SG11201407427WA - Extreme pcr - Google Patents

Extreme pcr

Info

Publication number
SG11201407427WA
SG11201407427WA SG11201407427WA SG11201407427WA SG11201407427WA SG 11201407427W A SG11201407427W A SG 11201407427WA SG 11201407427W A SG11201407427W A SG 11201407427WA SG 11201407427W A SG11201407427W A SG 11201407427WA SG 11201407427W A SG11201407427W A SG 11201407427WA
Authority
SG
Singapore
Prior art keywords
international
publication
rule
salt lake
lake city
Prior art date
Application number
SG11201407427WA
Inventor
Carl T Wittwer
Jared Steven Farrar
Original Assignee
Univ Utah Res Found
Carl T Wittwer
Jared Steven Farrar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Utah Res Found, Carl T Wittwer, Jared Steven Farrar filed Critical Univ Utah Res Found
Publication of SG11201407427WA publication Critical patent/SG11201407427WA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844Nucleic acid amplification reactions
    • C12Q1/686Polymerase chain reaction [PCR]
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00Heating or cooling apparatus; Heat insulating devices
    • B01L7/02Water baths; Sand baths; Air baths
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00Heating or cooling apparatus; Heat insulating devices
    • B01L7/52Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00Heating or cooling apparatus; Heat insulating devices
    • B01L7/52Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • B01L7/525Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples with physical movement of samples between temperature zones
    • B01L7/5255Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples with physical movement of samples between temperature zones by moving sample containers
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06Fluid handling related problems
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/06Auxiliary integrated devices, integrated components
    • B01L2300/0627Sensor or part of a sensor is integrated
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/18Means for temperature control
    • B01L2300/1894Cooling means; Cryo cooling
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Clinical Laboratory Science (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Apparatus For Radiation Diagnosis (AREA)
  • Management, Administration, Business Operations System, And Electronic Commerce (AREA)
  • Prostheses (AREA)
  • Dispersion Chemistry (AREA)
  • Hematology (AREA)

Abstract

(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 28 November 2013 (28.11.2013) WIPOIPCT (10) International Publication Number WO 2013/177429 A3 (51) International Patent Classification: C12P19/34 (2006.01) C12M1/10 (2006.01) (21) International Application Number: (22) International Filing Date: (25) Filing Language: (26) Publication Language: PCT/US2013/042473 23 May 2013 (23.05.2013) English English (30) Priority Data: 61/651,161 61/811,145 24 May 2012 (24.05.2012) US 12 April 2013 (12.04.2013) US (71) Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION [US/US]; 590 Wakara Way, Salt Lake City, UT 84108 (US). (72) Inventors; and (71) Applicants WITTWER, Carl, T. : [US/US]; 3479 Crest- wood Drive, Salt Lake City, UT 84109 (US). FARRAR, Jared, Steven [US/US]; 88 W 50 S, El, Salt Lake City, UT 84104 (US). (74) Agent: FAUCETT, Homer, W., Ill; Maginot, Moore & Beck LLP, One Indiana Square, Suite 2200, Indianapolis, IN 46204 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available)'. AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available)'. ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: — as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(H)) Published: — with international search report (Art. 21(3)) — with sequence listing part of description (Rule 5.2(a)) (88) Date of publication of the international search report: 13 March 2014 o\ CJ •t i> i> i-H o CJ (54) Title: EXTREME PCR (57) Abstract: Methods, devices, and kits are provided for performing PCR in <20 seconds cycle, with improved efficiency and yield.
SG11201407427WA 2012-05-24 2013-05-23 Extreme pcr SG11201407427WA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261651161P 2012-05-24 2012-05-24
US201361811145P 2013-04-12 2013-04-12
PCT/US2013/042473 WO2013177429A2 (en) 2012-05-24 2013-05-23 Extreme pcr

Publications (1)

Publication Number Publication Date
SG11201407427WA true SG11201407427WA (en) 2014-12-30

Family

ID=49624526

Family Applications (3)

Application Number Title Priority Date Filing Date
SG11201407427WA SG11201407427WA (en) 2012-05-24 2013-05-23 Extreme pcr
SG10201810110RA SG10201810110RA (en) 2012-05-24 2013-05-23 Extreme pcr
SG10201800645WA SG10201800645WA (en) 2012-05-24 2013-05-23 Extreme pcr

Family Applications After (2)

Application Number Title Priority Date Filing Date
SG10201810110RA SG10201810110RA (en) 2012-05-24 2013-05-23 Extreme pcr
SG10201800645WA SG10201800645WA (en) 2012-05-24 2013-05-23 Extreme pcr

Country Status (12)

Country Link
US (5) US9932634B2 (en)
EP (3) EP3539666B1 (en)
JP (3) JP6316802B2 (en)
CN (2) CN108251271A (en)
AU (1) AU2013266246B2 (en)
CA (1) CA2873991C (en)
DK (2) DK3539666T3 (en)
ES (2) ES2889348T3 (en)
PL (1) PL3539666T3 (en)
PT (2) PT3539666T (en)
SG (3) SG11201407427WA (en)
WO (1) WO2013177429A2 (en)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108251271A (en) 2012-05-24 2018-07-06 犹他州大学研究基金会 Extreme PCR
EP3066222B1 (en) * 2013-11-05 2020-01-08 BioFire Diagnostics, LLC Induction pcr
US10364458B2 (en) 2014-07-16 2019-07-30 Tangen Biosciences, Inc. Isothermal methods for amplifying nucleic acid samples
CN107208012B (en) 2014-11-03 2021-06-29 唐恩生物科学公司 Device and method for cell, spore or virus capture and disruption
US10544450B2 (en) * 2014-11-07 2020-01-28 Gna Biosolutions Gmbh Method for duplicating nucleic acids by means of a polymerase chain reaction
TW201641687A (en) * 2014-12-31 2016-12-01 卡尤迪生物科技(北京)有限公司 Apparatus and methods for conducting chemical reactions
WO2016106717A1 (en) * 2014-12-31 2016-07-07 Coyote Bioscience Co., Ltd. Apparatus and methods for conducting chemical reactions
US10718013B2 (en) 2015-06-02 2020-07-21 BioFire Defense, LLC. et al. Sample to sequence
JP7126445B2 (en) 2015-11-02 2022-08-26 バイオファイア・ダイアグノスティクス,リミテッド・ライアビリティ・カンパニー Sample preparation for difficult sample types
CA3000824C (en) * 2015-11-05 2024-02-13 University Of Utah Research Foundation Extreme reverse transcription pcr
WO2017139447A1 (en) * 2016-02-10 2017-08-17 Coyote Bioscience Usa Inc. Methods and systems for analyzing nucleic acids
AU2017223404B2 (en) 2016-02-22 2022-09-22 Biofire Defense, Llc Devices and methods for rapid PCR
ES2936823T3 (en) 2016-03-24 2023-03-22 Biofire Diagnostics Llc Procedures for quantitative amplification
US11786906B2 (en) 2016-04-15 2023-10-17 Biofire Defense, Llc Resistive heaters and anisotropic thermal transfer
SG10201700260XA (en) * 2016-06-10 2018-01-30 Star Array Pte Ltd Rapid thermal cycling for sample analyses and processing
WO2017213586A1 (en) * 2016-06-10 2017-12-14 Star Array Pte Ltd Rapid thermal cycling for sample analyses and processing
EP3491149A4 (en) 2016-07-28 2019-12-25 BioFire Diagnostics, LLC Self-contained nucleic acid processing
JP2018023360A (en) * 2016-07-29 2018-02-15 セイコーエプソン株式会社 Nucleic acid amplification reaction method, reagent, and method for using reagent
US10434515B2 (en) 2016-10-03 2019-10-08 University Of Utah Research Foundation Thermal gradient plug flow microfluidic devices for extreme PCR
EP3562592A4 (en) * 2016-12-29 2020-09-09 BioFire Defense, LLC Fast pcr with molecular crowding
US11192103B2 (en) 2017-05-04 2021-12-07 University Of Utah Research Foundation Micro-fluidic device for rapid PCR
CN107502657A (en) * 2017-07-12 2017-12-22 浙江大学 A kind of very fast PCR(PCR)Amplification and end-point detection method
US11398296B2 (en) 2017-07-21 2022-07-26 Biofire Diagnostics, Llc Detection using concurrent melting curves
CN107930716B (en) * 2017-12-31 2023-05-09 江苏科泰检测技术服务有限公司 Automatic rotary gradient constant-temperature water bath kettle for detection chamber and use method thereof
CN108251501A (en) * 2018-02-08 2018-07-06 中国农业大学 A kind of visualization of the dual gene of genetically modified crops quantifies screening new method
WO2019204588A1 (en) 2018-04-20 2019-10-24 Biofire Diagnostics, Llc Methods for normalization and quantification of sequencing data
US20210123089A9 (en) * 2018-06-07 2021-04-29 Biofire Diagnostics, Llc Rapid thermocycling methods
KR102116118B1 (en) * 2018-07-18 2020-05-27 주식회사 케이티앤지 Method for controlling temperature of heater of aerosol generator and apparatus thereof
GB201812192D0 (en) 2018-07-26 2018-09-12 Ttp Plc Variable temperature reactor, heater and control circuit for the same
CN108752418B (en) * 2018-08-08 2024-01-30 湖南科技学院 Multichannel polypeptide synthesis reaction device and operation method thereof
CN110114475B (en) * 2018-12-20 2021-06-18 广州市华南医学研究中心 Method for rapid nucleic acid amplification and equipment and application thereof
EP3898230A4 (en) 2018-12-21 2022-09-28 BioFire Diagnostics, LLC Apparatuses, methods, and systems for in-situ sealing of reaction containers
MX2021008567A (en) * 2019-01-17 2021-09-21 Univ Northwestern Rapid reverse transcription quantitative polymerase chain reaction.
CN110387325A (en) 2019-08-13 2019-10-29 广州市华南医学研究中心 A kind of very fast PCR reaction checking device and detection method
CN113493823A (en) * 2020-04-07 2021-10-12 中国农业大学 Visual detection method based on overspeed PCR and functional nucleic acid
CN111974480A (en) * 2020-09-02 2020-11-24 杭州潘达科技有限公司 Stabilize effectual constant temperature water bath with many interlayers
CN113967487B (en) * 2021-10-11 2022-12-02 华中科技大学 Nozzle, liquid drop photo-thermal control system and application thereof
GB202115637D0 (en) 2021-11-01 2021-12-15 Anglia Ruskin Univ Higher Education Corporation Nucleic acid amplification method
CN114214465A (en) * 2022-01-26 2022-03-22 山东仕达思生物产业有限公司 Primer, probe, kit and detection method for shortening detection time of novel coronavirus

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2065719A1 (en) * 1991-04-30 1992-10-31 John B. Findlay Nucleic acid amplification and detection methods using rapid polymerase chain reaction cycle
US5436149A (en) 1993-02-19 1995-07-25 Barnes; Wayne M. Thermostable DNA polymerase with enhanced thermostability and enhanced length and efficiency of primer extension
WO1995004161A1 (en) * 1993-07-29 1995-02-09 Sergio Danilo Junho Pena Method for recognition of the nucleotide sequence of a purified dna segment
DE69638318D1 (en) 1995-06-07 2011-02-17 Gilead Sciences Inc Nucleic acid ligands that bind to and inhibit DNA polymerases
WO1997011085A1 (en) 1995-09-19 1997-03-27 University Of Massachusetts Inhibited biological degradation of oligodeoxynucleotides
US6210882B1 (en) 1998-01-29 2001-04-03 Mayo Foundation For Medical Education And Reseach Rapid thermocycling for sample analysis
US6780588B2 (en) * 2001-05-07 2004-08-24 Applera Corporation Methods for the reduction of stutter in microsatellite amplification
KR20030073875A (en) 2002-03-13 2003-09-19 주식회사 하이닉스반도체 Method for forming isolation pattern of semiconductor device
US20040241655A1 (en) * 2003-05-29 2004-12-02 Yuchi Hwang Conditional touchdown multiplex polymerase chain reaction
US8232091B2 (en) * 2006-05-17 2012-07-31 California Institute Of Technology Thermal cycling system
KR20080029233A (en) 2006-09-28 2008-04-03 삼성전자주식회사 Method and apparatus for accomplishing nucleic acid amplification and hybridization in single solid support
JP5191041B2 (en) 2007-04-05 2013-04-24 エフ.ホフマン−ラ ロシュ アーゲー Rapid one-step RT-PCR
WO2009105499A1 (en) * 2008-02-20 2009-08-27 Termaat Joel R Thermocycler and sample vessel for rapid amplification of dna
CA2658520C (en) 2008-03-19 2016-11-08 F. Hoffmann-La Roche Ag Nucleic acid amplification in the presence of modified randomers
WO2009135093A2 (en) 2008-04-30 2009-11-05 Integrated Dna Technologies, Inc. Rnase-h-based assays utilizing modified rna monomers
WO2010059323A2 (en) * 2008-11-18 2010-05-27 Life Technologies Corporation Sequence amplification with target primers
CN101407850B (en) * 2008-11-20 2011-01-05 江苏出入境检验检疫局动植物与食品检测中心 PCR fast detecting reagent kit and detecting method for monkeypox virus
EP2406614A1 (en) * 2009-03-10 2012-01-18 Agency For Science, Technology And Research Apparatus for processing a biological and/or chemical sample
PT2539472E (en) * 2010-02-26 2015-09-24 Life Technologies Corp Fast pcr for str genotyping
US9005895B2 (en) 2010-06-21 2015-04-14 Life Technologies Corporation Compositions, methods and kits for nucleic acid synthesis and amplification
JP2012118055A (en) * 2010-11-12 2012-06-21 Sony Corp Reaction treatment apparatus and reaction treatment method
CA2821580A1 (en) * 2010-12-17 2012-06-21 Bjs Ip Limited Methods and systems for fast pcr heating
US10273532B2 (en) * 2012-03-09 2019-04-30 National Institute Of Advanced Industrial Science And Technology Nucleic acid amplification method
CN108251271A (en) 2012-05-24 2018-07-06 犹他州大学研究基金会 Extreme PCR
US9353409B2 (en) 2013-01-15 2016-05-31 Jun Euihum Lee Compositions and methods for RT-PCR
EP3066222B1 (en) 2013-11-05 2020-01-08 BioFire Diagnostics, LLC Induction pcr

Also Published As

Publication number Publication date
JP2020115878A (en) 2020-08-06
SG10201800645WA (en) 2018-02-27
US20180179581A1 (en) 2018-06-28
EP3957748A1 (en) 2022-02-23
US20150118715A1 (en) 2015-04-30
ES2749700T3 (en) 2020-03-23
JP6731012B2 (en) 2020-07-29
DK3539666T3 (en) 2021-09-13
CA2873991A1 (en) 2013-11-28
US10144960B2 (en) 2018-12-04
US11834708B2 (en) 2023-12-05
PT2855692T (en) 2019-10-25
PT3539666T (en) 2021-09-23
EP3539666B1 (en) 2021-08-11
US20210254132A1 (en) 2021-08-19
CN104662160B (en) 2018-02-23
SG10201810110RA (en) 2018-12-28
EP2855692A4 (en) 2016-08-17
WO2013177429A3 (en) 2014-03-13
JP6316802B2 (en) 2018-04-25
CN104662160A (en) 2015-05-27
US9932634B2 (en) 2018-04-03
DK2855692T3 (en) 2019-10-14
AU2013266246A1 (en) 2014-12-18
PL3539666T3 (en) 2022-01-31
JP2015520614A (en) 2015-07-23
WO2013177429A2 (en) 2013-11-28
AU2013266246B2 (en) 2017-02-02
CA2873991C (en) 2020-08-25
EP2855692B1 (en) 2019-07-24
EP2855692A2 (en) 2015-04-08
CN108251271A (en) 2018-07-06
ES2889348T3 (en) 2022-01-12
US11021744B2 (en) 2021-06-01
WO2013177429A4 (en) 2014-05-01
US20190055591A1 (en) 2019-02-21
US20240068021A1 (en) 2024-02-29
JP7032818B2 (en) 2022-03-09
EP3539666A1 (en) 2019-09-18
JP2018117632A (en) 2018-08-02

Similar Documents

Publication Publication Date Title
SG11201407427WA (en) Extreme pcr
SG11201407851RA (en) Synthesis of pyrrolo [2, 3 - b] pyridines
SG11201900635QA (en) Chimeric antigen receptors targeting bcma and methods of use thereof
SG11201907561PA (en) Anti-lag-3 antibodies and uses thereof
SG11201900772YA (en) Gene editing of car-t cells for the treatment of t cell malignancies with chimeric antigen receptors
SG11201810600WA (en) Fxr (nr1h4) modulating compounds
SG11201804375WA (en) Compositions and methods for internalizing enzymes
SG11201408780XA (en) Optimization of antibodies that bind lymphocyte activation gene-3 (lag-3), and uses thereof
SG11201804134YA (en) Fgfr2 inhibitors alone or in combination with immune stimulating agents in cancer treatment
SG11201407417VA (en) Encoding and reconstruction of residual data based on support information
SG11201406903SA (en) Cell culture compositions and methods for polypeptide production
SG11201407486PA (en) Compositions and methods for modulating utrn expression
SG11201407859YA (en) Methods of treating cancer using pd-l1 axis binding antagonists and vegf antagonists
SG11201403106SA (en) Anti-phf-tau antibodies and their uses
SG11201408251SA (en) A pharmaceutical composition containing nicotinic acid and/or nicotinamide and/or tryptophan for positively influencing the intestinal microbiota
SG11201408769QA (en) Methods of reducing the risk of a cardiovascular event in a subject on statin therapy
SG11201407343XA (en) Subfamily e simian adenoviruses a1302, a1320, a1331 and a1337 and uses thereof
SG11201407774XA (en) Conversion of biomass
SG11201407200TA (en) Liquid formulation
SG11201407662WA (en) Process for the preparation of treprostinil and derivatives thereof
SG11201406787TA (en) Rnai-based therapies for cardiomyopathies, muscular dystrophies and laminopathies
SG11201407800SA (en) Selective binding of biological targets to solid phase ureides
SG11201408536WA (en) METHOD FOR PRODUCING SOLUBLE FcR AS Fc-FUSION WITH INERT IMMUNOGLOBULIN Fc-REGION AND USES THEREOF
SG11201408303WA (en) Adhesive compositions of propylene-based and ethylene-based polymers
SG11201408198QA (en) Jumper tube locking assembly and method