SE7905862L - SUBSTITUTED 4-ARYL-2,5-DIHYDRO-FURAN-2-ONER AND 4-ARYL-1,5-DIHYDRO-2H-PYRROL-2-ONER AND SET FOR THEIR PREPARATION - Google Patents

SUBSTITUTED 4-ARYL-2,5-DIHYDRO-FURAN-2-ONER AND 4-ARYL-1,5-DIHYDRO-2H-PYRROL-2-ONER AND SET FOR THEIR PREPARATION

Info

Publication number
SE7905862L
SE7905862L SE7905862A SE7905862A SE7905862L SE 7905862 L SE7905862 L SE 7905862L SE 7905862 A SE7905862 A SE 7905862A SE 7905862 A SE7905862 A SE 7905862A SE 7905862 L SE7905862 L SE 7905862L
Authority
SE
Sweden
Prior art keywords
group
aryl
dihydro
oner
carbon atoms
Prior art date
Application number
SE7905862A
Other languages
Swedish (sv)
Inventor
E Cohen
Original Assignee
Beiersdorf Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19782829414 external-priority patent/DE2829414A1/en
Priority claimed from DE19792912951 external-priority patent/DE2912951A1/en
Application filed by Beiersdorf Ag filed Critical Beiersdorf Ag
Publication of SE7905862L publication Critical patent/SE7905862L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/38—2-Pyrrolones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/58—One oxygen atom, e.g. butenolide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)

Abstract

Substituted 4-aryl-2,5- dihydrofuran-2-ones and 4-aryl-1,5- dihydro-2H-pyrrol-2-ones of the general formula <IMAGE> wherein each of R<1> and R<2>, which can be the same or different, represents a hydrogen or halogen atom, an alkyl or acylamino group with 1 to 6 carbon atoms, or a carbamoylmethyl group, each of R<3> and R<4>, which can be the same or different, represents a hydrogen atom or a methyl group, R<5> represents a hydrogen atom, a dimethoxyphenyl group or an acylamino group of the general formula R<6>-CONH- (wherein R<6> represents an alkyl group with 1 to 4 carbon atoms), and A represents an oxygen atom, an imino group, or an alkylamino group with 1 to 4 carbon atoms, and their physiologically acceptable acid addition salts, are characterised by beta -andrenolytic and blood pressure reducing action and can accordingly be used, e.g. as pharmaceutical compositions, for the treatment of angina pectoris, hypertonia and arrhythemia.
SE7905862A 1978-07-05 1979-07-04 SUBSTITUTED 4-ARYL-2,5-DIHYDRO-FURAN-2-ONER AND 4-ARYL-1,5-DIHYDRO-2H-PYRROL-2-ONER AND SET FOR THEIR PREPARATION SE7905862L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19782829414 DE2829414A1 (en) 1978-07-05 1978-07-05 Beta-adrenergic blocking and hypotensive 2(5H)-furanone derivs. - prepd. by reacting 4-hydroxyphenyl-2(5H)-furanone with epihalohydrin and isopropylamine or tert.-butylamine
DE19792912951 DE2912951A1 (en) 1979-03-31 1979-03-31 Substd. 4-aryl-di:hydro-2-furanone and -pyrrolone derivs. - useful as beta-adrenolytic and hypotensive agents

Publications (1)

Publication Number Publication Date
SE7905862L true SE7905862L (en) 1980-01-06

Family

ID=25774894

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7905862A SE7905862L (en) 1978-07-05 1979-07-04 SUBSTITUTED 4-ARYL-2,5-DIHYDRO-FURAN-2-ONER AND 4-ARYL-1,5-DIHYDRO-2H-PYRROL-2-ONER AND SET FOR THEIR PREPARATION

Country Status (8)

Country Link
AT (1) AT377984B (en)
CA (1) CA1133494A (en)
CH (1) CH641451A5 (en)
FR (1) FR2430422A1 (en)
GB (1) GB2027694B (en)
IT (1) IT1122012B (en)
NL (1) NL7905218A (en)
SE (1) SE7905862L (en)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2356153A (en) * 1941-03-21 1944-08-22 Lilly Co Eli beta-substituted-delta alpha,beta-gamma-butyrolactones and methods of preparing them
DE1920176A1 (en) * 1969-04-21 1970-10-22 Thomae Gmbh Dr K Hydroxycrotonic acid lactone prodn
FR2132570B1 (en) * 1971-04-09 1974-08-02 Lipha

Also Published As

Publication number Publication date
NL7905218A (en) 1980-01-08
CH641451A5 (en) 1984-02-29
CA1133494A (en) 1982-10-12
AT377984B (en) 1985-05-28
IT1122012B (en) 1986-04-23
GB2027694A (en) 1980-02-27
ATA466679A (en) 1984-10-15
FR2430422B1 (en) 1982-12-31
FR2430422A1 (en) 1980-02-01
GB2027694B (en) 1983-01-06
IT7924101A0 (en) 1979-07-04

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