SG11201607751SA - Chemical compounds - Google Patents

Chemical compounds

Info

Publication number
SG11201607751SA
SG11201607751SA SG11201607751SA SG11201607751SA SG11201607751SA SG 11201607751S A SG11201607751S A SG 11201607751SA SG 11201607751S A SG11201607751S A SG 11201607751SA SG 11201607751S A SG11201607751S A SG 11201607751SA SG 11201607751S A SG11201607751S A SG 11201607751SA
Authority
SG
Singapore
Prior art keywords
chemical compounds
compounds
chemical
Prior art date
Application number
SG11201607751SA
Other languages
English (en)
Inventor
Susanne Elisabeth Berglund
Stephen Connolly
Martin Hemmerling
Nafizal Hossain
Anna Kristoffersson
Johan Rune Michael Lundkvist
Grigorios Nikitidis
Lena Elisabeth Ripa
Igor Shamovsky
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of SG11201607751SA publication Critical patent/SG11201607751SA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965Non-condensed pyrazines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965Non-condensed pyrazines
    • A61K31/497Non-condensed pyrazines containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/12Drugs for disorders of the metabolism for electrolyte homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D241/00Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D241/26Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D241/00Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D241/26Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
    • C07D241/28Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms in which said hetero-bound carbon atoms have double bonds to oxygen, sulfur or nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
SG11201607751SA 2014-03-18 2015-03-17 Chemical compounds SG11201607751SA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461954674P 2014-03-18 2014-03-18
PCT/GB2015/050765 WO2015140527A1 (fr) 2014-03-18 2015-03-17 Composés chimiques

Publications (1)

Publication Number Publication Date
SG11201607751SA true SG11201607751SA (en) 2016-10-28

Family

ID=52780553

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201607751SA SG11201607751SA (en) 2014-03-18 2015-03-17 Chemical compounds

Country Status (38)

Country Link
US (3) US9873678B2 (fr)
EP (1) EP3119752B1 (fr)
JP (1) JP6502469B2 (fr)
KR (1) KR102296041B1 (fr)
CN (1) CN106103423B (fr)
AP (1) AP2016009447A0 (fr)
AR (1) AR099790A1 (fr)
AU (1) AU2015233195B2 (fr)
CA (1) CA2941807C (fr)
CL (1) CL2016002303A1 (fr)
CR (1) CR20160479A (fr)
CY (1) CY1120509T1 (fr)
DK (1) DK3119752T3 (fr)
DO (1) DOP2016000232A (fr)
EA (1) EA029952B1 (fr)
ES (1) ES2679618T3 (fr)
GT (1) GT201600190A (fr)
HR (1) HRP20181123T1 (fr)
HU (1) HUE039425T2 (fr)
IL (1) IL247610B (fr)
LT (1) LT3119752T (fr)
ME (1) ME03056B (fr)
MX (1) MX368577B (fr)
NI (1) NI201600134A (fr)
NZ (1) NZ724063A (fr)
PE (1) PE20170205A1 (fr)
PH (1) PH12016501808A1 (fr)
PL (1) PL3119752T3 (fr)
PT (1) PT3119752T (fr)
RS (1) RS57487B1 (fr)
SG (1) SG11201607751SA (fr)
SI (1) SI3119752T1 (fr)
SV (1) SV2016005278A (fr)
TR (1) TR201810207T4 (fr)
TW (1) TWI687410B (fr)
UY (1) UY36034A (fr)
WO (1) WO2015140527A1 (fr)
ZA (1) ZA201607136B (fr)

Family Cites Families (37)

* Cited by examiner, † Cited by third party
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US3577418A (en) 1969-02-12 1971-05-04 Merck & Co Inc Pyrazinamide derivatives and processes for their preparation
US3573306A (en) 1969-03-05 1971-03-30 Merck & Co Inc Process for preparation of n-substituted 3,5-diamino-6-halopyrazinamides
FI820266L (fi) 1981-02-02 1982-08-03 Ici Plc Alkanolaminderivater
US4550111A (en) 1982-01-29 1985-10-29 Imperial Chemical Industries Plc Alkanolamine derivatives
GB8810933D0 (en) 1987-05-26 1988-06-15 Ici America Inc Heterocyclic compounds
GB8810934D0 (en) 1987-05-26 1988-06-15 Ici America Inc Amides
US4803206A (en) 1988-03-07 1989-02-07 Schering Corporation Antihypertensive acylpyrazines
GB8812342D0 (en) 1988-05-25 1988-06-29 Ici America Inc Bicyclic compounds
GB8812343D0 (en) 1988-05-25 1988-06-29 Ici America Inc Amino compounds
CN1248968A (zh) 1997-02-26 2000-03-29 辉瑞大药厂 杂芳基-己酸酰胺衍生物、其制备方法及其作为MIP-1α与其CCRI受体结合的选择性抑制剂的用途
GB9930557D0 (en) 1999-12-23 2000-02-16 Rolic Ag Optically active materials
CA2408408C (fr) 2000-05-12 2013-07-09 Genzyme Corporation Modulateurs de marquage du tnf-alpha
NZ533107A (en) 2001-11-08 2007-04-27 Upjohn Co N, N'-substituted-1,3-diamino-2-hydroxypropane derivatives
US6858615B2 (en) 2002-02-19 2005-02-22 Parion Sciences, Inc. Phenyl guanidine sodium channel blockers
US7154002B1 (en) 2002-10-08 2006-12-26 Takeda San Diego, Inc. Histone deacetylase inhibitors
US20040087571A1 (en) 2002-10-30 2004-05-06 Pfizer Inc Methods of using CCR1 antagonists as immunomodulatory agents
CA2510815A1 (fr) 2002-12-20 2004-07-08 Pfizer Products Inc. Inhibiteurs de proteine de transfert de triglyceride microsomale
US6903105B2 (en) 2003-02-19 2005-06-07 Parion Sciences, Inc. Sodium channel blockers
EP1812378A2 (fr) 2004-10-13 2007-08-01 University of Connecticut Ligands lipidiques cannabinergiques
GB0511065D0 (en) 2005-05-31 2005-07-06 Novartis Ag Organic compounds
GB0526244D0 (en) 2005-12-22 2006-02-01 Novartis Ag Organic compounds
GB0526240D0 (en) 2005-12-22 2006-02-01 Novartis Ag Organic compounds
MX2009009304A (es) 2007-03-01 2009-11-18 Novartis Ag Inhibidores de cinasa pim y metodos para su uso.
BRPI0811562A2 (pt) 2007-05-07 2014-12-09 Novartis Ag Compostos orgânicos
TWI439462B (zh) 2007-12-10 2014-06-01 Novartis Ag 作為enac阻抑劑之螺環胍化合物
AU2008345225A1 (en) 2007-12-21 2009-07-09 University Of Rochester Method for altering the lifespan of eukaryotic organisms
CA2723938A1 (fr) 2008-05-13 2009-11-19 Novartis Ag Derives d'acide 3,5-diamino-6-chloro-pyrazine-2-carboxylique et leur utilisation comme bloqueurs de canal du sodium epithelial pour le traitement de maladies des voies respiratoires
US9315449B2 (en) 2008-05-15 2016-04-19 Duke University Substituted pyrazoles as heat shock transcription factor activators
CN102112130A (zh) 2008-06-10 2011-06-29 诺瓦提斯公司 作为上皮钠通道阻滞剂的吡嗪衍生物
WO2011028740A1 (fr) 2009-09-03 2011-03-10 Glaxo Group Limited Bloqueurs du canal enac
WO2011079087A1 (fr) 2009-12-23 2011-06-30 Glaxo Group Limited Bloqueurs du canal enac
US8372845B2 (en) 2010-09-17 2013-02-12 Novartis Ag Pyrazine derivatives as enac blockers
AR086745A1 (es) 2011-06-27 2014-01-22 Parion Sciences Inc 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida
US9505735B2 (en) 2012-06-21 2016-11-29 Whitehead Institute For Biomedical Research Compounds for treating infectious diseases
RS55618B1 (sr) 2012-12-17 2017-06-30 Parion Sciences Inc Derivati hloropirazin karboksamida korisni za lečenje bolesti kojima pogoduje nedovoljna hidracija sluznica
ES2674665T3 (es) 2012-12-17 2018-07-03 Parion Sciences, Inc. Compuestos de 3,5-diamino-6-cloro-N-(N-(4-fenilbutilo)carbamimidoilo)-pirazina-2-carboxamida
BR112015014178A2 (pt) 2012-12-17 2017-07-11 Parion Sciences Inc compostos de 3,5-diamino-6-cloro-n-(n-(4-fenilbutil)carbamimidoil) pirazina-2- carboxamida

Also Published As

Publication number Publication date
IL247610A0 (en) 2016-11-30
US10954211B2 (en) 2021-03-23
CA2941807C (fr) 2023-03-07
UY36034A (es) 2015-09-30
AR099790A1 (es) 2016-08-17
SI3119752T1 (en) 2018-08-31
PL3119752T3 (pl) 2018-09-28
EA201691641A1 (ru) 2017-02-28
GT201600190A (es) 2019-07-29
TW201620880A (zh) 2016-06-16
EA029952B1 (ru) 2018-06-29
CN106103423B (zh) 2019-12-06
US10336725B2 (en) 2019-07-02
US9873678B2 (en) 2018-01-23
CL2016002303A1 (es) 2017-01-13
DOP2016000232A (es) 2016-10-16
WO2015140527A1 (fr) 2015-09-24
JP6502469B2 (ja) 2019-04-17
TWI687410B (zh) 2020-03-11
IL247610B (en) 2019-05-30
TR201810207T4 (tr) 2018-08-27
KR20160127135A (ko) 2016-11-02
ME03056B (fr) 2018-10-20
CY1120509T1 (el) 2019-07-10
AU2015233195A1 (en) 2016-09-22
CR20160479A (es) 2017-02-24
EP3119752B1 (fr) 2018-05-16
CN106103423A (zh) 2016-11-09
PH12016501808B1 (en) 2017-01-09
SV2016005278A (es) 2016-11-30
MX368577B (es) 2019-10-08
CA2941807A1 (fr) 2015-09-24
HUE039425T2 (hu) 2018-12-28
NZ724063A (en) 2018-02-23
RS57487B1 (sr) 2018-10-31
KR102296041B1 (ko) 2021-08-30
AP2016009447A0 (en) 2016-09-30
ZA201607136B (en) 2018-04-25
US20190330187A1 (en) 2019-10-31
ES2679618T3 (es) 2018-08-29
PT3119752T (pt) 2018-07-24
HRP20181123T1 (hr) 2018-09-21
PE20170205A1 (es) 2017-04-06
LT3119752T (lt) 2018-08-10
DK3119752T3 (en) 2018-07-30
PH12016501808A1 (en) 2017-01-09
MX2016011681A (es) 2016-10-28
US20170107195A1 (en) 2017-04-20
US20180162838A1 (en) 2018-06-14
EP3119752A1 (fr) 2017-01-25
JP2017512830A (ja) 2017-05-25
NI201600134A (es) 2017-03-13
AU2015233195B2 (en) 2017-04-20

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