GB2027694B - Substituted 4-aryl-2,5-dihydro-furan-2-ones and 4-aryl-1,5-dihydro-2h-pyrrol-2-ones and pharmaceutical compositions containing such compounds - Google Patents
Substituted 4-aryl-2,5-dihydro-furan-2-ones and 4-aryl-1,5-dihydro-2h-pyrrol-2-ones and pharmaceutical compositions containing such compoundsInfo
- Publication number
- GB2027694B GB2027694B GB7923561A GB7923561A GB2027694B GB 2027694 B GB2027694 B GB 2027694B GB 7923561 A GB7923561 A GB 7923561A GB 7923561 A GB7923561 A GB 7923561A GB 2027694 B GB2027694 B GB 2027694B
- Authority
- GB
- United Kingdom
- Prior art keywords
- dihydro
- aryl
- ones
- pyrrol
- furan
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000001875 compounds Chemical class 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
- C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
- C07D207/38—2-Pyrrolones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/58—One oxygen atom, e.g. butenolide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19782829414 DE2829414A1 (en) | 1978-07-05 | 1978-07-05 | Beta-adrenergic blocking and hypotensive 2(5H)-furanone derivs. - prepd. by reacting 4-hydroxyphenyl-2(5H)-furanone with epihalohydrin and isopropylamine or tert.-butylamine |
DE19792912951 DE2912951A1 (en) | 1979-03-31 | 1979-03-31 | Substd. 4-aryl-di:hydro-2-furanone and -pyrrolone derivs. - useful as beta-adrenolytic and hypotensive agents |
Publications (2)
Publication Number | Publication Date |
---|---|
GB2027694A GB2027694A (en) | 1980-02-27 |
GB2027694B true GB2027694B (en) | 1983-01-06 |
Family
ID=25774894
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB7923561A Expired GB2027694B (en) | 1978-07-05 | 1979-07-05 | Substituted 4-aryl-2,5-dihydro-furan-2-ones and 4-aryl-1,5-dihydro-2h-pyrrol-2-ones and pharmaceutical compositions containing such compounds |
Country Status (8)
Country | Link |
---|---|
AT (1) | AT377984B (en) |
CA (1) | CA1133494A (en) |
CH (1) | CH641451A5 (en) |
FR (1) | FR2430422A1 (en) |
GB (1) | GB2027694B (en) |
IT (1) | IT1122012B (en) |
NL (1) | NL7905218A (en) |
SE (1) | SE7905862L (en) |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2356153A (en) * | 1941-03-21 | 1944-08-22 | Lilly Co Eli | beta-substituted-delta alpha,beta-gamma-butyrolactones and methods of preparing them |
DE1920176A1 (en) * | 1969-04-21 | 1970-10-22 | Thomae Gmbh Dr K | Hydroxycrotonic acid lactone prodn |
FR2132570B1 (en) * | 1971-04-09 | 1974-08-02 | Lipha |
-
1979
- 1979-07-04 SE SE7905862A patent/SE7905862L/en not_active Application Discontinuation
- 1979-07-04 NL NL7905218A patent/NL7905218A/en not_active Application Discontinuation
- 1979-07-04 CA CA331,082A patent/CA1133494A/en not_active Expired
- 1979-07-04 IT IT24101/79A patent/IT1122012B/en active
- 1979-07-04 AT AT0466679A patent/AT377984B/en not_active IP Right Cessation
- 1979-07-05 CH CH630579A patent/CH641451A5/en not_active IP Right Cessation
- 1979-07-05 GB GB7923561A patent/GB2027694B/en not_active Expired
- 1979-07-05 FR FR7917463A patent/FR2430422A1/en active Granted
Also Published As
Publication number | Publication date |
---|---|
NL7905218A (en) | 1980-01-08 |
SE7905862L (en) | 1980-01-06 |
CH641451A5 (en) | 1984-02-29 |
CA1133494A (en) | 1982-10-12 |
AT377984B (en) | 1985-05-28 |
IT1122012B (en) | 1986-04-23 |
GB2027694A (en) | 1980-02-27 |
ATA466679A (en) | 1984-10-15 |
FR2430422B1 (en) | 1982-12-31 |
FR2430422A1 (en) | 1980-02-01 |
IT7924101A0 (en) | 1979-07-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PCNP | Patent ceased through non-payment of renewal fee |