SG11201806647VA - Systems and methods for allergen detection - Google Patents

Systems and methods for allergen detection

Info

Publication number
SG11201806647VA
SG11201806647VA SG11201806647VA SG11201806647VA SG11201806647VA SG 11201806647V A SG11201806647V A SG 11201806647VA SG 11201806647V A SG11201806647V A SG 11201806647VA SG 11201806647V A SG11201806647V A SG 11201806647VA SG 11201806647V A SG11201806647V A SG 11201806647VA
Authority
SG
Singapore
Prior art keywords
massachusetts
international
detection
sample
sachusetts
Prior art date
Application number
SG11201806647VA
Inventor
Adi Gilboa-Geffen
Renuka Babu Brown
Sarah Stidham
Valerie Villareal
Adam J Young
Joshua Glenn Anthony
Patrick Murphy
John H Kepler
Adam Jacobs
Original Assignee
Dots Tech Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dots Tech Corp filed Critical Dots Tech Corp
Publication of SG11201806647VA publication Critical patent/SG11201806647VA/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/02—Food
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M1/00—Apparatus for enzymology or microbiology
    • C12M1/34—Measuring or testing with condition measuring or sensing means, e.g. colony counters
    • C12M1/3446—Photometry, spectroscopy, laser technology
    • C12M1/3476—Fluorescence spectroscopy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/02—Devices for withdrawing samples
    • G01N1/04—Devices for withdrawing samples in the solid state, e.g. by cutting
    • G01N1/08—Devices for withdrawing samples in the solid state, e.g. by cutting involving an extracting tool, e.g. core bit
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/02—Devices for withdrawing samples
    • G01N1/10—Devices for withdrawing samples in the liquid or fluent state
    • G01N1/14—Suction devices, e.g. pumps; Ejector devices
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/286—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q involving mechanical work, e.g. chopping, disintegrating, compacting, homogenising
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5302—Apparatus specially adapted for immunological test procedures
    • G01N33/5304—Reaction vessels, e.g. agglutination plates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5308—Immunoassay; Biospecific binding assay; Materials therefor for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/16—Aptamers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/10—Applications; Uses in screening processes
    • C12N2320/11—Applications; Uses in screening processes for the determination of target sites, i.e. of active nucleic acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/02—Devices for withdrawing samples
    • G01N1/10—Devices for withdrawing samples in the liquid or fluent state
    • G01N1/14—Suction devices, e.g. pumps; Ejector devices
    • G01N2001/1418—Depression, aspiration
    • G01N2001/1427—Positive displacement, piston, peristaltic
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/286—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q involving mechanical work, e.g. chopping, disintegrating, compacting, homogenising
    • G01N2001/2866—Grinding or homogeneising

Abstract

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2017/160616 Al 21 September 2017 (21.09.2017) WIPO I PCT 1111111111111101110101011111010111110111011110011011111101111111111111111110111111 (51) International Patent Classification: B01J 19/00 (2006.01) G01N 33/02 (2006.01) C12M 1/34 (2006.01) G01N 33/50 (2006.01) C12Q 1/68 (2006.01) (21) International Application Number: PCT/US2017/021737 (22) International Filing Date: 10 March 2017 (10.03.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/308,376 15 March 2016 (15.03.2016) US 62/308,377 15 March 2016 (15.03.2016) US (71) Applicant: DOTS TECHNOLOGY CORP. [US/US]; 16 Tech Circle, 2nd Floor, Natick, Massachusetts 01760 (US). (72) Inventors: GILBOA-GEFFEN, Adi; 31 Alden Rd., Way- land, Massachusetts 01778 (US). BABU BROWN, Re- nuka; 536 Glen Road, Weston, Massachusetts 02493 (US). STIDHAM, Sarah; 12 James St. #3, Brookline, Mas- sachusetts 02446 (US). VILLAREAL, Valerie; 129 Com- monwealth Avenue, Boston, Massachusetts 02116 (US). YOUNG, Adam J.; 82 Monroe Street, Dedham, Mas- sachusetts 02026 (US). ANTHONY, Joshua Glenn; 39 Sunset Rock Lane, Reading, Massachusetts 01867 (US). MURPHY, Patrick; 16 Valentine St., Cambridge, Mas- sachusetts 02139 (US). KEPLER, John H.; 19 Summer Street, Lexington, Massachusetts 02420 (US). JACOBS, Adam; 15 Crestwood Drive, Hollis, New Hampshire 03049 (US). (74) Agents: WARD, Donna T. et al.; DT Ward, P.C., 142A Main Street, Groton, Massachusetts 01450 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, [Continued on next page] (54) Title: SYSTEMS AND METHODS FOR ALLERGEN DETECTION Fig. 1a 1 W O 20 17 / 1606 16 Al (57) : The present invention provides systems, devices, signaling poly- nucleotides (SPNs), detection agents and methods for detecting the presence and/or absence of one or more allergens in a sample particularly a food sample. The de- tection system includes a separate sampler, at least one disposable detection vessel for receiving and processing a test sample and a detection device for measuring a fluores- cent signal. SPNs derived from aptamer that bind allergens are also provided as al- 30 lergen detection agents. SPNs have a single open structure, and are probed with a fluorophore. Changes in fluorescence polarization of detection agents upon the binding of allergens are measured to cal- culate the allergen content in a sample. WO 2017/160616 Al MIDEDIMOMOIDEIRMEMOMOHINIMEMOHIMMOIMIE LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) with sequence listing part of description (Rule 5.2(a))
SG11201806647VA 2016-03-15 2017-03-10 Systems and methods for allergen detection SG11201806647VA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662308377P 2016-03-15 2016-03-15
US201662308376P 2016-03-15 2016-03-15
PCT/US2017/021737 WO2017160616A1 (en) 2016-03-15 2017-03-10 Systems and methods for allergen detection

Publications (1)

Publication Number Publication Date
SG11201806647VA true SG11201806647VA (en) 2018-09-27

Family

ID=59851843

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201806647VA SG11201806647VA (en) 2016-03-15 2017-03-10 Systems and methods for allergen detection

Country Status (9)

Country Link
US (2) US10908139B2 (en)
EP (1) EP3429741A4 (en)
JP (1) JP2019511715A (en)
CN (1) CN108780027A (en)
AU (1) AU2017234548B2 (en)
CA (1) CA3013386A1 (en)
MX (1) MX2018010800A (en)
SG (1) SG11201806647VA (en)
WO (1) WO2017160616A1 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110325841A (en) 2017-02-21 2019-10-11 多茨技术公司 System for Allergic skin test
WO2019094968A1 (en) * 2017-11-13 2019-05-16 Base Pair Biotechnologies, Inc. Detection of tenofovir
US20210311032A1 (en) * 2018-02-21 2021-10-07 Dots Technology Corp. Systems and methods for allergen detection
EP3830569A4 (en) * 2018-08-03 2023-10-25 DOTS Technology Corp. Methods for aptamer selection
FR3098917A1 (en) * 2019-07-17 2021-01-22 Commissariat à l'Energie Atomique et aux Energies Alternatives Method and system for detecting an analyte present in a liquid sample
EP4028744A1 (en) * 2019-09-11 2022-07-20 Global Biyomedikal Saglik Hizmetleri Sanayi ve Ticaret Limited Sirketi A tissue disaggregation, homogenization, photoactivation device
CA3152627A1 (en) * 2019-09-27 2021-04-01 Amandeep SANDHU Analyte detection method and device
US11053556B1 (en) * 2020-06-26 2021-07-06 4233999 Canada Inc. Pathogen detection using aptamer molecular photonic beacons using a mobile device
US10927404B1 (en) * 2020-06-26 2021-02-23 4233999 Canada Inc. Pathogen detection using aptamer molecular beacons using a mobile device
CN112414984B (en) * 2020-11-06 2023-04-25 中国计量大学 Portable milk powder protein content detection box
FR3128021A1 (en) * 2021-10-12 2023-04-14 Universite Grenoble Alpes A method of detecting a target analyte in a sample using Nile Blue, a composition for detecting a target analyte and its use.
CN114075565B (en) * 2022-01-19 2022-04-19 中国农业大学 Bifunctional G-quadruplex allosteric biosensor for detecting beta-lactoglobulin
WO2023190098A1 (en) * 2022-03-31 2023-10-05 日本ハム株式会社 Examination kit and examination method for peanut allergen
CN114923974B (en) * 2022-07-14 2022-10-04 深圳中食匠心食品有限公司 Portable bread heavy metal detection device and detection method thereof
CN116698680B (en) * 2023-08-04 2023-09-29 天津创盾智能科技有限公司 Automatic monitoring method and system for biological aerosol

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5953251U (en) * 1982-10-01 1984-04-07 日本甜菜製糖株式会社 sample collection tube
US5166052A (en) * 1986-05-27 1992-11-24 Boris Cercek Method for measuring polarization of bathochromically shifted fluorescence
WO1998005962A1 (en) 1996-08-02 1998-02-12 Panvera Corporation A method for quantitating competitive binding of molecules to proteins utilizing fluorescence polarization
US6398402B1 (en) 1998-02-11 2002-06-04 Chris Thomas Disposable disruptor agitator tool having a bladed rotor disposed in a stator
US6032368A (en) * 1998-08-27 2000-03-07 The Pampered Chef, Ltd. Apple corer
FR2802640B1 (en) * 1999-12-17 2003-01-03 Pasteur Sanofi Diagnostics DEVICE AND METHOD FOR COLLECTING A BIOLOGICAL SAMPLE
US6566143B2 (en) * 2000-02-25 2003-05-20 Cambridge Research & Instrumentation, Inc. Multiple label fluorescence polarization assay system and method
WO2001083933A1 (en) * 2000-05-03 2001-11-08 Cybersonics, Inc. Smart-ultrasonic/sonic driller/corer
US10533998B2 (en) * 2008-07-18 2020-01-14 Bio-Rad Laboratories, Inc. Enzyme quantification
FI20031294A0 (en) * 2003-09-10 2003-09-10 Thermo Labsystems Oy Fluorometer calibration
JP2005189341A (en) * 2003-12-24 2005-07-14 Nisca Corp Image reading apparatus
WO2005085847A1 (en) 2004-03-05 2005-09-15 Prima Meat Packers, Ltd. Method of detecting allergen
EP1771724A1 (en) * 2004-07-29 2007-04-11 MNT Innovations Pty Ltd Biological saw sensor
ITTO20040743A1 (en) 2004-10-27 2005-01-27 Gianmarco Roggero DISPOSABLE HOMOGENIZING DEVICE, AND ITS USE FOR THE PREPARATION OF HOMOGENIZED SAMPLES
JP4795765B2 (en) * 2005-09-29 2011-10-19 シスメックス株式会社 Sample processing equipment
JP2007120976A (en) * 2005-10-25 2007-05-17 Matsushita Electric Ind Co Ltd Immunoassay, its kit, its device and reader used in immunoassay
WO2007081386A2 (en) * 2006-01-11 2007-07-19 Raindance Technologies, Inc. Microfluidic devices and methods of use
CN101542273B (en) * 2006-08-24 2011-01-26 新加坡科技研究局 Compact optical detection system
US20100285490A1 (en) 2006-12-29 2010-11-11 Invitrogen Corporation Detection apparatus
US20100210033A1 (en) * 2007-10-07 2010-08-19 Jordan Scott Portable device for detecting food allergens
JP4803561B2 (en) * 2009-12-24 2011-10-26 独立行政法人土木研究所 Simple snow density measuring instrument
DE102010015964A1 (en) * 2010-03-15 2011-09-15 Leica Microsystems Cms Gmbh Apparatus and method for multimodal imaging in nonlinear Raman microscopy
WO2012078455A1 (en) * 2010-12-06 2012-06-14 Exploramed Iii, Inc. Allergen test kit
US20120264232A1 (en) * 2011-04-15 2012-10-18 Aliment Health, Inc. Antigen detection system and methods of use
US8211715B1 (en) 2011-11-15 2012-07-03 Harrogate Holdings, Ltd. Co. Consumer food testing device providing remote monitoring
JP5970293B2 (en) * 2012-08-21 2016-08-17 シスメックス株式会社 Crusher
CA2888316C (en) * 2012-10-17 2021-05-04 Integrated Nano-Technologies, Llc Method and system for sample preparation
WO2014160861A1 (en) * 2013-03-29 2014-10-02 6SensorLabs, Inc. A portable device for detection of harmful substances
EP3733868A3 (en) 2013-10-28 2021-01-13 DOTS Technology Corp. Allergen detection
EP3083054A2 (en) * 2013-12-20 2016-10-26 3M Innovative Properties Company Systems and methods for sample concentration and detection
JP6414907B2 (en) * 2014-03-31 2018-10-31 Ｎｅｃソリューションイノベータ株式会社 Nucleic acid molecules that bind to buckwheat allergens and uses thereof
US10835897B2 (en) 2015-03-16 2020-11-17 Dots Technology Corp. Portable allergen detection system

Also Published As

Publication number Publication date
US20190079063A1 (en) 2019-03-14
AU2017234548B2 (en) 2021-03-25
EP3429741A4 (en) 2019-11-27
JP2019511715A (en) 2019-04-25
AU2017234548A1 (en) 2018-08-30
MX2018010800A (en) 2018-11-09
WO2017160616A1 (en) 2017-09-21
CN108780027A (en) 2018-11-09
US10908139B2 (en) 2021-02-02
CA3013386A1 (en) 2017-09-21
US20210109076A1 (en) 2021-04-15
EP3429741A1 (en) 2019-01-23

Similar Documents

Publication Publication Date Title
SG11201806647VA (en) Systems and methods for allergen detection
SG11201811343SA (en) System and methods for detecting online fraud
SG11201803667RA (en) Systems and methods for region-adaptive defect detection
SG11201807334SA (en) Methods, compositions, and devices for information storage
SG11201809913PA (en) Methods for detecting target nucleic acids in a sample
SG11201809294RA (en) Systems and methods for sensor data analysis through machine learning
SG11201807307VA (en) System and method for aerial system discrimination and action
SG11201805532XA (en) Multivalent and multispecific 41bb-binding fusion proteins
SG11201807002TA (en) Intention signaling for an autonomous vehicle
SG11201903286RA (en) User identity authentication using virtual reality
SG11201806595UA (en) Using cell-free dna fragment size to determine copy number variations
SG11201900269XA (en) Channel sensing for independent links
SG11201805797SA (en) Machine learning based webinterface generation and testing system
SG11201807369UA (en) System and method for beam adjustment request
SG11201808014SA (en) Compositions, devices, and methods for cell separation
SG11201811468UA (en) Fluid control
CA3015496A1 (en) Voice control of a media playback system
SG11201407560RA (en) Card disposal system for table game
SG11201811484QA (en) Extrapolating probabilistic predictions for skills using unanswered questions and determining corresponding instructional content
SG11201808959QA (en) Analyte detection methods and apparatus using dielectrophoresis and electroosmosis
SG11201907541TA (en) Systems for allergen detection
SG11201806385PA (en) Magnetic electrochemical sensing
SG11201907140UA (en) Multi-signal analysis for compromised scope identification
SG11201407190TA (en) Cancer immunotherapy by disrupting pd-1/pd-l1 signaling
SG11201906413XA (en) Exposure apparatus