
AU2018257582B2 (en) 2022-06-16
CN110536892B (en) 2023-05-12
DOP2019000275A (en) 2019-11-15
CO2019011877A2 (en) 2020-01-17
RU2019138221A (en) 2021-05-27
BR112019022383A2 (en) 2020-05-19
JP7261747B2 (en) 2023-04-20
WO2018197401A1 (en) 2018-11-01
TWI780147B (en) 2022-10-11
EP3585791A1 (en) 2020-01-01
ZA201907834B (en) 2022-06-29
RU2019138221A3 (en) 2021-05-27
UY37705A (en) 2018-11-30
MX2019012803A (en) 2020-01-23
JP2020517683A (en) 2020-06-18
US11130768B2 (en) 2021-09-28
CL2019003078A1 (en) 2020-04-03
AU2018257582A1 (en) 2019-10-24
KR20190141725A (en) 2019-12-24
US20200190111A1 (en) 2020-06-18
CA3061406A1 (en) 2018-11-01
TW201841925A (en) 2018-12-01
CN110536892A (en) 2019-12-03
KR102596307B1 (en) 2023-10-30

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