SG11201700703XA - Salt of monocyclic pyridine derivative and crystal thereof - Google Patents
Salt of monocyclic pyridine derivative and crystal thereofInfo
- Publication number
- SG11201700703XA SG11201700703XA SG11201700703XA SG11201700703XA SG11201700703XA SG 11201700703X A SG11201700703X A SG 11201700703XA SG 11201700703X A SG11201700703X A SG 11201700703XA SG 11201700703X A SG11201700703X A SG 11201700703XA SG 11201700703X A SG11201700703X A SG 11201700703XA
- Authority
- SG
- Singapore
- Prior art keywords
- salt
- crystal
- pyridine derivative
- monocyclic pyridine
- monocyclic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
- C07C55/02—Dicarboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
- C07C55/02—Dicarboxylic acids
- C07C55/10—Succinic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2014166118 | 2014-08-18 | ||
PCT/JP2015/073047 WO2016027781A1 (ja) | 2014-08-18 | 2015-08-17 | 単環ピリジン誘導体の塩およびその結晶 |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201700703XA true SG11201700703XA (en) | 2017-03-30 |
Family
ID=55350725
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201700703XA SG11201700703XA (en) | 2014-08-18 | 2015-08-17 | Salt of monocyclic pyridine derivative and crystal thereof |
Country Status (14)
Country | Link |
---|---|
US (1) | US9951047B2 (ru) |
EP (1) | EP3184520B1 (ru) |
JP (1) | JP5925978B1 (ru) |
KR (1) | KR102344105B1 (ru) |
CN (1) | CN106660997B (ru) |
AU (1) | AU2015304465B2 (ru) |
BR (1) | BR112017002268B1 (ru) |
CA (1) | CA2956270C (ru) |
ES (1) | ES2914072T3 (ru) |
IL (1) | IL250290B (ru) |
MX (1) | MX369646B (ru) |
RU (1) | RU2658821C1 (ru) |
SG (1) | SG11201700703XA (ru) |
WO (1) | WO2016027781A1 (ru) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2017104739A1 (ja) * | 2015-12-17 | 2017-06-22 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 乳がん治療剤 |
EP3694513A4 (en) * | 2017-10-12 | 2021-06-30 | Eisai R&D Management Co., Ltd. | PHARMACEUTICAL COMPOSITION WITH FGFR-SELECTIVE TYROSINKINAS INHIBITOR |
EP3777860A4 (en) * | 2018-03-28 | 2021-12-15 | Eisai R&D Management Co., Ltd. | THERAPEUTIC FOR HEPATOCELLULAR CARCINOMA |
BR112022020786A2 (pt) | 2020-04-17 | 2022-11-29 | Eisai R&D Man Co Ltd | Agente terapêutico de câncer de mama |
AU2021315234A1 (en) | 2020-07-31 | 2023-01-19 | Eisai R&D Management Co., Ltd. | Therapeutic agent for breast cancer |
WO2022092085A1 (ja) | 2020-10-28 | 2022-05-05 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 腫瘍治療用医薬組成物 |
EP4361143A1 (en) | 2021-08-31 | 2024-05-01 | Eisai R&D Management Co., Ltd. | Method for producing monocyclic pyridine derivative |
CA3227445A1 (en) | 2021-08-31 | 2023-03-09 | Eisai R&D Management Co., Ltd. | Production method for synthetic intermediate of monocyclic pyridine derivative |
WO2023174400A1 (zh) * | 2022-03-18 | 2023-09-21 | 上海润石医药科技有限公司 | 一种取代的氨基六元氮杂环类化合物的盐及其晶型、制备方法和应用 |
Family Cites Families (60)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10006139A1 (de) | 2000-02-11 | 2001-08-16 | Merck Patent Gmbh | Indol-3-yl-Derivate |
ES2318649T3 (es) * | 2000-10-20 | 2009-05-01 | EISAI R&D MANAGEMENT CO., LTD. | Procedimiento de preparacion de derivados de 4-fenoxi quinolinas. |
US20030187026A1 (en) | 2001-12-13 | 2003-10-02 | Qun Li | Kinase inhibitors |
JP4183193B2 (ja) | 2002-08-30 | 2008-11-19 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 含窒素芳香環誘導体 |
US7098332B2 (en) | 2002-12-20 | 2006-08-29 | Hoffmann-La Roche Inc. | 5,8-Dihydro-6H-pyrido[2,3-d]pyrimidin-7-ones |
CN100497339C (zh) | 2003-04-10 | 2009-06-10 | 霍夫曼-拉罗奇有限公司 | 嘧啶并化合物 |
US20050256154A1 (en) | 2004-05-04 | 2005-11-17 | Kin-Chun Luk | 4-Amino-thieno[3,2-c]pyridine-7-carboxylic acid amides |
GB0512324D0 (en) | 2005-06-16 | 2005-07-27 | Novartis Ag | Organic compounds |
FR2883286B1 (fr) | 2005-03-16 | 2008-10-03 | Sanofi Aventis Sa | NOUVEAUX DERIVES D'IMIDAZO[1,5-a]PYRIDINES, INHIBITEURS DE FGFs, LEUR PROCEDE DE PREPARATION ET LES COMPOSITIONS PHARMACEUTIQUES LES CONTENANT |
EP2266974A1 (en) | 2005-05-23 | 2010-12-29 | Novartis AG | Crystalline and other forms of 4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-Quinolin-2-one lactic acid salts |
EA016438B1 (ru) | 2005-12-21 | 2012-05-30 | Новартис Аг | Производные пиримидиниларилмочевины в качестве ингибиторов фактора роста фибробластов (fgf-фактора) |
TW200811134A (en) | 2006-07-12 | 2008-03-01 | Irm Llc | Compounds and compositions as protein kinase inhibitors |
EP1891955A1 (en) | 2006-07-24 | 2008-02-27 | Sanofi-Aventis | Use of 1,2,3-substituted indolizine derivatives, inhibitors of FGFs, for the preparation of a medicament intended for the treatment of degenerative joint diseases |
US7737149B2 (en) | 2006-12-21 | 2010-06-15 | Astrazeneca Ab | N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-2H-pyrazol-3-yl]-4-(3,5-dimethylpiperazin-1-yl)benzamide and salts thereof |
JP5442449B2 (ja) | 2006-12-22 | 2014-03-12 | アステックス、セラピューティックス、リミテッド | 新規化合物 |
US8895745B2 (en) | 2006-12-22 | 2014-11-25 | Astex Therapeutics Limited | Bicyclic heterocyclic compounds as FGFR inhibitors |
US8131527B1 (en) | 2006-12-22 | 2012-03-06 | Astex Therapeutics Ltd. | FGFR pharmacophore compounds |
CA2690355A1 (en) | 2007-06-25 | 2008-12-31 | Qinetiq Limited | Preconcentrator device incorporating a polymer of intrinsic microporosity |
WO2009019518A1 (en) | 2007-08-09 | 2009-02-12 | Astrazeneca Ab | Pyrimidine compounds having a fgfr inhibitory effect |
GB0720038D0 (en) | 2007-10-12 | 2007-11-21 | Astex Therapeutics Ltd | New compounds |
GB0720041D0 (en) | 2007-10-12 | 2007-11-21 | Astex Therapeutics Ltd | New Compounds |
WO2009056886A1 (en) | 2007-11-01 | 2009-05-07 | Astrazeneca Ab | Pyrimidine derivatives and their use as modulators of fgfr activity |
CL2008003675A1 (es) | 2007-12-13 | 2009-03-20 | Wyeth Corp | Compuestos derivados de 5-alquil o alquenil 3-cianopiridinas, procedimiento de preparacion, composicion farmaceutica, util para reducir la actividad incrementada de una enzima en un mamifero, en donde dicha enzima es una proteina quinasa, destinado al tratamiento de la inflamacion, asma, colitis, esclerosis multiple, soriasis, artritis reumatoide. |
CN102036963B (zh) | 2008-05-23 | 2013-08-21 | 诺瓦提斯公司 | 作为蛋白酪氨酸激酶抑制剂的喹啉类和喹喔啉类衍生物 |
GB0810902D0 (en) | 2008-06-13 | 2008-07-23 | Astex Therapeutics Ltd | New compounds |
KR20110020904A (ko) | 2008-06-19 | 2011-03-03 | 아스트라제네카 아베 | 피라졸 화합물 436 |
CA2748174A1 (en) | 2008-12-30 | 2010-07-08 | Arqule, Inc. | Substituted 1h-pyrazolo[3,4-d]pyrimidine-6-amine compounds |
CA2748491C (en) | 2008-12-30 | 2019-08-06 | Arqule, Inc. | Substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine compounds |
AU2009335016A1 (en) | 2008-12-30 | 2011-08-18 | Arqule, Inc. | Substituted pyrazolo [3, 4-b] pyridine compounds |
US9002427B2 (en) | 2009-03-30 | 2015-04-07 | Lifewave Biomedical, Inc. | Apparatus and method for continuous noninvasive measurement of respiratory function and events |
GB0906470D0 (en) | 2009-04-15 | 2009-05-20 | Astex Therapeutics Ltd | New compounds |
GB0906472D0 (en) | 2009-04-15 | 2009-05-20 | Astex Therapeutics Ltd | New compounds |
EP2270043A1 (en) | 2009-07-03 | 2011-01-05 | Sanofi-Aventis | Extracellular allosteric inhibitor binding domain from a tyrosine kinase receptor |
FR2947546B1 (fr) | 2009-07-03 | 2011-07-01 | Sanofi Aventis | Derives de pyrazoles, leur preparation et leur application en therapeutique |
MX2012001653A (es) | 2009-08-07 | 2012-06-19 | Hoffmann La Roche | Derivado de aminopirazol. |
EP2493864B1 (en) | 2009-10-30 | 2014-10-01 | Novartis AG | N-oxide of 3-(2,6-dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-methyl-urea |
AR079257A1 (es) | 2009-12-07 | 2012-01-04 | Novartis Ag | Formas cristalinas de 3-(2,6-dicloro-3-5-dimetoxi-fenil)-1-{6-[4-(4-etil-piperazin-1-il)-fenil-amino]-pirimidin-4-il}-1-metil-urea y sales de las mismas |
GB201007286D0 (en) | 2010-04-30 | 2010-06-16 | Astex Therapeutics Ltd | New compounds |
FR2962437B1 (fr) | 2010-07-06 | 2012-08-17 | Sanofi Aventis | Derives d'imidazopyridine, leur procede de preparation et leur application en therapeutique |
GB201020179D0 (en) | 2010-11-29 | 2011-01-12 | Astex Therapeutics Ltd | New compounds |
WO2012088266A2 (en) | 2010-12-22 | 2012-06-28 | Incyte Corporation | Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3 |
PE20141681A1 (es) | 2011-07-19 | 2014-11-14 | Merck Sharp And Dohme B V | Inhibidores de btk |
EP2548877A1 (en) * | 2011-07-19 | 2013-01-23 | MSD Oss B.V. | 4-(5-Membered fused pyridinyl)benzamides as BTK-inhibitors |
GB201118654D0 (en) | 2011-10-28 | 2011-12-07 | Astex Therapeutics Ltd | New compounds |
GB201118652D0 (en) | 2011-10-28 | 2011-12-07 | Astex Therapeutics Ltd | New compounds |
GB201118675D0 (en) | 2011-10-28 | 2011-12-14 | Astex Therapeutics Ltd | New compounds |
GB201118656D0 (en) | 2011-10-28 | 2011-12-07 | Astex Therapeutics Ltd | New compounds |
FR2984325A1 (fr) | 2011-12-14 | 2013-06-21 | Sanofi Sa | Derives de pyrazolopyridine, leur procede de preparation et leur application en therapeutique |
SG2014009286A (en) | 2012-01-19 | 2014-04-28 | Taiho Pharmaceutical Co Ltd | 3,5-disubstituted alkynylbenzene compound and salt thereof |
WO2013129369A1 (ja) | 2012-02-28 | 2013-09-06 | アステラス製薬株式会社 | 含窒素芳香族へテロ環化合物 |
GB201209609D0 (en) | 2012-05-30 | 2012-07-11 | Astex Therapeutics Ltd | New compounds |
PT3176170T (pt) | 2012-06-13 | 2019-02-05 | Incyte Holdings Corp | Compostos tricíclicos substituídos como inibidores de fgfr |
JPWO2014007369A1 (ja) | 2012-07-05 | 2016-06-02 | 国立研究開発法人国立がん研究センター | Fgfr2融合遺伝子 |
KR102163776B1 (ko) | 2012-07-11 | 2020-10-12 | 블루프린트 메디신즈 코포레이션 | 섬유아세포 성장인자 수용체의 저해제 |
US9388185B2 (en) | 2012-08-10 | 2016-07-12 | Incyte Holdings Corporation | Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors |
WO2014044846A1 (en) | 2012-09-24 | 2014-03-27 | Evotec (Uk) Ltd. | 3-(aryl- or heteroaryl-amino)-7-(3,5-dimethoxyphenyl)isoquinoline derivatives as fgfr inhibitors useful for the treatment of proliferative disorders or dysplasia |
WO2014048878A1 (en) | 2012-09-26 | 2014-04-03 | Evotec (Uk) Ltd. | Phenyl- or pyridyl- pyrrolo[2,3b]pyrazine derivatives useful in the treatment or prevention of proliferative disorders or dysplasia |
JP6117222B2 (ja) | 2012-09-27 | 2017-04-19 | 中外製薬株式会社 | Fgfr3融合遺伝子およびそれを標的とする医薬 |
AR094812A1 (es) | 2013-02-20 | 2015-08-26 | Eisai R&D Man Co Ltd | Derivado de piridina monocíclico como inhibidor del fgfr |
TWI628176B (zh) | 2013-04-04 | 2018-07-01 | 奧利安公司 | 蛋白質激酶抑制劑 |
-
2015
- 2015-08-17 KR KR1020177002791A patent/KR102344105B1/ko active IP Right Grant
- 2015-08-17 CN CN201580042132.3A patent/CN106660997B/zh active Active
- 2015-08-17 CA CA2956270A patent/CA2956270C/en active Active
- 2015-08-17 JP JP2015560425A patent/JP5925978B1/ja active Active
- 2015-08-17 US US15/500,429 patent/US9951047B2/en active Active
- 2015-08-17 SG SG11201700703XA patent/SG11201700703XA/en unknown
- 2015-08-17 BR BR112017002268-0A patent/BR112017002268B1/pt active IP Right Grant
- 2015-08-17 WO PCT/JP2015/073047 patent/WO2016027781A1/ja active Application Filing
- 2015-08-17 AU AU2015304465A patent/AU2015304465B2/en active Active
- 2015-08-17 ES ES15834302T patent/ES2914072T3/es active Active
- 2015-08-17 MX MX2017001624A patent/MX369646B/es active IP Right Grant
- 2015-08-17 RU RU2017103439A patent/RU2658821C1/ru active
- 2015-08-17 EP EP15834302.0A patent/EP3184520B1/en active Active
-
2017
- 2017-01-25 IL IL250290A patent/IL250290B/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
MX2017001624A (es) | 2017-04-27 |
US9951047B2 (en) | 2018-04-24 |
BR112017002268A2 (pt) | 2017-11-21 |
RU2658821C1 (ru) | 2018-06-25 |
BR112017002268B1 (pt) | 2022-11-08 |
CA2956270A1 (en) | 2016-02-25 |
IL250290B (en) | 2020-06-30 |
MX369646B (es) | 2019-11-15 |
EP3184520A1 (en) | 2017-06-28 |
IL250290A0 (en) | 2017-03-30 |
CN106660997A (zh) | 2017-05-10 |
AU2015304465B2 (en) | 2019-05-09 |
JPWO2016027781A1 (ja) | 2017-04-27 |
EP3184520A4 (en) | 2018-04-18 |
ES2914072T3 (es) | 2022-06-07 |
JP5925978B1 (ja) | 2016-05-25 |
CA2956270C (en) | 2022-08-09 |
KR102344105B1 (ko) | 2021-12-29 |
EP3184520B1 (en) | 2022-03-23 |
WO2016027781A1 (ja) | 2016-02-25 |
AU2015304465A1 (en) | 2017-02-23 |
US20170217935A1 (en) | 2017-08-03 |
CN106660997B (zh) | 2019-05-21 |
KR20170035927A (ko) | 2017-03-31 |
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