SG10202103445QA - Humanized sirpa-il15 knockin mice and methods of use thereof - Google Patents

Humanized sirpa-il15 knockin mice and methods of use thereof

Info

Publication number
SG10202103445QA
SG10202103445QA SG10202103445QA SG10202103445QA SG10202103445QA SG 10202103445Q A SG10202103445Q A SG 10202103445QA SG 10202103445Q A SG10202103445Q A SG 10202103445QA SG 10202103445Q A SG10202103445Q A SG 10202103445QA SG 10202103445Q A SG10202103445Q A SG 10202103445QA
Authority
SG
Singapore
Prior art keywords
methods
knockin mice
humanized sirpa
sirpa
humanized
Prior art date
Application number
SG10202103445QA
Inventor
Dietmar Herndler-Brandstetter
Richard A Flavell
Davor Frleta
Cagan Gurer
Markus Gabriel Manz
Andrew J Murphy
Noah W Palm
Liang Shan
Sean Stevens
Till Strowig
George D Yancopoulos
Zoete Marcel De
Original Assignee
Regeneron Pharma
Univ Yale
Institute For Res In Biomedicine Irb
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma, Univ Yale, Institute For Res In Biomedicine Irb filed Critical Regeneron Pharma
Publication of SG10202103445QA publication Critical patent/SG10202103445QA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
    • A01K67/027—New breeds of vertebrates
    • A01K67/0271—Chimeric animals, e.g. comprising exogenous cells
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
    • A01K67/027—New breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Humanized animals, e.g. knockin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • A61K49/0008—Screening agents using (non-human) animal models or transgenic animal models or chimeric hosts, e.g. Alzheimer disease animal model, transgenic model for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5443—IL-15
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/12—Animals modified by administration of exogenous cells
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/15—Animals comprising multiple alterations of the genome, by transgenesis or homologous recombination, e.g. obtained by cross-breeding
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0331—Animal model for proliferative diseases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0337—Animal models for infectious diseases
SG10202103445QA 2015-04-13 2016-04-12 Humanized sirpa-il15 knockin mice and methods of use thereof SG10202103445QA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562146938P 2015-04-13 2015-04-13
US201562148667P 2015-04-16 2015-04-16
US201662287842P 2016-01-27 2016-01-27

Publications (1)

Publication Number Publication Date
SG10202103445QA true SG10202103445QA (en) 2021-05-28

Family

ID=55910354

Family Applications (2)

Application Number Title Priority Date Filing Date
SG11201708380WA SG11201708380WA (en) 2015-04-13 2016-04-12 Humanized sirpa-il15 knockin mice and methods of use thereof
SG10202103445QA SG10202103445QA (en) 2015-04-13 2016-04-12 Humanized sirpa-il15 knockin mice and methods of use thereof

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG11201708380WA SG11201708380WA (en) 2015-04-13 2016-04-12 Humanized sirpa-il15 knockin mice and methods of use thereof

Country Status (16)

Country Link
US (4) US10123518B2 (en)
EP (2) EP4248740A3 (en)
JP (3) JP6752221B2 (en)
KR (1) KR102658190B1 (en)
CN (3) CN107896479B (en)
AU (2) AU2016247892B2 (en)
CA (1) CA2981186A1 (en)
DK (1) DK3282835T3 (en)
ES (1) ES2950399T3 (en)
FI (1) FI3282835T3 (en)
IL (2) IL254727B2 (en)
MX (3) MX2017013285A (en)
PT (1) PT3282835T (en)
RU (2) RU2020124128A (en)
SG (2) SG11201708380WA (en)
WO (1) WO2016168212A1 (en)

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CN107896479A (en) 2018-04-10
DK3282835T3 (en) 2023-06-26
IL254727B1 (en) 2023-06-01
CN115943929A (en) 2023-04-11
KR20180019521A (en) 2018-02-26
FI3282835T3 (en) 2023-07-20
MX2022001201A (en) 2022-02-22
PT3282835T (en) 2023-07-25
RU2017139008A (en) 2019-05-13
KR102658190B1 (en) 2024-04-17
EP4248740A3 (en) 2023-12-27
US10561126B2 (en) 2020-02-18
CN107896479B (en) 2021-07-13
IL302370A (en) 2023-06-01
CA2981186A1 (en) 2016-10-20
US11576356B2 (en) 2023-02-14
EP3282835B1 (en) 2023-05-31
AU2016247892A1 (en) 2017-10-19
EP4248740A2 (en) 2023-09-27
JP2020202853A (en) 2020-12-24
US20160295844A1 (en) 2016-10-13
US20230292721A1 (en) 2023-09-21
RU2020124128A (en) 2020-09-22
CN113424798B (en) 2023-01-13
RU2017139008A3 (en) 2019-07-17
JP2018512156A (en) 2018-05-17
WO2016168212A1 (en) 2016-10-20
CN113424798A (en) 2021-09-24
AU2022221378A1 (en) 2022-09-15
IL254727B2 (en) 2023-10-01
IL254727A0 (en) 2017-11-30
MX2017013285A (en) 2018-08-01
RU2730599C2 (en) 2020-08-24
JP2022111334A (en) 2022-07-29
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ES2950399T3 (en) 2023-10-09
EP3282835A1 (en) 2018-02-21
US20200229410A1 (en) 2020-07-23
US20180295820A1 (en) 2018-10-18
AU2016247892B2 (en) 2022-05-26
JP7088992B2 (en) 2022-06-21
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