SE7902742L - Disubstituerade 3-cefem-4-karboxylsyraderivat samt forfarande for framstellning derav - Google Patents

Disubstituerade 3-cefem-4-karboxylsyraderivat samt forfarande for framstellning derav

Info

Publication number
SE7902742L
SE7902742L SE7902742A SE7902742A SE7902742L SE 7902742 L SE7902742 L SE 7902742L SE 7902742 A SE7902742 A SE 7902742A SE 7902742 A SE7902742 A SE 7902742A SE 7902742 L SE7902742 L SE 7902742L
Authority
SE
Sweden
Prior art keywords
disubstituted
preparation
carboxylic acid
cefem
procedures
Prior art date
Application number
SE7902742A
Other languages
English (en)
Swedish (sv)
Inventor
T Takaya
M Murata
Original Assignee
Fujisawa Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB1537877A external-priority patent/GB1602965A/en
Application filed by Fujisawa Pharmaceutical Co filed Critical Fujisawa Pharmaceutical Co
Publication of SE7902742L publication Critical patent/SE7902742L/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/587—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with aliphatic hydrocarbon radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms, said aliphatic radicals being substituted in the alpha-position to the ring by a hetero atom, e.g. with m >= 0, Z being a singly or a doubly bound hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
SE7902742A 1978-01-23 1979-03-27 Disubstituerade 3-cefem-4-karboxylsyraderivat samt forfarande for framstellning derav SE7902742L (sv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB265078 1978-01-23
GB1537877A GB1602965A (en) 1978-03-28 1978-03-28 3,7-disubstituted-3-cephem-4-carboxylic acid compounds and processes for the preparation thereof

Publications (1)

Publication Number Publication Date
SE7902742L true SE7902742L (sv) 1979-09-29

Family

ID=26237639

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7902742A SE7902742L (sv) 1978-01-23 1979-03-27 Disubstituerade 3-cefem-4-karboxylsyraderivat samt forfarande for framstellning derav

Country Status (11)

Country Link
US (2) US4288436A (de)
JP (2) JPS53149993A (de)
CA (1) CA1152062A (de)
CH (1) CH641469A5 (de)
DE (1) DE2814641A1 (de)
DK (1) DK125179A (de)
ES (2) ES478967A1 (de)
FR (1) FR2387235A1 (de)
IT (1) IT1096178B (de)
NL (1) NL7902408A (de)
SE (1) SE7902742L (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE878433A (fr) * 1978-08-31 1980-02-25 Fujisawa Pharmaceutical Co Procede de preparation de derives d'acide 3-cephem-4-carboxylique 3,7-disubstitue, nouveaux produits ainsi obtenus et leur utilisation pour leur activite antibacterienne
BE878514A (fr) * 1978-09-04 1980-02-29 Fujisawa Pharmaceutical Co Procede de preparation de composes d'acide 3-cephem-4-carboxylique a disubstitution en positions 3 et 7, nouveaux produits ainsi obtenus et leur utilisation pour leur activite antibacterienne
US4464369A (en) * 1977-03-14 1984-08-07 Fujisawa Pharmaceutical Co., Ltd. 7-Acylamino-3-cephem-4-carboxylic acid derivatives and pharmaceutical compositions
JPS5444695A (en) * 1977-09-13 1979-04-09 Fujisawa Pharmaceut Co Ltd 3,7-disubstituted-3-cephem-4-carboxylic acid and its salt and their preparation
DE2822860A1 (de) * 1978-05-26 1979-11-29 Hoechst Ag Cephemderivate und verfahren zu ihrer herstellung
AU536842B2 (en) * 1978-12-29 1984-05-24 Fujisawa Pharmaceutical Co., Ltd. Cephalosporin antibiotics
US4331666A (en) * 1979-05-11 1982-05-25 Farmitalia Carlo Erba S.P.A. 3-[(8-Carboxy-6-tetrazolo[1,5-b]pyridazinyl)-thiomethyl]-7-[2-(2-amino-4-thiazolyl)-2-methoxyimino-acetamido]-3-cephem-4-carboxylic acid
US4409214A (en) * 1979-11-19 1983-10-11 Fujisawa Pharmaceutical, Co., Ltd. 7-Acylamino-3-vinylcephalosporanic acid derivatives and processes for the preparation thereof
US4420477A (en) 1979-11-30 1983-12-13 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
IL61458A0 (en) 1979-12-07 1980-12-31 Erba Farmitalia N-substituted thiazolyl derivatives of oximino-substituted cephalosporins, their preparation and pharmalceutical compositions containing them
US4346076A (en) * 1980-09-17 1982-08-24 Eli Lilly And Company Bis-tetrazoylmethyl substituted cephalosporin antibiotics
DE3037997A1 (de) * 1980-10-08 1982-05-13 Bayer Ag (beta) -lactamantibiotika, verfahren zu deren herstellung sowie sie enthaltende mittel
US4521413A (en) * 1981-09-14 1985-06-04 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
JPS591490A (ja) * 1982-06-29 1984-01-06 Dai Ichi Seiyaku Co Ltd ３−セフェム−４−カルボン酸誘導体
US4698338A (en) * 1986-02-19 1987-10-06 Eli Lilly And Company 7[2-(2-aminothiazol-4-yl)-2-benzyloximino]acetamido-3[4-alkyl-5-oxo-6-hydroxy-3,4-dihydro-1,2,4-triazin-3-yl]thiomethyl cephalosporins
CN104478825A (zh) * 2014-11-21 2015-04-01 山东金城医药化工股份有限公司 氨噻肟酸的合成方法
CN112094247A (zh) * 2020-08-21 2020-12-18 宁夏农林科学院农业资源与环境研究所（宁夏土壤与植物营养重点实验室） 头孢菌素类药物中间体及其合成方法
CN112457271A (zh) * 2020-11-18 2021-03-09 河北合佳医药科技集团股份有限公司 一种氨噻肟酸中间体的连续流合成方法

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4297489A (en) * 1974-09-03 1981-10-27 Bristol-Myers Company 7-α-Amino-substituted acylamino-3-(1-carboxymethyltetrazol-5-ylthiomethyl)-3-cephem-4-carboxylic acids
GB1536281A (en) * 1975-06-09 1978-12-20 Takeda Chemical Industries Ltd Cephem compounds
DK154939C (da) * 1974-12-19 1989-06-12 Takeda Chemical Industries Ltd Analogifremgangsmaade til fremstilling af thiazolylacetamido-cephemforbindelser eller farmaceutisk acceptable salte eller estere deraf
JPS525787A (en) * 1975-06-27 1977-01-17 Bristol Myers Co Antiibacterial agent
SE440655B (sv) * 1976-01-23 1985-08-12 Roussel Uclaf Sett att framstella nya oximderivat av 7-amino-tiazolyl-acetamido-cefalosporansyra
NO770703L (no) * 1976-03-03 1977-09-06 Sumitomo Chemical Co Fremgangsm}te for fremstilling av cefalosporiner
GB1575803A (en) * 1976-03-09 1980-10-01 Fujisawa Pharmaceutical Co 3,7 disubstituted 3 cephem 4 carboxylic acid compounds andprocesses for the preparation thereof
FR2345153A1 (fr) * 1976-03-25 1977-10-21 Roussel Uclaf Nouvelles alcoyloximes derivees de l'acide 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
US4202893A (en) * 1976-03-25 1980-05-13 Roussel Uclaf Alkyloximes of 7-amino-thiazolyl-acetamido-cephalosporanic acids
US4166115A (en) * 1976-04-12 1979-08-28 Fujisawa Pharmaceutical Co., Ltd. Syn 7-oxoimino substituted derivatives of cephalosporanic acid
DE2715385A1 (de) * 1976-04-14 1977-11-10 Takeda Chemical Industries Ltd Cephalosporinderivate, verfahren zu ihrer herstellung und sie enthaltende arzneimittel
US4220644A (en) * 1976-05-03 1980-09-02 Smithkline Corporation 7-Acylamino-3-(substituted tetrazolyl thiomethyl) cephalosporins
US4278670A (en) * 1976-07-12 1981-07-14 Smithkline Corporation 7-Alpha-oxyiminoacylcephalosporins
JPS6011713B2 (ja) * 1976-09-08 1985-03-27 武田薬品工業株式会社 セフアロスポリン誘導体およびその製造法
ES467601A1 (es) * 1977-03-12 1979-06-16 Hoechst Ag Procedimiento para la preparacion de derivados de cefem.
DE2714880A1 (de) * 1977-04-02 1978-10-26 Hoechst Ag Cephemderivate und verfahren zu ihrer herstellung
US4268509A (en) * 1978-07-10 1981-05-19 Fujisawa Pharmaceutical Co., Ltd. New cephem compounds and processes for preparation thereof

Also Published As

Publication number Publication date
DE2814641A1 (de) 1978-10-19
FR2387235B1 (de) 1981-11-06
FR2387235A1 (fr) 1978-11-10
CH641469A5 (de) 1984-02-29
ES478967A1 (es) 1980-08-16
CA1152062A (en) 1983-08-16
ES8102141A1 (es) 1980-12-16
JPS53149993A (en) 1978-12-27
DK125179A (da) 1979-09-29
US4411898A (en) 1983-10-25
NL7902408A (nl) 1979-10-02
US4288436A (en) 1981-09-08
IT1096178B (it) 1985-08-17
ES487938A0 (es) 1980-12-16
IT7822238A0 (it) 1978-04-12
JPS54132592A (en) 1979-10-15

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