SG11201408536WA - METHOD FOR PRODUCING SOLUBLE FcR AS Fc-FUSION WITH INERT IMMUNOGLOBULIN Fc-REGION AND USES THEREOF - Google Patents

METHOD FOR PRODUCING SOLUBLE FcR AS Fc-FUSION WITH INERT IMMUNOGLOBULIN Fc-REGION AND USES THEREOF

Info

Publication number
SG11201408536WA
SG11201408536WA SG11201408536WA SG11201408536WA SG11201408536WA SG 11201408536W A SG11201408536W A SG 11201408536WA SG 11201408536W A SG11201408536W A SG 11201408536WA SG 11201408536W A SG11201408536W A SG 11201408536WA SG 11201408536W A SG11201408536W A SG 11201408536WA
Authority
SG
Singapore
Prior art keywords
international
penzberg
pct
fusion
denotes
Prior art date
Application number
SG11201408536WA
Inventor
Petra Rueger
Tilman Schlothauer
Stefan Seeber
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of SG11201408536WA publication Critical patent/SG11201408536WA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70535—Fc-receptors, e.g. CD16, CD32, CD64 (CD2314/705F)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
    • G01N2333/70535—Fc-receptors, e.g. CD16, CD32, CD64 (CD2314/705F)

Abstract

(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau „ (10) International Publication Number (43) International Publication Date ^ ^ WO 2014/020056 A1 6 February 2014 (06.02.2014) WIPO I PCT (51) International Patent Classification: C12N15/79 (2006.01) (21) International Application Number: (22) International Filing Date: (25) Filing Language: (26) Publication Language: PCT/EP2013/066065 31 July 2013 (31.07.2013) English English (30) Priority Data: 12179025.7 2 August 2012 (02.08.2012) (71) Applicant (for all designated States except US): F. HOFF­ MANN-LA ROCHE AG [CH/CH]; Grenzacher Strasse 124, CH-4070 Basel (CH). (71) Applicant (for US only): HOFFMANN-LA ROCHE INC. [US/US]; 340 Kingsland Street, Nutley, New Jersey 07110 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. I |i (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). (72) Inventors: RUEGER, Petra; Auf der Leiten 4, 82377 Penzberg (DE). SCHLOTHAUER, Tilman; Sommer- strasse 3a, 82377 Penzberg (DE). SEEBER, Stefan; Bre- unetsrieder Weg 22, 82377 Penzberg (DE). (74) Agents: SKOLAUT, Alexander et al.; Roche Diagnostics GmbH, Patent Department (LPP 6164), P.O.Box 11 52, 82372 Penzberg (DE). Published: — with international search report (Art. 21(3)) — with sequence listing part of description (Rule 5.2(a)) V© © o CJ o o CJ o & (54) Title: METHOD FOR PRODUCING SOLUBLE FcR AS Fc-FUSION WITH INERT IMMUNOGLOBULIN Fc-REGION AND USES THEREOF (57) Abstract: Herein is a fusion polypeptide with the formula R1-FC-R2, wherein R1 denotes a first Fc-receptor, R2 denotes a second Fc-receptor, and FC denotes heavy chain Fc-region polypeptide, wherein a R1 or R2 or both are present, wherein FC does not substantially bind to R1 and/or R2 and uses thereof.
SG11201408536WA 2012-08-02 2013-07-31 METHOD FOR PRODUCING SOLUBLE FcR AS Fc-FUSION WITH INERT IMMUNOGLOBULIN Fc-REGION AND USES THEREOF SG11201408536WA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12179025 2012-08-02
PCT/EP2013/066065 WO2014020056A1 (en) 2012-08-02 2013-07-31 METHOD FOR PRODUCING SOLUBLE FcR AS Fc-FUSION WITH INERT IMMUNOGLOBULIN Fc-REGION AND USES THEREOF

Publications (1)

Publication Number Publication Date
SG11201408536WA true SG11201408536WA (en) 2015-01-29

Family

ID=48986096

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201408536WA SG11201408536WA (en) 2012-08-02 2013-07-31 METHOD FOR PRODUCING SOLUBLE FcR AS Fc-FUSION WITH INERT IMMUNOGLOBULIN Fc-REGION AND USES THEREOF

Country Status (17)

Country Link
US (2) US10011644B2 (en)
EP (1) EP2880170B1 (en)
JP (1) JP6307077B2 (en)
KR (1) KR20150038511A (en)
CN (1) CN104508132B (en)
BR (1) BR112015002263A2 (en)
CA (1) CA2876096A1 (en)
DK (1) DK2880170T3 (en)
ES (1) ES2602030T3 (en)
HK (1) HK1208881A1 (en)
HU (1) HUE029634T2 (en)
MX (1) MX2015000681A (en)
PL (1) PL2880170T3 (en)
RU (1) RU2630659C2 (en)
SG (1) SG11201408536WA (en)
SI (1) SI2880170T1 (en)
WO (1) WO2014020056A1 (en)

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US10400029B2 (en) 2011-06-28 2019-09-03 Inhibrx, Lp Serpin fusion polypeptides and methods of use thereof
RU2746550C2 (en) * 2014-10-27 2021-04-15 Инхибркс, Инк. Fused serpine polypeptides and methods of their application
US11566082B2 (en) 2014-11-17 2023-01-31 Cytiva Bioprocess R&D Ab Mutated immunoglobulin-binding polypeptides
RU2746486C2 (en) * 2015-03-13 2021-04-14 Юниверсити Оф Мэрилэнд, Балтимор Universal antibody-mediated biosensor
EP3356829A4 (en) * 2015-10-02 2019-02-27 The Macfarlane Burnet Institute For Medical Research And Public Health Ltd Binding assays and method for probing antibody function with fc binding multimers
US10889615B2 (en) 2016-05-11 2021-01-12 Cytiva Bioprocess R&D Ab Mutated immunoglobulin-binding polypeptides
US10703774B2 (en) 2016-09-30 2020-07-07 Ge Healthcare Bioprocess R&D Ab Separation method
US10654887B2 (en) 2016-05-11 2020-05-19 Ge Healthcare Bio-Process R&D Ab Separation matrix
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US10696722B2 (en) 2016-08-10 2020-06-30 Ajou University Industry-Academic Cooperation Foundation Heterodimeric Fc-fused cytokine and pharmaceutical composition comprising the same
CN112585165A (en) 2018-04-25 2021-03-30 普罗米修斯生物科学公司 Optimized anti-TL 1A antibodies
JP2022512629A (en) * 2018-10-23 2022-02-07 マジェンタ セラピューティクス インコーポレイテッド Fc silenced antibody drug conjugate (ADC) and its use
BR112021007175A2 (en) 2018-10-23 2021-08-10 Dragonfly Therapeutics, Inc. proteins fused to heterodimeric FC
CN114901311A (en) 2019-10-24 2022-08-12 普罗米修斯生物科学公司 Humanized antibodies to TNF-like ligand 1A (TL1A) and uses thereof
GB2595299B (en) 2020-05-21 2022-08-03 Mabsolve Ltd Modified immunoglobulin FC regions

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Also Published As

Publication number Publication date
CN104508132A (en) 2015-04-08
HUE029634T2 (en) 2017-03-28
PL2880170T3 (en) 2017-02-28
DK2880170T3 (en) 2016-10-24
JP6307077B2 (en) 2018-04-04
US10011644B2 (en) 2018-07-03
SI2880170T1 (en) 2016-12-30
EP2880170B1 (en) 2016-08-24
RU2630659C2 (en) 2017-09-11
US20150140683A1 (en) 2015-05-21
US20180265564A1 (en) 2018-09-20
ES2602030T3 (en) 2017-02-17
CN104508132B (en) 2017-09-15
CA2876096A1 (en) 2014-02-06
JP2015526429A (en) 2015-09-10
EP2880170A1 (en) 2015-06-10
MX2015000681A (en) 2015-04-10
HK1208881A1 (en) 2016-03-18
BR112015002263A2 (en) 2017-12-12
RU2015104625A (en) 2016-09-20
US10093714B1 (en) 2018-10-09
WO2014020056A1 (en) 2014-02-06
KR20150038511A (en) 2015-04-08

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