SG11201908547VA - Hydrogel cross-linked hyaluronic acid prodrug compositions and methods - Google Patents

Hydrogel cross-linked hyaluronic acid prodrug compositions and methods

Info

Publication number
SG11201908547VA
SG11201908547VA SG11201908547VA SG11201908547VA SG 11201908547V A SG11201908547V A SG 11201908547VA SG 11201908547V A SG11201908547V A SG 11201908547VA SG 11201908547V A SG11201908547V A SG 11201908547VA
Authority
SG
Singapore
Prior art keywords
heidelberg
california
international
ascendis
rule
Prior art date
Application number
Inventor
Sebastian Stark
Thomas Knappe
Harald Rau
Nicola Bisek
Burkhardt Laufer
Samuel Weisbrod
Tobias Voigt
Germaine Fuh
Patrick Koenig
Chingwei Vivian Lee
Daniela Bumbaca Yadav
Original Assignee
Genentech Inc
Ascendis Pharma As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc, Ascendis Pharma As filed Critical Genentech Inc
Publication of SG11201908547VA publication Critical patent/SG11201908547VA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6903—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being semi-solid, e.g. an ointment, a gel, a hydrogel or a solidifying gel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Abstract

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 27 September 2018 (27.09.2018) WIP0 I PCT O V SID o Ho Imo En VII IE (10) International Publication Number WO 2018/175788 Al (51) International Patent Classification: A61K 47/61 (2017.01) A61K 47/69 (2017.01) (21) International Application Number: PCT/US2018/023857 (22) International Filing Date: 22 March 2018 (22.03.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/475,094 22 March 2017 (22.03.2017) US (71) Applicants: GENENTECH, INC. [US/US]; 1 DNA Way, South San Francisco, California 94080 (US). ASCENDIS PHARMA A/S [DK/DK]; Tuborg Boulevard 5, 2900 Hellerup (DK). (72) Inventors: STARK, Sebastian; c/o Ascendis Pharma GmbH, Im Neuenheimer Feld 584, D-69120 Heidelberg (DE). KNAPPE, Thomas; c/o Ascendis Pharman GmbH, Im Neuenheimer Feld 584, D-69120 Heidelberg (DE). RAU, Harald; c/o Ascendis Pharma GmbH, Im Neuen- heimer Feld 584, D-69120 Heidelberg (DE). BISEK, Nico- la; c/o Ascendis Pharma GmbH, Im Neuenheimer Feld 584, D-69120 Heidelberg (DE). LAUFER, Burkhardt; c/o Ascendis Pharma GmbH, Im Neuenheimer Feld 584, D-69120 Heidelberg (DE). WEISBROD, Samuel; c/o As- cendis Pharma GmbH, Im Neuenheimer Feld 584, D-69120 Heidelberg (DE). VOIGT, Tobias; c/o Ascendis Pharma GmbH, Im Neuenheimer Feld 584, D-69120 Heidelberg (DE). FUH, Germaine; 149 Amapola Avenue, Pacifica, California 94044 (US). KOENIG, Patrick; 4116A 17th Street, San Francisco, California 94114 (US). LEE, Ching- wei Vivian; 342 Menhaden Ct., Foster City, California 94404 (US). YADAV, Daniela Bumbaca; c/o Genentech, Inc., 1 DNA Way, South San Francisco, California 94080 (US). OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(ii)) as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) Published: — with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) with sequence listing part of description (Rule 5.2(a)) W O 20 18/ 1757 88 Al (74) Agent: HALL, Robert C. et al.; c/o Genentech, Inc., 1 DNA Way, South San Francisco, California 94080 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, (54) Title: HYDROGEL CROSS-LINKED HYALURONIC ACID PRODRUG COMPOSITIONS AND METHODS (57) : The present invention relates to hydrogel prodrug compositions comprising cross-linked hyaluronic acid (HA), or a derivative or a salt thereof, wherein the cross-linker system comprises a biodegradable spacer, wherein the cross-linked HA comprises a conjugated drug-linker, and wherein the linker is capable of releasing the drug under physiological conditions. The present invention further relates to methods for preparing the hydrogel prodrug compositions. The present invention further relates to methods for treating an ocular condition using the hydrogel compositions.
SG11201908547V 2017-03-22 2018-03-22 Hydrogel cross-linked hyaluronic acid prodrug compositions and methods SG11201908547VA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762475094P 2017-03-22 2017-03-22
PCT/US2018/023857 WO2018175788A1 (en) 2017-03-22 2018-03-22 Hydrogel cross-linked hyaluronic acid prodrug compositions and methods

Publications (1)

Publication Number Publication Date
SG11201908547VA true SG11201908547VA (en) 2019-10-30

Family

ID=61906882

Family Applications (2)

Application Number Title Priority Date Filing Date
SG10202107829YA SG10202107829YA (en) 2017-03-22 2018-03-22 Hydrogel cross-linked hyaluronic acid prodrug compositions and methods
SG11201908547V SG11201908547VA (en) 2017-03-22 2018-03-22 Hydrogel cross-linked hyaluronic acid prodrug compositions and methods

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG10202107829YA SG10202107829YA (en) 2017-03-22 2018-03-22 Hydrogel cross-linked hyaluronic acid prodrug compositions and methods

Country Status (15)

Country Link
US (2) US11642415B2 (en)
EP (1) EP3600441A1 (en)
JP (2) JP7216006B2 (en)
KR (1) KR20200007776A (en)
CN (1) CN110891611B (en)
AR (1) AR111190A1 (en)
AU (1) AU2018240375C1 (en)
BR (1) BR112019019658A2 (en)
CA (1) CA3055985A1 (en)
IL (1) IL269506B2 (en)
MA (1) MA49265A (en)
SG (2) SG10202107829YA (en)
TW (1) TW201842936A (en)
WO (1) WO2018175788A1 (en)
ZA (1) ZA201905930B (en)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9840553B2 (en) 2014-06-28 2017-12-12 Kodiak Sciences Inc. Dual PDGF/VEGF antagonists
RU2744860C2 (en) 2015-12-30 2021-03-16 Кодиак Сайенсиз Инк. Antibodies and their conjugates
AU2019246390A1 (en) 2018-03-28 2020-08-06 Ascendis Pharma A/S Conjugates
JP2021519336A (en) 2018-03-28 2021-08-10 アセンディス ファーマ オンコロジー ディヴィジョン エー／エス IL-2 conjugate
MX2021003184A (en) * 2018-09-26 2021-08-11 Ascendis Pharma As Degradable hyaluronic acid hydrogels.
SG11202104966XA (en) 2019-01-04 2021-06-29 Ascendis Pharma Oncology Div A/S Sustained local drug levels for innate immune agonists
EP3906065A1 (en) 2019-01-04 2021-11-10 Ascendis Pharma Oncology Division A/S Minimization of systemic inflammation
US20220062273A1 (en) 2019-01-04 2022-03-03 Ascendis Pharma Oncology Division A/S Conjugates of pattern recognition receptor agonists
SG11202105437UA (en) 2019-01-04 2021-06-29 Ascendis Pharma Oncology Div A/S Induction of sustained local inflammation
WO2020254607A1 (en) 2019-06-21 2020-12-24 Ascendis Pharma Oncology Division A/S Anti-ctla4 compounds with localized pd properties
AU2020295725A1 (en) 2019-06-21 2021-12-02 Ascendis Pharma Oncology Division A/S Anti-CTLA4 conjugates
WO2020254613A1 (en) 2019-06-21 2020-12-24 Ascendis Pharma Oncology Division A/S Controlled-release tyrosine kinase inhibitor compounds with localized pk properties
WO2020254617A1 (en) 2019-06-21 2020-12-24 Ascendis Pharma Oncology Division A/S Anti-ctla4 compounds with localized pk properties
WO2020254612A1 (en) 2019-06-21 2020-12-24 Ascendis Pharma Oncology Division A/S Controlled-release tyrosine kinase inhibitor compounds with localized pd properties
TW202114660A (en) 2019-06-21 2021-04-16 丹麥商阿仙帝斯製藥公司 Tyrosine kinase inhibitor conjugates
CA3157509A1 (en) 2019-10-10 2021-04-15 Kodiak Sciences Inc. Methods of treating an eye disorder
CA3161098A1 (en) 2020-01-03 2021-07-08 Ascendis Pharma A/S Conjugates undergoing intramolecular rearrangements
EP4146281A1 (en) 2020-05-04 2023-03-15 Ascendis Pharma A/S Hydrogel irradiation
JP2023527919A (en) 2020-06-03 2023-06-30 アセンディス ファーマ オンコロジー ディヴィジョン エー／エス IL-2 sequences and uses thereof
BR112023003476A2 (en) 2020-08-28 2023-04-11 Ascendis Pharma Oncology Div A/S IL-2 GLYCOSYLATED PROTEINS AND USES THEREOF
AU2022246997A1 (en) 2021-04-01 2023-09-28 Ascendis Pharma A/S Use of long-acting growth hormone for treating inflammation-induced diseases
CN116059312A (en) * 2021-07-23 2023-05-05 百奥泰生物制药股份有限公司 Integrin GPIIb/IIIa antagonists and their use in combination with anti-VEGF antibodies
WO2023110727A2 (en) 2021-12-13 2023-06-22 Ascendis Pharma Oncology Division A/S Novel cancer treatments with tlr7/8 agonists
WO2023201335A2 (en) * 2022-04-15 2023-10-19 Valitor, Inc. Purified multivalent protein-hyaluronic acid polymer conjugates
CN115389681B (en) * 2022-11-01 2023-01-20 常州百瑞吉生物医药有限公司 Detection method for dithiothreitol residue in thiolated hyaluronic acid derivative

Family Cites Families (235)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4716224A (en) 1984-05-04 1987-12-29 Seikagaku Kogyo Co. Ltd. Crosslinked hyaluronic acid and its use
US5128326A (en) 1984-12-06 1992-07-07 Biomatrix, Inc. Drug delivery systems based on hyaluronans derivatives thereof and their salts and methods of producing same
US4676980A (en) 1985-09-23 1987-06-30 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Target specific cross-linked heteroantibodies
US6548640B1 (en) 1986-03-27 2003-04-15 Btg International Limited Altered antibodies
US4937270A (en) 1987-09-18 1990-06-26 Genzyme Corporation Water insoluble derivatives of hyaluronic acid
EP0326111A3 (en) 1988-01-29 1989-12-27 New York Blood Center, Inc. Peptide derivatives rendered immunogenic when administered with alum as an adjuvant
IT1219587B (en) 1988-05-13 1990-05-18 Fidia Farmaceutici SELF-CROSS-LINKED CARBOXYLY POLYSACCHARIDES
KR0184860B1 (en) 1988-11-11 1999-04-01 메디칼 리써어치 카운실 Single domain ligands receptors comprising said ligands methods for their production and use of said ligands
SE8900422D0 (en) 1989-02-08 1989-02-08 Pharmacia Ab CIRCULATED HYALURONATE GELS AND PROCEDURES FOR PREPARING THESE
DE3920358A1 (en) 1989-06-22 1991-01-17 Behringwerke Ag BISPECIFIC AND OLIGO-SPECIFIC, MONO- AND OLIGOVALENT ANTI-BODY CONSTRUCTS, THEIR PRODUCTION AND USE
US5356883A (en) 1989-08-01 1994-10-18 Research Foundation Of State University Of N.Y. Water-insoluble derivatives of hyaluronic acid and their methods of preparation and use
US5959177A (en) 1989-10-27 1999-09-28 The Scripps Research Institute Transgenic plants expressing assembled secretory antibodies
DE69127081T2 (en) 1990-06-14 1998-02-05 Vitaphore Corp POLYURETHANE BIOPOLYMER CONNECTION
ATE135721T1 (en) 1990-07-26 1996-04-15 Monsanto Co METHOD FOR PRODUCING CROSS-LINKED POLYAMINE
ES2113940T3 (en) 1990-12-03 1998-05-16 Genentech Inc ENRICHMENT METHOD FOR PROTEIN VARIANTS WITH ALTERED UNION PROPERTIES.
US5571894A (en) 1991-02-05 1996-11-05 Ciba-Geigy Corporation Recombinant antibodies specific for a growth factor receptor
US5144088A (en) 1991-04-26 1992-09-01 Aristech Chemical Corporation Manufacture of neopentyl glycol (I)
ES2206447T3 (en) 1991-06-14 2004-05-16 Genentech, Inc. HUMANIZED ANTIBODY FOR HEREGULINE.
GB9114948D0 (en) 1991-07-11 1991-08-28 Pfizer Ltd Process for preparing sertraline intermediates
US7018809B1 (en) 1991-09-19 2006-03-28 Genentech, Inc. Expression of functional antibody fragments
US5587458A (en) 1991-10-07 1996-12-24 Aronex Pharmaceuticals, Inc. Anti-erbB-2 antibodies, combinations thereof, and therapeutic and diagnostic uses thereof
AU3124793A (en) 1991-10-29 1993-06-07 Clover Consolidated, Limited Crosslinkable polysaccharides, polycations and lipids useful for encapsulation and drug release
WO1993008829A1 (en) 1991-11-04 1993-05-13 The Regents Of The University Of California Compositions that mediate killing of hiv-infected cells
JPH07501451A (en) 1991-11-25 1995-02-16 エンゾン・インコーポレイテッド Multivalent antigen binding protein
AU675929B2 (en) 1992-02-06 1997-02-27 Curis, Inc. Biosynthetic binding protein for cancer marker
US5514379A (en) 1992-08-07 1996-05-07 The General Hospital Corporation Hydrogel compositions and methods of use
GB9216925D0 (en) 1992-08-10 1992-09-23 Royal Holloway Microspheres of polyhydroxylic materials
JP3107488B2 (en) 1993-09-29 2000-11-06 株式会社資生堂 Sustained-release preparation and embolic agent using cross-linked hyaluronic acid
US5658592A (en) 1994-05-13 1997-08-19 Kuraray Co., Ltd. Medical crosslinked polymer gel of carboxylic polysaccharide and diaminoalkane
US6063396A (en) 1994-10-26 2000-05-16 Houston Biotechnology Incorporated Methods and compositions for the modulation of cell proliferation and wound healing
US5789199A (en) 1994-11-03 1998-08-04 Genentech, Inc. Process for bacterial production of polypeptides
US5690961A (en) 1994-12-22 1997-11-25 Hercules Incorporated Acidic polysaccharides crosslinked with polycarboxylic acids and their uses
US5731168A (en) 1995-03-01 1998-03-24 Genentech, Inc. Method for making heteromultimeric polypeptides
US5840523A (en) 1995-03-01 1998-11-24 Genetech, Inc. Methods and compositions for secretion of heterologous polypeptides
US5869046A (en) 1995-04-14 1999-02-09 Genentech, Inc. Altered polypeptides with increased half-life
IT1281886B1 (en) 1995-05-22 1998-03-03 Fidia Advanced Biopolymers Srl PROCESS FOR THE PREPARATION OF HYDROGELS OBTAINED FROM CHEMICAL DERIVATIVES OF HYALURONIC ACID BY MEANS OF ULTRAVIOLET IRRADIATION AND THEIR
US5612321A (en) 1995-06-22 1997-03-18 Hercules Incorporated Antioxidant grafted polysaccharides
JP3130234B2 (en) 1995-09-29 2001-01-31 デンセイ・ラムダ株式会社 Inverter device
KR20040010739A (en) 1996-02-09 2004-01-31 암젠 인코포레이티드 Fusion protein comprising interleukin-1 receptor antagonist and pharmaceutical composition thereof
EP1011690A4 (en) 1997-07-03 2006-08-23 Depuy Spine Inc Cross-linked polysaccharide drug carrier
JPH1133104A (en) 1997-07-16 1999-02-09 Res Inst For Prod Dev Medical material with adhesiveness to organism tissue
US6040498A (en) 1998-08-11 2000-03-21 North Caroline State University Genetically engineered duckweed
ATE531812T1 (en) 1997-12-05 2011-11-15 Scripps Research Inst HUMANIZATION OF RODENT ANTIBODIES
US6624142B2 (en) 1997-12-30 2003-09-23 Enzon, Inc. Trimethyl lock based tetrapartate prodrugs
KR20010025040A (en) 1998-05-20 2001-03-26 나가야마 오사무 Remedies for joint diseases bound to hyaluronic acid
ITPD980169A1 (en) 1998-07-06 2000-01-06 Fidia Advanced Biopolymers Srl AMIDES OF HYALURONIC ACID AND ITS DERIVATIVES AND PROCESS FOR THEIR PREPARATION.
US6630457B1 (en) 1998-09-18 2003-10-07 Orthogene Llc Functionalized derivatives of hyaluronic acid, formation of hydrogels in situ using same, and methods for making and using same
JP2000119196A (en) 1998-10-07 2000-04-25 Menicon Co Ltd Sustained release drug for ophthalmology and its production
IT1303735B1 (en) 1998-11-11 2001-02-23 Falorni Italia Farmaceutici S CROSS-LINKED HYALURONIC ACIDS AND THEIR MEDICAL USES.
WO2000033764A1 (en) 1998-12-04 2000-06-15 Pathak Chandrashekhar P Biocompatible crosslinked polymers
US6472379B1 (en) 1999-03-15 2002-10-29 Trustees Of Boston University Angiogenesis inhibition
AU782626B2 (en) 1999-10-04 2005-08-18 Medicago Inc. Method for regulating transcription of foreign genes
US7125978B1 (en) 1999-10-04 2006-10-24 Medicago Inc. Promoter for regulating expression of foreign genes
CA2392419A1 (en) 1999-11-26 2001-06-07 The Regents Of The University Of Michigan Reversible cross-linked hydrogels
AU784983B2 (en) 1999-12-15 2006-08-17 Genentech Inc. Shotgun scanning, a combinatorial method for mapping functional protein epitopes
ES2528794T3 (en) 2000-04-11 2015-02-12 Genentech, Inc. Multivalent antibodies and uses thereof
JP2004505065A (en) 2000-07-31 2004-02-19 アイサイエンス　コーポレイション Medical microparticle biomaterial composition
IT1317358B1 (en) 2000-08-31 2003-06-16 Fidia Advanced Biopolymers Srl CROSS-LINKATED DERIVATIVES OF HYALURONIC ACID.
WO2002049501A2 (en) 2000-12-18 2002-06-27 Board Of Regents, University Of Texas System Local regional chemotherapy and radiotherapy using in situ hydrogel
DE60207831D1 (en) 2001-02-22 2006-01-12 Anika Therapeutics Inc THIOL-MODIFIED HYALURONAN DERIVATIVES
ITMI20011238A1 (en) 2001-06-12 2002-12-12 Bartholdy Consultadoria E Serv POLYSACCHARIDIC POLYMERS OF NATURAL ORIGIN CHEMICALLY CONJUGATED AS PHARMACOLOGICALLY OR BIOLOGICALLY ACTIVE SUBSTANCES AND THEIR PROPERTIES
ITPD20020064A1 (en) 2002-03-12 2003-09-12 Fidia Advanced Biopolymers Srl FOREIGN DERIVATIVES OF HYALURONIC ACID FOR THE PREPARATION OF HYDROGELD FOR USE IN THE BIOMEDICAL, SANITARY AND SURGICAL FIELD AND AS A SYSTEM
CA2479920A1 (en) 2002-03-29 2003-10-09 The Regents Of The University Of California Microgel particles for the delivery of bioactive materials
JPWO2003084571A1 (en) 2002-04-08 2005-08-11 電気化学工業株式会社 Composition for treating bone infection
EP2226316B1 (en) 2002-05-30 2016-01-13 The Scripps Research Institute Copper-catalysed ligation of azides and acetylenes
EP1513879B1 (en) 2002-06-03 2018-08-22 Genentech, Inc. Synthetic antibody phage libraries
KR100507545B1 (en) 2002-09-03 2005-08-09 주식회사 엘지생명과학 Hyaluronic acid derivatives and processes for preparing them
JP5156890B2 (en) 2002-09-11 2013-03-06 独立行政法人物質・材料研究機構 Crosslinked polymer and method for producing the same
WO2004046200A1 (en) 2002-11-21 2004-06-03 Chugai Seiyaku Kabushiki Kaisha Sustained release drug carrier
US7531191B2 (en) 2002-12-17 2009-05-12 Massachusetts Institute Of Technology Stimuli-responsive systems for controlled drug delivery
AU2004205631A1 (en) 2003-01-16 2004-08-05 Genentech, Inc. Synthetic antibody phage libraries
EP1631375B1 (en) 2003-01-17 2011-11-02 Cornell Research Foundation, Inc. Injectable hydrogel microspheres from aqueous two-phase system
US7332164B2 (en) 2003-03-21 2008-02-19 Enzon Pharmaceuticals, Inc. Heterobifunctional polymeric bioconjugates
CA2521784C (en) 2003-04-08 2012-03-27 Yeda Research And Development Co. Ltd. Reversible pegylated drugs
AU2003901834A0 (en) 2003-04-17 2003-05-01 Clearcoll Pty Ltd Cross-linked polysaccharide compositions
CA2523246C (en) 2003-04-25 2009-12-01 Kos Life Sciences, Inc. Formation of strong superporous hydrogels
JP2004323454A (en) 2003-04-25 2004-11-18 Chisso Corp Medicinal agent
WO2005044853A2 (en) * 2003-11-01 2005-05-19 Genentech, Inc. Anti-vegf antibodies
US7758859B2 (en) 2003-08-01 2010-07-20 Genentech, Inc. Anti-VEGF antibodies
US20050106667A1 (en) 2003-08-01 2005-05-19 Genentech, Inc Binding polypeptides with restricted diversity sequences
US8153591B2 (en) 2003-08-26 2012-04-10 Gel-Del Technologies, Inc. Protein biomaterials and biocoacervates and methods of making and using thereof
US7690003B2 (en) 2003-08-29 2010-03-30 Fuller Jeffrey C System and method for increasing data throughput using thread scheduling
US8124120B2 (en) 2003-12-22 2012-02-28 Anika Therapeutics, Inc. Crosslinked hyaluronic acid compositions for tissue augmentation
EP1576952A1 (en) 2004-03-18 2005-09-21 OctoPlus Technologies B.V. Hydrogel microspheres with improved release profile
AU2005232371B2 (en) 2004-03-23 2010-10-14 Complex Biosystems Gmbh Polymeric prodrug with a self-immolative linker
MXPA06011199A (en) 2004-03-31 2007-04-16 Genentech Inc Humanized anti-tgf-beta antibodies.
US7785903B2 (en) 2004-04-09 2010-08-31 Genentech, Inc. Variable domain library and uses
US8293890B2 (en) 2004-04-30 2012-10-23 Advanced Cardiovascular Systems, Inc. Hyaluronic acid based copolymers
US20050244472A1 (en) 2004-04-30 2005-11-03 Allergan, Inc. Intraocular drug delivery systems containing excipients with reduced toxicity and related methods
GB0411583D0 (en) 2004-05-24 2004-06-23 Univ Bath Process
US7968085B2 (en) 2004-07-05 2011-06-28 Ascendis Pharma A/S Hydrogel formulations
US7371738B2 (en) 2005-04-15 2008-05-13 University Of South Florida Method of transdermal drug delivery using hyaluronic acid nanoparticles
GB2427360A (en) 2005-06-22 2006-12-27 Complex Biosystems Gmbh Aliphatic prodrug linker
CN101217982B (en) 2005-07-06 2012-10-10 生化学工业株式会社 Drug-containing photocrosslinked hyaluronic acid derivative gel
US8679536B2 (en) 2005-08-24 2014-03-25 Actamax Surgical Materials, Llc Aldol-crosslinked polymeric hydrogel adhesives
EP1937701A4 (en) 2005-09-02 2009-09-16 Colbar Lifescience Ltd Cross-linked polysaccharide and protein matrices and methods for their preparation
JP2009508991A (en) 2005-09-15 2009-03-05 ユニバーシティ オブ ユタ リサーチ ファウンデーション Polymer composition and methods for making and using the same
WO2007035080A1 (en) 2005-09-21 2007-03-29 Universiteit Van Amsterdam Novel cross-linkers for obtaining structure information on molecule complexes
CN103120701B (en) 2005-10-12 2014-11-05 生化学工业株式会社 Application of gag including hydrophobic group in preparation of drug for preventing or treating epithelium
WO2007047997A2 (en) 2005-10-19 2007-04-26 Smartcells, Inc. Methods for reducing the mitogenicity of lectin compositions
ES2577292T3 (en) 2005-11-07 2016-07-14 Genentech, Inc. Binding polypeptides with diversified VH / VL hypervariable sequences and consensus
US20070237764A1 (en) 2005-12-02 2007-10-11 Genentech, Inc. Binding polypeptides with restricted diversity sequences
CA2633954A1 (en) 2005-12-14 2007-06-21 Anika Therapeutics, Inc. Meniscal implant of hyaluronic acid derivatives for treatment of meniscal defects
US7879818B2 (en) 2005-12-23 2011-02-01 Janos Borbely Hyaluronic acid-based cross-linked nanoparticles
US20070202186A1 (en) 2006-02-22 2007-08-30 Iscience Interventional Corporation Apparatus and formulations for suprachoroidal drug delivery
AU2007240613B2 (en) 2006-04-20 2013-11-28 University Of Utah Research Foundation Polymeric compositions and methods of making and using thereof
CA2651567A1 (en) 2006-05-09 2007-11-22 Genentech, Inc. Binding polypeptides with optimized scaffolds
EP2471816A1 (en) 2006-08-30 2012-07-04 Genentech, Inc. Multispecific antibodies
ITMI20061726A1 (en) 2006-09-11 2008-03-12 Fidia Farmaceutici CROSSLINKATI DERIVATIVES BASED ON HYALURONIC ACID RETICULATED VIA CLICK CHEMISTRY
CN101534643A (en) 2006-09-15 2009-09-16 安佐制药股份有限公司 Hindered ester-based biodegradable linkers for oligonucleotide delivery
US20080089923A1 (en) 2006-09-29 2008-04-17 Burkstrand Michael J Biodegradable ocular implants and methods for treating ocular conditions
EP1942117A1 (en) 2006-12-29 2008-07-09 Sigea S.R.L. Derivatives of acid polysaccharides
KR20080073419A (en) 2007-02-06 2008-08-11 주식회사 핸슨바이오텍 Microbead of hyaluronic acid derivatives for medical purpose and process for preparing the same
EP1992364A1 (en) 2007-05-16 2008-11-19 Biosuma S.r.l. Carboxylated polysaccharides phosphated or bisphosphonated derivatives, optionally cross-linked, and their preparation and biomedical uses
CN100592373C (en) 2007-05-25 2010-02-24 群康科技(深圳)有限公司 Liquid crystal panel drive device and its drive method
CA2693616A1 (en) 2007-07-11 2009-01-15 Enzon Pharmaceuticals, Inc. Polymeric drug delivery system containing a multi-substituted aromatic moiety
US8318695B2 (en) 2007-07-30 2012-11-27 Allergan, Inc. Tunably crosslinked polysaccharide compositions
EP2090592A1 (en) 2007-07-31 2009-08-19 OctoPlus Sciences B.V. Biodegradable hydrogels based on click chemistry
KR101062320B1 (en) 2007-08-01 2011-09-05 포항공과대학교 산학협력단 Method for preparing crosslinkable hyaluronic acid derivative and crosslinked product of hyaluronic acid derivative thereof
MX2010001629A (en) 2007-08-10 2010-08-09 Alessandro Sannino Polymer hydrogels and methods of preparation thereof.
WO2009048280A2 (en) 2007-10-09 2009-04-16 Postech Academy-Industry Foundation Long acting hyaluronic acid - peptide conjugate
US9522218B2 (en) 2007-10-11 2016-12-20 INSERM (Institut National de la Santé et de la Recherche Médicale) Method for preparing porous scaffold for tissue engineering, cell culture and cell delivery
WO2009047347A1 (en) 2007-10-11 2009-04-16 Inserm (Institut National De Sante Et De La Recherche Medicale) Method for preparing porous scaffold for tissue engineering
US8394782B2 (en) 2007-11-30 2013-03-12 Allergan, Inc. Polysaccharide gel formulation having increased longevity
US20090143348A1 (en) 2007-11-30 2009-06-04 Ahmet Tezel Polysaccharide gel compositions and methods for sustained delivery of drugs
EP2222715B1 (en) 2007-12-19 2019-07-24 Evonik Degussa GmbH Crosslinked hyaluronic acid in emulsion
EP2219679A1 (en) 2007-12-21 2010-08-25 Encecor AB Cross-linked hydrogel containing an active substance
PT2235064E (en) 2008-01-07 2016-03-01 Amgen Inc Method for making antibody fc-heterodimeric molecules using electrostatic steering effects
MX2010008024A (en) 2008-02-01 2010-12-21 Ascendis Pharma As Prodrug comprising a self-cleavable linker.
IE20080211A1 (en) 2008-03-20 2009-11-25 Nat Univ Ireland Biodegradable nanoshells for delivery of therapeutic and/or imaging molecules
CN101538377A (en) 2008-03-20 2009-09-23 上海昊海生物科技有限公司 Cross-linked hyaluronic acid gel and preparation method thereof
AU2009228217A1 (en) 2008-03-28 2009-10-01 The Regents Of The University Of California Polypeptide-polymer conjugates and methods of use thereof
JP2011520983A (en) 2008-05-23 2011-07-21 エンゾン ファーマシューティカルズ，インコーポレーテッド Polymer systems containing intracellular releasable disulfide linkers for oligonucleotide delivery
US8821870B2 (en) 2008-07-18 2014-09-02 Allergan, Inc. Method for treating atrophic age related macular degeneration
US8357795B2 (en) 2008-08-04 2013-01-22 Allergan, Inc. Hyaluronic acid-based gels including lidocaine
GB0816496D0 (en) 2008-09-10 2008-10-15 Zhao Xiaobin Hyaluronic acid cryogel
CN101721349B (en) 2008-10-16 2011-07-20 常州百瑞吉生物医药有限公司 Injectable in-situ crosslinking aquogel and preparation method and application thereof
US20100098772A1 (en) * 2008-10-21 2010-04-22 Allergan, Inc. Drug delivery systems and methods for treating neovascularization
ITRM20080636A1 (en) 2008-11-28 2010-05-29 Univ Palermo PROCEDURE FOR THE PRODUCTION OF FUNCTIONAL DERIVATIVES OF HYALURONIC ACID AND RELATIVE HYDROGELS.
US8133979B2 (en) 2008-12-16 2012-03-13 Hoffmann-La Roche Inc. Antibodies against human angiopoietin 2
US11090387B2 (en) 2008-12-22 2021-08-17 The Trustees Of The University Of Pennsylvania Hydrolytically degradable polysaccharide hydrogels
FR2945949B1 (en) 2009-05-26 2011-05-13 Anteis Sa HYDROGEL INJECTION FOR GLYCEROL SUPPLEMENTATION IN SKIN OVER LONG TERM.
KR20140014405A (en) * 2009-05-28 2014-02-06 글락소 그룹 리미티드 Combination of a tnf-alpha antagonist and a vegf antagonist for use in the treatment or prevention of diseases of the eye
WO2010138074A1 (en) 2009-05-29 2010-12-02 Hilborn Joens Hyaluronic acid based delivery systems
IT1399351B1 (en) 2009-06-16 2013-04-16 Fidia Farmaceutici PROCEDURE FOR THE SYNTHESIS OF GLYCOSAMINOGLICAN CONJUGATES (GAG) WITH BIOLOGICALLY ACTIVE MOLECULES, POLYMERIC CONJUGATES AND RELATIVE USES
KR101091028B1 (en) 2009-07-02 2011-12-09 아주대학교산학협력단 In situ forming hydrogel and biomedical use thereof
EP2448604B1 (en) 2009-07-02 2016-03-23 Actamax Surgical Materials LLC Hydrogel tissue adhesive for medical use
WO2011012722A1 (en) 2009-07-31 2011-02-03 Ascendis Pharma As Prodrugs containing an aromatic amine connected by an amido bond to a linker
LT2459220T (en) 2009-07-31 2020-12-28 Ascendis Pharma A/S Biodegradable polyethylene glycol based water-insoluble hydrogels
WO2011019323A1 (en) 2009-08-11 2011-02-17 Agency For Science Technology And Research Particulate hyaluronic acid formulations for cellular delivery of bioactive agents
JO3008B1 (en) 2009-08-13 2016-09-05 Seikagaku Kogyo Co Ltd Pharmaceutical Composition For Relieving Pain
KR101103423B1 (en) 2009-09-04 2012-01-06 아주대학교산학협력단 In situ forming hydrogel for tissue adhesives and biomedical use thereof
US20120282211A1 (en) * 2009-11-24 2012-11-08 Carnegie Mellon University Antibodies and conjugates for modulators of angiogenesis
CA2782863A1 (en) 2009-12-22 2011-06-30 Lifebond Ltd Modification of enzymatic crosslinkers for controlling properties of crosslinked matrices
CN102724967A (en) 2009-12-31 2012-10-10 安龙制药公司 Polymeric conjugates of aromatic amine containing compounds including releasable urea linker
WO2011089216A1 (en) 2010-01-22 2011-07-28 Ascendis Pharma As Dipeptide-based prodrug linkers for aliphatic amine-containing drugs
US9561285B2 (en) 2010-01-22 2017-02-07 Ascendis Pharma As Carrier-linked carbamate prodrug linkers
WO2011089215A1 (en) 2010-01-22 2011-07-28 Ascendis Pharma As Dipeptide-based prodrug linkers for aromatic amine-containing drugs
WO2011109129A1 (en) 2010-03-01 2011-09-09 Tautona Group Lp Threads of cross-linked hyaluronic acid and methods of use thereof
JP2013523752A (en) 2010-03-29 2013-06-17 エボニック デグサ コーポレイション Compositions and methods for improving retention of pharmaceutical compositions at the site of topical administration
CN103153927B (en) 2010-04-27 2017-02-15 西纳福克斯股份有限公司 Fused cyclooctyne compounds and their use in metal-free click reactions
CN103025165B (en) 2010-05-05 2016-06-08 普罗林科斯有限责任公司 From the controlled release of macromolecular conjugates
CN103025164B (en) 2010-05-05 2017-03-08 普罗林科斯有限责任公司 The control release of medicine from solid support
WO2011148116A2 (en) 2010-05-27 2011-12-01 Laboratoire Idenov Modified hyaluronic acid, method for manufacturing same and uses thereof
WO2011163069A2 (en) 2010-06-21 2011-12-29 The Trustees Of The University Of Pennsylvania Protease triggered release of molecules from hydrogels
DK2585586T3 (en) 2010-06-22 2017-07-03 Univ Rouen IMPROVED cross-linked HYALURONIC ACID HYDROGLES FOR 3D CELL CULTURE
IT1401498B1 (en) 2010-07-30 2013-07-26 Mero Srl HYDROGEL BASED ON HYALURONIC ACID AND ITS USE IN ORTHOPEDICS
US20130274222A1 (en) 2010-10-20 2013-10-17 Tautona Group Lp Threads of cross-linked hyaluronic acid and methods of preparation and use thereof
FR2967677B1 (en) 2010-11-18 2014-05-16 Centre Nat Rech Scient POLYSACCHARIDE DERIVATIVES COMPRISING ALKENOUS PATTERN AND THIO-CLICK CHEMICAL COUPLING REACTION
US20140038826A1 (en) 2011-01-28 2014-02-06 The Regents Of The University Of Colorado, A Body Corporate Covalently cross linked hydrogels and methods of making and using same
WO2012118189A1 (en) 2011-03-03 2012-09-07 中外製薬株式会社 Hyaluronic acid derivative modified by amino-carbonic acid
CZ304072B6 (en) 2011-04-26 2013-09-25 Contipro Biotech S.R.O. Amphoteric material based on crosslinked hyaluronic acid, process for its preparation, materials containing active agents enclosed in hyaluronate network, process for their preparation and their use
ES2878089T3 (en) 2011-04-28 2021-11-18 Harvard College Injectable preformed macroscopic three-dimensional scaffolds for minimally invasive administration
EP2716662A4 (en) 2011-05-31 2014-11-19 Univ Tokyo Hydrogel and method for producing same
CA2838237C (en) 2011-06-03 2020-05-26 Allergan, Inc. Dermal filler compositions including antioxidants
CN102226009B (en) 2011-06-09 2013-04-10 西安力邦制药有限公司 Method for preparing crosslinking hyaluronic acid gel
US9592251B2 (en) 2011-06-16 2017-03-14 The Hong Kong University Of Science And Technology Multi-vinylsulfone containing molecule
CA2843506C (en) 2011-08-12 2020-05-12 Ascendis Pharma A/S Carrier-linked prodrugs having reversible carboxylic ester linkages
US9044515B2 (en) 2011-09-06 2015-06-02 University Of Delaware Chemical conjugates for targeted degradation under reducing conditions
WO2013036847A1 (en) 2011-09-07 2013-03-14 Prolynx Llc Hydrogels with biodegradable crosslinking
WO2013036857A1 (en) 2011-09-07 2013-03-14 Prolynx Llc Sulfone linkers
US20130066063A1 (en) 2011-09-09 2013-03-14 John Cooke Hodges Bicyclo[6.1.0]non-4-yne regents for chemical modification of oligonucleotides
WO2013055832A1 (en) 2011-10-11 2013-04-18 Tautona Group Lp Threads of cross-linked hyaluronic acid and methods of use thereof
MY171920A (en) 2011-10-12 2019-11-07 Ascendis Pharma Ophthalmology Div A/S Prevention and treatment of ocular conditions
CN103917256A (en) 2011-11-11 2014-07-09 米巴医疗股份有限公司 Injectable filler
US20140107025A1 (en) 2012-04-16 2014-04-17 Jade Therapeutics, Llc Ocular drug delivery system
US20150087688A1 (en) 2012-04-25 2015-03-26 Ascendis Pharma A/S Prodrugs of hydroxyl-comprising drugs
KR101374271B1 (en) 2012-05-02 2014-03-14 주식회사 제네웰 Crosslinked hyaluronic acid epoxide and manufacturing method thereof
WO2013171485A1 (en) 2012-05-18 2013-11-21 Medical Research Council Methods of incorporating an amino acid comprising a bcn group into a polypeptide using an orthogonal codon encoding it and an orthorgonal pylrs synthase.
HUE056217T2 (en) 2012-07-13 2022-02-28 Roche Glycart Ag Bispecific anti-vegf/anti-ang-2 antibodies and their use in the treatment of ocular vascular diseases
CZ304512B6 (en) 2012-08-08 2014-06-11 Contipro Biotech S.R.O. Hyaluronic acid derivative, process for its preparation, modification process and use thereof
US9827321B2 (en) 2012-08-14 2017-11-28 The Trustees Of The University Of Pennsylvania Stabilizing shear-thinning hydrogels
KR101445265B1 (en) 2012-09-18 2014-09-30 포항공과대학교 산학협력단 Hyaluronic acid-nucleic acid conjugate and composition for nucleic acid delivery containing the same
US9644076B2 (en) 2012-09-25 2017-05-09 Max-Planck-Gesellschaft zur Foerderung der Wissenschafen e. V. Cross-linkers for hydrogels, hydrogels including these cross-linkers and applications thereof
JP2015533132A (en) 2012-10-11 2015-11-19 アセンディス ファーマ オフサルモロジー ディヴィジョン エー／エス VEGF neutralizing prodrug for the treatment of ocular conditions
CN102942699B (en) 2012-10-26 2014-07-02 暨南大学 Self-reinforced bi-crosslinking hyaluronic acid hydrogel and preparation method thereof
CN102911380B (en) 2012-10-29 2015-03-18 北京爱美客生物科技有限公司 Hyaluronan and biodegradable high polymer modified material and preparation method
WO2014169301A1 (en) 2013-04-12 2014-10-16 Bui The Duy Systems and methods for delivering cross-linked halyuronic acid into a patient
EP2727597A1 (en) 2012-11-06 2014-05-07 Centre National de la Recherche Scientifique (CNRS) Glucose responsive hydrogel comprising pba-grafted hyaluronic acid (ha)
ITPD20120360A1 (en) 2012-11-30 2014-05-31 Fidia Farmaceutici "NEW VISCOELASTIC GELES IN OPHTHALMIC SURGERY"
WO2014099997A1 (en) 2012-12-18 2014-06-26 Novartis Ag Compositions and methods that utilize a peptide tag that binds to hyaluronan
WO2014096257A1 (en) 2012-12-19 2014-06-26 Novozymes Biopharma Dk A/S Freeze-dried cross-linked hyaluronic acid sponge
US9498539B2 (en) 2012-12-27 2016-11-22 Molly Sandra Shoichet Affinity-based controlled release system
JP6533932B2 (en) 2012-12-28 2019-06-26 アボット カーディオバスキュラー システムズ インコーポレイテッド Therapeutic composition comprising an antibody
US10494453B2 (en) 2013-02-20 2019-12-03 The University Of Queensland Conjugate compound and uses of same
US9644040B2 (en) 2013-03-14 2017-05-09 Anacoti Ltd. Hyaluronic acid derivatives
JP6411454B2 (en) 2013-03-27 2018-10-24 センター ホスピタリアー ユニヴェルシテール ヴァルド（シー．エイチ．ユー．ヴィ） Pharmaceutical preparations used for the treatment and / or prevention of restenosis
KR102049568B1 (en) 2013-04-01 2019-11-27 삼성전자주식회사 Composition for nucleic acid delivery containing hyaluronic acid
US9744260B2 (en) 2013-04-12 2017-08-29 Phi Nguyen Timing controlled in-situ cross-linking of halyuronic acid during injection
US20150190517A1 (en) 2013-04-12 2015-07-09 Miba Medical Inc. Systems and methods for delivering cross-linked halyuronic acid into a patient
WO2014169299A1 (en) 2013-04-12 2014-10-16 Bui The Duy Temperature-release catalyst for cross-linking halyuronic acid during injection
EP2988783A1 (en) * 2013-04-22 2016-03-02 Ascendis Pharma A/S Hydrogel-linked prodrugs releasing modified drugs
WO2014172784A1 (en) 2013-04-25 2014-10-30 Aluron Biopharma Inc. Crosslinked hyaluronic acid compositions
US10137199B2 (en) 2013-05-14 2018-11-27 Biotime, Inc. Thiolated hyaluronan-based hydrogels cross-linked using oxidized glutathione
WO2014198406A1 (en) 2013-06-11 2014-12-18 Anteis S.A. Method for crosslinking hyaluronic acid; method for preparing an injectable hydrogel; hydrogel obtained; use of the obtained hydrogel
CA2914765A1 (en) 2013-06-14 2014-12-18 Galderma S.A. Compositions comprising cross-linked hyaluronic acid and cyclodextrin
WO2014206500A1 (en) 2013-06-28 2014-12-31 Galderma S.A. Method for manufacturing a shaped cross-linked hyaluronic acid product
WO2015001087A2 (en) 2013-07-05 2015-01-08 Therakine Biodelivery Gmbh Drug-delivery composition for topical applications and injections and ophtalmic formulations, method for manufacturing thereof, and methods for delivery a drug-delivery composition
US10738134B2 (en) 2013-09-27 2020-08-11 Virginia Tech Intellectual Properties, Inc. Cross-metathesized polysaccharide derivatives and processes for preparing them
WO2015053281A1 (en) 2013-10-08 2015-04-16 キユーピー株式会社 Crosslinked product of carboxymethyl-group-containing modified hyaluronic acid and/or salt thereof, and method for producing same
JPWO2015053282A1 (en) 2013-10-08 2017-03-09 キユーピー株式会社 Carboxymethyl group-containing modified hyaluronic acid and / or a salt thereof and a method for producing the same
CA2925190C (en) 2013-10-08 2021-10-12 Ascendis Pharma A/S Protecting group comprising a purification tag
US9782345B2 (en) 2013-10-17 2017-10-10 Jade Therapeutics, Inc. Ocular composition and method
KR101459070B1 (en) 2013-12-09 2014-11-17 (주) 뉴메딕 Long lasting crosslinked polysaccharide gel formulation
AU2015209264A1 (en) * 2014-01-23 2016-08-04 Akebia Therapeutics, Inc. Compositions and methods for treating ocular diseases
WO2016020373A1 (en) 2014-08-06 2016-02-11 Ascendis Pharma A/S Prodrugs comprising an aminoalkyl glycine linker
WO2016073157A1 (en) 2014-11-06 2016-05-12 Genentech, Inc. Anti-ang2 antibodies and methods of use thereof
ES2756275T3 (en) 2014-11-07 2020-04-27 Sesen Bio Inc Enhanced anti-IL-6 antibodies
KR20180014042A (en) 2015-05-29 2018-02-07 알바트로스 테크놀로지스 리미티드 Cross-linked hyaluronic acid for delivering drugs and pharmaceutical preparations using the same
US11298427B2 (en) 2015-05-29 2022-04-12 Ascendis Pharma A/S Prodrugs comprising a pyroglutamate linker
AR105319A1 (en) 2015-06-05 2017-09-27 Sanofi Sa PROPHARMS THAT INCLUDE A DUAL AGONIST GLU-1 / GLUCAGON CONJUGATE HIALURONIC ACID CONNECTOR
WO2017053807A2 (en) 2015-09-23 2017-03-30 Genentech, Inc. Optimized variants of anti-vegf antibodies
CN113546178A (en) 2015-12-09 2021-10-26 加利福尼亚大学董事会 Methods of treating ocular diseases or disorders
AR110299A1 (en) 2016-12-02 2019-03-13 Sanofi Sa CONJUGATES UNDERSTANDING A DUAL GLP-1 / GLUCAGON AGONIST, A CONNECTOR AND Hyaluronic Acid

Also Published As

Publication number Publication date
AU2018240375A1 (en) 2019-09-26
CA3055985A1 (en) 2018-09-27
BR112019019658A2 (en) 2020-04-22
AU2018240375A2 (en) 2020-03-05
JP7216006B2 (en) 2023-01-31
US20230414770A1 (en) 2023-12-28
AU2018240375C1 (en) 2024-02-01
JP2023058511A (en) 2023-04-25
IL269506A (en) 2019-11-28
TW201842936A (en) 2018-12-16
IL269506B1 (en) 2023-12-01
AU2018240375B2 (en) 2023-08-03
CN110891611B (en) 2024-03-29
KR20200007776A (en) 2020-01-22
AR111190A1 (en) 2019-06-12
RU2019133326A3 (en) 2021-10-19
US11642415B2 (en) 2023-05-09
ZA201905930B (en) 2024-01-31
CN110891611A (en) 2020-03-17
EP3600441A1 (en) 2020-02-05
JP2020515545A (en) 2020-05-28
US20200222547A1 (en) 2020-07-16
IL269506B2 (en) 2024-04-01
WO2018175788A1 (en) 2018-09-27
RU2019133326A (en) 2021-04-22
MA49265A (en) 2020-02-05
SG10202107829YA (en) 2021-08-30

Similar Documents

Publication Publication Date Title
SG11201908547VA (en) Hydrogel cross-linked hyaluronic acid prodrug compositions and methods
SG11201906297QA (en) Nucleic acids encoding crispr-associated proteins and uses thereof
SG11201900910TA (en) RNAi AGENTS FOR HEPATITIS B VIRUS INFECTION
SG11201809912UA (en) Hybrid carriers for nucleic acid cargo
SG11201811432WA (en) Rna for cancer therapy
SG11201810834WA (en) Hepatitis b antiviral agents
SG11201808214TA (en) Pyrazolopyrimidine derivatives
SG11201907034PA (en) Methods of treating influenza
SG11201806700RA (en) Haloallylamine indole and azaindole derivative inhibitors of lysyl oxidases and uses thereof
SG11201900349VA (en) Somatostatin modulators and uses thereof
SG11201907604UA (en) Crystalline forms of the 4-pyrimidinesulfamide derivative aprocitentan
SG11202000266VA (en) Quinoline derivatives for treating infections with helminths
SG11201908650PA (en) Optimized antibody compositions for treatment of ocular disorders
SG11201908512YA (en) Somatostatin modulators and uses thereof
SG11201804263PA (en) Cancer treatment using 2-deoxy-2-fluoro-l-fucose in combination with a checkpoint inhibitor
SG11201906959RA (en) Aryl hydrocarbon receptor (ahr) modulator compounds
SG11201804395PA (en) Pharmaceutical compositions comprising levodopa amide and uses thereof
SG11201906958TA (en) Aryl hydrocarbon receptor (ahr) modulator compounds
SG11201901534VA (en) Combination therapy with controlled-release cnp agonists
SG11201807977XA (en) Cancer therapy with an oncolytic virus combined with a checkpoint inhibitor
SG11201903312VA (en) Sulfoxyalkyl organonitro and related compounds and pharmaceutical compositions for use in medicine
SG11201906436VA (en) Novel heterocyclic compound, its preparation method, and pharmaceutical composition comprising the same
SG11201907196YA (en) Composition and methods for preventing radiation injury and promoting tissue regeneration
SG11201900021PA (en) Methods and compositions for the treatment of cancer
SG11201900238UA (en) Compounds and methods for modulation of smn2