SE9103612D0 - New peptide derivatives - Google Patents
New peptide derivativesInfo
- Publication number
- SE9103612D0 SE9103612D0 SE9103612A SE9103612A SE9103612D0 SE 9103612 D0 SE9103612 D0 SE 9103612D0 SE 9103612 A SE9103612 A SE 9103612A SE 9103612 A SE9103612 A SE 9103612A SE 9103612 D0 SE9103612 D0 SE 9103612D0
- Authority
- SE
- Sweden
- Prior art keywords
- peptide derivatives
- new peptide
- hypercoaguability
- treating
- disclosed
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
- C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
- C07C279/12—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
- C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (33)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9103612A SE9103612D0 (sv) | 1991-12-04 | 1991-12-04 | New peptide derivatives |
TW081109412A TW223078B (de) | 1991-12-04 | 1992-11-24 | |
ZA929099A ZA929099B (en) | 1991-12-04 | 1992-11-24 | New peptide derivatives. |
IL103910A IL103910A0 (en) | 1991-12-04 | 1992-11-27 | New peptide derivatives and pharmaceutical compositions containing them |
EP92924993A EP0618926B1 (de) | 1991-12-04 | 1992-12-01 | Neuartige peptidderivate |
HU9401474A HUT70431A (en) | 1991-12-04 | 1992-12-01 | New peptide derivatives |
DE69230727T DE69230727T2 (de) | 1991-12-04 | 1992-12-01 | Neuartige peptidderivate |
CZ953338A CZ333895A3 (en) | 1991-12-04 | 1992-12-01 | Starting compounds for synthesis of serine-prosthetic inhibitor |
CZ941296A CZ129694A3 (en) | 1991-12-04 | 1992-12-01 | Novel peptide derivatives |
AT92924993T ATE190066T1 (de) | 1991-12-04 | 1992-12-01 | Neuartige peptidderivate |
NZ246106A NZ246106A (en) | 1991-12-04 | 1992-12-01 | Modified peptides derived from human fibrinogen aalpha-chain |
CA002125175A CA2125175C (en) | 1991-12-04 | 1992-12-01 | New peptide derivatives |
SK631-94A SK63194A3 (en) | 1991-12-04 | 1992-12-01 | Peptide derivatives |
JP51005393A JP3306826B2 (ja) | 1991-12-04 | 1992-12-01 | 新規なペプチド誘導体 |
AU31209/93A AU670052B2 (en) | 1991-12-04 | 1992-12-01 | New peptide derivatives |
PCT/SE1992/000832 WO1993011152A1 (en) | 1991-12-04 | 1992-12-01 | New peptide derivatives |
NZ280762A NZ280762A (en) | 1991-12-04 | 1992-12-01 | Noragmatine derivatives and their use in preparing serine protease inhibitors |
US07/984,884 US5614499A (en) | 1991-12-04 | 1992-12-02 | Peptide derivatives as thrombin inhibitors |
MX9206938A MX9206938A (es) | 1991-12-04 | 1992-12-02 | Nuevos derivados peptidos, proceso para su preparacion y preparacion farmaceutica que comprende tales derivados. |
MA23019A MA22729A1 (fr) | 1991-12-04 | 1992-12-02 | Nouveaux derives de peptide |
IS3954A IS3954A (is) | 1991-12-04 | 1992-12-03 | Hliðstæð aðferð við framleiðslu nýrra peptíðafleiða |
TNTNSN92109A TNSN92109A1 (fr) | 1991-12-04 | 1992-12-03 | Nouveaux derives de peptide |
CN92115304A CN1076199A (zh) | 1991-12-04 | 1992-12-04 | 新的肽衍生物 |
APAP/P/1992/000457A AP353A (en) | 1991-12-04 | 1992-12-04 | New peptides derivatives. |
YU104592A YU104592A (sh) | 1991-12-04 | 1992-12-04 | Novi peptidni derivati |
SI19929200363A SI9200363A (en) | 1991-12-04 | 1992-12-04 | New peptide derivatives |
FI942645A FI115770B (fi) | 1991-12-04 | 1994-06-03 | Menetelmä farmakologisesti aktiivisten peptidijohdannaisten valmistamiseksi |
NO19942066A NO311361B1 (no) | 1991-12-04 | 1994-06-03 | Peptidderivater, fremgangsmåte for fremstilling, farmasöytisk preparat og anvendelse av peptidderivatene |
EE9400455A EE9400455A (et) | 1991-12-04 | 1994-11-23 | Peptiidi derivaadid, nende valmistamise protsess, neid sisaldavad ravimpreparaadid ja nende kasutamine |
US08/484,426 US5747460A (en) | 1991-12-04 | 1995-06-07 | Method of treatment and prophylaxis of venous thrombosis |
US08/480,818 US5955433A (en) | 1991-12-04 | 1995-06-07 | Method of thrombin inhibition |
US08/481,810 US5736521A (en) | 1991-12-04 | 1995-06-07 | Method of treatment and prophylaxis of arterial thrombosis |
AU50616/96A AU683793B2 (en) | 1991-12-04 | 1996-04-12 | Synthesis of a serine protease inhibitor |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9103612A SE9103612D0 (sv) | 1991-12-04 | 1991-12-04 | New peptide derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
SE9103612D0 true SE9103612D0 (sv) | 1991-12-04 |
Family
ID=20384531
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE9103612A SE9103612D0 (sv) | 1991-12-04 | 1991-12-04 | New peptide derivatives |
Country Status (27)
Country | Link |
---|---|
US (4) | US5614499A (de) |
EP (1) | EP0618926B1 (de) |
JP (1) | JP3306826B2 (de) |
CN (1) | CN1076199A (de) |
AP (1) | AP353A (de) |
AT (1) | ATE190066T1 (de) |
AU (2) | AU670052B2 (de) |
CA (1) | CA2125175C (de) |
CZ (2) | CZ333895A3 (de) |
DE (1) | DE69230727T2 (de) |
EE (1) | EE9400455A (de) |
FI (1) | FI115770B (de) |
HU (1) | HUT70431A (de) |
IL (1) | IL103910A0 (de) |
IS (1) | IS3954A (de) |
MA (1) | MA22729A1 (de) |
MX (1) | MX9206938A (de) |
NO (1) | NO311361B1 (de) |
NZ (2) | NZ246106A (de) |
SE (1) | SE9103612D0 (de) |
SI (1) | SI9200363A (de) |
SK (1) | SK63194A3 (de) |
TN (1) | TNSN92109A1 (de) |
TW (1) | TW223078B (de) |
WO (1) | WO1993011152A1 (de) |
YU (1) | YU104592A (de) |
ZA (1) | ZA929099B (de) |
Families Citing this family (73)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6534536B1 (en) | 1994-03-16 | 2003-03-18 | Bristol-Myers Squibb Company | Alkylsulfonamido heterocyclic thrombin inhibitors |
US5583146A (en) * | 1992-12-02 | 1996-12-10 | Bristol-Myers Squibb Company | Heterocyclic thrombin inhibitors |
SE9301916D0 (sv) * | 1993-06-03 | 1993-06-03 | Ab Astra | New peptides derivatives |
US6984627B1 (en) | 1993-06-03 | 2006-01-10 | Astrazeneca Ab | Peptide derivatives |
SE9900043D0 (sv) * | 1999-01-11 | 1999-01-11 | Astra Ab | New use |
EP0648780A1 (de) * | 1993-08-26 | 1995-04-19 | Bristol-Myers Squibb Company | Heterozyklische Thrombinhemmer |
GB9318637D0 (en) * | 1993-09-08 | 1993-10-27 | Ferring Res Ltd | Enzyme inhibitors |
US5488037A (en) * | 1994-03-04 | 1996-01-30 | Eli Lilly And Company | Antithrombotic agents |
US5885967A (en) * | 1994-03-04 | 1999-03-23 | Eli Lilly And Company | Antithrombotic agents |
US5484772A (en) * | 1994-03-04 | 1996-01-16 | Eli Lilly And Company | Antithrombotic agents |
US5707966A (en) * | 1994-03-04 | 1998-01-13 | Eli Lilly And Company | Antithrombotic agents |
US5726159A (en) * | 1994-03-04 | 1998-03-10 | Eli Lilly And Company | Antithrombotic agents |
US5602101A (en) * | 1994-03-04 | 1997-02-11 | Eli Lilly And Company | Antithrombotic agents |
US5705487A (en) * | 1994-03-04 | 1998-01-06 | Eli Lilly And Company | Antithrombotic agents |
ZA951618B (en) * | 1994-03-04 | 1996-08-27 | Lilly Co Eli | Antithrombotic agents |
IL112795A (en) * | 1994-03-04 | 2001-01-28 | Astrazeneca Ab | Derivatives of peptides as antithrombotic drugs, their preparation, and pharmaceutical preparations containing them |
US5439888A (en) * | 1994-03-04 | 1995-08-08 | Eli Lilly And Company | Antithrombotic agents |
US5691356A (en) * | 1994-03-21 | 1997-11-25 | Bristol-Myers Squibb Company | Disubstituted heterocyclic thrombin inhibitors |
US5681844A (en) * | 1994-04-18 | 1997-10-28 | Corvas International, Inc. | Methionine sulfone and s-substituted cysteine sulfone derivatives as enzyme inhibitors |
US5561146A (en) * | 1994-06-10 | 1996-10-01 | Bristol-Myers Squibb Company | Modified guanidino and amidino thrombin inhibitors |
DE4421052A1 (de) | 1994-06-17 | 1995-12-21 | Basf Ag | Neue Thrombininhibitoren, ihre Herstellung und Verwendung |
DE4436772A1 (de) * | 1994-10-14 | 1996-04-18 | Boehringer Mannheim Gmbh | Neues Dipeptid-Derivat, Verfahren zu seiner Herstellung sowie diese Verbindung enthaltende Arzneimittel |
SE504185C2 (sv) * | 1994-11-08 | 1996-12-02 | Astra Ab | Lagringsstabil vattenlösning för infusion av trombininhibitorer |
SE9404196D0 (sv) * | 1994-12-02 | 1994-12-02 | Astra Ab | New antithrombotic formulation |
DE4443390A1 (de) * | 1994-12-06 | 1996-06-13 | Basf Ag | Neue dipeptidische p-Amidinobenzylamide mit N-terminalen Sulfonyl- bzw. Aminosulfonylresten |
JPH11500120A (ja) * | 1995-02-17 | 1999-01-06 | ビーエーエスエフ アクチェンゲゼルシャフト | 新規なトロンビンインヒビター |
US5914319A (en) * | 1995-02-27 | 1999-06-22 | Eli Lilly And Company | Antithrombotic agents |
US5710130A (en) * | 1995-02-27 | 1998-01-20 | Eli Lilly And Company | Antithrombotic agents |
DE19512484A1 (de) | 1995-04-04 | 1996-10-17 | Bayer Ag | Kohlenhydratmodifizierte Cytostatika |
SA96170106A (ar) | 1995-07-06 | 2005-12-03 | أسترا أكتيبولاج | مشتقات حامض أميني جديدة |
TWI238827B (en) | 1995-12-21 | 2005-09-01 | Astrazeneca Ab | Prodrugs of thrombin inhibitors |
SE9600216D0 (sv) * | 1996-01-18 | 1996-01-18 | Hans Arne Hansson | Styrning av läkningsprocesser |
US5811402A (en) * | 1996-03-22 | 1998-09-22 | Eli Lilly And Company | Antithrombotic diamides |
CA2200163A1 (en) * | 1996-03-22 | 1997-09-22 | Michael Robert Wiley | Antithrombotic diamides |
SE9602263D0 (sv) | 1996-06-07 | 1996-06-07 | Astra Ab | New amino acid derivatives |
US5863929A (en) * | 1996-06-25 | 1999-01-26 | Eli Lilly And Company | Anticoagulant agents |
US6200967B1 (en) | 1996-06-25 | 2001-03-13 | Eli Lilly And Company | Anticoagulant agents |
SE9602646D0 (sv) | 1996-07-04 | 1996-07-04 | Astra Ab | Pharmaceutically-useful compounds |
SE9603724D0 (sv) * | 1996-10-11 | 1996-10-11 | Astra Ab | New pharmaceutical parenteral formulation of a thrombin inhibitor |
US5877156A (en) * | 1997-04-24 | 1999-03-02 | Akzo Nobel, N.V. | Thrombin inhibitors |
AR013084A1 (es) | 1997-06-19 | 2000-12-13 | Astrazeneca Ab | Derivados de amidino utiles como inhibidores de la trombina, composicion farmaceutica, utilizacion de dichos compuestos para la preparacion demedicamentos y proceso para la preparacion de los compuestos mencionados |
SE9704543D0 (sv) | 1997-12-05 | 1997-12-05 | Astra Ab | New compounds |
WO1999037668A1 (de) | 1998-01-26 | 1999-07-29 | Basf Aktiengesellschaft | Thrombininhibitoren |
US6417161B1 (en) * | 1998-04-24 | 2002-07-09 | 3-Dimensional Pharmaceuticals, Inc. | Amino acid amidinohydrazones, alkoxyguanidines and aminoguanidines as protease inhibitors |
SE9802938D0 (sv) * | 1998-09-01 | 1998-09-01 | Astra Ab | Improved stability for injection solutions |
SE9802973D0 (sv) | 1998-09-03 | 1998-09-03 | Astra Ab | Immediate release tablet |
SE9804313D0 (sv) | 1998-12-14 | 1998-12-14 | Astra Ab | New compounds |
DE60037183T2 (de) | 1999-01-13 | 2008-10-09 | Astrazeneca Ab | Neue amidinbenzylamin-derivate und ihre verwendung als thrombin-inhibitoren |
KR20000060566A (ko) * | 1999-03-17 | 2000-10-16 | 이경하 | 치환된 방향족 아미딘 유도체 및 이를 함유하는 의약조성물 |
AR023510A1 (es) | 1999-04-21 | 2002-09-04 | Astrazeneca Ab | Un equipo de partes, formulacion farmaceutica y uso de un inhibidor de trombina. |
AR023819A1 (es) * | 1999-05-03 | 2002-09-04 | Astrazeneca Ab | FORMULACIoN FARMACEUTICA, KIT DE PARTES Y UTILIZACION DE DICHA FORMULACION |
US6290662B1 (en) * | 1999-05-28 | 2001-09-18 | John K. Morris | Portable, self-contained apparatus for deep vein thrombosis (DVT) prophylaxis |
SE9902202D0 (sv) | 1999-06-10 | 1999-06-10 | Astra Ab | Production of aggregates |
SE0001803D0 (sv) | 2000-05-16 | 2000-05-16 | Astrazeneca Ab | New compounds i |
US6433186B1 (en) | 2000-08-16 | 2002-08-13 | Astrazeneca Ab | Amidino derivatives and their use as thormbin inhibitors |
JP2002155086A (ja) * | 2000-11-16 | 2002-05-28 | Ube Ind Ltd | 7a−アルコキシ−4H−ピラノ[3,2−d]−オキサゾール−2(3H)−オン類、及びその製造法 |
US7129233B2 (en) | 2000-12-01 | 2006-10-31 | Astrazeneca Ab | Mandelic acid derivatives and their use as thrombin inhibitors |
AR035216A1 (es) | 2000-12-01 | 2004-05-05 | Astrazeneca Ab | Derivados de acido mandelico ,derivados farmaceuticamente aceptables, uso de estos derivados para la fabricacion de medicamentos, metodos de tratamiento ,procesos para la preparacion de estos derivados, y compuestos intermediarios |
AR034517A1 (es) | 2001-06-21 | 2004-02-25 | Astrazeneca Ab | Formulacion farmaceutica |
SE0201661D0 (sv) | 2002-05-31 | 2002-05-31 | Astrazeneca Ab | New salts |
SE0201659D0 (sv) | 2002-05-31 | 2002-05-31 | Astrazeneca Ab | Modified release pharmaceutical formulation |
US7332227B2 (en) * | 2003-03-14 | 2008-02-19 | Becton, Dickinson And Company | Non-volatile lubricant system for medical devices |
WO2004091463A2 (en) | 2003-04-11 | 2004-10-28 | Hill-Rom Services, Inc. | System for compression therapy |
US7795205B2 (en) | 2004-04-12 | 2010-09-14 | Canyon Pharmaceuticals, Inc. | Methods for effecting regression of tumor mass and size in a metastasized pancreatic tumor |
GB0507577D0 (en) | 2005-04-14 | 2005-05-18 | Novartis Ag | Organic compounds |
WO2007044278A2 (en) * | 2005-10-05 | 2007-04-19 | Gurbel Paul A | The detection of restenosis risk in patients receiving a stent |
TW200827336A (en) | 2006-12-06 | 2008-07-01 | Astrazeneca Ab | New crystalline forms |
CN102924567B (zh) * | 2008-10-28 | 2014-06-04 | 上海医药工业研究院 | 一类肽化合物、其制备方法及用途 |
CN102464701B (zh) | 2010-11-08 | 2015-10-21 | 上海医药工业研究院 | 一类新型化合物、其制备方法及用途 |
US20140128572A1 (en) * | 2011-06-16 | 2014-05-08 | Lonza Braine S.A. | Process For Extraction Of Peptides And Its Application In Liquid Phase Peptide Synthesis |
US9737454B2 (en) | 2012-03-02 | 2017-08-22 | Hill-Rom Services, Inc. | Sequential compression therapy compliance monitoring systems and methods |
EP3207911B1 (de) | 2016-02-18 | 2019-04-03 | Hill-Rom Services, Inc. | Patientenliegevorrichtung mit integrierter gliedmassenkompressionsvorrichtung |
RU2712194C1 (ru) * | 2019-10-02 | 2020-01-27 | Федеральное государственное бюджетное учреждение "Государственный научно-исследовательский институт генетики и селекции промышленных микроорганизмов Национального исследовательского центра "Курчатовский институт" (НИЦ "Курчатовский институт" - ГосНИИгенетика) | Антикоагулянтное лекарственное средство, представляющее собой синтетический дипептид Ac-Trp-Arg-Pip ⋅HCl, фармацевтическая композиция, включающая это антикоагулянтное лекарственное средство |
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TW201303B (de) * | 1990-07-05 | 1993-03-01 | Hoffmann La Roche | |
GB9019558D0 (en) * | 1990-09-07 | 1990-10-24 | Szelke Michael | Enzyme inhibitors |
GB9024129D0 (en) * | 1990-11-06 | 1990-12-19 | Thrombosis Research Trust | Inhibitors and substrates of thrombin |
EP0503203A1 (de) * | 1991-03-15 | 1992-09-16 | Merrell Dow Pharmaceuticals Inc. | Neue Thrombin-Inhibitoren |
SE9102462D0 (sv) * | 1991-08-28 | 1991-08-28 | Astra Ab | New isosteric peptides |
CZ333492A3 (en) * | 1991-11-12 | 1993-09-15 | Lilly Co Eli | Dipeptide of l-azetidine-2-carboxylic acids and l-argininaldehyde, process of its preparation and pharmaceutical preparation in which said dipeptide is comprised |
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1991
- 1991-12-04 SE SE9103612A patent/SE9103612D0/xx unknown
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1992
- 1992-11-24 TW TW081109412A patent/TW223078B/zh active
- 1992-11-24 ZA ZA929099A patent/ZA929099B/xx unknown
- 1992-11-27 IL IL103910A patent/IL103910A0/xx unknown
- 1992-12-01 JP JP51005393A patent/JP3306826B2/ja not_active Expired - Fee Related
- 1992-12-01 CA CA002125175A patent/CA2125175C/en not_active Expired - Fee Related
- 1992-12-01 SK SK631-94A patent/SK63194A3/sk unknown
- 1992-12-01 EP EP92924993A patent/EP0618926B1/de not_active Expired - Lifetime
- 1992-12-01 AU AU31209/93A patent/AU670052B2/en not_active Ceased
- 1992-12-01 DE DE69230727T patent/DE69230727T2/de not_active Expired - Lifetime
- 1992-12-01 WO PCT/SE1992/000832 patent/WO1993011152A1/en active IP Right Grant
- 1992-12-01 HU HU9401474A patent/HUT70431A/hu unknown
- 1992-12-01 NZ NZ246106A patent/NZ246106A/en not_active IP Right Cessation
- 1992-12-01 CZ CZ953338A patent/CZ333895A3/cs unknown
- 1992-12-01 NZ NZ280762A patent/NZ280762A/en not_active IP Right Cessation
- 1992-12-01 AT AT92924993T patent/ATE190066T1/de not_active IP Right Cessation
- 1992-12-01 CZ CZ941296A patent/CZ129694A3/cs unknown
- 1992-12-02 MX MX9206938A patent/MX9206938A/es unknown
- 1992-12-02 MA MA23019A patent/MA22729A1/fr unknown
- 1992-12-02 US US07/984,884 patent/US5614499A/en not_active Expired - Lifetime
- 1992-12-03 IS IS3954A patent/IS3954A/is unknown
- 1992-12-03 TN TNTNSN92109A patent/TNSN92109A1/fr unknown
- 1992-12-04 CN CN92115304A patent/CN1076199A/zh active Pending
- 1992-12-04 AP APAP/P/1992/000457A patent/AP353A/en active
- 1992-12-04 SI SI19929200363A patent/SI9200363A/sl unknown
- 1992-12-04 YU YU104592A patent/YU104592A/sh unknown
-
1994
- 1994-06-03 NO NO19942066A patent/NO311361B1/no not_active IP Right Cessation
- 1994-06-03 FI FI942645A patent/FI115770B/fi not_active IP Right Cessation
- 1994-11-23 EE EE9400455A patent/EE9400455A/xx unknown
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1995
- 1995-06-07 US US08/481,810 patent/US5736521A/en not_active Expired - Lifetime
- 1995-06-07 US US08/484,426 patent/US5747460A/en not_active Expired - Lifetime
- 1995-06-07 US US08/480,818 patent/US5955433A/en not_active Expired - Fee Related
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1996
- 1996-04-12 AU AU50616/96A patent/AU683793B2/en not_active Ceased
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