SG11201702628XA - Boronic acid derivatives - Google Patents

Boronic acid derivatives

Info

Publication number: SG11201702628XA
Authority: SG; Singapore
Prior art keywords: acid derivatives; boronic acid; boronic; derivatives; acid
Prior art date: 2014-10-01

Application number

SG11201702628XA

Inventor

Markus Klein

Oliver Schadt

Philipp Haselmayer

Mireille Krier

Original Assignee

Merck Patent Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2014-10-01

Filing date

2015-10-01

Publication date

2017-04-27

2015-10-01 Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh

2017-04-27 Publication of SG11201702628XA publication Critical patent/SG11201702628XA/en

Links

150000001642 boronic acid derivatives Chemical class 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/69—Boron compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Epidemiology (AREA)
Orthopedic Medicine & Surgery (AREA)
Neurology (AREA)
Physical Education & Sports Medicine (AREA)
Urology & Nephrology (AREA)
Cardiology (AREA)
Pulmonology (AREA)
Dermatology (AREA)
Heart & Thoracic Surgery (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Transplantation (AREA)
Hematology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Gastroenterology & Hepatology (AREA)
Vascular Medicine (AREA)
Oncology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

SG11201702628XA 2014-10-01 2015-10-01 Boronic acid derivatives SG11201702628XA (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP14003389		2014-10-01
PCT/EP2015/001973 WO2016050358A1 (en)	2014-10-01	2015-10-01	Boronic acid derivatives

Publications (1)

Publication Number	Publication Date
SG11201702628XA true SG11201702628XA (en)	2017-04-27

Family

ID=51751859

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SG11201702628XA SG11201702628XA (en)	2014-10-01	2015-10-01	Boronic acid derivatives

Country Status (21)

Country	Link
US (1)	US10669289B2 (en)
EP (1)	EP3201206B1 (en)
JP (1)	JP6662865B2 (en)
KR (1)	KR102457840B1 (en)
CN (1)	CN107001391B (en)
AU (1)	AU2015327345B9 (en)
BR (1)	BR112017006622A2 (en)
CA (1)	CA2963203A1 (en)
CL (1)	CL2017000792A1 (en)
DK (1)	DK3201206T3 (en)
ES (1)	ES2761774T3 (en)
IL (1)	IL251302B (en)
MX (1)	MX2017003999A (en)
MY (1)	MY186911A (en)
NZ (1)	NZ730981A (en)
PH (1)	PH12017500293A1 (en)
RU (1)	RU2717558C2 (en)
SG (1)	SG11201702628XA (en)
UA (1)	UA122672C2 (en)
WO (1)	WO2016050358A1 (en)
ZA (1)	ZA201703007B (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US9453018B2 (en)	2014-10-01	2016-09-27	Bristol-Myers Squibb Company	Pyrimidinones as factor XIa inhibitors
AU2015327346B2 (en)	2014-10-01	2019-12-05	Merck Patent Gmbh	Boronic acid derivatives
MX2017004043A (en)	2014-10-01	2017-07-04	Merck Patent Gmbh	Boronic acid derivatives.
RU2017115193A (en)	2014-10-01	2018-11-06	Мерк Патент Гмбх	Derivatives of Boronic Acid
JP7071400B6 (en)	2017-01-18	2022-06-07	プリンシピアバイオファーマインコーポレイテッド	Immune proteasome inhibitor
PL3672977T3 (en)	2017-08-24	2022-09-26	Merck Patent Gmbh	Boronic acid derivatives
WO2019042301A1 (en) *	2017-08-29	2019-03-07	浙江海正药业股份有限公司	(E)-α,β-UNSATURATED AMIDE COMPOUND AND PREPARATION METHOD AND USE THEREOF
EP3694528A4 (en) *	2017-10-13	2021-07-28	The Regents of the University of California	Mtorc1 modulators
MA50906A (en) *	2017-11-16	2020-09-23	Principia Biopharma Inc	IMMUNOPROTEASOME INHIBITORS
PL3710457T3 (en) *	2017-11-16	2023-02-20	Principia Biopharma Inc.	Immunoproteasome inhibitors
US20210317145A1 (en)	2018-07-26	2021-10-14	Merck Patent Gmbh	Boronic Acid Derivatives
CN113135944A (en) *	2020-01-19	2021-07-20	首药控股(北京)有限公司	Boronic acid derivatives
CN113135943A (en) *	2020-01-19	2021-07-20	首药控股(北京)有限公司	Boronic acid derivatives
WO2023006863A1 (en)	2021-07-29	2023-02-02	Merck Patent Gmbh	Novel crystalline forms of [(1r)-2-(1-benzofuran-3-yl)-1-{[(1s,2r,4r)-7- oxabicyclo[2.2.1]heptan-2-yl]formamido}ethyl]boronic acid, adducts thereof, and processes to obtain
KR20240090392A (en) *	2021-10-14	2024-06-21	쇼우야오 홀딩스 (베이징) 코., 엘티디.	boronic acid derivatives
WO2023232830A1 (en)	2022-06-02	2023-12-07	Merck Patent Gmbh	Boronic acid adducts

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5658885A (en) *	1993-04-27	1997-08-19	The Dupont Merck Pharmaceutical Company	Amidino and guanidino substituted boronic acid inhibitors of trypsin-like enzymes
US5462964A (en) *	1993-10-20	1995-10-31	The Du Pont Merck Pharmaceutical Company	Dipeptide boronic acid inhibitors of trypsin-like enzymes
IL111175A0 (en) *	1993-10-07	1994-12-29	Du Pont Merck Pharma	Electrophilic peptide analogs as inhibitors of trypsin-like serine proteases and pharmaceutical compositions containing them
AU5788800A (en) *	1999-07-07	2001-01-22	Du Pont Pharmaceuticals Company	Peptide boronic acid inhibitors of hepatitis c virus protease
EP1466916B1 (en) *	2002-09-09	2007-10-24	Trigen Limited	Peptide boronic acids useful in making salts thereof
US7576206B2 (en) *	2003-08-14	2009-08-18	Cephalon, Inc.	Proteasome inhibitors and methods of using the same
MY162518A (en) *	2003-08-14	2017-06-15	Cephalon Inc	Proteasome inhibitors and methods of using the same
AR075090A1 (en) *	2008-09-29	2011-03-09	Millennium Pharm Inc	ACID DERIVATIVES 1-AMINO-2-CYCLLOBUTILETILBORONICO PROTEOSOMA INHIBITORS, USEFUL AS ANTI-BANKER AGENTS, AND PHARMACEUTICAL COMPOSITIONS THAT UNDERSTAND THEM.
MY162535A (en) *	2010-04-22	2017-06-15	Mars Inc	Inhibitors of arginase and their therapeutic applications
CA2860142C (en) *	2011-12-22	2020-10-27	Ares Trading S.A.	Alpha-amino boronic acid derivatives, selective immunoproteasome inhibitors
IL307212A (en)	2014-01-31	2023-11-01	Bristol Myers Squibb Co	Macrocycles with hetrocyclic p2' groups as factor xia inhibitors
MX2017004043A (en)	2014-10-01	2017-07-04	Merck Patent Gmbh	Boronic acid derivatives.
CN107001265B (en)	2014-10-01	2021-06-15	杨森制药公司	Monosubstituted or disubstituted indoles as inhibitors of dengue virus replication
NO2721243T3 (en)	2014-10-01	2018-10-20
MX2017004299A (en)	2014-10-01	2017-07-19	Janssen Pharmaceuticals Inc	Mono- or di-substituted indole derivatives as dengue viral replication inhibitors.
RU2017115193A (en)	2014-10-01	2018-11-06	Мерк Патент Гмбх	Derivatives of Boronic Acid
AU2015327346B2 (en)	2014-10-01	2019-12-05	Merck Patent Gmbh	Boronic acid derivatives

2015
- 2015-10-01 BR BR112017006622-0A patent/BR112017006622A2/en not_active Application Discontinuation
- 2015-10-01 NZ NZ730981A patent/NZ730981A/en unknown
- 2015-10-01 MY MYPI2017701058A patent/MY186911A/en unknown
- 2015-10-01 CN CN201580053501.9A patent/CN107001391B/en active Active
- 2015-10-01 CA CA2963203A patent/CA2963203A1/en active Pending
- 2015-10-01 MX MX2017003999A patent/MX2017003999A/en active IP Right Grant
- 2015-10-01 UA UAA201704168A patent/UA122672C2/en unknown
- 2015-10-01 WO PCT/EP2015/001973 patent/WO2016050358A1/en active Application Filing
- 2015-10-01 ES ES15778613T patent/ES2761774T3/en active Active
- 2015-10-01 DK DK15778613.8T patent/DK3201206T3/en active
- 2015-10-01 RU RU2017115192A patent/RU2717558C2/en active
- 2015-10-01 AU AU2015327345A patent/AU2015327345B9/en active Active
- 2015-10-01 SG SG11201702628XA patent/SG11201702628XA/en unknown
- 2015-10-01 JP JP2017518070A patent/JP6662865B2/en active Active
- 2015-10-01 US US15/516,427 patent/US10669289B2/en active Active
- 2015-10-01 EP EP15778613.8A patent/EP3201206B1/en active Active
- 2015-10-01 KR KR1020177011562A patent/KR102457840B1/en active IP Right Grant
2017
- 2017-02-16 PH PH12017500293A patent/PH12017500293A1/en unknown
- 2017-03-21 IL IL251302A patent/IL251302B/en active IP Right Grant
- 2017-03-31 CL CL2017000792A patent/CL2017000792A1/en unknown
- 2017-04-28 ZA ZA2017/03007A patent/ZA201703007B/en unknown

Also Published As

Publication number	Publication date
MY186911A (en)	2021-08-26
EP3201206A1 (en)	2017-08-09
AU2015327345B9 (en)	2020-06-18
ES2761774T3 (en)	2020-05-21
RU2017115192A (en)	2018-11-06
AU2015327345B2 (en)	2019-12-05
RU2017115192A3 (en)	2019-03-26
AU2015327345A1 (en)	2017-05-18
IL251302B (en)	2020-03-31
MX2017003999A (en)	2018-02-09
KR102457840B1 (en)	2022-10-21
CL2017000792A1 (en)	2017-11-10
EP3201206B1 (en)	2019-09-18
WO2016050358A1 (en)	2016-04-07
CA2963203A1 (en)	2016-04-07
JP6662865B2 (en)	2020-03-11
KR20170067802A (en)	2017-06-16
US20180179232A1 (en)	2018-06-28
US10669289B2 (en)	2020-06-02
CN107001391B (en)	2020-11-27
IL251302A0 (en)	2017-05-29
UA122672C2 (en)	2020-12-28
DK3201206T3 (en)	2019-12-16
ZA201703007B (en)	2022-05-25
RU2717558C2 (en)	2020-03-24
PH12017500293A1 (en)	2017-06-28
JP2017531646A (en)	2017-10-26
CN107001391A (en)	2017-08-01
NZ730981A (en)	2024-01-26
BR112017006622A2 (en)	2018-07-03

Publication	Publication Date	Title
ZA201703007B (en)	2022-05-25	Boronic acid derivatives
GB201419865D0 (en)	2014-12-24	Solution
GB201517022D0 (en)	2015-11-11	No details
SG11201702620SA (en)	2017-04-27	Boronic acid derivatives
GB201410907D0 (en)	2014-08-06	No details
SG11201702625PA (en)	2017-04-27	Boronic acid derivatives
GB201517404D0 (en)	2015-11-18	No details
SG11201702623TA (en)	2017-04-27	Boronic acid derivatives
GB201418217D0 (en)	2014-11-26	No details
GB201418216D0 (en)	2014-11-26	No details
SG11201609205WA (en)	2016-12-29	Heterocyclyl-butanamide derivatives
PT3131898T (en)	2020-06-17	Fluoroalkylfluorene derivatives
GB201517412D0 (en)	2015-11-18	No details
PL3164393T3 (en)	2019-03-29	Flavagline derivatives
GB201516796D0 (en)	2015-11-04	No details
IL248773A0 (en)	2017-01-31	Naphthyridinedione derivatives
IL248629A0 (en)	2017-01-31	Cycloalkyl-linked diheterocycle derivatives
PT3672977T (en)	2022-09-23	Boronic acid derivatives
GB201517574D0 (en)	2015-11-18	No details
DK3200779T3 (en)	2022-06-20	Novel anthranilic acid derivatives
SI3097076T1 (en)	2019-10-30	Novel cyp-eicosanoid derivatives
PL3119744T3 (en)	2019-07-31	2-cyano-3-cyclopropyl-3-hydroxy-n-aryl-thioacrylamide derivatives
GB201410910D0 (en)	2014-08-06	No details
GB201417986D0 (en)	2014-11-26	No details
GB201407585D0 (en)	2014-06-11	SMA-Inter Act