SG11201810550WA - Generation of human pluripotent stem cell derived functional beta cells showing a glucose-dependent mitochondrial respiration and two-phase insulin secretion response - Google Patents

Generation of human pluripotent stem cell derived functional beta cells showing a glucose-dependent mitochondrial respiration and two-phase insulin secretion response

Info

Publication number: SG11201810550WA
Authority: SG; Singapore
Prior art keywords: international; beta cells; glucose; insulin secretion; blar001
Prior art date: 2016-06-21

Application number

SG11201810550WA

Other languages

English (en)

Inventor

Sebastian Rieck

Alireza Rezania

Original Assignee

Janssen Biotech Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2016-06-21

Filing date

2017-06-14

Publication date

2019-01-30

2017-06-14 Application filed by Janssen Biotech Inc filed Critical Janssen Biotech Inc

2019-01-30 Publication of SG11201810550WA publication Critical patent/SG11201810550WA/en

Links

WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 title abstract 4
239000008103 glucose Substances 0.000 title abstract 4
230000003914 insulin secretion Effects 0.000 title abstract 3
230000006540 mitochondrial respiration Effects 0.000 title abstract 3
230000001419 dependent effect Effects 0.000 title abstract 2
210000000227 basophil cell of anterior lobe of hypophysis Anatomy 0.000 title 1
210000001778 pluripotent stem cell Anatomy 0.000 title 1
210000002237 B-cell of pancreatic islet Anatomy 0.000 abstract 3
210000004027 cell Anatomy 0.000 abstract 2
239000003795 chemical substances by application Substances 0.000 abstract 2
101000939387 Homo sapiens Urocortin-3 Proteins 0.000 abstract 1
101710183548 Pyridoxal 5'-phosphate synthase subunit PdxS Proteins 0.000 abstract 1
102100035459 Pyruvate dehydrogenase protein X component, mitochondrial Human genes 0.000 abstract 1
102100029794 Urocortin-3 Human genes 0.000 abstract 1
230000004069 differentiation Effects 0.000 abstract 1
210000003890 endocrine cell Anatomy 0.000 abstract 1
OGQSCIYDJSNCMY-UHFFFAOYSA-H iron(3+);methyl-dioxido-oxo-$l^{5}-arsane Chemical compound [Fe+3].[Fe+3].C[As]([O-])([O-])=O.C[As]([O-])([O-])=O.C[As]([O-])([O-])=O OGQSCIYDJSNCMY-UHFFFAOYSA-H 0.000 abstract 1
210000004153 islets of langerhan Anatomy 0.000 abstract 1
230000008520 organization Effects 0.000 abstract 1
230000009996 pancreatic endocrine effect Effects 0.000 abstract 1
210000000130 stem cell Anatomy 0.000 abstract 1

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- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0676—Pancreatic cells
- C12N5/0678—Stem cells; Progenitor cells; Precursor cells
- A—HUMAN NECESSITIES
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- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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- A61K35/39—Pancreas; Islets of Langerhans
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SG11201810550WA 2016-06-21 2017-06-14 Generation of human pluripotent stem cell derived functional beta cells showing a glucose-dependent mitochondrial respiration and two-phase insulin secretion response SG11201810550WA (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US201662352968P	2016-06-21	2016-06-21
PCT/US2017/037373 WO2017222879A1 (en)	2016-06-21	2017-06-14	Generation of human pluripotent stem cell derived functional beta cells showing a glucose-dependent mitochondrial respiration and two-phase insulin secretion response

Publications (1)

Publication Number	Publication Date
SG11201810550WA true SG11201810550WA (en)	2019-01-30

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SG11201810550WA SG11201810550WA (en)	2016-06-21	2017-06-14	Generation of human pluripotent stem cell derived functional beta cells showing a glucose-dependent mitochondrial respiration and two-phase insulin secretion response

Country Status (15)

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US (2)	US10633635B2 (ja)
EP (2)	EP3472303B1 (ja)
JP (3)	JP7044726B2 (ja)
KR (4)	KR20230169395A (ja)
CN (2)	CN116286663A (ja)
AR (1)	AR108847A1 (ja)
AU (2)	AU2017282638C1 (ja)
CA (1)	CA3027879A1 (ja)
DK (1)	DK3472303T3 (ja)
ES (1)	ES2939233T3 (ja)
MA (1)	MA45502A (ja)
RU (1)	RU2752499C2 (ja)
SG (1)	SG11201810550WA (ja)
TW (1)	TW201809266A (ja)
WO (1)	WO2017222879A1 (ja)

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JP7311116B2 (ja) *	2018-04-27	2023-07-19	株式会社カネカ	膵臓β細胞の製造方法
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AU2019320072A1 (en)	2018-08-10	2021-02-25	Vertex Pharmaceuticals Incorporated	Stem cell derived islet differentiation
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CA3139585C (en)	2019-05-31	2024-01-23	W. L. Gore & Associates, Inc.	A biocompatible membrane composite
US20220234006A1 (en)	2019-05-31	2022-07-28	W. L. Gore & Associates, Inc.	A biocompatible membrane composite
CN114173837A (zh)	2019-05-31	2022-03-11	W.L.戈尔及同仁股份有限公司	生物相容性膜复合材料
EP3990624A1 (en) *	2019-06-25	2022-05-04	Vertex Pharmaceuticals Incorporated	Enhanced differentiation of beta cells
CN114390924A (zh) *	2019-06-27	2022-04-22	达纳-法伯癌症研究公司	用于蛋白质降解的化合物、组合物和方法
WO2021102305A1 (en) *	2019-11-20	2021-05-27	Washington University	Methods and compositions for generating functionally mature beta cells and uses thereof
WO2021233116A1 (zh) *	2020-05-21	2021-11-25	北京大学	多能干细胞的成分明确、无异源的培养***
KR20230146008A (ko)	2020-12-31	2023-10-18	크리스퍼 테라퓨틱스 아게	범용 공여자 세포
WO2022204377A1 (en) *	2021-03-24	2022-09-29	Salk Institute For Biological Studies	NOVEL CHEMICAL COMBINATIONS AND METHODS OF USE THEREOF, TOWARDS DIFFERENTIATION OF HUMAN PROGENITOR CELLS INTO FUNCTIONAL β CELLS
WO2022236173A1 (en) *	2021-05-07	2022-11-10	Mayo Foundation For Medical Education And Research	Treating liver disease
US20220403340A1 (en) *	2021-06-11	2022-12-22	Washington University	Media for cryopreserved cells and methods of making and using same
IL311636A (en)	2021-11-01	2024-05-01	Vertex Pharma	Differentiation of stem cell-derived pancreatic islets
CN114317401B (zh) *	2021-12-07	2022-10-04	浙江大学	一种促进胰岛前体细胞长期稳定传代的方法

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JP7429680B2 (ja)	2024-02-08
JP7044726B2 (ja)	2022-03-30
EP4194548A1 (en)	2023-06-14
WO2017222879A1 (en)	2017-12-28
AR108847A1 (es)	2018-10-03
KR102376911B1 (ko)	2022-03-18
KR20220039833A (ko)	2022-03-29
AU2017282638B2 (en)	2022-10-06
US20200208116A1 (en)	2020-07-02
CN109415693A (zh)	2019-03-01
CN116286663A (zh)	2023-06-23
ES2939233T3 (es)	2023-04-20
AU2017282638A1 (en)	2018-12-06
US10633635B2 (en)	2020-04-28
RU2752499C2 (ru)	2021-07-28
US11952591B2 (en)	2024-04-09
RU2019101200A3 (ja)	2021-01-18
TW201809266A (zh)	2018-03-16
US20170362572A1 (en)	2017-12-21
EP3472303A4 (en)	2020-02-19
KR20230011507A (ko)	2023-01-20
MA45502A (fr)	2019-04-24
AU2022291632A1 (en)	2023-02-02
JP2024012312A (ja)	2024-01-30
KR102489946B1 (ko)	2023-01-18
JP2022033900A (ja)	2022-03-02
EP3472303B1 (en)	2022-12-14
KR102607813B1 (ko)	2023-11-29
EP3472303A1 (en)	2019-04-24
CA3027879A1 (en)	2017-12-28
CN109415693B (zh)	2023-03-21
JP2019518465A (ja)	2019-07-04
RU2019101200A (ru)	2020-07-21
KR20230169395A (ko)	2023-12-15
DK3472303T3 (da)	2023-01-23
KR20190011268A (ko)	2019-02-01

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