SG11201807785VA - Neuroactive steroids, compositions, and uses thereof - Google Patents
Neuroactive steroids, compositions, and uses thereofInfo
- Publication number
- SG11201807785VA SG11201807785VA SG11201807785VA SG11201807785VA SG11201807785VA SG 11201807785V A SG11201807785V A SG 11201807785VA SG 11201807785V A SG11201807785V A SG 11201807785VA SG 11201807785V A SG11201807785V A SG 11201807785VA SG 11201807785V A SG11201807785V A SG 11201807785VA
- Authority
- SG
- Singapore
- Prior art keywords
- international
- applicant
- tremor
- pct
- rule
- Prior art date
Links
- 150000003431 steroids Chemical class 0.000 title abstract 4
- 239000000203 mixture Substances 0.000 title abstract 3
- AURFZBICLPNKBZ-YZRLXODZSA-N 3alpha-hydroxy-5beta-pregnan-20-one Chemical compound C([C@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H](C(=O)C)[C@@]2(C)CC1 AURFZBICLPNKBZ-YZRLXODZSA-N 0.000 abstract 2
- 208000019901 Anxiety disease Diseases 0.000 abstract 2
- AURFZBICLPNKBZ-UHFFFAOYSA-N Pregnanolone Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(=O)C)C1(C)CC2 AURFZBICLPNKBZ-UHFFFAOYSA-N 0.000 abstract 2
- 206010044565 Tremor Diseases 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 208000035475 disorder Diseases 0.000 abstract 2
- 201000006517 essential tremor Diseases 0.000 abstract 2
- DUHUCHOQIDJXAT-OLVMNOGESA-N 3-hydroxy-(3-α,5-α)-Pregnane-11,20-dione Chemical compound C([C@@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H](C(=O)C)[C@@]2(C)CC1=O DUHUCHOQIDJXAT-OLVMNOGESA-N 0.000 abstract 1
- 208000020401 Depressive disease Diseases 0.000 abstract 1
- PGTVWKLGGCQMBR-FLBATMFCSA-N Ganaxolone Chemical compound C([C@@H]1CC2)[C@](C)(O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H](C(=O)C)[C@@]2(C)CC1 PGTVWKLGGCQMBR-FLBATMFCSA-N 0.000 abstract 1
- -1 alphadalone Chemical compound 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- AAOVKJBEBIDNHE-UHFFFAOYSA-N diazepam Chemical compound N=1CC(=O)N(C)C2=CC=C(Cl)C=C2C=1C1=CC=CC=C1 AAOVKJBEBIDNHE-UHFFFAOYSA-N 0.000 abstract 1
- 229960003529 diazepam Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229950007402 eltanolone Drugs 0.000 abstract 1
- 229950006567 ganaxolone Drugs 0.000 abstract 1
- 230000008520 organization Effects 0.000 abstract 1
- 235000002020 sage Nutrition 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/40—Cyclodextrins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Inorganic Chemistry (AREA)
- Dermatology (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Psychology (AREA)
Abstract
Extrasynapticx(336 1250 0 Compound 9 1000 Diazepam '47; 750 4- , 0 500 2 0 0.01 Concentration (PM) FIG. 1A W O 20 17 / 15 6 103 Al 1 0 (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2017/156103 Al 14 September 2017 (14.09.2017) WIPO I PCT (51) International Patent Classification: (72) Inventor; and A61K 31/57 (2006.01) A61K 31/575 (2006.01) (71) Applicant : COLQUHOUN, Helen [US/US]; 23 Regis A61K 31/56 (2006.01) A61K 31/58 (2006.01) Road, Arlington, MA 02474 (US). 111111111111110111011111111111010111110 0111111111111101011111011111111111110111111 (21) International Application Number: PCT/US2017/021325 (22) International Filing Date: 8 March 2017 (08.03.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/305,279 8 March 2016 (08.03.2016) US 62/355,174 27 June 2016 (27.06.2016) US 62/355,669 28 June 2016 (28.06.2016) US 62/360,762 11 July 2016 (11.07.2016) US 62/360,758 11 July 2016 (11.07.2016) US (71) Applicant: SAGE THERAPEUTICS, INC. [US/US]; 215 First Street, Cambridge, MA 02142 (US). (72) Inventor: KANES, Stephen, Jay; 125 Guernsey Rd, Swartmore, PA 19081 (US). (74) Agent: MCCARTY, Catherine, M.; LANDO & ANA- STASI, LLP, Riverfront Office Park, One Main Street, Suite 1100, Cambridge, MA 02142 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. [Continued on next page] (54) Title: NEUROACTIVE STEROIDS, COMPOSITIONS, AND USES THEREOF (57) : Described herein are methods of treating a disorder, e.g., tremor, e.g., essential tremor; depres- sion, e.g., postpostum depression; and anxiety disorder, the method compris- ing administering to a human subject suffering from a disorder, e.g., tremor, e.g., essential tremor; depression, e.g., postpostum depression, an anxiety dis- order with a neuroactive steroid or a composition comprising a neuroactive steroid (e.g., pregnanolone, allopreg- nanolone, alphadalone, ganaxolone, or alphaxolone). WO 2017/156103 Al MIDEDIMOMOIDEIRMEMOMOHIMOMMIUMEMOIS (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(ii)) as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) Published: with international search report (Art. 21(3))
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662305279P | 2016-03-08 | 2016-03-08 | |
| US201662355174P | 2016-06-27 | 2016-06-27 | |
| US201662355669P | 2016-06-28 | 2016-06-28 | |
| US201662360762P | 2016-07-11 | 2016-07-11 | |
| US201662360758P | 2016-07-11 | 2016-07-11 | |
| PCT/US2017/021325 WO2017156103A1 (en) | 2016-03-08 | 2017-03-08 | Neuroactive steroids, compositions, and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201807785VA true SG11201807785VA (en) | 2018-10-30 |
Family
ID=59789807
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201807785VA SG11201807785VA (en) | 2016-03-08 | 2017-03-08 | Neuroactive steroids, compositions, and uses thereof |
Country Status (19)
| Country | Link |
|---|---|
| US (4) | US20200306265A1 (en) |
| EP (1) | EP3426257A4 (en) |
| JP (3) | JP6838074B2 (en) |
| KR (2) | KR102408399B1 (en) |
| CN (2) | CN109414444A (en) |
| AU (2) | AU2017229656B2 (en) |
| BR (1) | BR112018067998A2 (en) |
| CA (2) | CA3017172C (en) |
| HK (1) | HK1258616A1 (en) |
| IL (2) | IL300422A (en) |
| JO (1) | JOP20170059B1 (en) |
| MA (1) | MA43815A (en) |
| MX (2) | MX2018010902A (en) |
| PH (1) | PH12018501923A1 (en) |
| RU (2) | RU2022102537A (en) |
| SG (1) | SG11201807785VA (en) |
| TW (2) | TWI798173B (en) |
| WO (1) | WO2017156103A1 (en) |
| ZA (1) | ZA201805905B (en) |
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| CN108976272B (en) | 2011-10-14 | 2021-05-25 | 萨奇治疗股份有限公司 | 3, 3-disubstituted 19-norpregnane compounds, compositions, and uses thereof |
| RU2019104004A (en) | 2012-01-23 | 2019-03-07 | Сейдж Терапьютикс, Инк. | MEDICINAL FORMS OF NEUROACTIVE STEROIDS AND METHODS OF TREATING CNS DISORDERS |
| DK2925327T3 (en) | 2012-11-30 | 2024-03-25 | Univ California | Allopregnanolone for the treatment, reduction or relief of symptoms of postpartum depression |
| HUE051403T2 (en) | 2013-04-17 | 2021-03-01 | Sage Therapeutics Inc | 19-nor neuroactive steroids for methods of treatment |
| US9725481B2 (en) | 2013-04-17 | 2017-08-08 | Sage Therapeutics, Inc. | 19-nor C3, 3-disubstituted C21-C-bound heteroaryl steroids and methods of use thereof |
| KR20230172622A (en) | 2013-04-17 | 2023-12-22 | 세이지 테라퓨틱스, 인크. | 19-nor c3,3-disubstituted c21-n-pyrazolyl steroids and methods of use thereof |
| WO2014169836A1 (en) | 2013-04-17 | 2014-10-23 | Sage Therapeutics, Inc. | 19-nor neuroactive steroids and methods of use thereof |
| PT3021852T (en) | 2013-07-19 | 2021-04-21 | Sage Therapeutics Inc | Neuroactive steroids, compositions, and uses thereof |
| CA2921512A1 (en) | 2013-08-23 | 2015-02-26 | Sage Therapeutics, Inc. | Neuroactive steroids, compositions, and uses thereof |
| WO2015195962A1 (en) | 2014-06-18 | 2015-12-23 | Sage Therapeutics, Inc. | Neuroactive steroids, compositions, and uses thereof |
| HUE051488T2 (en) | 2014-10-16 | 2021-03-01 | Sage Therapeutics Inc | Compositions and methods for treating cns disorders |
| US10577390B2 (en) | 2014-10-16 | 2020-03-03 | Sage Therapeutics, Inc. | Compositions and methods for treating CNS disorders |
| EP3719029A1 (en) | 2014-11-27 | 2020-10-07 | Sage Therapeutics, Inc. | Compositions for inducing sedation |
| DK3250210T3 (en) | 2015-01-26 | 2021-03-08 | Sage Therapeutics Inc | COMPOSITIONS AND METHODS FOR TREATING CNS DISORDERS |
| US10329320B2 (en) | 2015-02-20 | 2019-06-25 | Sage Therapeutics, Inc. | Neuroactive steroids, compositions, and uses thereof |
| MA43815A (en) | 2016-03-08 | 2021-04-07 | Sage Therapeutics Inc | NEUROACTIVE STEROIDS, COMPOSITIONS, AND THEIR USES |
| RU2019103590A (en) | 2016-07-11 | 2021-02-11 | Сейдж Терапьютикс, Инк. | C17-, C20- AND C21-SUBSTITUTED NEUROACTIVE STEROIDS AND METHODS OF THEIR APPLICATION |
| JP2019524853A (en) | 2016-08-23 | 2019-09-05 | セージ セラピューティクス， インコーポレイテッド | Crystalline 19-nor C3,3-disubstituted C21-N-pyrazolyl steroid |
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| WO2019075362A1 (en) * | 2017-10-12 | 2019-04-18 | Sage Therapeutics, Inc. | Method of treating cns disorders with neurosteroids and gabaergic compounds |
| CN111565724A (en) * | 2017-11-10 | 2020-08-21 | 马瑞纳斯制药公司 | Ganaxolone for treating hereditary epilepsy |
| US20200291059A1 (en) | 2017-12-08 | 2020-09-17 | Sage Therapeutics, Inc. | Compositions and methods for treating cns disorders |
| MX2020008182A (en) * | 2018-02-11 | 2020-09-22 | Jiangsu Hansoh Pharmaceutical Group Co Ltd | Steroid derivative regulators, method for preparing the same, and uses thereof. |
| CA3103421A1 (en) * | 2018-06-12 | 2019-12-19 | Sage Therapeutics, Inc. | A 19-nor c3,3-disubstituted c21 -n-pyrazolyl steroid and methods of use thereof |
| CA3118688A1 (en) * | 2018-11-05 | 2020-05-14 | Ovid Therapeutics Inc. | Use of gaboxadol, ganaxolone and allopregnanolone to treat movement disorders |
| CN109503694A (en) * | 2018-11-21 | 2019-03-22 | 苏州闻天医药科技有限公司 | A kind of novel GABAAReceptor modulators and application thereof |
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| KR20210116523A (en) * | 2019-01-14 | 2021-09-27 | 베이징 슈안이 파마사이언시스 컴퍼니, 리미티드 | Tetrazolone Substituted Steroids and Uses Thereof |
| US11497754B2 (en) | 2019-02-05 | 2022-11-15 | Washington University | Neurosteroids and enantiomers thereof for the prevention and treatment of neurodegenerative conditions |
| JP2022534424A (en) | 2019-05-31 | 2022-07-29 | セージ セラピューティクス， インコーポレイテッド | Neuroactive steroids and compositions thereof |
| JP2022543837A (en) | 2019-08-05 | 2022-10-14 | マリナス ファーマシューティカルズ， インコーポレイテッド | Ganaxolone for use in treating status epilepticus |
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