SG11201908719QA - Biomarkers and car t cell therapies with enhanced efficacy - Google Patents

Biomarkers and car t cell therapies with enhanced efficacy

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Publication number
SG11201908719QA
SG11201908719QA SG11201908719QA SG11201908719QA SG 11201908719Q A SG11201908719Q A SG 11201908719QA SG 11201908719Q A SG11201908719Q A SG 11201908719QA SG 11201908719Q A SG11201908719Q A SG 11201908719QA
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Singapore
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international
rule
pct
cell therapies
methods
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Joseph Fraietta
Jan Melenhorst
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Novartis Ag
Univ Pennsylvania
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Publication of SG11201908719QA publication Critical patent/SG11201908719QA/en

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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases RNAses, DNAses
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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Abstract

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 27 September 2018 (27.09.2018) WIPO I PCT onion °nolo oloinomll n ono oimIE (10) International Publication Number WO 2018/175733 Al (51) International Patent Classification: A61K 39/00 (2006.01) C07K 16/28 (2006.01) (21) International Application Number: PCT/US2018/023785 (22) International Filing Date: 22 March 2018 (22.03.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/474,991 22 March 2017 (22.03.2017) US 62/621,356 24 January 2018 (24.01.2018) US (71) Applicants: NOVARTIS AG [CH/CH]; Lichtstrasse 35, 4056 Basel (CH). THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA [US/US]; 3160 Chestnut Street, Suite 200, Philadelphia, PA 19104 (US). (72) Inventors: FRAIETTA, Joseph, A.; 18 Saddle Lane, Cherry Hill, NJ 08002 (US). MELENHORST, Jan, J.; 11 Exton Circle, Cherry Hill, NJ 08003 (US). (74) Agent: COLLAZO, Diana M. et al.; Lando & Anastasi, LLP, Riverfront Office Park, One Main Street, Suite 1100, Cambridge, MA 02142 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(ii)) as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) with sequence listing part of description (Rule 5.2(a)) 1-1 (54) Title: BIOMARKERS AND CAR T CELL THERAPIES WITH ENHANCED EFFICACY (57) : The invention provides compositions and methods improved CART cell therapies. Specifically, the invention provides 0 cells with altered expression and/or function of one or more genes, e.g., associated with Tet2, and methods of use therefore. The \" invention further provides inhibitors of the one or more genes and methods of use therefore in connection with CART cells.
SG11201908719Q 2017-03-22 2018-03-22 Biomarkers and car t cell therapies with enhanced efficacy SG11201908719QA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762474991P 2017-03-22 2017-03-22
US201862621356P 2018-01-24 2018-01-24
PCT/US2018/023785 WO2018175733A1 (en) 2017-03-22 2018-03-22 Biomarkers and car t cell therapies with enhanced efficacy

Publications (1)

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SG11201908719QA true SG11201908719QA (en) 2019-10-30

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US (1) US20200087376A1 (en)
EP (1) EP3600392A1 (en)
JP (2) JP2020513828A (en)
KR (1) KR20190127892A (en)
CN (1) CN110831619A (en)
AU (1) AU2018240295A1 (en)
BR (1) BR112019019426A2 (en)
CA (1) CA3057306A1 (en)
IL (1) IL269412A (en)
RU (1) RU2019133286A (en)
SG (1) SG11201908719QA (en)
WO (1) WO2018175733A1 (en)

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