SG11201702625PA - Boronic acid derivatives - Google Patents

Boronic acid derivatives

Info

Publication number: SG11201702625PA
Authority: SG; Singapore
Prior art keywords: acid derivatives; boronic acid; boronic; derivatives; acid
Prior art date: 2014-10-01

Application number

SG11201702625PA

Inventor

Markus Klein

Oliver Schadt

Philipp Haselmayer

Michael Busch

Original Assignee

Merck Patent Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2014-10-01

Filing date

2015-10-01

Publication date

2017-04-27

2015-10-01 Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh

2017-04-27 Publication of SG11201702625PA publication Critical patent/SG11201702625PA/en

Links

150000001642 boronic acid derivatives Chemical class 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/69—Boron compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Epidemiology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Neurology (AREA)
Urology & Nephrology (AREA)
Dermatology (AREA)
Pulmonology (AREA)
Rheumatology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Transplantation (AREA)
Oncology (AREA)
Hematology (AREA)
Vascular Medicine (AREA)
Pain & Pain Management (AREA)
Gastroenterology & Hepatology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Peptides Or Proteins (AREA)
Enzymes And Modification Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

SG11201702625PA 2014-10-01 2015-10-01 Boronic acid derivatives SG11201702625PA (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP14003390		2014-10-01
PCT/EP2015/001930 WO2016050355A1 (en)	2014-10-01	2015-10-01	Boronic acid derivatives

Publications (1)

Publication Number	Publication Date
SG11201702625PA true SG11201702625PA (en)	2017-04-27

Family

ID=51690787

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SG11201702625PA SG11201702625PA (en)	2014-10-01	2015-10-01	Boronic acid derivatives

Country Status (14)

Country	Link
US (1)	US10640520B2 (en)
EP (1)	EP3201205B1 (en)
JP (1)	JP6835710B2 (en)
KR (1)	KR20170066506A (en)
CN (1)	CN107108660B (en)
AU (1)	AU2015327411B2 (en)
BR (1)	BR112017006368A2 (en)
CA (1)	CA2963186A1 (en)
ES (1)	ES2811273T3 (en)
IL (1)	IL251300A0 (en)
MX (1)	MX2017004037A (en)
RU (1)	RU2017115193A (en)
SG (1)	SG11201702625PA (en)
WO (1)	WO2016050355A1 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
MY186911A (en)	2014-10-01	2021-08-26	Merck Patent Gmbh	Boronic acid derivatives
US10294246B2 (en)	2014-10-01	2019-05-21	Merck Patent Gmbh	Substituted boronic acids and boronate esters as immunoproteasome inhibitors
US10253049B2 (en)	2014-10-01	2019-04-09	Merck Patent Gmbh	Boronic acid derivatives
EP3672586A1 (en) *	2017-08-23	2020-07-01	Kezar Life Sciences	Immunoproteasome inhibitors and immunosuppressive agent in the treatment of autoimmune disorders
ES2927283T3 (en) *	2017-08-24	2022-11-03	Merck Patent Gmbh	Boronic acid derivatives
CA3107377A1 (en) *	2018-07-26	2020-01-30	Merck Patent Gmbh	Boronic acid derivatives
KR20210071982A (en) *	2018-10-04	2021-06-16	케자르 라이프 사이언스	Immunoproteasome inhibitory agents
CN113135944A (en) *	2020-01-19	2021-07-20	首药控股(北京)有限公司	Boronic acid derivatives
CN113135943A (en) *	2020-01-19	2021-07-20	首药控股(北京)有限公司	Boronic acid derivatives
CN114075227B (en) *	2020-08-19	2023-07-04	北京嵩润医药科技有限责任公司	Pyrazole boric acid compound, pharmaceutical composition containing pyrazole boric acid compound and application of pyrazole boric acid compound and pharmaceutical composition
EP4377324A1 (en)	2021-07-29	2024-06-05	Merck Patent GmbH	Novel crystalline forms of [(1r)-2-(1-benzofuran-3-yl)-1-{[(1s,2r,4r)-7- oxabicyclo[2.2.1]heptan-2-yl]formamido}ethyl]boronic acid, adducts thereof, and processes to obtain
WO2023232830A1 (en)	2022-06-02	2023-12-07	Merck Patent Gmbh	Boronic acid adducts

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5563127A (en) *	1993-03-24	1996-10-08	The Dupont Merck Pharmaceutical Company	Boronic acid and ester inhibitors of thrombin
IL111175A0 (en)	1993-10-07	1994-12-29	Du Pont Merck Pharma	Electrophilic peptide analogs as inhibitors of trypsin-like serine proteases and pharmaceutical compositions containing them
US6060462A (en) *	1993-10-20	2000-05-09	Dupont Pharmaceuticals Company	Electrophilic peptide analogs as inhibitors of trypsin-like enzymes
FR2758329B1 (en) *	1997-01-16	1999-02-12	Synthelabo	BORONIC IMIDAZOLE-4-BUTANE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE
CA2705393A1 (en) *	2007-11-13	2009-05-22	Protez Pharmaceuticals, Inc.	Beta-lactamase inhibitors
US20100120715A1 (en) *	2007-11-13	2010-05-13	Burns Christopher J	Beta-lactamase inhibitors
AR075090A1 (en) *	2008-09-29	2011-03-09	Millennium Pharm Inc	ACID DERIVATIVES 1-AMINO-2-CYCLLOBUTILETILBORONICO PROTEOSOMA INHIBITORS, USEFUL AS ANTI-BANKER AGENTS, AND PHARMACEUTICAL COMPOSITIONS THAT UNDERSTAND THEM.
BR112014015363A2 (en) *	2011-12-22	2017-06-13	Ares Trading Sa	alpha-amino boronic acid derivatives, selective immunoproteasome inhibitors
EP2970340B1 (en) *	2013-03-14	2020-02-12	Venatorx Pharmaceuticals, Inc.	Beta-lactamase inhibitors
MY186911A (en)	2014-10-01	2021-08-26	Merck Patent Gmbh	Boronic acid derivatives
US10294246B2 (en)	2014-10-01	2019-05-21	Merck Patent Gmbh	Substituted boronic acids and boronate esters as immunoproteasome inhibitors
US10253049B2 (en)	2014-10-01	2019-04-09	Merck Patent Gmbh	Boronic acid derivatives

2015
- 2015-10-01 WO PCT/EP2015/001930 patent/WO2016050355A1/en active Application Filing
- 2015-10-01 BR BR112017006368A patent/BR112017006368A2/en not_active IP Right Cessation
- 2015-10-01 AU AU2015327411A patent/AU2015327411B2/en active Active
- 2015-10-01 CN CN201580053424.7A patent/CN107108660B/en active Active
- 2015-10-01 EP EP15775380.7A patent/EP3201205B1/en active Active
- 2015-10-01 CA CA2963186A patent/CA2963186A1/en active Pending
- 2015-10-01 MX MX2017004037A patent/MX2017004037A/en unknown
- 2015-10-01 KR KR1020177011627A patent/KR20170066506A/en unknown
- 2015-10-01 ES ES15775380T patent/ES2811273T3/en active Active
- 2015-10-01 US US15/516,420 patent/US10640520B2/en active Active
- 2015-10-01 JP JP2017518069A patent/JP6835710B2/en active Active
- 2015-10-01 SG SG11201702625PA patent/SG11201702625PA/en unknown
- 2015-10-01 RU RU2017115193A patent/RU2017115193A/en not_active Application Discontinuation
2017
- 2017-03-21 IL IL251300A patent/IL251300A0/en unknown

Also Published As

Publication number	Publication date
CN107108660B (en)	2020-09-15
JP2018502049A (en)	2018-01-25
IL251300A0 (en)	2017-05-29
WO2016050355A1 (en)	2016-04-07
BR112017006368A2 (en)	2017-12-19
CN107108660A (en)	2017-08-29
EP3201205A1 (en)	2017-08-09
AU2015327411A1 (en)	2017-05-18
AU2015327411B2 (en)	2020-01-02
RU2017115193A3 (en)	2019-02-08
US20180179231A1 (en)	2018-06-28
EP3201205B1 (en)	2020-05-13
US10640520B2 (en)	2020-05-05
MX2017004037A (en)	2017-07-04
KR20170066506A (en)	2017-06-14
CA2963186A1 (en)	2016-04-07
RU2017115193A (en)	2018-11-06
ES2811273T3 (en)	2021-03-11
JP6835710B2 (en)	2021-02-24

Publication	Publication Date	Title
ZA201703007B (en)	2022-05-25	Boronic acid derivatives
GB201419865D0 (en)	2014-12-24	Solution
GB201517022D0 (en)	2015-11-11	No details
SG11201702620SA (en)	2017-04-27	Boronic acid derivatives
GB201410907D0 (en)	2014-08-06	No details
SG11201702625PA (en)	2017-04-27	Boronic acid derivatives
GB201517404D0 (en)	2015-11-18	No details
SG11201702623TA (en)	2017-04-27	Boronic acid derivatives
GB201418217D0 (en)	2014-11-26	No details
GB201418216D0 (en)	2014-11-26	No details
SG11201609205WA (en)	2016-12-29	Heterocyclyl-butanamide derivatives
PT3131898T (en)	2020-06-17	Fluoroalkylfluorene derivatives
GB201517412D0 (en)	2015-11-18	No details
IL248773A0 (en)	2017-01-31	Naphthyridinedione derivatives
IL248629A0 (en)	2017-01-31	Cycloalkyl-linked diheterocycle derivatives
PT3672977T (en)	2022-09-23	Boronic acid derivatives
GB201517574D0 (en)	2015-11-18	No details
DK3200779T3 (en)	2022-06-20	Novel anthranilic acid derivatives
PL3418273T3 (en)	2022-08-01	Flavagline derivatives
HUE044703T2 (en)	2019-11-28	Novel cyp-eicosanoid derivatives
GB201516796D0 (en)	2015-11-04	No details
PL3119744T3 (en)	2019-07-31	2-cyano-3-cyclopropyl-3-hydroxy-n-aryl-thioacrylamide derivatives
GB201410910D0 (en)	2014-08-06	No details
GB201417986D0 (en)	2014-11-26	No details
GB201407585D0 (en)	2014-06-11	SMA-Inter Act