SE537715C2 - INHALING DEVICE FOR SUBSTANCES IN POWDER FORM - Google Patents

Abstract

537 7 SAM MAN DRAG Uppfinningen avser en multidos-inhalator for amnen i pulverform exempelvis innefattande minst en dosring (2) med ett flertal foretradesvis i cirkel anordnade pulverkammare (1), avsedda for var sin dos pulverformat amne och att en frammatningsmekanism (5) är anordnad att mata fram dosringen (2) eller dosringarna (2) i avsedd rorelseriktning, att minst en tatning (11,22) är anordnad att tata pulverkamrarna (1) fran varandra och Iran omgivningen for kvarhallande av pulverdoserna i respektive pulverkammare (1). Uppfinningen uppnas genom att frammatningsmekanismen (5) är anordnad att mata fram dosringen (2) eller dosringarna (2) sá att minst tva pulverkammare (1) at gangen forflyttas fram till ett lage for avgivning av pulverdoserna, att en luftkanal (7) innefattande minst en luftkanalsdel (7a,b) är anordnad i laget for de pulverkammare (1) som frammatats, att luftkanalen (7) eller dess luftkanalsdelar (7a,b) är anordnadie att medge att minst tva pulverkammare (1) vid inhalation oppnas vasentligen samtidigt mot luftkanalen (7) sá att pulverkamrarna (1) och deras pulverdoser exponeras mot luftkanalen (7) varigenom pulverdoserna tillats passera ut genom luftkanalen (7) och blandas med varandra med hjalp av luftflOdet. The invention relates to a multi-dose inhaler for the powdered substance, for example comprising at least one dosing ring (2) with a plurality of preferably in-circle powder chambers (1), each intended for its own dose of powdered substance and that a feed mechanism (5) is arranged to feed the dosing ring (2) or the dosing rings (2) in the intended direction of movement, that at least one seal (11,22) is arranged to seal the powder chambers (1) from each other and Iran the environment for retaining the powder doses in the respective powder chambers (1). The invention is achieved in that the feeding mechanism (5) is arranged to feed the dosing ring (2) or the dosing rings (2) so that at least two powder chambers (1) are moved at a time to a layer for dispensing the powder doses, that an air duct (7) comprising at least an air duct part (7a, b) is arranged in the layer of the powder chambers (1) which are advanced, that the air duct (7) or its air duct parts (7a, b) are arranged to allow at least two powder chambers (1) to be opened substantially simultaneously at inhalation towards the air duct (7) so that the powder chambers (1) and their powder doses are exposed to the air duct (7) whereby the powder doses are allowed to pass out through the air duct (7) and are mixed with each other by means of the air flow.

Description

537 7 INHALATIONSANORDNING FOR AMNEN I PULVERFORM TEKNISKT OMRADE FOreliggande uppfinning avser generellt multidos inhalationsanordningar fOr amnen i pulverform avsedd for inandning. Speciellt avser den en sá kallad multidos inhalator (DPI, Dry Powder Inhaler) som drivs av anvandarens egen respirationsfOrmaga. Multidos-inhalatorer är framst avsedda att lindra sjukdomstillstand orsakade av astma eller andra akommor som fOrhindrar normal respiration. TECHNICAL FIELD The present invention relates generally to multidose inhalation devices for the powdered substance intended for inhalation. In particular, it refers to a so-called multidose inhaler (DPI, Dry Powder Inhaler) which is powered by the user's own respiratory capacity. Multidose inhalers are primarily intended to alleviate medical conditions caused by asthma or other ailments that prevent normal respiration.

TEKNIKENS BAKGRUND Pa marknaden idag finns ett stort antal inhalatorer for amnen i pulverform av vilka de flesta är sa kallade multidos-inhalatorer. De senaste aren har forskning och kliniska studier visat att en behandling med tva aktiva substanser samtidigt kan ge en avsevard battre effekt i behandlingen an att bara anvanda en som historiskt har varit den dominerande behandlingsmetoden. LAMA/LABA behandlingar behover en inhalator som kan farvara doserna med de olika aktiva substanserna atskilda till dess att anvandaren ska inhalera. Doserna far alltsa inte blanda sig med varandra i inhalatorn utan endast Ora det i ogonblicket nar de andas in av patienten. Fa inhalatorer idag kan fOrvara doserna atskilda for att sedan leverera dem bagge forst nar inandning sker. Dessutom är de som for narvarande marknadsfors idag, vare sig de ska leverera en aktiv substans eller tva, relativt stora och klumpiga i sitt utforande vilket medfor att forvaringen i klader/handvaskor och handhavandet av dem, inte är anvandarvanligt. Ett annat problem är att de inte alltid levererar en exakt och avsedd dos och att oavsiktlig frammatning av ny dos är mojlig d.v.s. att anvandaren kan, av misstag, fa i sig en dubbel dos. Nar dosen är frammatad i lage for att inhaleras sá kan anvandaren av misstag blasa in luft i multidos-inhalatorn, vilket medfor att fukt kan ansamlas och orsaka att det pulverformiga amnet klibbar ihop. Vidare sä bestar kanda multidos-inhalatorer, av manga delar vilket Or dem komplicerade och dyra att tillverka och darmed ocksa dyra att kopa for slutanvandaren. Ett stOrre antal delar okar ocksa antalet felkallor. Vid en given kvalitetsniva okar i princip antalet fel linjart med antalet delar. FOreliggande innovation loser ovan beskrivna problematik kring handhavandet och antalet delar samtidigt som den ger mojlighet till att forvara tva 1 537 7 aktiva substanser i inhalatorn for att forst vid inhalation leverera de bada pa en gang sa att de beblandas forst nar de kommer in i kroppen pa patienten. BACKGROUND ART On the market today there are a large number of inhalers for the substances in powder form, most of which are so-called multidose inhalers. In recent years, research and clinical studies have shown that a treatment with two active substances at the same time can give a significantly better effect in the treatment than using only one that has historically been the dominant treatment method. LAMA / LABA treatments need an inhaler that can color the doses with the different active substances separately until the user inhales. The doses must therefore not be mixed with each other in the inhaler, but only Ora it at the moment when they are inhaled by the patient. Few inhalers today can keep the doses separate and then deliver them in a bag only when inhaling. In addition, those that are currently marketed today, whether they are to deliver an active substance or two, are relatively large and clumsy in their design, which means that the storage in clothes / washbasins and the handling of them is not user-friendly. Another problem is that they do not always deliver an exact and intended dose and that unintentional delivery of a new dose is possible, i.e. that the user may, by mistake, ingest a double dose. When the dose is fed in a state to be inhaled, the user may inadvertently blow air into the multidose inhaler, which may cause moisture to accumulate and cause the powdered substance to stick together. Furthermore, kanda consists of multidose inhalers, of many parts which Or they complicated and expensive to manufacture and thus also expensive to buy for the end user. A larger number of parts also increases the number of error calls. At a given quality level, in principle, the number of errors linearly increases with the number of parts. The present innovation solves the problems described above regarding the handling and the number of parts at the same time as it gives the possibility to store two active substances in the inhaler so that when inhaled they deliver both at once so that they are mixed only when they enter the body. patients.

Multidos-inhalatorer pa marknaden likval kanda patenterade varianter sasom exempelvis US6273085, US7275538B2, US6871647, US7395821B2 samt US2009205657A1, bestar av minst nio eller fler delar och flagon form av sluten inkapsling av det pulverformiga amnet som skall inhaleras. For att frilagga det pulverformiga amnet maste inkapslingen mekaniskt penetreras, en tatning lyftas, rullas upp, rivas av eller liknande for att ge atkomst till det pulverformiga amnet. Denna inkapsling eller snarare mekanismen som behovs for att bryta forseglingen är den enskilt mest avgarande faktorn for att minska antalet enskilda delar och aven for att kunna reducera storleken pa multidos-inhalatorn. Dessa problem lOses av foreliggande uppfinning. lngen av dessa är designanade for att kunna forvara tva olika former av aktiva substanser kir att sedan leverera desamma vid inhalation. Multi-dose inhalers on the market as well as patented variants such as, for example, US6273085, US7275538B2, US6871647, US7395821B2 and US2009205657A1, consist of at least nine or more parts and flake form of closed encapsulation of the powdered substance to be inhaled. To expose the powdered blank, the encapsulation must be mechanically penetrated, a seal lifted, rolled up, torn off or the like to provide access to the powdered blank. This encapsulation or rather the mechanism needed to break the seal is the single most crucial factor in reducing the number of individual parts and also in being able to reduce the size of the multidose inhaler. These problems are solved by the present invention. None of these are designed to store two different forms of active substances that can then be delivered by inhalation.

US627308beskriver en inhalator med en separat kassett for pulvret. Kassetten 15 utgOrs av en skiva som har axiella hal som utgOr pulverkammare. Pa Over och undersidan finns en tatning som innesluter halen i skivan och darmed tatar pulverkammaren. Tatningstrycket astadkommes genom en Owe och undre fjaderbricka. Darmed anvands fern delar bara till funktionen att innesluta pulverkammarna. I foreliggande uppfinning anvandes tva delar for samma funktion, dos-ring och ovre holjesdel. En ovre holjesdel finns i bada losningarna. I fOreliggande uppfinning utgor ovre holjesdel en av de tva delarna for att bilda en innesluten pulverkammare. Med den logiken har foreliggande uppfinning en del jamfort med det kanda patentets fern delar. De farre delarna ger lagre tillverkningskostnad, lagre sammansattningskostnad samt farre felkallor. US627308 discloses an inhaler with a separate cartridge for the powder. The cassette 15 consists of a disc which has axial slides which constitute a powder chamber. On the top and bottom there is a seal that encloses the tail in the disc and thus seals the powder chamber. The tapping pressure is achieved through an Owe and lower spring washer. Thus, four parts are used only for the function of enclosing the powder chambers. In the present invention, two parts are used for the same function, dosing ring and upper housing part. An upper housing part is found in both solutions. In the present invention, the upper housing portion is one of the two portions to form an enclosed powder chamber. By that logic, the present invention has some similarities with the four parts of the known patent. The fewer parts result in lower manufacturing costs, lower assembly costs and fewer error calls.

US7275538B2 beskriver en inhalator med pulverkammare, i form av en cylinder, vilka ligger efter varandra i en disk dar man anvander en tryckanordning med en nal som penetrerar en kammare i taget for att frilagga densamma och Ora det mojligt att inhalera dess innehall. Varje kammare matas fram, en at gangen, varefter den penetreras fran den inre delen av disken. Penetreringsanordningen innebar att bygghojden är ca 11 ganger sa hog som luftkanalens hojd. pa nalen som penetrerar bada kamrarna kan medikament fastna, pulvret kan ocksa hamna i aerodynamisk skugga under eller bakom de delar av folien som viks mat i pulverkammaren vid 2 537 7 penetreringen, samt kan folien kontaminera pulvret. Losningen forsvarar dessutom produktionen eftersom kamrarna skall fyllas med medikament och darefter forslutas pa bade den inre saval som den yttre delen av disken. Antalet delar uppgar till minst nio stycken. 5 I US6871647 beskrivs en anordning som bestar av tre ganger sá manga delar som foreliggande uppfinningen. For att frilagga dosen som ska inhaleras fran kamrarna "Iyfts" en tackande inkapsling/tejp upp eller "skalas" ay. Detta komplicerade oppnande av kamrarna riskerar ocksa att delar av den tackande inkapslingen kan blandas med amnet i pulverkammaren och saledes kontaminera det. Att doma av figurerna och de delar som beskrivs i dokumentet är den inhalatorn avsevart tjockare och pa alla satt stare i storlek och saledes mer skrymmande i sin design an foreliggande uppfinning och darmed mer otymplig att forvara och hantera. US7275538B2 discloses an inhaler with a powder chamber, in the form of a cylinder, which lie one after the other in a disk using a pressure device with a squeegee which penetrates one chamber at a time to expose it and it is possible to inhale its contents. Each chamber is fed, one at a time, after which it is penetrated from the inner part of the disk. The penetration device meant that the construction height is about 11 times as high as the height of the air duct. on the needle that penetrates both chambers, drugs can get stuck, the powder can also end up in aerodynamic shadow during or behind the parts of the foil that are folded into the powder chamber during the penetration, and the foil can contaminate the powder. The solution also defends production because the chambers must be filled with medicine and then closed on both the inner saliva and the outer part of the disk. The number of parts is at least nine. US6871647 describes a device consisting of three times as many parts as the present invention. To expose the dose to be inhaled from the chambers "Iyfts" a thankful encapsulation / tape up or "peeled" ay. This complicated opening of the chambers also risks that parts of the filling encapsulation can be mixed with the substance in the powder chamber and thus contaminate it. Judging by the figures and the parts described in the document, the inhaler is considerably thicker and in all respects larger in size and thus more bulky in its design than the present invention and thus more awkward to store and handle.

I US7395821B2 beskrivs en anordning som bestar av tolv delar dar den tackande tejpen som är anordnad pa kamrarna med medikament skall penetreras f6r att sedan inhaleras genom den "nal" som anvands vid penetrationen. Kontaminering av amnet som ska inhaleras riskeras darmed samt aven att det pulverformiga amnet i pulverkammaren kan hannna i "aerodynamisk skugga" d.v.s. att inte hela den tillgangliga dosen kan inhaleras eftersom pulver kan fastna pa nalen som penetrerat kammaren samt hamna utanfor densamma vid inhalationen. Frammatningen av 20 doser och handhavandet vid inhalation kraver ocksa att tva hander maste anvandas nar den ska hanteras eftersom den ovre och undre delen ska roteras at var sitt hall for att en ny dos ska matas fram och en "nal" ska tryckas ned for att penetrera det tackande holjet under vilket amnet som ska inhaleras är placerat. Att doma av figurerna och de delar som beskrivs är inhalatorn avsevart tjockare och pa alla satt storre i storlek och saledes mer skrymmande i sin design an foreliggande uppfinning och darmed mer otymplig att forvara och hantera. US7395821B2 discloses a device consisting of twelve parts in which the tacking tape arranged on the chambers with medicament is to be penetrated and then inhaled through the "needle" used in the penetration. Contamination of the substance to be inhaled is thereby also at risk, as well as the fact that the powdered substance in the powder chamber may end up in "aerodynamic shadow", i.e. that not the entire available dose can be inhaled as powder can get stuck on the needle that penetrated the chamber and end up outside it during inhalation. The feeding of 20 doses and the handling during inhalation also require that two hands must be used when it is to be handled because the upper and lower part must be rotated at each hall so that a new dose is fed and a "squeegee" is pressed down to penetrate. the abrasive shell under which the substance to be inhaled is placed. Judging by the figures and the parts described, the inhaler is considerably thicker and in all cases larger in size and thus more bulky in its design than the present invention and thus more awkward to store and handle.

US2009205657A1 beskriver en anordning som innehaller dubbelt sa manga delar som foreliggande uppfinning, samt dar det tackande holjet Over medikamentkamrarna maste dras bort, penetreras, dras isar (blisterpack) etc, for att anvandaren skall kunna inhalera amnet i pulverform. Konstruktionen anvander alltsa en helt annan tatningslosning an foreliggande uppf inning med den ovan beskrivna kontamineringsrisken som foljd. Dessa tatningslosningar innebar ocksa att utrymme 3 537 7 tas i ansprak for oppningsmekanismen som behovs for att frilagga det pulver som ska inhaleras. Det i sin tur medfor att storleken pa multidos-inhalatorn oundvikligen kommer att bli storre an foreliggande uppfinning eftersom metoden att frilagga det pulverformiga amnet eliminerar nodvandigheten av en sadan mekanism. Att doma av figurerna och de delar som beskrivs sä är denna kanda inhalator avsevart tjockare och storre i storlek och saledes mer skrymmande i sin design an var innovation och darmed mer otymplig att fOrvara och hantera. US2009205657A1 describes a device which contains twice as many parts as the present invention, and in which the thanking cover over the medicament chambers must be removed, penetrated, drawn ice (blister pack) etc, in order for the user to be able to inhale the substance in powder form. The construction thus uses a completely different sealing solution than the present invention with the above-described contamination risk as follows. These sealing solutions also meant that space was taken up for the opening mechanism needed to expose the powder to be inhaled. This in turn means that the size of the multidose inhaler will inevitably be larger than the present invention since the method of exposing the powdered substance eliminates the necessity of such a mechanism. Judging by the figures and the parts described, this well-known inhaler is considerably thicker and larger in size and thus more bulky in its design than was innovation and thus more awkward to store and handle.

SAMMANFATTNING AV UPPFINNINGEN Multidos-inhalatorn bestar enligt uppfinningen av en dosring innehallande pulverkammare, i form av fordjupningar eller urtagningar i namnda dosring, orienterade i en cirkel. Varannan av dosringens pulverkam mare är forladdad med en forsta aktiv substans medan varannan innehaller en andra aktiv substans. Dosringen ligger an mot ett tatande material, som är anordnad i direkt anslutning till namnda fordjupningar/pulverkammare. I tatningen är anordnat minst ett oppningsbart element med en yta faretradesvis dimensionerad till tre fjardedelar av vane pulverkammares uppat oppna area. De oppningsbara elementen är skurna eller stansade sa att de bildar en flik i tatningen. En kant av det Oppningsbara elementet är inte genomskuren utan bildar en form av "gangjarn" mot tatningen. lnget material har tagits bort vilket gar att det Oppningsbara elementet passar exakt i det omgivande tatningsmaterialet, och det pulverformiga amnet kan inte passera forbi det Oppningsbara elementet eller genom slitsen. Tatningen kan t.ex. limmas eller fastas mot dosringen via urtagningar mellan pulverkamrarna i vilken motsvarande forhojningar i tatningsringen passar. Endast i ena langsidan av pulverkammaren är tatningen fast i dosringen. lnhalatorns holje pressar mot pulverkamrarnas tatning och hjalper saledes till att halla tatningen pa plats vid pulverkamrarna. Holjet kan forslagsvis vara forsett med en lokal upphojning vid luftkanalen, dar tatningsfunktionen mellan holjet, tatningen och dosringen upphor. Nar skyddet for munstycket, som samtidigt fungerar som frammatningsmekanism, oppnas roteras dosringen fram ett steg och minst tva pulverkam mare matas darmed fram till luftkanalen och exponeras for luftstrommen 30 som uppstar vid inandning genom inhalatorn. De tva frammatade pulverkamrarna innehaller de tva olika aktiva substanserna. Luftkanalen är utformad sá att ett undertryck, faretradesvis en venturi-effekt, uppstar i omradet vid pulverkamrarna. En strypning är foretradesvis anordnad nedstroms pulverkamrarna som skall avge 4 537 7 pulverdoserna. Denna strypning orsakar en hastighetsokning hos luftstrommen. Efter strypningen vidgas luftkanalen gradvis vilket ger ett lokalt undertryck. Vidgningen är placerad i omradet over pulverkamrarna som skall avge pulverdoserna. Undertrycket lyfter upp det oppningsbara elementet och den forbistrommande luften drar med sig pulvret ur respektive pulverkammare. Alternativt kan man anordna ett oppningsbart element for varje pulverkam mare och dar de oppnas samtidigt for de pulverkam mare som skall avge pulverdoser. Vid inhalation fungerar inhalatorn p5 ovan beskrivna satt d.v.s. att undertrycket lyfter det eller de oppningsbara elementen och innehallet i de tva frammatade pulverkamrarna innehallandes de tv5 olika aktiva substanserna dras med av luftstrommen. SUMMARY OF THE INVENTION According to the invention, the multidose inhaler consists of a dosing ring containing a powder chamber, in the form of depressions or recesses in said dosing ring, oriented in a circle. Every other of the powder chamber of the dosing ring is preloaded with a first active substance while every other contains a second active substance. The dosing ring abuts against a resilient material, which is arranged in direct connection to said recesses / powder chambers. In the seal, at least one openable element is arranged with a surface dangerously dimensioned to three quarters of the upwardly open area of the usual powder chamber. The openable elements are cut or punched so that they form a flap in the seam. An edge of the openable element is not cut through but forms a form of "hinge" against the seam. No material has been removed, which means that the openable element fits exactly into the surrounding sealing material, and the powdered blank cannot pass past the openable element or through the slot. Tatningen can e.g. glued or fastened to the dosing ring via recesses between the powder chambers in which the corresponding elevations in the sealing ring fit. Only in one long side of the powder chamber is the seal fixed in the dosing ring. The housing of the inhaler presses against the seal of the powder chambers and thus helps to hold the seal in place at the powder chambers. The casing may be provided with a local elevation at the air duct, where the sealing function between the casing, the sealing and the metering ring ceases. When the cover of the nozzle, which simultaneously acts as a feeding mechanism, is opened, the dosing ring is rotated one step and at least two powder chambers are thus fed to the air duct and exposed to the air stream 30 which arises when inhaling through the inhaler. The two feed powder chambers contain the two different active substances. The air duct is designed so that a negative pressure, preferably a venturi effect, arises in the area at the powder chambers. A throttle is preferably provided downstream of the powder chambers which are to dispense the powder doses. This throttling causes an increase in the velocity of the air stream. After the throttling, the air duct gradually widens, which gives a local negative pressure. The widening is located in the area above the powder chambers that are to deliver the powder doses. The negative pressure lifts the openable element and the by-passing air pulls the powder out of the respective powder chamber. Alternatively, an openable element can be provided for each powder chamber and where they are opened simultaneously for the powder chambers which are to deliver powder doses. When inhaled, the inhaler p5 functions described above, i.e. that the negative pressure lifts the openable element or elements and the contents of the two supplied powder chambers containing the two different active substances are drawn along by the air stream.

Syftet med uppfinningen är att skapa en s5 tunn men and5 funktionell multidosinhalator som mojligt som samtidigt kan leverera minst tva olika aktiva substanser vid ett och samma inhalationstillfalle. Ambitionen är att samtidigt reducera bygghajden pa multidos-inhalatorn sa att den bekvamt skall kunna forvaras till exempel i en brostficka. Langd och bredd är reducerad till ungefar kreditkortsstorlek vilket innebar att multidos-inhalatorn är betydligt mindre an vad som är normalt bland kanda multidos-inhalatorer och tjockleken bara cirka en tredjedel. Den reducerade bygghojden är en viktig fordel for anvandaren. Det 5stadkommes genom att den geometriska formen är anordnad s5 att bygghojden är ungefar summan av godstjocklek i undre holjesdel samt godstjocklek i dosringens botten och pulverkammarens hojd och godstjockleken i ovre holje. Denna bygghojd galler Over den allra storsta delen av inhalatorns ovre yta. Denna geometriska form ger fordelaktig effekt genom att den mojliggor en avsevart lagre bygghojd an kanda inhalatorer. Ett ytterligare andam5I med uppfinningen är att utforma inhalatorn med sa f5 delar som mojligt for att underlatta produktionen och darmed Ora inhalatorn mer kostnadseffektiv att producera, vilket ger slutanvandaren ett betydligt billigare alternativ av multidos-inhalator an vad som star tillbuds pa marknaden idag. Delarna är huvudsakligen en ovre och en undre hOljesdel som innesluter dosringen, tatningen som ligger i direkt anslutning till pulverkamrarna och frammatningsmekanismen. The object of the invention is to create a thin but and functional multidose inhaler as possible which can simultaneously deliver at least two different active substances in one and the same inhalation case. The ambition is to simultaneously reduce the construction height of the multidose inhaler so that it can be conveniently stored, for example in a breast pocket. Length and width are reduced to approximately credit card size, which meant that the multidose inhaler is significantly smaller than what is normal among known multidose inhalers and the thickness is only about one third. The reduced construction height is an important advantage for the user. This is achieved by the geometric shape being arranged so that the construction height is approximately the sum of the wall thickness in the lower casing part and the wall thickness in the bottom of the dosing ring and the height of the powder chamber and the wall thickness in the upper casing. This construction height grille covers the vast majority of the inhaler's upper surface. This geometric shape gives a beneficial effect by enabling a considerably lower construction height than inhalers. A further object of the invention is to design the inhaler with as few parts as possible to facilitate production and thus make the inhaler more cost-effective to produce, which gives the end user a much cheaper alternative of multidose inhaler than what is available on the market today. The parts are mainly an upper and a lower housing part which encloses the dosing ring, the seal which is in direct connection with the powder chambers and the feed mechanism.

Sammanlagt alltsa fern delar. Med hjalp av de f5 delarna och den specifika uppbyggnaden blir multidos-inhalatorn okomplicerad och kostnadseffektiv att montera. Automatisering av produktionen kan genomforas med standardiserade plockrobotar eftersom alla komponenter har samma monteringsriktning. Oppningarna 537 7 i tatningen som ligger mot pulverkamrarna kan stansas ut ur metervara. Saledes behover inga manuella operationer anvandas vid tillverkningen. Tatningen kan som alternativ dubbel-formsprutas pa dosringen istallet for att stansas ut ur metervara. I det fallet utgar tatningen ur monteringsprocessen, den tillfors istallet i formsprut- ningsprocessen. I det fallet utgar aven det Oppningsbara elementet da det är inte är mojligt att integrera i en process for dubbelformsprutning. Det oppningsbara elementet är en fordel vad galler skyddande av dosen am en anvandare oavsiktligt blaser in i inhalatorn omedelbart fore in andningen. Dock har de fiesta inhalatorer inte ett skydd far dosen om anvandaren oavsiktligt blaser in i inhalatorn, alla Ovriga far en inhalator centrala funktioner är intakta aven med den dubbelformsprutade losningen. A total of four parts. With the help of the f5 parts and the specific construction, the multidose inhaler becomes uncomplicated and cost-effective to install. Automation of production can be carried out with standardized picking robots because all components have the same mounting direction. The openings 537 7 in the socket which lie against the powder chambers can be punched out by meter. Thus, no manual operations need be used in the manufacture. The seal can alternatively be double-molded onto the metering ring instead of being punched out by the meter. In that case, the seal is based on the assembly process, it is supplied instead in the injection molding process. In that case, the Openable element also goes out as it is not possible to integrate in a process for double injection molding. The openable member is advantageous in protecting the dose if a user inadvertently blows into the inhaler immediately before inhaling. However, most inhalers do not have protection for the dose if the user inadvertently blows into the inhaler, all other functions for an inhaler central functions are intact even with the double-injection molded solution.

Tatningstrycket astadkommes pa samma satt far en tatning stansad ur metervara med oppningsbara element som en pa dosringen dubbelformsprutad tatning. Tatningstrycket astadkommes genom att byre och undre holje som omsluter dosringen är clipsade, skruvade eller svetsade samman far att pressa axiellt pa namnda dos-ring. Tatningen kan alternativt vara separat formsprutad istallet for dubbelformsprutning. Tatningen kan alternativt fastas mot en holjesdel som anligger den sida av dosringen dar pulverkammare är anordnade. The sealing pressure is achieved in the same way for a seal punched out of fabric with openable elements as a double-injection molded seal on the metering ring. The sealing pressure is achieved by clamping, screwing or welding together the upper and lower casings enclosing the dosing ring to cause axial pressing on said dosing ring. The seal may alternatively be separately injection molded instead of double injection molding. The seal can alternatively be fastened to a housing part which abuts the side of the dosing ring where powder chambers are arranged.

Ett annat andamal med uppfinningen är att handhavandet av multidos-inhalatorn ska vara sa latt och anvandarvanlig som mojligt samtidigt som mojlig felanvandning undanrojes. Man kan ta den ur, till exempel en brostficka, satta tummen pa frammatningsmekanismen, mata fram de tva doserna, inhalera, sedan stanga och lagga tillbaka den i brostfickan, alit i en manuell och sammanhangande rorelse. Konstruktionen medfor alltsa att anvandaren kan hantera multidos-inhalatorn med hjalp av endast en hand samtidigt som det, oavsett hur anvandaren hailer i den, sakerstalls att dosen inhaleras i sin helhet. Anordningen eliminerar ocksa risken av att, av misstag, inhalera en dubbelt sa stor dos som avsett, eller mer, vid fullbordad frammatning och inhalation. Efter det att doserna är forbrukade kasseras multidos-inhalatorn. 6 537 7 Ett unikt sardrag har uppnatts genom att oppna pulverkammaren genom att holjets inneslutande tatande effekt upphor vid luftkanalen i holjet over namnda pulverkamrar och att undertrycket skapat av luftstrommen som lyfter upp minst ett oppningsbart element i tatningen som tacker pulverkammarna och kamrarna toms av den forbistrOmmande luften. Tatningen är fast endast vid ena langsidan av pulverkamrarna. Vid varje frammatning av dosringen frilaggs tva pulverkammare i taget fran sin tatade inneslutning, genom att tatningen pa dosringen glider mot holjet vid tatningsytan. Pulverkammrarna transporteras pa detta satt i rotationsriktningen fram mot luftkanalen, kir att vara frilagda med endast tatningens 10 forberedda oppningsbara element, som tacker-namnda kammare, nar frammatningen är fullbordad. Losningen eliminerar behovet av anordningar som punkterar en folie, river upp en folie, mekaniskt lyfter en gummitatning eller mekaniskt lyfter ett tatande lock. Eftersom frilaggandet av pulverkammaren sker pa detta unika satt kan bygghojden och antal delar reduceras till ett minimum med bibehallen sakerhet och 15 god anvandbarhet. Varje kam mare ligger separerade under det tackande ovre holjet fram till frammatningstillfallet. Det innebar att tva aktiva substanserna omojligen kan blandas med varandra. Konstruktionen eliminerar ocksa risken for kontaminering av pulvret som en kand punkteringsanordning kan orsaka och att delar av substansen hamnar i aerodynamisk skugga av delar av den perforerade pulverinneslutande folien. Another object of the invention is that the operation of the multidose inhaler should be as light and user-friendly as possible while eliminating possible misuse. You can take it out, for example a breast pocket, put your thumb on the feed mechanism, feed the two doses, inhale, then close and put it back in the breast pocket, all in a manual and continuous motion. The design therefore means that the user can handle the multidose inhaler with the help of only one hand, while, regardless of how the user hails in it, it is ensured that the dose is inhaled in its entirety. The device also eliminates the risk of inadvertently inhaling a dose twice as large as intended, or more, upon completed delivery and inhalation. After the doses have been consumed, the multidose inhaler is discarded. 6 537 7 A unique feature has been achieved by opening the powder chamber by terminating the enclosing sealing effect of the housing at the air duct in the housing above said powder chambers and by the negative pressure created by the air stream lifting at least one openable element in the gasket thanking the powder chambers and chambers. the air. The fitting is fixed only to one long side of the powder chambers. During each feeding of the dosing ring, two powder chambers are exposed at a time from their sealed enclosure, in that the seal on the dosing ring slides towards the housing at the sealing surface. The powder chambers are transported in this way in the direction of rotation towards the air duct, which should be exposed with only the opening openable elements of the seal 10, such as the said chamber, when the feed is completed. The solution eliminates the need for devices that puncture a foil, tear a foil, mechanically lift a rubber seal or mechanically lift a sealing lid. Since the exposure of the powder chamber takes place in this unique way, the construction height and number of parts can be reduced to a minimum while maintaining safety and good usability. Each chamber is separated under the thanking upper housing until the feed case. This meant that the two active substances could not possibly be mixed with each other. The construction also eliminates the risk of contamination of the powder that a known puncturing device can cause and that parts of the substance end up in aerodynamic shadow of parts of the perforated powder enclosing foil.

Multidos inhalatorn skulle i ett alternativt utforande kunna forses med tva separata luftkanaler som i ovrigt är konstruerade som ovan beskrivna luftkanal och saledes leder en luftstrom Over var sin av de frammatade kamrarna i avgivningslaget. De har bagge den tidigare beskrivna strypningen strax innan namnda pulverkammare for att 25 astadkomma det undertryck som kravs for att oppna respektive oppningsbart element. Den ena luftkanalen leder saledes fram till den ena frammatade kammaren och den andra leder fram till den andra frammatade pulverkammaren. Luftkanalerna kan alternativt hallas franskilda anda ut till munstycket sä att det blir forst i munhalan/luftstrupen som de tva aktiva substanserna blandas. 7 537 7 I ett alternativt utforande skulle en uppfinningsenlig dosring kunna anordnas med pulverkammare anordnade i dess yta dar pulverkamrarna anordnas i exempelvis minst tva huvudsakligen cirkelformade rader, en yttre och en inre, alternativt i spiralform dar varje pulverkammare placeras vid ett gradvis forandrat avstand fran dosringens centrum. In an alternative embodiment, the multidos inhaler could be provided with two separate air ducts which are otherwise designed as the air duct described above and thus lead an air stream Over each of the fed chambers in the delivery layer. They have rammed the previously described throttling just before said powder chamber to provide the negative pressure required to open the respective openable element. One air duct thus leads to one fed chamber and the other leads to the other fed powder chamber. The air ducts can alternatively be held in a separate spirit out to the nozzle so that it is only in the oral cavity / trachea that the two active substances are mixed. In an alternative embodiment, a dosing ring according to the invention could be arranged with powder chambers arranged in its surface where the powder chambers are arranged in, for example, at least two substantially circular rows, an outer and an inner one, alternatively in spiral form where each powder chamber is placed at a gradually changing distance from the dosing ring. center.

Vid varje frammatning placeras tva nya doser vid avgivningslaget. Den ena aktiva substansen ligger i den inre raden av pulverkammare och den andra i den yttre raden. Bada tOms samtidigt vid inhalation. At each feed, two new doses are placed at the delivery layer. One active substance is in the inner row of powder chambers and the other in the outer row. Bathe tOms at the same time when inhaling.

Pa detta satt kan minst dubbla rader av pulverkammare orienteras i dosringen med hjalp av endast ytterligare en detalj. 60 doser eller fler kan darmed erbjudas och inhalatorn bestar exempelvis av 6 istallet for 5 delar men det är fortfarande betydligt farre an de ca 13 delar plus band med pulverkammare som dominerande konkurrenter anvander. In this way, at least double rows of powder chambers can be oriented in the dosing ring by means of only one further detail. 60 doses or more can thus be offered and the inhaler consists, for example, of 6 instead of 5 parts, but it is still significantly less than the approximately 13 parts plus bands with powder chambers used by dominant competitors.

Foreliggande uppfinning kan ocksa innehalla fler an tva rader av pulverkammare. Dock kommer en sadan inhalator att bli storre eftersom dosringens diameter maste rymma exempelvis fyra rader av kammare och darmed frangas ett av uppfinningens syften. The present invention may also contain more than two rows of powder chambers. However, such an inhaler will be larger because the diameter of the dosing ring must accommodate, for example, four rows of chambers and thus one of the objects of the invention is fulfilled.

Tva dosringar kan ocksa monteras pa eller intill varandra med separata kammare i varje ring. De ligger i en sadan losning precis mitt emot eller over och under varandra sa att tva kammare, placeras i lage for avgivning av doserna, vid varje frammatning. Tjockleken pa inhalatorn kommer vid en sadan losning att Oka men totala antalet delar och dess tjocklek halls fortfarande pa en lagre niva an de inhalatorer som for narvarande finns pa marknaden. Two dosing rings can also be mounted on or next to each other with separate chambers in each ring. They lie in such a solution just opposite or above and below each other so that two chambers, placed in position to deliver the doses, at each feed. The thickness of the inhaler will increase with such a solution, but the total number of parts and its thickness will still be kept at a lower level than the inhalers currently on the market.

Den beskrivna multidos-inhalatorn är alltsa avsevart mindre och framforallt tunnare an kanda multidos-inhalatorer. Den kombinerar fa antal delar och lattare och sakrare handhavande med att kunna leverera minst tva olika aktiva substanser vid varje inhaleringstillfalle. Konstruktionen sakerstaller ocksa att de tva aktiva substanserna ligger, innan inhalation, separerade i sina respektive kammare. lnhalatorn kommer ocksa, med foreslagen konstruktion, att bli enkel och saledes billig att tillverka. 8 537 7 De ovan namnda och ytterligare andamal och fordelar uppnas enligt uppfinningen med hjalp av en multidos-inhalator i enlighet med de i patentkravets 1 kannetecknande del angivna sardragen. The multidose inhaler described is therefore considerably smaller and, above all, thinner than multidose inhalers. It combines a small number of parts and lighter and safer handling with being able to deliver at least two different active substances at each inhalation event. The construction also states that the two active substances are, before inhalation, separated in their respective chambers. The inhaler will also, with the proposed construction, be simple and thus inexpensive to manufacture. The above-mentioned and further objects and advantages are achieved according to the invention with the aid of a multidose inhaler in accordance with the features stated in the jugging part of claim 1.

KORTFATTAD RITNINGSFORTECKNING Uppfinningen beskrivs narmare nedan i nagra foredragna utforingsexempel med led fling av bifogade ritningar. BRIEF DESCRIPTION OF THE DRAWINGS The invention is described in more detail below in some preferred embodiments with reference to the accompanying drawings.

Figur 1A och 1B visar en uppfinningsenlig multidos-inhalator i exploderad vy. Figures 1A and 1B show an inventive multidose inhaler in exploded view.

Figur 2A och tvarsnitt 2B visar en uppfinningsenlig inhalator visar luftkanalens strypning och hur areaexpanderingen over pulverkamrarna skapar ett undertryck (venturieffekt) som Oppnar det Oppningsbara elementet och drar med sig pulvret samtidigt ur respektive kammare. Figure 2A and cross-section 2B show an inhaler according to the invention shows the throttling of the air duct and how the area expansion over the powder chambers creates a negative pressure (venturi effect) which opens the openable element and at the same time pulls the powder out of the respective chamber.

Figur 2C samt visar hur en flik per kammare kan anordnas likval som en for de tva frammatade doskamrarna. Figure 2C and shows how one tab per chamber can be arranged in the same way as one for the two advanced dose chambers.

Figur 3A visar en uppfinningsenlig multidos-inhalator hur tva parallellt placerade 15 pulverkammare samt hur figur 3B visar tva seriellt placerade pulverkammare matas tram till luftkanalen och hur luftstrommen transporterar amnena i pulverform samtidigt ur respektive kammare. Figure 3A shows a multidose inhaler according to the invention how two powder chambers placed in parallel and how Figure 3B shows two serially placed powder chambers are fed by tram to the air duct and how the air stream transports the blanks in powder form simultaneously from each chamber.

Figur 4A och tvarsnitt 4B visar en ytterligare alternativ losning pa hur pulverkamrarna kan anordnas att matas tram minst tva i taget och hur luftstrommen transporterar amnena i pulverform samtidigt ur respektive kammare. Figure 4A and cross-section 4B show a further alternative solution to how the powder chambers can be arranged to be fed tram at least twice at a time and how the air stream transports the blanks in powder form simultaneously from each chamber.

Figur 5A och tvarsnitt 5B visar en ytterligare alternativ losning pa hur pulverkamrarna kan anordnas att matas tram minst tva i taget och hur luftstrommen transporterar amnena i pulverform, samtidigt ur respektive kammare. Figure 5A and cross-section 5B show a further alternative solution on how the powder chambers can be arranged to be fed tram at least twice at a time and how the air stream transports the blanks in powder form, simultaneously from the respective chambers.

Figur 6A och tvarsnitt 6B visar en ytterligare alternativ lasning pa hur pulverkamrarna kan anordnas att matas fram minst tva i taget och hur luftstrommen transporterar amnena i pulverform, samtidigt ur respektive kammare. Figure 6A and cross-section 6B show a further alternative reading on how the powder chambers can be arranged to be fed at least two at a time and how the air stream transports the blanks in powder form, simultaneously from each chamber.

Figur 7A och tvarsnitt 7B visar en ytterligare alternativ losning pa hur pulverkamrarna kan anordnas att matas tram minst tva i taget och hur luftstrommen transporterar amnena i pulverform, samtidigt ur respektive kammare. Figure 7A and cross-section 7B show a further alternative solution on how the powder chambers can be arranged to be fed tram at least twice at a time and how the air stream transports the blanks in powder form, simultaneously from the respective chambers.

Figur 8A, B, C och D visar ytterligare varianter pa hur doserna kan vara anordnade for att matas tram minst tva i taget. 9 537 7 Figur 9 visar ett alternativt satt att lagga tatningen av pulverkamrarna. Figures 8A, B, C and D show further variants of how the doses can be arranged to be fed tram at least twice at a time. 9 537 7 Figure 9 shows an alternative way of laying the seal of the powder chambers.

Figur 10A och 10B visar en uppfinningsenlig multidos-inhalator dar frammatningen sker under en forsta halft av frammatningsmekanismens utfallning samt hur frammatningsmekanismen är kopplad till frilaggandet av munstycket. Figures 10A and 10B show a multi-dose inhaler according to the invention where the feed takes place during a first half of the failure of the feed mechanism and how the feed mechanism is connected to the exposure of the nozzle.

BESKRIVNING AV FOREDRAGNA UTFORANDEFORMER Figur 1A visar en uppfinningsenlig multidos-inhalator bestaende av ett antal pulverkammare 1 anordnade i en dosring 2 och orienterade i cirkelform vardera innehallande en forladdad mangd amne i pulverform. Dosringen 2 är i sin tur anordnad mellan en ovre rotationsfast holjesdel 3 och en nedre rotationsfast hOljesdel 4. Pulverkamrarna 1 är med sina oppningar orienterade mot den ena ovre rotationsfasta hOljesdelen 3. Multidos-inhalatorn är fOrsedd med en frammatningsmekanism innefattande en tackande kapa som, samtidigt som den bppnar upp fOr munstycket 6 ocksa matar fram dosringen 2 minst tva pulverkammare 1 i taget till ett lage for inhalation i luftkanalen 7. I den nedre rotationsfasta holjesdelen 4 finns anordnat ett luftinlopp 8 for luftkanalen 7. DESCRIPTION OF PREFERRED EMBODIMENTS Figure 1A shows a multidose inhaler according to the invention consisting of a number of powder chambers 1 arranged in a dosing ring 2 and oriented in a circular shape each containing a pre-charged plurality of powdered substance. The dosing ring 2 is in turn arranged between an upper rotationally fixed housing part 3 and a lower rotationally fixed housing part 4. The powder chambers 1 are oriented with their openings towards one upper rotationally fixed housing part 3. The multidose inhaler is provided with a feeding mechanism comprising a as it opens up for the nozzle 6, the dosing ring 2 also feeds at least two powder chambers 1 at a time to a layer for inhalation in the air duct 7. In the lower rotationally fixed housing part 4 an air inlet 8 for the air duct 7 is arranged.

Luftinloppet 8 bestar av ett eller flera lufthal 9. Nedstroms lufthalen 9, efter inloppet 8, är en spiral utformad vars syfte är att, som en extra sakerhetsatgard, fanga upp pulver som skulle kunna falla ur flagon av pulverkamrarna 1 om anvandaren exempelvis skakar inhalatorn och/eller om den halls i lodratt lage efter en frammatning. Pa sá satt sakerstalls att pulver fangas upp innan det passerar ut genom lufthalen 9. Losningen innebar alltsa att amnet som dosen bestar av, med sakerhet kommer att inhaleras i sin helhet oavsett hur multidos-inhalatorn orienteras eller hanteras av anvandaren vid anvandningstillfallet. The air inlet 8 consists of one or more air halls 9. Downstream of the air hall 9, after the inlet 8, a spiral is designed whose purpose is, as an extra safety measure, to catch powders which could fall out of the flakes of the powder chambers 1 if the user shakes the inhaler and / or if it is held in vertical layer after a feed. This means that powder is captured before it passes out through the airway 9. The discharge therefore means that the substance of which the dose consists will certainly be inhaled in its entirety, regardless of how the multidose inhaler is oriented or handled by the user in the event of use.

En tatning 11 är vidare anordnad med for-stansade oppningsbara element 12 varvid 25 tatningen 11 kan anordnas mot dosringen 2 dar de oppningsbara elementen passas in mot en pulverkammare 1 i dosringen 2. Materialet i tatningen 11 kan lampligtvis, men inte nadvandigtvis, utgoras av EPDM (ethylene propylene diene monomer) som kan formsprutas i mycket tunna skikt. De oppningsbara elementen kan ocksa tacka tva pulverkammare (ej visat) likval som ett oppningsbart element for vane kammare. A seal 11 is further provided with punched openable elements 12, wherein the seal 11 can be arranged against the dosing ring 2 where the openable elements are fitted against a powder chamber 1 in the dose ring 2. The material in the seal 11 can suitably, but not necessarily, be EPDM (ethylene propylene diene monomer) which can be injection molded in very thin layers. The openable elements can also thank two powder chambers (not shown) as well as an openable element for habit chambers.

Figuren visar aven att frammatningsmekanismen bestar av en kuggforsedd 13 frammatningsarm 14. Vid oppning av inhalatorn driver frammatningsarmen 14 via 537 7 kuggarna 13 pa dosringens kuggkrans sá att nasta pulverkammare 1 matas fram till luftkanalsdelen 7a som är placerad tvars dosringens 2 rotationsriktning. Luftkanalsdelens 7a inre langd och bredd är foretradesvis nagot storre an minst tva pulverkammares 1 oppningsarea, eller i vane fall vasentligen tacker minst tva pulverkammares oppningsarea, for att sakerstalla att hela pulverkamrarnas 1 oppningsarea exponeras for luftkanalsdelen 7a. Det är ocksa tankbart att luftkanalsdelen 7a utformas i sjalva godset i den byre haljesdelen 3 utan att en forhojning i holjesdelen 3 behover goras som stracker sig utanfor holjesdelens 3 huvudsakliga yttre yta. The figure also shows that the feed mechanism consists of a toothed feed feed 14. When opening the inhaler, the feed arm 14 drives via 537 7 the teeth 13 on the ring ring gear ring so that the next powder chamber 1 is fed to the air duct part 7a which is placed transversely to the rotation ring 2. The inner length and width of the air duct part 7a is preferably slightly larger than the opening area of at least two powder chambers 1, or in the essential case substantially thanks to the opening area of at least two powder chambers, in order to ensure that the entire opening area of the powder chambers 1 is exposed to the air duct part 7a. It is also conceivable that the air duct part 7a is formed in the goods themselves in the upper part of the housing part 3 without an elevation in the housing part 3 having to be made which extends outside the main outer surface of the housing part 3.

Vid luftkanalsdelen 7a exponeras alltsa de frammatade pulverkamrarna 1 och endast tatningen 11 med dess fOrberedda Oppningsbara element 12 tacker i detta lage pulverkammaren 1. Vid frammatningen frilaggs alltsa minst tva pulverkammare 1 i taget fran sitt slutna lage mot det Ovre rotationsfasta haljet 3 och exponeras mot luftkanalsdelen 7a. Thus, at the air duct portion 7a, the fed powder chambers 1 are exposed and only the seal 11 with its Prepared Openable Elements 12 tacks in this layer of the powder chamber 1. At the feed, at least two powder chambers 1 at a time are exposed from their closed layer towards the Upper rotational fixed portion 3 and exposed to the air duct portion 7a.

Efter inhalation, nar anvandaren stanger frammatningsmekanismen 5, fjadrar frammatningsarmen 14 undan for dosringens 2 kuggkrans pa sin vag tillbaka till utgangslaget. Backsparrar 16 som är integrerade i dosringen 2, farhindrar att dosringen 2 roterar baklanges genom att de griper in i kuggkransen 17 som är anordnad och integrerad i den nedre holjesdelen 4. Dosringens kuggkrans tillsammans med backsparrarna 16 och den i det nedre hOljet integrerade kuggkransen 17, sakerstaller saledes att endast en pulverkammare 1 at gangen kan matas fram i lage for inhalation. Backsparrarna 16 är anordnade att fjadra nagot sá att de vid dosringens 2 frammatning kan fjadra upp over kuggarna i det nedre holjets 4 kuggkrans 17. Losningen innebar att endast en pulverkammare 1 at gangen kan placeras i lage vid luftkanalsdelen 7a. After inhalation, when the user closes the feed mechanism 5, the feed arm 14 springs away from the ring gear of the metering ring 2 on its way back to the initial layer. Backrests 16 integrated in the dosing ring 2 prevent the dosing ring 2 from rotating backwards by engaging in the ring gear 17 which is arranged and integrated in the lower housing part 4. The gear ring of the dosing ring together with the jaws 16 and the gear ring 17 integrated in the lower housing sakerstaller such that only one powder chamber 1 at a time can be fed in stock for inhalation. The jaws 16 are arranged to spring slightly so that when the dosing ring 2 is fed, they can spring up over the teeth in the gear ring 17 of the lower housing 4. The release meant that only one powder chamber 1 at a time can be placed in position at the air duct part 7a.

Figur 1A visar ocksa att det, i den nedre holjesdelen 4, finns en cirkulart utformad kantvagg 18 som hailer dosringen 2 i lage. I nedre holjesdelen 4 finns ocksa ett styrhal 19 for frammatningsmekanismen 5. Vid monteringen av inhalatorn placeras forst den nedre holjesdelen 4 i en fixtur (ej visad). Dosringen 2 och frammatnings- mekanismen placeras sedan i denna del. Darefter fylls det pulverformiga amnet pa i dosringens pulverkammare 1. Tatningen 11 placeras sedan mot dosringen 2. Sam sista moment forseglas multidos-inhalatorn med den byre holjesdelen 3. 11 537 7 Figur 1B visar undersidan pa den ovre holjesdelen 3. Figure 1A also shows that, in the lower housing part 4, there is a circularly shaped edge cradle 18 which hails the dosing ring 2 in position. In the lower casing part 4 there is also a guide hall 19 for the feed mechanism 5. When mounting the inhaler, the lower casing part 4 is first placed in a fixture (not shown). The dosing ring 2 and the feed mechanism are then placed in this part. The powdered substance is then filled into the powder chamber 1 of the dosing ring. The seal 11 is then placed against the dosing ring 2. At the last moment, the multi-dose inhaler is sealed with the upper housing part 3. Figure 53 shows the underside of the upper housing part 3.

Figur 2A och 2B visar hur luftkanalsdelen 7a, sett i luftens flodesriktning, är anordnad med en strypning som innebar att luftens hastighet okar vid inandning i omradet strax fore de frammatade pulverkamrarna. I omradet Over pulverkamararna 1 vidgas luftkanalsdelen 7a gradvis vilket resulterar i ett undertryck som lyfter det oppningsbara elementet 12 i tatningen 11 och hur den forbistrommande luften drar med sig pulvret ur pulverkamrarna 1. Det lokala undertrycket som skapas med hjalp av strypningen orsakas av en sá kallad venturieffekt. Tatningens 11 forberedda oppningsbara element 12 kan liknas vid en flik eller lucka. Pulvret exponeras saledes for luftstrommen 21 och dras ut ur inhalatorn tillsammans med inandningsluften och ned i anvandarens svalg. I detta exempel är det oppningsbara elementet 12 anordnat i tatningen 11 och tacker bagge de frammatade pulverkamrarna 1. Det Oppningsbara elementet kan alternativt ocksa vara anordnat i tatningen 11 sa att de frammatade kamrarna är tackt av var sitt oppningsbart element. Alternativt kan det oppningsbara elementet ocksa vara fast endast vid luftkanalsdelen 7a (vilket figur 2A visar). I det senare fallet anvands alltsa samma oppningsbara element for alla de kammare 1 som matas fram till luftkanalsdelen 7a. Dosringen 2 kan alltsa vara fOrsedd med ett antal oppningsbara element (12) svarande mot halva antalet pulverkammare 1 i dosringen 2. Figures 2A and 2B show how the air duct part 7a, seen in the flow direction of the air, is arranged with a restriction which meant that the speed of the air increases when inhaling in the area just before the fed powder chambers. In the area above the powder chambers 1, the air duct part 7a gradually widens, which results in a negative pressure which lifts the openable element 12 in the seal 11 and how the by-passing air draws the powder from the powder chambers 1. The local negative pressure created by the throttling is caused by a so-called venturi effect. The prepared opening element 12 of the seal 11 can be likened to a flap or hatch. The powder is thus exposed to the air stream 21 and is drawn out of the inhaler together with the inhaled air and down into the user's throat. In this example, the openable element 12 is arranged in the socket 11 and tacks the fed powder chambers 1. The openable element can alternatively also be arranged in the socket 11 so that the fed-on chambers are each filled by an openable element. Alternatively, the openable element can also be fixed only to the air duct part 7a (as Figure 2A shows). In the latter case, therefore, the same openable element is used for all the chambers 1 which are fed to the air duct part 7a. The dosing ring 2 can thus be provided with a number of openable elements (12) corresponding to half the number of powder chambers 1 in the dosing ring 2.

Figur 2B visar ett tvarsnitt genom den ovre och den undre holjesdelen med mellanliggande dosring 2 och tatning 11 och visar luftkanalsdelen 7a och de pulverkammare 1 som frilagts i densamma. I figuren tydliggors hur det oppningsbara elementet 12 som tacker de tva frammatade pulverkamrarna oppnar sig samtidigt nar luften strommar forbi och hur pulvret frigors ur respektive pulverkammare. Figure 2B shows a cross-section through the upper and the lower housing part with intermediate dosing ring 2 and seal 11 and shows the air duct part 7a and the powder chambers 1 exposed in it. The figure clarifies how the openable element 12 which thanks the two fed powder chambers opens simultaneously when the air flows past and how the powder is released from the respective powder chambers.

Figur 2C och Figur visar att en flik 12 per doskammare 1 kan anordnas likval som en flik som tacker tva kammare som visats i Figur 2A och B. Bagge flikarna kan frambringas att oppnas av det undertryck som skapas av namnda venturieffekt, nar kamrarna har frammatats till luftkanalsdelen 7a. Figure 2C and Figure show that a flap 12 per dose chamber 1 can be arranged as well as a flap thanking two chambers shown in Figures 2A and B. The ram flaps can be made to be opened by the negative pressure created by said venturi effect, when the chambers have been advanced to the air duct part 7a.

Figur 3A med tvarsnittet 3B visar en alternativ utforandeform och tatningen av doskamrarna 1 for att kunna mata tram dem minst tva i taget. I detta exempel ligger pulverkamrarna 1 sida vid sida av varandra sasom tidigare beskrivits. Vid vane 12 537 7 frammatning placeras minst tva kammare i taget i luftkanalsdelen 7a vid en och samma frammatning. Tatningen 11 är i detta exempel anordnad direkt i holjesdelen narmast ovan pulverkamrarna. Figure 3A with the cross-section 3B shows an alternative embodiment and the sealing of the dosing chambers 1 in order to be able to feed them at least two at a time. In this example, the powder chambers are side by side as previously described. In the case of habit feeding, at least two chambers are placed at a time in the air duct part 7a at one and the same feeding. In this example, the socket 11 is arranged directly in the housing part closest to the powder chambers.

Figur 4A med tvarsnittet 4B visar en alternativ utforandeform av doskamrarna 1 for att kunna mata fram dem minst tva i taget. I detta exempel ligger de i linje med varandra sett inifran inhalatorns centrum ut mot periferin. Vid vane frammatning placeras minst tva kam mare i luftkanalsdelen 7a vid en och samma frammatning. Luftkanalsdelen 7a är aningen langre i detta exempel an vad tidigare beskrivits sa att de bagge kamrarna skall kunna frilaggas samtidigt i densamma. I ovrigt är inhalatorn identisk i sin design och storlek. Tatningen 11 är i detta exempel anordnad direkt i hOljesdelen narmast ovan kamrarna. Man kan tanka sig ett Oppningsbart element sasom tidigare beskrivits. Dock visas inte det exemplet i denna figur. Figure 4A with the cross section 4B shows an alternative embodiment of the dosing chambers 1 in order to be able to feed them at least two at a time. In this example, they are aligned with each other from the center of the inhaler toward the periphery. In the case of habitual feeding, at least two chambers are placed in the air duct part 7a at one and the same feeding. The air duct part 7a is slightly longer in this example than what has been previously described, so that the ram chambers can be exposed simultaneously in it. Otherwise, the inhaler is identical in its design and size. In this example, the socket 11 is arranged directly in the housing part closest to the chambers. One can imagine an openable element as previously described. However, that example is not shown in this figure.

Figur 5A med tvarsnittet 5B visar pa en alternativ utforandeform av placeringen av pulverkamrarna 1 for att kunna mata fram dem minst tva i taget. I detta exempel har tva dosringar 2 placerats intill varandra, men pa visst avstand fran varandra. Figure 5A with the cross section 5B shows an alternative embodiment of the location of the powder chambers 1 in order to be able to feed them at least two at a time. In this example, two dosing rings 2 have been placed next to each other, but at a certain distance from each other.

Pulverkamrarna ligger pa varandra med respektive oppning riktad mot det ovre holjet 3. Vid vane frammatning placeras bagge pulverkamrarna i luftkanalsdelen 7a. Pulverkamrarna maste ligga precis pa varandra och saledes maste dosringarna vara av identisk storlek for att bagge pulverkamrarna, en i respektive dosring 1 samtidigt ska kunna matas fram i lage for avgivning. lnhalatorn blir i detta fall en aning tjockare an am, som tidigare beskrivits, endast en dosring 1 anvands där tva pulverkammare matas fram info!' varje nytt anvandningstillfalle. Fordelen är att pa detta s5tt kan tier doser fa plats i inhalatorn utan att inhalatorns yttre area andras. lnhalatorns tjocklek akar emellertid en aning. Tatningen 11 ar i detta exempel anordnad direkt i delarna 25 narmast ovan pulverkamrarna. Man kan tanka sig ett oppningsbart element for vane pulverkammare sasom tidigare beskrivits. Dock visas inte det exemplet i denna figur. The powder chambers lie on top of each other with the respective opening directed towards the upper casing 3. During normal feeding, the powder chambers are placed in the air duct part 7a. The powder chambers must lie exactly on top of each other and thus the dosing rings must be of identical size in order to bag the powder chambers, one in each dosing ring 1 must at the same time be able to be fed in a position for delivery. The inhaler in this case becomes a little thicker than am, as previously described, only a dosing ring 1 is used where two powder chambers are fed info! ' each new use case. The advantage is that in this way ten doses can fit in the inhaler without changing the outer area of the inhaler. However, the thickness of the inhaler increases slightly. The socket 11 in this example is arranged directly in the parts 25 closest above the powder chambers. One can imagine an openable element for conventional powder chambers as previously described. However, that example is not shown in this figure.

I likhet med luftkanalen 7a kan aven den ovre dosringen 2 vara utformad med en nagot sluttande undersida, atminstone vid omradet for respektive doskammare, sa att luftkanalen 7b bildar en gradvis okande tvarsnittsarea i luftstrommens riktning, for att uppna venturieffekt och darmed en effektivare utblasning av pulvret. 13 537 7 Figur 6A med tvarsnittet 6B visar pa en alternativ utforandeform av placeringen av pulverkamrarna 1 for att kunna mata fram dem minst tva i taget. Aven i detta exempel har tva dosringar 2 placerats intill eller pa varandra. Dosringarna 2 är i detta exempel placerade riktade mot varandra men anordnade pa visst avstand fran varandra sa att en luftkanal 7 bildas daremellan. Vid vane frammatning placeras [pada kamrarna i luftkanalsdelen 7a som i detta exempel ligger inkorporerad i inhalatorn snarare an att vara placerad utanpa sasom visas i Figur 1. Pulverkamrarna maste aven har ligga precis pa varandra och saledes maste dosringarna vara av identisk storlek fOr att bagge pulverkamrarna, en i respektive dosring 2 samtidigt ska kunna matas fram i lage for avgivning. Storleken pa inhalatorn blir identisk med det alternativ som forklarats i figur 3 med den skillnaden att ingen luftkanalsdel 7a är helt innesluten i inhalatorn. Tatningen 11 är i detta exempel anordnad direkt i holjesdelen narmast ovan pulverkamrarna. Man kan tanka sig ett Oppningsbart element sasom tidigare beskrivits. Dock visas inte det exemplet i denna figur. Like the air duct 7a, the upper metering ring 2 can also be formed with a slightly sloping underside, at least at the area of the respective metering chamber, so that the air duct 7b forms a gradually increasing cross-sectional area in the direction of air flow, to achieve venturi effect and thus more efficient blowout of the powder. . Figure 6A with the cross section 6B shows an alternative embodiment of the location of the powder chambers 1 in order to be able to feed them at least two at a time. Also in this example, two dosing rings 2 have been placed next to or on top of each other. The dosing rings 2 are in this example placed directed towards each other but arranged at a certain distance from each other so that an air duct 7 is formed therebetween. In the case of conventional feeding, the chambers of the air duct part 7a which in this example are incorporated in the inhaler are placed rather than being placed outside as shown in Figure 1. The powder chambers must also be exactly on top of each other and thus the dosing rings must be of identical size to bag the powder chambers. , one in the respective dosing ring 2 at the same time must be able to be fed in the stock for delivery. The size of the inhaler becomes identical to the alternative explained in Figure 3 with the difference that no air duct part 7a is completely enclosed in the inhaler. In this example, the socket 11 is arranged directly in the housing part closest to the powder chambers. One can imagine an openable element as previously described. However, that example is not shown in this figure.

Tatningen 11 är alltsa anordnad med en Oppning for att bilda luftkanalen 7 och tatningens sidokanter kan utformas med sneda ytor sa att luftkanalen 7 ges en storre area nedstroms an uppstroms pulverkamrarna. Harigenom uppnas en gradvis okande tvarsnittsarea i luftstrommens riktning, med den tekniska effekten att en venturieffekt och darmed en effektivare utblasning/utsugning av pulvret uppnas. The seal 11 is thus provided with an opening for forming the air duct 7 and the side edges of the seal can be formed with inclined surfaces so that the air duct 7 is given a larger area downstream of the upstream powder chambers. As a result, a gradually increasing cross-sectional area is obtained in the direction of the air stream, with the technical effect that a venturi effect and thus a more efficient blow-out / extraction of the powder is achieved.

Figur 7A med tvarsnittet 7B visar pa en alternativ utforandeform av placeringen av pulverkamrarna 1 for att kunna mata fram dem minst tva i taget. I detta exempel anvands en dosring 2 dar pulverkammare 1 har anordnats precis mitt emot varandra pa var sin sida av densamma. Vid varje frammatning placeras bagge pulverkamrarna 25 i luftkanalsdelarna 7a och7b som i detta exempel bestar av en upphojning pa bagge sidor av dosringen sa att de frammatade pulverkamrarna gar fria Iran sina respektive inneslutningar mellan ovre respektive undre 3, 4 holje och motsvarande sida av dosringen 2. Tjockleken pa inhalatorn blir formodligen aningen stbrre an som beskrivits i Figur 1 eftersom dosringen i detta exempel skall inrymma tva pulverkammare placerade mitt emot varandra. Tatningen 11 är i detta exempel anordnad direkt i holjesdelen narmast ovan pulverkamrarna. Man kan tanka sig ett bppningsbart element sasom tidigare beskrivits. Dock visas inte det exemplet i denna figur. 14 537 7 Figur 8A, B, C och D visar pa ytterligare utforandeformer av hur pulverkammare kan anordnas for att kunna matas fram minst tva i taget. Dosringar som tidigare beskrivits är inte det enda sattet att anordna pulverkamrarna for att de ska kunna matas fram minst tva at gangen. De hittills exemplifierade satten att placera pulverkamrarna 1 behover alltsa inte nadvandigtvis vara i en dosring 2. De kan vara placerade pa en remsa (typ blisterpack) sasom visas i figur 8C, en ring sasom i figur 8A eller i en oavbruten rad sasom visas i 8D. Figur 8B visar dock pa en dosring dar kamrarna har placerats utanfor respektive innanfor varandra sasom tidigare beskrivits i figur 4A och B. Figure 7A with the cross section 7B shows an alternative embodiment of the location of the powder chambers 1 in order to be able to feed them at least two at a time. In this example a dosing ring 2 is used where powder chamber 1 has been arranged exactly opposite each other on each side thereof. At each feed, the ram powder chambers 25 are placed in the air duct portions 7a and 7b which in this example consist of an elevation on the ram sides of the dose ring so that the feed powder chambers free their respective inclusions between the upper and lower 3, 4 casings and the corresponding side of the dose ring 2. The thickness of the inhaler will probably be slightly larger than described in Figure 1, since the dosing ring in this example will accommodate two powder chambers placed opposite each other. In this example, the socket 11 is arranged directly in the housing part closest to the powder chambers. One can imagine an openable element as previously described. However, that example is not shown in this figure. Figures 8A, B, C and D show further embodiments of how powder chambers can be arranged to be able to be fed at least two at a time. Dosage rings as previously described are not the only way to arrange the powder chambers so that they can be fed at least twice at a time. The methods exemplified so far for placing the powder chambers 1 do not necessarily have to be in a dosing ring 2. They can be placed on a strip (type blister pack) as shown in Figure 8C, a ring as in Figure 8A or in a continuous row as shown in 8D . Figure 8B, however, shows a dosing ring where the chambers have been placed outside and inside each other, respectively, as previously described in Figures 4A and B.

Figur 9 visar ett alternativt satt att lagga tatningen 22. lstallet for att som i figur 1 ha en separat tatning med Oppningsbara element kan den laggas exempelvis pa undersidan pa den ovre holjesdelen 3. Tatningen 22 for amnet i pulverkamrarna 1 är i detta exempel fast anordnad i hOjdled och är placerad i kontaktytan mellan dosringen 2 och den ovre holjesdelen 3. Tatningen 22 kan pa detta satt aven laggas mot den undre holjesdelen 4 exempelvis i det fall, som visas i figur 7, dar dosringen har pulverkammare 1 pa bagge sidor. Denna typ av tatning 22 kan forslagsvis astadkommas genom dubbelformsprutning och ges en mjuk yta. I detta exempel anvands inte oppningsbara element utan dosringen 2 glider mot tatningen 22 i kontaktytan vid vane frammatning. Figure 9 shows an alternative way of laying the seal 22. Instead of having a separate seal with openable elements as in Figure 1, it can be laid, for example, on the underside of the upper casing part 3. The seal 22 for the blank in the powder chambers 1 is fixedly arranged in this example. in height and is placed in the contact surface between the dosing ring 2 and the upper housing part 3. The seal 22 can in this way also be laid against the lower housing part 4, for example in the case shown in figure 7, where the dosing ring has powder chamber 1 on ram sides. This type of seal 22 can be proposed by double injection molding and given a soft surface. In this example, openable elements are not used, but the dosing ring 2 slides against the socket 22 in the contact surface during usual feeding.

Alternativt kan tatningen ocksa formsprutas att ligga integrerad direkt i dosringen(arna) mellan pulverkamrarna. Detta alternativ visas dock inte i figur 9. Alternatively, the seal can also be injection molded to be integrated directly in the dosing ring (s) between the powder chambers. However, this option is not shown in Figure 9.

Figur 10A och 10B visar hur en multidos-inhalatorn, med en eller flera dosringar, oppnas och, nar detta sker, hur de matas fram ett steg samt hur munstycket 6 frilaggs med hjalp av den i frammatningsarmen 14 integrerade 25 frammatningsmekanismen 5. Figures 10A and 10B show how a multi-dose inhaler, with one or more dose rings, is opened and, when this happens, how they are advanced one step and how the nozzle 6 is exposed by means of the feeding mechanism 5 integrated in the feed arm 14.

Beskrivningen ovan är i forsta hand avsedd att underlatta forstaelsen for uppfinningen och är naturligtvis inte begransad till de angivna utforingsformerna utan aven andra varianter av uppfinningen är mojliga och tankbara inom ramen for uppfinningstanken och efterfoljande patentkravs skyddsomfang. Salunda är det tankbart att i stallet for en cirkular dosring anvanda pulverkammare som anordnats i en rat linje, t.ex. i form av ett band, en rulle eller liknande! The above description is primarily intended to facilitate the understanding of the invention and is of course not limited to the stated embodiments, but also other variants of the invention are possible and conceivable within the scope of the inventive concept and the scope of the appended claims. Salunda, it is conceivable to use powder chambers arranged in a straight line instead of a circular dosing ring, e.g. in the form of a band, a roll or the like!

Claims (4)

537 7 PATENT KRAV537 7 PATENT CLAIMS 1. Multidos-inhalator for amnen i pulverform innefattande en dosring (2) med ett flertal foretradesvis i cirkel anordnade pulverkammare (1), avsedda for var sin dos pulverformat amne, - att en frammatningsmekanism (5) är anordnad att mata fram dosringen (2) i avsedd rorelseriktning, - att minst en tatning (11,22) är anordnad att tata pulverkamrarna (1) fran varandra och fran omgivningen for kvarhallande av pulverdoserna i respektive pulverkammare (1), kannetecknad av - att frammatningsmekanismen (5) är anordnad att mata fram dosringen (2) sá att minst tva pulverkammare (1), placerade sida vid sida sett i dosringens (2) rarelseriktning, at gangen farflyttas fram till ett lage far avgivning av pulverdoserna, - att en luftkanal (7) innefattande minst en luftkanalsdel (7a,b) är anordnad i laget for de pulverkammare (1) som frammatats, - att luftkanalen (7) eller dess delar (7a,b) är anordnade sá att dess/deras inre langd och bredd vasentligen tacker de minst tva pulverkamrarnas (1) oppningsarea for att sakerstalla att dessa i sin helhet kan exponeras mot luftkanalen (7) eller dess luftkanalsdelar (7a,b) och for det luftflode som uppstar dari vid inhalation, - att luftkanalen (7) eller dess luftkanalsdelar (7a,b) är anordnad/e att medge att de minst tva pulverkamrarna (1) vid inhalation oppnas vasentligen samtidigt mot luftkanalen (7), pa grund av det undertryck som bildas av luftflodet, sá att pulverkamrarna (1) och deras pulverdoser exponeras mot luftkanalen (7) varigenom pulverdoserna tillats passera ut genom luftkanalen (7) och blandas med varandra med hjalp av luftflodet, - att tatningen (11) är anordnad med minst ett oppningsbart element (12) vilket eller vilka är anordnat/anordnade att vasentligen samtidigt oppna och exponera minst tva pulverkammare (1) at gangen mot luftkanalen (7) i laget for avgivning av pulverdoserna, dá det oppningsbara elementet eller elementen utsatts for namnda undertryck, varvid pulverkamrarnas pulverdoser kan passera ut genom luftkanalen (7). 16 537 7A multidose inhaler for the powdered substance comprising a dosing ring (2) with a plurality of preferably circular chambers (1) arranged in a circle, each for a dose of powdered substance, - that a feeding mechanism (5) is arranged to feed the dosing ring (2). ) in the intended direction of movement, - that at least one seal (11, 22) is arranged to seal the powder chambers (1) from each other and from the environment for retaining the powder doses in the respective powder chamber (1), characterized in that - the feed mechanism (5) is arranged to feed the dosing ring (2) so that at least two powder chambers (1), placed side by side seen in the direction of dosing of the dosing ring (2), move at a time to a low delivery of the powder doses, - that an air duct (7) comprising at least one air duct part (7a, b) are arranged in the layer of the powder chambers (1) which are fed, - that the air duct (7) or its parts (7a, b) are arranged so that its / their inner length and width substantially thank the at least two powder chambers ( 1) opening to ensure that these can be exposed in their entirety to the air duct (7) or its air duct parts (7a, b) and to the air flow arising therefrom during inhalation, - that the air duct (7) or its air duct parts (7a, b) are arranged / e to allow the at least two powder chambers (1) to be opened substantially simultaneously against the air duct (7), due to the negative pressure formed by the air flow, so that the powder chambers (1) and their powder doses are exposed to the air duct (7) whereby the powder doses allowed to pass out through the air duct (7) and mixed with each other by means of the air flow, - that the seal (11) is arranged with at least one openable element (12) which or are arranged to substantially simultaneously open and expose at least two powder chambers ( 1) that the passage towards the air duct (7) in the layer for dispensing the powder doses, when the openable element or elements are subjected to said negative pressure, whereby the powder doses of the powder chambers can pass out through the air duct (7). 16 537 7 2. Multidos-inhalator enligt patentkrav 1, kannetecknad av - att luftkanalsdelen (7a,b), är anordnad med en gradvis okande tvarsnittsarea sett i luftens flodesriktning, dvs sá att tvarsnittsarean uppstroms i ett forsta omrade är mindre an tvarsnittsarean nedstroms i ett andra omrade, sa att ett undertryck, eller en s.k. venturieffekt, uppstar i omradet vid det eller de oppningsbara elementen (12) och medverkar att Oppna detta/dessa.Multidose inhaler according to claim 1, characterized in that - the air duct part (7a, b) is provided with a gradually increasing cross-sectional area seen in the flow direction of the air, i.e. so that the cross-sectional area upstream in a first area is smaller than the cross-sectional area downstream in a second area , said that a negative pressure, or a so-called venturi effect, arises in the area at the opening element (s) (12) and helps to open this / these. 3. Multidos-inhalator enligt patentkrav 1, kannetecknad av - att tatningen (11) är anordnad att forflyttas med dosringen (2) och forsedd med ett antal oppningsbara element (12) svarande mot halva antalet pulverkammare (1) i dosringen (2). 4. Multidos-inhalator enligt patentkrav 1, kannetecknad av - att luftkanalsdelen (7a), i omradet vid dosringen (2) med dess pulverkammare (1) och oppningsbara element (12) är anordnad med en strypning (20) eller en gradvis okande tvarsnittsarea, sett i luftens flodesriktning, dvs sá att tvarsnittsarean i ett forsta omrade är mindre an tvarsnittsarean i ett andra omrade, sá att ett undertryck eller en s.k. venturieffekt uppstar i omradet vid de i detta lage exponerade oppningsbara elementen (12) och medverkar till att Oppna detta/dessa. 5. Multidos-inhalator enligt nagot av faregaende patentkrav, kannetecknad av - att luftkanalsdelens (7a) langd och bredd, vid rotationslaget kir avgivning av pulverdosen, är anordnad att minst tacka ytan av det eller de i detta lage exponerade oppningsbara elementen (12). 17 537 7 6. Multidos-inhalator enligt nagot av foregaende patentkrav, kannetecknad av - att tatningen (11) vid omradet for luftkanalen (7) är anordnad med sneda sidokanter i syfte att uppna en gradvis okande tvarsnittsarea i luftstrommens riktning, med den tekniska effekten att en venturieffekt och darmed en effektivare utblasning/utsugning av pulvret uppnas. 7. Multidos-inhalator enligt nagot av foregaende patentkrav, kannetecknad av - att dosringarna (2) är anordnade intill, men pa avstand fran, varandra. 18 537 7 tv,\ot LU 537 7 NJ I-A NJ N.) 537 7 537 7 I-1 1-1I-1 NJ IV 1-1 -n 537 7 Co cri 1-4 1. " oo 7 cr7.1 01 537 7 LI „ ... .,.\.,. ...... ..., /''\ 1-1[ 1, iv< 0..-/...3 rs. CO4Multi-dose inhaler according to claim 1, characterized in that - the socket (11) is arranged to be moved with the dosing ring (2) and provided with a number of openable elements (12) corresponding to half the number of powder chambers (1) in the dosing ring (2). Multi-dose inhaler according to claim 1, characterized in that - in the area of the dosing ring (2) with its powder chamber (1) and openable elements (12), the air duct part (7a) is arranged with a choke (20) or a gradually increasing cross-sectional area. , seen in the flow direction of the air, ie so that the cross-sectional area in a first area is smaller than the cross-sectional area in a second area, so that a negative pressure or a so-called venturi effect arises in the area at the openable elements (12) exposed in this layer and contributes to opening this / these. A multidose inhaler according to any one of the preceding claims, characterized in that - the length and width of the air duct part (7a), at the rotational stroke and delivery of the powder dose, are arranged to at least thank the surface of the openable element (12) exposed therein. A multidose inhaler according to any one of the preceding claims, characterized in that - the seal (11) at the area of the air duct (7) is arranged with oblique side edges in order to achieve a gradually increasing cross-sectional area in the direction of the air stream, with the technical effect that a venturi effect and thus a more efficient blowing / extraction of the powder is achieved. A multidose inhaler according to any one of the preceding claims, characterized in that the dosing rings (2) are arranged next to, but at a distance from, each other. 18 537 7 tv, \ ot LU 537 7 NJ IA NJ N.) 537 7 537 7 I-1 1-1I-1 NJ IV 1-1 -n 537 7 Co cri 1-4 1. "oo 7 cr7.1 01 537 7 LI „....,. \.,. ...... ..., / '' \ 1-1 [1, iv <0 ..- / ... 3 rs. CO4 4. ., .. - ' 4 7 1/4,01.4.1....................a./I/I, '714.., .. - '4 7 1 / 4,01.4.1 .................... a./I/I, '71