ES2102295A1 - Nuevos compuestos derivados de la n-benzoilmetil-piperidina. - Google Patents

Nuevos compuestos derivados de la n-benzoilmetil-piperidina.

Info

Publication number
ES2102295A1
ES2102295A1 ES09400582A ES9400582A ES2102295A1 ES 2102295 A1 ES2102295 A1 ES 2102295A1 ES 09400582 A ES09400582 A ES 09400582A ES 9400582 A ES9400582 A ES 9400582A ES 2102295 A1 ES2102295 A1 ES 2102295A1
Authority
ES
Spain
Prior art keywords
new
benzoylmethyl
substituted
paroxetine
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES09400582A
Other languages
English (en)
Other versions
ES2102295B1 (es
Inventor
Ambros Rafael Fouguet
Ribera Santiago Gubert
Munoz Aurelio Sacristan
Hernandez Jose A Ortiz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ferrer Internacional SA
Original Assignee
Ferrer Internacional SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ferrer Internacional SA filed Critical Ferrer Internacional SA
Priority to ES09400582A priority Critical patent/ES2102295B1/es
Priority to TW084101572A priority patent/TW416956B/zh
Priority to IL112763A priority patent/IL112763A/en
Priority to PH51032A priority patent/PH31388A/en
Priority to ZA951963A priority patent/ZA951963B/xx
Priority to US08/557,008 priority patent/US5665736A/en
Priority to NZ283130A priority patent/NZ283130A/en
Priority to PCT/EP1995/001007 priority patent/WO1995025732A1/en
Priority to DK95928869T priority patent/DK0699198T3/da
Priority to AU21094/95A priority patent/AU678320B2/en
Priority to DE69510510T priority patent/DE69510510T2/de
Priority to CA002163253A priority patent/CA2163253C/en
Priority to JP52437595A priority patent/JP3213324B2/ja
Priority to EP95928869A priority patent/EP0699198B1/en
Priority to AT95928869T priority patent/ATE181734T1/de
Priority to KR1019950705161A priority patent/KR0182093B1/ko
Priority to FI955387A priority patent/FI108862B/fi
Priority to NO954538A priority patent/NO308002B1/no
Publication of ES2102295A1 publication Critical patent/ES2102295A1/es
Application granted granted Critical
Publication of ES2102295B1 publication Critical patent/ES2102295B1/es
Priority to GR990402380T priority patent/GR3031282T3/el
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, ***e

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

NUEVOS COMPUESTOS DERIVADOS DE LA N-BENZOILMETIL-PIPERIDINA.CONSISTE EN LOS NUEVOS COMPUESTOS DERIVADOS DE LA N-BENZOILMETIL-PIPERIDINA, DE FORMULA GENERAL (I): FORMULA DONDE X ES UN ATOMO DE HALOGENO, ASI COMO SUS SALES DE ADICION FARMACEUTICAMENTE ACEPTABLES. ESTOS COMPUESTOS SON DE USO POTENCIAL PARA TRATAR LAS DEPRESIONES.
ES09400582A 1994-03-18 1994-03-18 Nuevos compuestos derivados de la n-benzoilmetil-piperidina. Expired - Fee Related ES2102295B1 (es)

Priority Applications (19)

Application Number Priority Date Filing Date Title
ES09400582A ES2102295B1 (es) 1994-03-18 1994-03-18 Nuevos compuestos derivados de la n-benzoilmetil-piperidina.
TW084101572A TW416956B (en) 1994-03-18 1995-02-21 New n-benzoylmethyl-piperidines
IL112763A IL112763A (en) 1994-03-18 1995-02-23 History of 4-phenyl-3-] 3,4) methylenedioxy (phenolic [methyl] -N benzoylmethyl-piperidine
PH51032A PH31388A (en) 1994-03-18 1995-02-27 N-benzoylmethyl-piperidines.
ZA951963A ZA951963B (en) 1994-03-18 1995-03-09 N-benzoylmethyl-piperidines
AT95928869T ATE181734T1 (de) 1994-03-18 1995-03-17 N-benzoylmethylsubstituierte paroxetinderivate
PCT/EP1995/001007 WO1995025732A1 (en) 1994-03-18 1995-03-17 N-p-HALOBENZOYLMETHYL DERIVATIVES OF 4-(p-FLUOROPHENYL)-3-((3,4-METHYLENE-DIOXY)PHENOXY)METHYL)PIPERIDINE
DK95928869T DK0699198T3 (da) 1994-03-18 1995-03-17 N-benzoylmethyl-substituerede paroxetinderivater
AU21094/95A AU678320B2 (en) 1994-03-18 1995-03-17 N-p-Halobenzoylmethyl derivatives of 4-(p-fluorophenyl)-3-((3,4-(methylene-dioxy)phenoxy)methyl) piperidine
DE69510510T DE69510510T2 (de) 1994-03-18 1995-03-17 N-benzoylmethylsubstituierte paroxetinderivate
US08/557,008 US5665736A (en) 1994-03-18 1995-03-17 N-benzoylmethyl-piperidines
JP52437595A JP3213324B2 (ja) 1994-03-18 1995-03-17 新規なｎ−ベンゾイルメチル−ピペリジン類
EP95928869A EP0699198B1 (en) 1994-03-18 1995-03-17 N-benzoylmethyl substituted paroxetine derivatives
NZ283130A NZ283130A (en) 1994-03-18 1995-03-17 N-benzoylmethyl substituted paroxetine derivatives, preparation and pharmaceutical compositions thereof
KR1019950705161A KR0182093B1 (ko) 1994-03-18 1995-03-17 4-(p-플로오로페닐)-3-[(3,4-(메틸렌디옥시)페녹시)메틸]피페리딘의 n-p-할로벤조일메틸 유도체
CA002163253A CA2163253C (en) 1994-03-18 1995-03-17 N-p-halobenzoylmethyl derivatives of 4-(p-fluorophenyl)-3-¬¬3,4-methylenedioxy)phenoxy|methyl|piperidine
FI955387A FI108862B (fi) 1994-03-18 1995-11-08 4(p-fluorifenyyli)-3-[[3,4-(metyleenidioksi)fenoksi]metyyli]-piperidiinin N-p-halogeenibentsoyylimetyylijohdannaiset
NO954538A NO308002B1 (no) 1994-03-18 1995-11-10 N-p-halogenbenzoylmetylderivater av 4-(p-fluorfenyl)-3-[[3,4- metylendioksy)fenoksy]metyl]piperidin, farmasøytisk preparat inneholdende slike derivater, og anvendelse derav
GR990402380T GR3031282T3 (en) 1994-03-18 1999-09-22 New n-benzoylmethyl substituted paroxetine derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES09400582A ES2102295B1 (es) 1994-03-18 1994-03-18 Nuevos compuestos derivados de la n-benzoilmetil-piperidina.

Publications (2)

Publication Number Publication Date
ES2102295A1 true ES2102295A1 (es) 1997-07-16
ES2102295B1 ES2102295B1 (es) 1998-04-01

Family

ID=8285616

Family Applications (1)

Application Number Title Priority Date Filing Date
ES09400582A Expired - Fee Related ES2102295B1 (es) 1994-03-18 1994-03-18 Nuevos compuestos derivados de la n-benzoilmetil-piperidina.

Country Status (19)

Country Link
US (1) US5665736A (es)
EP (1) EP0699198B1 (es)
JP (1) JP3213324B2 (es)
KR (1) KR0182093B1 (es)
AT (1) ATE181734T1 (es)
AU (1) AU678320B2 (es)
CA (1) CA2163253C (es)
DE (1) DE69510510T2 (es)
DK (1) DK0699198T3 (es)
ES (1) ES2102295B1 (es)
FI (1) FI108862B (es)
GR (1) GR3031282T3 (es)
IL (1) IL112763A (es)
NO (1) NO308002B1 (es)
NZ (1) NZ283130A (es)
PH (1) PH31388A (es)
TW (1) TW416956B (es)
WO (1) WO1995025732A1 (es)
ZA (1) ZA951963B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2117557B1 (es) * 1996-02-29 1999-07-01 Ferrer Int Nuevo procedimiento de obtencion de (-)-trans -n-p-fluorobenzoilmetil-4-(p-fluorofenil)-3- ((3,4-(metilendioxi)fenoxi ) metil)-piperidina.
EP1394160A1 (en) * 1996-06-13 2004-03-03 SUMIKA FINE CHEMICALS Co., Ltd. Process for preparing crystalline paroxetin hydrochloride
GB9623359D0 (en) * 1996-11-09 1997-01-08 Smithkline Beecham Plc Novel process
GB9700690D0 (en) 1997-01-15 1997-03-05 Smithkline Beecham Plc Novel process
AU7708998A (en) 1997-05-29 1998-12-30 Smithkline Beecham Corporation Novel process
GB9826175D0 (en) * 1998-11-28 1999-01-20 Smithkline Beecham Plc Novel process
US7294637B2 (en) 2000-09-11 2007-11-13 Sepracor, Inc. Method of treating addiction or dependence using a ligand for a monamine receptor or transporter
EP1318988A2 (en) 2000-09-11 2003-06-18 Sepracor, Inc. Ligands for monoamine receptors and transporters, and methods of use thereof (neurotransmission)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3912743A (en) * 1973-01-30 1975-10-14 Ferrosan As 4-Phenylpiperidine compounds
EP0190496A2 (en) * 1984-12-13 1986-08-13 Beecham Group Plc Piperidine derivatives having a gastro-intestinal activity
EP0266574A2 (en) * 1986-11-03 1988-05-11 Novo Nordisk A/S Piperidine compounds and their preparation and use
EP0339579A2 (en) * 1988-04-28 1989-11-02 Novo Nordisk A/S Piperidine compositions and their preparation and use

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0223403B1 (en) * 1985-10-25 1993-08-04 Beecham Group Plc Piperidine derivative, its preparation, and its use as medicament
US5017585A (en) * 1986-11-03 1991-05-21 Novo Nordisk A/S Method of treating calcium overload

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3912743A (en) * 1973-01-30 1975-10-14 Ferrosan As 4-Phenylpiperidine compounds
US4007196A (en) * 1973-01-30 1977-02-08 A/S Ferrosan 4-Phenylpiperidine compounds
EP0190496A2 (en) * 1984-12-13 1986-08-13 Beecham Group Plc Piperidine derivatives having a gastro-intestinal activity
EP0266574A2 (en) * 1986-11-03 1988-05-11 Novo Nordisk A/S Piperidine compounds and their preparation and use
EP0339579A2 (en) * 1988-04-28 1989-11-02 Novo Nordisk A/S Piperidine compositions and their preparation and use

Also Published As

Publication number Publication date
FI108862B (fi) 2002-04-15
JP3213324B2 (ja) 2001-10-02
KR960702456A (ko) 1996-04-27
IL112763A0 (en) 1995-05-26
AU2109495A (en) 1995-10-09
NO954538D0 (no) 1995-11-10
NO954538L (no) 1995-11-10
EP0699198B1 (en) 1999-06-30
FI955387A0 (fi) 1995-11-08
CA2163253A1 (en) 1995-09-28
ATE181734T1 (de) 1999-07-15
CA2163253C (en) 2004-08-10
FI955387A (fi) 1995-11-08
US5665736A (en) 1997-09-09
JPH08510477A (ja) 1996-11-05
GR3031282T3 (en) 1999-12-31
WO1995025732A1 (en) 1995-09-28
KR0182093B1 (ko) 1999-05-01
NZ283130A (en) 1996-11-26
DE69510510T2 (de) 1999-11-18
EP0699198A1 (en) 1996-03-06
NO308002B1 (no) 2000-07-03
TW416956B (en) 2001-01-01
ZA951963B (en) 1996-03-11
IL112763A (en) 1998-03-10
ES2102295B1 (es) 1998-04-01
AU678320B2 (en) 1997-05-22
PH31388A (en) 1998-10-29
DK0699198T3 (da) 1999-11-22
DE69510510D1 (de) 1999-08-05

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20060321