SG11201806385PA - Magnetic electrochemical sensing - Google Patents

Abstract

310 110,130,140,150 340 120 320 160 FIG. 3 W O 20 17 / 13 25 6 4 A2 (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2017/132564 A2 3 August 2017 (03.08.2017) WIPO I PCT (51) International Patent Classification: G01N 27/28 (2006.01) (21) International Application Number: PCT/US2017/015433 (22) International Filing Date: 27 January 2017 (27.01.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/287,719 27 January 2016 (27.01.2016) US 62/288,254 28 January 2016 (28.01.2016) US 62/339,519 20 May 2016 (20.05.2016) US (71) Applicants: THE GENERAL HOSPITAL CORPORA- TION [US/US]; 55 Fruit Street, Boston, Massachusetts 02114 (US). THE BRIGHAM AND WOMEN'S HOS- PITAL, INC. [US/US]; 75 Francis Street, Boston, Mas- sachusetts 02115 (US). (72) Inventors: LEE, Hakho; 9 Evergreen Road, Acton, Mas- sachusetts 01720 (US). WEISSLEDER, Ralph; 11 Nich- ols Lane, Peabody, Massachusetts 01960 (US). JEONG, Sangmoo; 504 E. 63rd Street, Apt 12o, New York, New York 10065 (US). PARK, Jongmin; 10 Akron Street, #612, Cambridge, Massachusetts 02138 (US). CASTRO, Caesar; 7 Perkins Avenue, Reading, Pennsylvania 01867 (US). LIN, Hsing-Ying; No.2, Xingyi St., Xiaogang Dist., Kaohsiung City, 812 (TW). AZZI, Jamil; 64 Forest Street, Chestnut Hill, Massachusetts 02467 (US). (74) Agents: WONG, Richard et al.; Fish & Richardson P.C., P.O. Box 1022, Minneapolis, Minnesota 55440-1022 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). [Continued on next page] (54) Title: MAGNETIC ELECTROCHEMICAL SENSING (57) : Target analyte detection devices include a housing having a potentiostat and a microcontroller coupled to the poten- tiostat. The device also includes a substrate having a plurality of electrodes on a first surface of the substrate. A first set of electrodes of the plurality of electrodes defines a first sample detection region. The substrate is removably attachable to the housing such that the first set of electrodes is coupled to the potentiostat upon attaching the substrate to the housing. The device also includes a magnet assembly couplable to a second surface of the substrate. The magnet assembly includes a magnet positioned in the magnet assembly such that a magnetic field from the magnet extends through the substrate and the first set of electrodes into an area above the first sample detection region upon coupling the magnet assembly to the substrate. 111111111111110111011111111111010111110 011101110111111111001111111111111110111111 WO 2017/132564 A2 11111101MO11111 1111NMEM3011110111111111111111111111111111111111111111 Published: without international search report and to be republished upon receipt of that report (Rule 48.2(g))