SG11201901525XA - Muscarinic m1 receptor positive allosteric modulators - Google Patents
Muscarinic m1 receptor positive allosteric modulatorsInfo
- Publication number
- SG11201901525XA SG11201901525XA SG11201901525XA SG11201901525XA SG11201901525XA SG 11201901525X A SG11201901525X A SG 11201901525XA SG 11201901525X A SG11201901525X A SG 11201901525XA SG 11201901525X A SG11201901525X A SG 11201901525XA SG 11201901525X A SG11201901525X A SG 11201901525XA
- Authority
- SG
- Singapore
- Prior art keywords
- road
- hyderabad
- serene
- chambers
- life sciences
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/325—Carbamic acids; Thiocarbamic acids; Anhydrides or salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/056—Ortho-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Abstract
International Patent Classification: CO7D 471/04 (2006.01) A61K 31/4375 (2006.01) A61K 31/436 (2006.01) C07D 491/04 (2006.01) A61K 31/4353 (2006.01) C07D 498/04 (2006.01) A61K 31/437 (2006.01) A61P 25/00 (2006.01) (21) International Application Number: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) REVISED VERSION (19) World Intellectual Property Organization International Bureau (43) International Publication Date 08 March 2018 (08.03.2018) WIPO I PCT 11111111111101101010111110111101011 110E 0111001110101E0M1110# (10) International Publication Number WO 2018/042362 A9 PCT/IB2017/055238 (22) International Filing Date: 31 August 2017 (31.08.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 201641030062 02 September 2016 (02.09.2016) IN 201741013343 13 April 2017 (13.04.2017) IN (71) Applicant: SUVEN LIFE SCIENCES LIMITED [IN/IN]; Serene Chambers, Road - 5, Avenue — 7, Banjara Hills, Hyderabad,Telangana 500 034 (IN). (72) Inventors: NIROGI, Ramakrishna; Suven Life Sciences Limited, Serene Chambers, Road-5, Avenue — 7, Banjara Hills, Hyderabad,Telangana 500034 (IN). SHINDE, Anil Karbhari; Suven Life Sciences Limited, Serene Chambers, Road-5, Avenue — 7, Banjara Hills, Hyderabad,Telangana 500034 (IN). MOHAMMED, Abdul Rasheed; Suven Life Sciences Limited, Serene Chambers, Road-5, Av- enue — 7, Banjara Hills, Hyderabad,Telangana 500034 (IN). BADANGE, Rajesh Kumar; Suven Life Sciences Limited, Serene Chambers, Road-5, Avenue — 7, Banjara Hills, Hyderabad,Telangana 500034 (IN). JAYARAJAN, Pradeep; Suven Life Sciences Limited, Serene Chambers, Road-5, Avenue — 7, Banjara Hills, Hyderabad, Telan- gana 500034 (IN). BHYRAPUNENI, Gopinadh; Suven Life Sciences Limited, Serene Chambers, Road-5, Av- enue — 7, Banjara Hills, Hyderabad,Telangana 500034 (IN). JASTI, Venkateswarlu; Suven Life Sciences Limit- ed, Serene Chambers, Road-5, Avenue — 7, Banjara Hills, Hyderabad,Telangana 500034 (IN). (74) Agent: KAPOOR, Divya et al.; Central Square, Suite-328, Plaza III, 20 Manoharlal Khurana Marg, Bara Hindu Rao (off Rani Jhansi Road), Delhi 110006 (IN). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: — as to applicant's entitlement to apply for and be granted a patent (Rule 4.1700) Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) (88) Date of publication of the revised international search report: 03 May 2018 (03.05.2018) (54) Title: MUSCARINIC Ml RECEPTOR POSITIVE ALLOSTERIC MODULATORS W O 20 18/04236 2 A9 (I) (57) : The present invention relates to compounds of formu- la (I), or their isotopic forms, stereoisomers, tautomers or pharmaceu- tically acceptable salt (s) thereof as muscarinic Ml receptor positive allosteric modulators (M1 PAMs). The present invention describes the preparation, pharmaceutical composition and the use of compound for- mula (I). [Continued on next page] WO 2018/042362 A9 MIDEDIMOM0101011MOIER1001111111111111111101111111011111110B10# (15) Information about Correction: see Notice of 03 May 2018 (03.05.2018)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN201641030062 | 2016-09-02 | ||
IN201741013343 | 2017-04-13 | ||
PCT/IB2017/055238 WO2018042362A1 (en) | 2016-09-02 | 2017-08-31 | Muscarinic m1 receptor positive allosteric modulators |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201901525XA true SG11201901525XA (en) | 2019-03-28 |
Family
ID=59982423
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201901525XA SG11201901525XA (en) | 2016-09-02 | 2017-08-31 | Muscarinic m1 receptor positive allosteric modulators |
Country Status (23)
Country | Link |
---|---|
US (1) | US11040026B2 (en) |
EP (1) | EP3507289B1 (en) |
JP (1) | JP6629486B2 (en) |
KR (1) | KR102017786B1 (en) |
CN (1) | CN109952302B (en) |
AU (1) | AU2017319609B2 (en) |
BR (1) | BR112019003932A2 (en) |
CA (1) | CA3034775C (en) |
CY (1) | CY1123479T1 (en) |
ES (1) | ES2824495T3 (en) |
HR (1) | HRP20201539T1 (en) |
HU (1) | HUE053586T2 (en) |
IL (1) | IL264951B (en) |
LT (1) | LT3507289T (en) |
MA (1) | MA46101B1 (en) |
MD (1) | MD3507289T2 (en) |
MX (1) | MX2019002180A (en) |
PL (1) | PL3507289T3 (en) |
PT (1) | PT3507289T (en) |
RS (1) | RS60875B1 (en) |
SG (1) | SG11201901525XA (en) |
SI (1) | SI3507289T1 (en) |
WO (1) | WO2018042362A1 (en) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA3014791A1 (en) | 2016-02-16 | 2017-08-24 | Vanderbilt University | Positive allosteric modulators of the muscarinic acetylcholine receptor m1 |
US10899759B2 (en) | 2016-09-30 | 2021-01-26 | Vanderbilt University | Positive allosteric modulators of the muscarinic acetylcholine receptor M1 |
AU2018289939B2 (en) * | 2017-06-20 | 2022-06-16 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
US11236099B2 (en) | 2017-06-20 | 2022-02-01 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
CA3078164C (en) * | 2017-10-27 | 2022-11-15 | Suven Life Sciences Limited | Polycyclic amides as muscarinic m1 receptor positive allosteric modulators |
IL277071B1 (en) | 2018-03-08 | 2024-03-01 | Incyte Corp | AMINOPYRAZINE DIOL COMPOUNDS AS PI3K-y INHIBITORS |
US11046658B2 (en) | 2018-07-02 | 2021-06-29 | Incyte Corporation | Aminopyrazine derivatives as PI3K-γ inhibitors |
CN112752760B (en) * | 2018-09-28 | 2024-01-19 | 武田药品工业株式会社 | Heterocyclic compounds |
US11970483B2 (en) | 2018-09-28 | 2024-04-30 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
WO2020067457A1 (en) | 2018-09-28 | 2020-04-02 | 武田薬品工業株式会社 | Condensed-cyclic compound |
MA53917A (en) * | 2018-10-17 | 2022-01-26 | Suven Life Sciences Ltd | PYRROLO-PYRIDAZINE DERIVATIVES AS POSITIVE ALLOSTERIC MODULATORS OF THE M1 MUSCARINIC RECEPTOR |
US20240083907A1 (en) | 2019-10-04 | 2024-03-14 | Vanderbilt University | Antagonists of the muscarinic acetylcholine receptor m4 |
WO2023114224A1 (en) | 2021-12-13 | 2023-06-22 | Sage Therapeutics, Inc. | Combination of muscarinic receptor positive modulators and nmda positive allosteric modulators |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20090298820A1 (en) | 2008-05-28 | 2009-12-03 | Wyeth | 3-substituted-1h-pyrrolo[2,3-b]pyridine and 3-substituted-1h-pyrrolo[3,2-b]pyridine compounds, their use as mtor kinase and pi3 kinase inhibitors, and their syntheses |
DK2512243T3 (en) * | 2009-12-17 | 2016-07-25 | Merck Sharp & Dohme | POSITIVE ALLOSTERIC QUINOLINAMIDE M1 RECEPTOR MODULATORS |
EP2575454B1 (en) | 2010-05-28 | 2018-08-29 | Merck Sharp & Dohme Corp. | Naphthalene carboxamide m1 receptor positive allosteric modulators |
EP2582676B1 (en) * | 2010-06-15 | 2016-12-14 | Merck Sharp & Dohme Corp. | Tetrahydroquinoline amide m1 receptor positive allosteric modulators |
EP2709621B1 (en) * | 2011-05-17 | 2016-11-02 | Merck Sharp & Dohme Corp. | N-linked quinolineamide m1 receptor positive allosteric modulators |
AR088082A1 (en) | 2011-10-13 | 2014-05-07 | Lilly Co Eli | ANDROGEN RECEIVER SELECTIVE MODULATORS |
TW201512197A (en) * | 2013-08-30 | 2015-04-01 | Hoffmann La Roche | Pyrrolopyridine or pyrazolopyridine derivatives |
KR20160098500A (en) * | 2014-01-22 | 2016-08-18 | 에프. 호프만-라 로슈 아게 | Fluoro-naphthyl derivatives |
WO2015190564A1 (en) * | 2014-06-13 | 2015-12-17 | 武田薬品工業株式会社 | Nitrogen-containing heterocyclic compound |
WO2016009297A1 (en) * | 2014-07-18 | 2016-01-21 | Pfizer Inc. | Pyridine derivatives as muscarinic m1 receptor positive allosteric modulators |
WO2016029454A1 (en) * | 2014-08-29 | 2016-03-03 | Merck Sharp & Dohme Corp. | TETRAHYDRONAPHTHYRIDINE DERIVATIVES AS mGluR2-NEGATIVE ALLOSTERIC MODULATORS, COMPOSITIONS, AND THEIR USE |
CA3014791A1 (en) * | 2016-02-16 | 2017-08-24 | Vanderbilt University | Positive allosteric modulators of the muscarinic acetylcholine receptor m1 |
-
2017
- 2017-08-31 KR KR1020197008723A patent/KR102017786B1/en active IP Right Grant
- 2017-08-31 SG SG11201901525XA patent/SG11201901525XA/en unknown
- 2017-08-31 PL PL17777380T patent/PL3507289T3/en unknown
- 2017-08-31 MX MX2019002180A patent/MX2019002180A/en unknown
- 2017-08-31 EP EP17777380.1A patent/EP3507289B1/en active Active
- 2017-08-31 MA MA46101A patent/MA46101B1/en unknown
- 2017-08-31 LT LTEP17777380.1T patent/LT3507289T/en unknown
- 2017-08-31 PT PT177773801T patent/PT3507289T/en unknown
- 2017-08-31 CA CA3034775A patent/CA3034775C/en active Active
- 2017-08-31 BR BR112019003932-5A patent/BR112019003932A2/en active Search and Examination
- 2017-08-31 CN CN201780063068.6A patent/CN109952302B/en active Active
- 2017-08-31 WO PCT/IB2017/055238 patent/WO2018042362A1/en active Search and Examination
- 2017-08-31 MD MDE20190759T patent/MD3507289T2/en unknown
- 2017-08-31 RS RS20201170A patent/RS60875B1/en unknown
- 2017-08-31 AU AU2017319609A patent/AU2017319609B2/en active Active
- 2017-08-31 HU HUE17777380A patent/HUE053586T2/en unknown
- 2017-08-31 ES ES17777380T patent/ES2824495T3/en active Active
- 2017-08-31 JP JP2019510925A patent/JP6629486B2/en active Active
- 2017-08-31 US US16/327,742 patent/US11040026B2/en active Active
- 2017-08-31 SI SI201730419T patent/SI3507289T1/en unknown
-
2019
- 2019-02-21 IL IL264951A patent/IL264951B/en unknown
-
2020
- 2020-09-28 HR HRP20201539TT patent/HRP20201539T1/en unknown
- 2020-10-08 CY CY20201100944T patent/CY1123479T1/en unknown
Also Published As
Publication number | Publication date |
---|---|
KR20190038666A (en) | 2019-04-08 |
MA46101B1 (en) | 2020-10-28 |
EP3507289A1 (en) | 2019-07-10 |
PL3507289T3 (en) | 2021-01-25 |
WO2018042362A1 (en) | 2018-03-08 |
MD3507289T2 (en) | 2020-11-30 |
NZ751569A (en) | 2020-11-27 |
PT3507289T (en) | 2020-10-01 |
HUE053586T2 (en) | 2021-07-28 |
ES2824495T3 (en) | 2021-05-12 |
LT3507289T (en) | 2020-10-12 |
US11040026B2 (en) | 2021-06-22 |
HRP20201539T1 (en) | 2021-02-05 |
KR102017786B1 (en) | 2019-09-03 |
US20190343812A1 (en) | 2019-11-14 |
RS60875B1 (en) | 2020-11-30 |
SI3507289T1 (en) | 2020-11-30 |
EP3507289B1 (en) | 2020-07-15 |
CY1123479T1 (en) | 2022-03-24 |
WO2018042362A9 (en) | 2018-05-03 |
AU2017319609A1 (en) | 2019-03-14 |
AU2017319609B2 (en) | 2019-11-14 |
IL264951B (en) | 2021-09-30 |
CA3034775C (en) | 2020-07-14 |
MA46101A (en) | 2019-07-10 |
MX2019002180A (en) | 2019-08-16 |
JP6629486B2 (en) | 2020-01-15 |
JP2019526566A (en) | 2019-09-19 |
BR112019003932A2 (en) | 2019-05-21 |
CN109952302A (en) | 2019-06-28 |
CA3034775A1 (en) | 2018-03-08 |
CN109952302B (en) | 2020-11-24 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
SG11201901525XA (en) | Muscarinic m1 receptor positive allosteric modulators | |
SG11201906412SA (en) | Pyridine compounds as allosteric shp2 inhibitors | |
SG11201810485SA (en) | Substituted carbonucleoside derivatives useful as anticancer agents | |
SG11201804152RA (en) | Heterocyclic compounds as immunomodulators | |
SG11201909011PA (en) | Niraparib compositions | |
SG11201906192SA (en) | Methods of treating cancer with anti-pd-1 antibodies | |
SG11201902938TA (en) | Compounds, devices, and uses thereof | |
SG11201809559UA (en) | Substituted pyridines as inhibitors of dnmt1 | |
SG11201808237UA (en) | Substituted indole compound derivatives as dengue viral replication inhibitors | |
SG11201810280YA (en) | Spiro-lactam nmda receptor modulators and uses thereof | |
SG11201807784SA (en) | 3-desoxy derivative and pharmaceutical compositions thereof | |
SG11201900634VA (en) | Chimeric antigen receptor | |
SG11201908786VA (en) | Substituted indoline derivatives as dengue viral replication inhibitors | |
SG11201803627XA (en) | N-substituted indole derivatives as pge2 receptor modulators | |
SG11201906163TA (en) | Nucleotide hemi-sulfate salt for the treatment of hepatitis c virus | |
SG11201902531QA (en) | Liquid pharmaceutical composition | |
SG11201810525XA (en) | Anti-gitr antibodies and uses thereof | |
SG11201810516UA (en) | Combinations comprising histone deacetylase inhibitors | |
SG11201900633XA (en) | Piperidine cxcr7 receptor modulators | |
SG11201900551WA (en) | Spiro-lactam nmda receptor modulators and uses thereof | |
SG11201900546UA (en) | Spiro-lactam and bis-spiro-lactam nmda receptor modulators and uses thereof | |
SG11201809497RA (en) | Processes for preparing phosphorodiamidate morpholino oligomers | |
SG11201901438VA (en) | Solid forms of cenicriviroc mesylate and processes of making solid forms of cenicriviroc mesylate | |
SG11201805149XA (en) | Compositions comprising 15-hepe and methods of using the same | |
SG11201903348UA (en) | Therapeutic compounds and methods of use thereof |