SE7905862L - SUBSTITUTED 4-ARYL-2,5-DIHYDRO-FURAN-2-ONER AND 4-ARYL-1,5-DIHYDRO-2H-PYRROL-2-ONER AND SET FOR THEIR PREPARATION - Google Patents
SUBSTITUTED 4-ARYL-2,5-DIHYDRO-FURAN-2-ONER AND 4-ARYL-1,5-DIHYDRO-2H-PYRROL-2-ONER AND SET FOR THEIR PREPARATIONInfo
- Publication number
- SE7905862L SE7905862L SE7905862A SE7905862A SE7905862L SE 7905862 L SE7905862 L SE 7905862L SE 7905862 A SE7905862 A SE 7905862A SE 7905862 A SE7905862 A SE 7905862A SE 7905862 L SE7905862 L SE 7905862L
- Authority
- SE
- Sweden
- Prior art keywords
- group
- aryl
- dihydro
- oner
- carbon atoms
- Prior art date
Links
- 125000004432 carbon atom Chemical group C* 0.000 abstract 3
- 125000004442 acylamino group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 206010002383 Angina Pectoris Diseases 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 206010020852 Hypertonia Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 230000036772 blood pressure Effects 0.000 abstract 1
- -1 carbamoylmethyl group Chemical group 0.000 abstract 1
- 125000005805 dimethoxy phenyl group Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000001841 imino group Chemical group [H]N=* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000001603 reducing effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
- C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
- C07D207/38—2-Pyrrolones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/58—One oxygen atom, e.g. butenolide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
Abstract
Substituted 4-aryl-2,5- dihydrofuran-2-ones and 4-aryl-1,5- dihydro-2H-pyrrol-2-ones of the general formula <IMAGE> wherein each of R<1> and R<2>, which can be the same or different, represents a hydrogen or halogen atom, an alkyl or acylamino group with 1 to 6 carbon atoms, or a carbamoylmethyl group, each of R<3> and R<4>, which can be the same or different, represents a hydrogen atom or a methyl group, R<5> represents a hydrogen atom, a dimethoxyphenyl group or an acylamino group of the general formula R<6>-CONH- (wherein R<6> represents an alkyl group with 1 to 4 carbon atoms), and A represents an oxygen atom, an imino group, or an alkylamino group with 1 to 4 carbon atoms, and their physiologically acceptable acid addition salts, are characterised by beta -andrenolytic and blood pressure reducing action and can accordingly be used, e.g. as pharmaceutical compositions, for the treatment of angina pectoris, hypertonia and arrhythemia.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19782829414 DE2829414A1 (en) | 1978-07-05 | 1978-07-05 | Beta-adrenergic blocking and hypotensive 2(5H)-furanone derivs. - prepd. by reacting 4-hydroxyphenyl-2(5H)-furanone with epihalohydrin and isopropylamine or tert.-butylamine |
DE19792912951 DE2912951A1 (en) | 1979-03-31 | 1979-03-31 | Substd. 4-aryl-di:hydro-2-furanone and -pyrrolone derivs. - useful as beta-adrenolytic and hypotensive agents |
Publications (1)
Publication Number | Publication Date |
---|---|
SE7905862L true SE7905862L (en) | 1980-01-06 |
Family
ID=25774894
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE7905862A SE7905862L (en) | 1978-07-05 | 1979-07-04 | SUBSTITUTED 4-ARYL-2,5-DIHYDRO-FURAN-2-ONER AND 4-ARYL-1,5-DIHYDRO-2H-PYRROL-2-ONER AND SET FOR THEIR PREPARATION |
Country Status (8)
Country | Link |
---|---|
AT (1) | AT377984B (en) |
CA (1) | CA1133494A (en) |
CH (1) | CH641451A5 (en) |
FR (1) | FR2430422A1 (en) |
GB (1) | GB2027694B (en) |
IT (1) | IT1122012B (en) |
NL (1) | NL7905218A (en) |
SE (1) | SE7905862L (en) |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2356153A (en) * | 1941-03-21 | 1944-08-22 | Lilly Co Eli | beta-substituted-delta alpha,beta-gamma-butyrolactones and methods of preparing them |
DE1920176A1 (en) * | 1969-04-21 | 1970-10-22 | Thomae Gmbh Dr K | Hydroxycrotonic acid lactone prodn |
FR2132570B1 (en) * | 1971-04-09 | 1974-08-02 | Lipha |
-
1979
- 1979-07-04 SE SE7905862A patent/SE7905862L/en not_active Application Discontinuation
- 1979-07-04 NL NL7905218A patent/NL7905218A/en not_active Application Discontinuation
- 1979-07-04 CA CA331,082A patent/CA1133494A/en not_active Expired
- 1979-07-04 IT IT24101/79A patent/IT1122012B/en active
- 1979-07-04 AT AT0466679A patent/AT377984B/en not_active IP Right Cessation
- 1979-07-05 CH CH630579A patent/CH641451A5/en not_active IP Right Cessation
- 1979-07-05 GB GB7923561A patent/GB2027694B/en not_active Expired
- 1979-07-05 FR FR7917463A patent/FR2430422A1/en active Granted
Also Published As
Publication number | Publication date |
---|---|
NL7905218A (en) | 1980-01-08 |
CH641451A5 (en) | 1984-02-29 |
CA1133494A (en) | 1982-10-12 |
AT377984B (en) | 1985-05-28 |
IT1122012B (en) | 1986-04-23 |
GB2027694A (en) | 1980-02-27 |
ATA466679A (en) | 1984-10-15 |
FR2430422B1 (en) | 1982-12-31 |
FR2430422A1 (en) | 1980-02-01 |
GB2027694B (en) | 1983-01-06 |
IT7924101A0 (en) | 1979-07-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
NAV | Patent application has lapsed |
Ref document number: 7905862-4 Effective date: 19860620 |